Immunologic and virologic findings in a bull chronically infected with noncytopathic bovine viral diarrhea virus

In February 1985, a 2-year-old bull with inappetence and weight loss of 1-week duration was examined by the field services staff of the Iowa State University College of Veterinary Medicine. The bull had a normal rectal temperature, decreased rumen activity, and loose feces and walked with a stiff gait. The hemogram was normal for hemoglobin concentration, PCV, and total plasma protein concentration, but the bull had a leukopenia which was primarily attributable to an absolute lymphopenia. Treatment consisted of antimicrobial drugs, an antidiarrheal medication, and a nonsteroidal anti-inflammatory and analgesic drug. After 3 weeks without improvement, the bull was admitted to the Iowa State University Large Animal Hospital

Experimental Reproduction of Severe Disease in CD/CD Pigs Coinfected with PRRSV and Type 2 Porcine Circovirus

Postweaning multisystemic wasting syndrome (PMWS) has been recognized worldwide and is characterized clinically by wasting, dyspnea, and occasionally by icterus in nursery and grow-finish pigs. Type 2 porcine circovirus (PCV2) is consistently demonstrated in PMWS lesions. At the Iowa State University Veterinary Diagnostic Laboratory, both porcine reproductive and respiratory syndrome virus (PRRSV) and PCV2 are detected in tissues from most cases of PMWS. Since PRRSV-PCV2 coinfection has also been associated with “atypical PRRS” hepatitis, 3 week old cesarean-derived, colostrum-deprived (CD/CD) pigs were inoculated with PRRSV, PCV2, both PRRSV and PCV2, or uninfected cell culture media in order to compare the independent and combined effects of these agents. PRRSV-inoculated pigs developed respiratory distress and interstitial pneumonia typical of that previously reported for this agent. None of the pigs in the PRRSV or control groups became moribund or developed hepatitis. PCV2-inoculated pigs developed lymphoid depletion and sporadic hepatitis associated with 40% mortality. Pigs in the PRRSV/PCV2 group developed severe and persistent pyrexia and dyspnea; mortality between 10 and 20 days was \u3e90% and was associated with severe interstitial pneumonia and/or hepatitis. We conclude that 1) PCV2 alone can induce clinical disease and lesions of PMWS in CD/CD pigs, 2) PCV2 alone does not induce significant respiratory disease in CD/CD pigs, 3) PCV2/PRRSV coinfection induces more severe clinical disease and lesions of PMWS than PCV2 alone, including severe interstitial pneumonia, and 4) PCV2 coinfection is responsible for the hepatitis associated with cases of “atypical PRRS.” Simultaneous coinfection of PRRSV and PCV2 has the potential to significantly exacerbate morbidity and mortality. The timing of exposure and decay of maternal antibody to PCV2 and other pathogens may play a critical role in determining whether PCV2 infection induces PMWS or remains subclinical

Spanning Boundaries in an Arizona Watershed Partnership: Information Networks as Tools for Entrenchment or Ties for Collaboration?

The need to develop successful collaborative strategies is an enduring problem in sustainable resource management. Our goal is to evaluate the relationship between information networks and conflict in the context of collaborative groundwater management in the rapidly growing central highland region of Arizona. In this region, water-management conflicts have emerged because of stakeholders’ differing geographic perspectives and competing scientific claims. Using social network analyses, we explored the extent to which the Verde River Basin Partnership (VRBP), which was charged with developing and sharing scientific information, has contributed to collaboration in the region. To accomplish this, we examined the role that this stakeholder partnership plays in reinforcing or overcoming the geographic, ideological, expert, and power conflicts among its members. Focusing on information sharing, we tested the extent to which several theoretically important elements of successful collaboration were evidenced by data from the VRBP. The structure of information sharing provides insight into ways in which barriers between diverse perspectives might be retained and elucidates weaknesses in the partnership. To characterize information sharing, we examined interaction ties among individuals with different geographic concerns, hierarchical scales of interest, belief systems (about science, the environment, and the role of the partnership), and self-identified expertise types. Results showed that the partnership’s information-sharing network spans most of these boundaries. Based on current theories of collaboration, we would expect the partnership network to be conducive to collaboration. We found that information exchanges are limited by differences in connection patterns across actor expertise and environmental-belief systems. Actors who view scientists as advocates are significantly more likely to occupy boundary-spanning positions, that appear to impede the success of the partnership. This analysis challenges widely held assumptions about the properties that separate successful collaborations from those that are less successful. It has implications for our understanding of the factors that constrain information processing, knowledge production, and collective-action capability in institutions

Discovery Investigative Group (DIG) Report, December 2016

This report is a response to the following charge from project sponsor DeeAnn Allison: Develop a working definition of the purpose and scope for a discovery tool that includes a description of what it should accomplish. How will it help scholars connect with information? The charge included a request to answer seven questions: 1. What content should be included and why? 2. What functions or search capabilities should be included? 3. What social media enhancements should be included? 4. How can it be structured to help both novice and advanced researchers? 5. Can you identify a “perfect” tool? If not, which ones are better and why? 6. Should we abandon Encore? Why or Why not? 7. What is the relation, or non-relation to Google products? Is a discovery tool just a variation of Google? Should it be? Over the course of the Fall 2016 semester, DIG committee members, comprised of seven Libraries faculty who voluntarily participated, met frequently to discuss the charge and determine how to best answer each question. Our answers were ultimately informed through a combination of reviewing the current literature, investigating peer institutions’ search tools, soliciting feedback from our library colleagues through a library-wide survey, and the committee members’ own insights. The responses to each of the following questions are a reflection of the consensus of the DIG committee members

Evaluation of a commercial E(rns)-capture ELISA for detection of BVDV in routine diagnostic cattle serum samples

BACKGROUND: Bovine viral diarrhoea virus (BVDV) is an important pathogen in cattle. The ability of the virus to cross the placenta during early pregnancy can result in the birth of persistently infected (PI) calves. These calves shed the virus during their entire lifespan and are the key transmitters of infection. Consequently, identification (and subsequent removal) of PI animals is necessary to rapidly clear infected herds from the virus. The objective of this study was to evaluate the suitability of a commercial E(rns)-capture ELISA, in comparison to the indirect immunoperoxidase test (IPX), for routine diagnostic detection of BVDV within a control programme. In addition, the effect of passive immunity and heat-inactivation of the samples on the performance of the ELISA was studied. METHODS: In the process of virus clearance within the Swedish BVDV control programme, all calves born in infected herds are tested for virus and antibodies. From such samples, sent in for routine diagnostics to SVA, we selected 220 sera collected from 32 beef herds and 29 dairy herds. All sera were tested for BVDV antigen using the E(rns )ELISA, and the results were compared to the results from the IPX used within the routine diagnostics. RESULTS: All 130 samples categorized as virus negative by IPX were tested negative in the ELISA, and all 90 samples categorized as virus positive were tested positive, i.e. the relative sensitivity and specificity of the ELISA was 100% in relation to IPX, and the agreement between the tests was perfect. CONCLUSION: We can conclude that the E(rns )ELISA is a valid alternative that has several advantages compared to IPX. Our results clearly demonstrate that it performs well under Swedish conditions, and that its performance is comparable with the IPX test. It is highly sensitive and specific, can be used for testing of heat-inactivated samples, precolostral testing, and probably to detect PI animals at an earlier age than the IPX

Discovery Investigative Group (DIG) Report, December 2016

This report is a response to the following charge from project sponsor DeeAnn Allison: Develop a working definition of the purpose and scope for a discovery tool that includes a description of what it should accomplish. How will it help scholars connect with information? The charge included a request to answer seven questions: 1. What content should be included and why? 2. What functions or search capabilities should be included? 3. What social media enhancements should be included? 4. How can it be structured to help both novice and advanced researchers? 5. Can you identify a “perfect” tool? If not, which ones are better and why? 6. Should we abandon Encore? Why or Why not? 7. What is the relation, or non-relation to Google products? Is a discovery tool just a variation of Google? Should it be? Over the course of the Fall 2016 semester, DIG committee members, comprised of seven Libraries faculty who voluntarily participated, met frequently to discuss the charge and determine how to best answer each question. Our answers were ultimately informed through a combination of reviewing the current literature, investigating peer institutions’ search tools, soliciting feedback from our library colleagues through a library-wide survey, and the committee members’ own insights. The responses to each of the following questions are a reflection of the consensus of the DIG committee members

The interaction effect of gender and residential environment, individual resources, and needs satisfaction on quality of life among older adults in the UK

Objectives: To examine the difference in gender and its impact on selected quality of life (QoL) domains of Social Production Function Theory among older adults in England. Methods: Based on an annual national adult social care service user survey conducted in the UK in 2016. QoL was assessed by a single-item construct and independent variables were home design, access to information and local area, self-rated health, perceived pain/discomfort, perceived anxiety/depression, activities of daily living, use and satisfaction of formal and informal care, and demographic variables. Results: 28,955 respondents aged 65+ were interviewed. Multinomial logistic regression analysis found four interaction effects for predicting a very good/good QoL: (1) Female receiving non-co-residing informal care (OR=1.501, p<.01), (2) Female feeling safe (OR=1.499, p<.01), (3) Female feeling satisfied with social contact with people (OR=1.465, p<.05), and (4) Female being helped in the use of time (OR=1.370, p<.05). Conclusion: Findings suggest gender differences in QoL as men and women are heterogenous with different health and disease patterns, health-/help-seeking behaviours, roles and responsibilities, and levels of resilience, needs, risks, and access and control resources. Practitioners should adopt a gender-specific assessment and personalised interventions to promote gender equality, empowerment, and long-term sustainable development for an ageing society.Peer reviewe

An interdisciplinary system dynamics model for post-disaster housing recovery

Many previous disasters have demonstrated the need for extensive personal, public, and governmental expenditures for housing recovery highlighting the importance of studying housing recovery. Yet, much research is still needed to fully understand the multi-faceted and complex nature of housing recovery. The goal of this paper is to present a holistic model to further the understanding of the dynamic processes and interdependencies of housing recovery. The impetus for this work is that inequalities in housing recovery could be addressed more effectively if we better understood interconnected factors and dynamic processes that slow down recovery for some. Currently, there is a lack of understanding about such factors and processes. Literature from engineering and social sciences was reviewed to develop an integrated system dynamics model for post-disaster housing recovery. While it is beyond current capabilities to quantify such complexities, the presented model takes a major stride toward articulating the complex phenomenon that is housing recovery

A Human Development Framework for CO2 Reductions

Although developing countries are called to participate in CO2 emission reduction efforts to avoid dangerous climate change, the implications of proposed reduction schemes in human development standards of developing countries remain a matter of debate. We show the existence of a positive and time-dependent correlation between the Human Development Index (HDI) and per capita CO2 emissions from fossil fuel combustion. Employing this empirical relation, extrapolating the HDI, and using three population scenarios, the cumulative CO2 emissions necessary for developing countries to achieve particular HDI thresholds are assessed following a Development As Usual approach (DAU). If current demographic and development trends are maintained, we estimate that by 2050 around 85% of the world's population will live in countries with high HDI (above 0.8). In particular, 300Gt of cumulative CO2 emissions between 2000 and 2050 are estimated to be necessary for the development of 104 developing countries in the year 2000. This value represents between 20% to 30% of previously calculated CO2 budgets limiting global warming to 2{\deg}C. These constraints and results are incorporated into a CO2 reduction framework involving four domains of climate action for individual countries. The framework reserves a fair emission path for developing countries to proceed with their development by indexing country-dependent reduction rates proportional to the HDI in order to preserve the 2{\deg}C target after a particular development threshold is reached. Under this approach, global cumulative emissions by 2050 are estimated to range from 850 up to 1100Gt of CO2. These values are within the uncertainty range of emissions to limit global temperatures to 2{\deg}C.Comment: 14 pages, 7 figures, 1 tabl