3,877 research outputs found
Fluctuations in depression and well-being are associated with sexual risk episodes among HIV-positive men
Peer reviewedPostprin
Investigating mechanisms of social support effectiveness: The case of locomotion motivation
Although social support can entail costs, individuals with a higher locomotion orientation, who are motivated to move and take action, benefit from support. In two dyadic studies, we tested whether perceived movement towards important goals would mediate the effect of recipients’ locomotion motivation on positive outcomes in support contexts. In Study 1, couples completed a 10-day diary and then recalled support interactions with their partner after the diary period. In Study 2, couples engaged in laboratory support interactions for important goals. Perceived goal movement mediated the effect of higher (vs. lower) locomotion on self-reported ratings and coder ratings of support outcomes. Higher locomotion recipients may benefit in support contexts because they perceive they can move smoothly towards their goals
Rapid screening of environmental chemicals for estrogen receptor binding capacity.
Over the last few years, an increased awareness of endocrine disrupting chemicals (EDCs) and their potential to affect wildlife and humans has produced a demand for practical screening methods to identify endocrine activity in a wide range of environmental and industrial chemicals. While it is clear that in vivo methods will be required to identify adverse effects produced by these chemicals, in vitro assays can define particular mechanisms of action and have the potential to be employed as rapid and low-cost screens for use in large scale EDC screening programs. Traditional estrogen receptor (ER) binding assays are useful for characterizing a chemical's potential to be an estrogen-acting EDC, but they involve displacement of a radioactive ligand from crude receptor preparations at low temperatures. The usefulness of these assays for realistically determining the ER binding interactions of weakly estrogenic environmental and industrial compounds that have low aqueous solubility is unclear. In this report, we present a novel fluorescence polarization (FP) method that measures the capacity of a competitor chemical to displace a high affinity fluorescent ligand from purified, recombinant human ER-[alpha] at room temperature. The ER-[alpha] binding interactions generated for 15 natural and synthetic compounds were found to be similar to those determined with traditional receptor binding assays. We also discuss the potential to employ this FP technology to binding studies involving ER-ss and other receptors. Thus, the assay introduced in this study is a nonradioactive receptor binding method that shows promise as a high throughput screening method for large-scale testing of environmental and industrial chemicals for ER binding interactions
SEASONALITY OF BIRD STRIKES: TOWARDS A BEHAVIOURAL EXPLANATION
It is well known that, at least in the Northern Hemisphere, there is a strong seasonal element in the annual pattern of bird strikes. This study undertakes a statistical analysis of an 11year data set collected at Dublin Airport, Ireland. It attempts to identify statistically significant trends in the seasonal trajectories of bird strikes, both in general and in respect of individual species and in comparison with seasonal trends in the abundance of birds generally and at Dublin Airport in particular. Hypotheses relating to the idea of “open” (i.e. intervals of through-put of naïve and young birds) and “closed” (i.e. intervals when throughput is declining or at a minimum) periods are tested. The results are discussed in the context of the probable ability of birds to learn to avoid aircraft. If birds possess a spatio-temporal memory then it is likely that this ability, or the lack of it, may explain some of the observed trends in the seasonal distribution of bird strikes
Учебная история болезни по внутренним болезням и военно-полевой терапии
ВНУТРЕННИЕ БОЛЕЗНИВОЕННО-ПОЛЕВАЯ ТЕРАПИЯИСТОРИЯ БОЛЕЗНИМЕТОДИЧЕСКИЕ УКАЗАНИЯМетодические указания учат студентов правильно оформлять историю болезни пациента
The Wdr1-LIMK-Cofilin axis controls B cell antigen receptor-induced actin remodeling and signaling at the immune synapse
Quantum Monte Carlo Calculations of Pion Scattering from Li
We show that the neutron and proton transition densities predicted by recent
quantum Monte Carlo calculations for A=6,7 nuclei are consistent with pion
scattering from 6Li and 7Li at energies near the Delta resonance. This has
provided a microscopic understanding of the enhancement factors for quadrople
excitations, which were needed to describe pion inelastic scattering within the
nuclear shell model of Cohen and Kurath.Comment: 10 pages, REVTeX, 3 postscript figures; added calculation of elastic
and inelastic pion scattering from 6Li at multiple energie
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