The Introduction of DTT in Latin America: Politics and Policies

The switch to digital terrestrial television is now a global trend. In Latin America, where the terrestrial platform has a dominant role, the introduction of DTT raises important questions for economic and industrial development, as well as pluralism. This article focuses on the earliest experiences (Brazil, México and Argentina) and those of the newcomers (Chile, Colombia and Uruguay). The aim is to outline the differences between the various political decision processes and the way with which they have been turned into communication policies, so as to draw some conclusions that contribute to visualizing the future of television in the region.Publicad

Ciencia de datos como herramienta de soporte en la gestión pública de calidad del agua

El agua es un recurso vital y como tal requiere una adecuada gestión de su calidad para la subsistencia de la población en todas sus dimensiones. En la provincia de Misiones, existen varias organizaciones que intervienen de alguna manera en la gestión de la calidad del agua, aunque se encuentran limitados respecto de la generación de información adecuada para la gestión, pese a esfuerzos individuales de algunas de estas organizaciones. La gestión de calidad del agua es un proceso que requiere datos. Estos datos son generados a un alto costo, ya que cada estudio implica un traslado al lugar donde se realizan las muestras, gastos en recursos humanos, y gastos en el análisis de las propiedades del agua para determinar su calidad, entre otros. En esta línea de investigación se aborda la aplicación de procesos de ciencia de datos que podrían contribuir en la generación de información dirigida a la gestión de calidad del agua. A través de un análisis descriptivo se determinaron parámetros asociados a la calidad del agua, destacándose la temperatura, turbidez, conductividad, pH, P-ortoFosfatos, solidos disueltos totales, oxígeno disuelto, sólidos suspendidos totales y coliformes fecales. Asimismo, se evidencia la necesidad de ampliar el desarrollo de conjuntos de datos que integren variables relevantes para la gestión de la calidad del agua.Red de Universidades con Carreras en Informátic

Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors

In this work, we are reporting that “Shock and Kill”, a therapeutic approach designed to eliminate latent HIV from cell reservoirs, is extrapolatable to cancer therapy. This is based on the observation that malignant cells express a spectrum of human endogenous retroviral elements (HERVs) which can be transcriptionally boosted by HDAC inhibitors. The endoretroviral gene HERV-V2 codes for an envelope protein, which resembles syncytins. It is significantly overexpressed upon exposure to HDAC inhibitors and can be effectively targeted by simultaneous application of TLR7/8 agonists, triggering intrinsic apoptosis. We demonstrated that this synergistic cytotoxic effect was accompanied by the functional disruption of the TLR7/8-NFκB, Akt/PKB, and Ras-MEK-ERK signalling pathways. CRISPR/Cas9 ablation of TLR7 and HERV-V1/V2 curtailed apoptosis significantly, proving the pivotal role of these elements in driving cell death. The effectiveness of this new approach was confirmed in ovarian tumour xenograft studies, revealing a promising avenue for future cancer therapies

From intentions to births: Gendered paths of realization in a multi-dimensional life course perspectives.

In the literature pregnancy intentions are studied in isolation from intentions pertaining to other spheres of life. In this paper, we overcome this gap and investigate birth intentions and subsequent outcomes in a context of multiple life course domains encompassing partnership, education, work and residence. Using longitudinal data from the Household and Labour Dynamics in Australia (HILDA), we examine the matching processes of birth intentions and outcomes separately for women and men under the assumption that life courses are gendered. Results show that adults do often have multidimensional plans and that intentions other than childbearing facilitate or hinder the realisation of fertility intentions depending on whether they are expressed by men or women. Planning to move in a new dwelling is functional to the realization of birth intentions if expressed by men while other intentions, like changing job, or resuming studies, hinder childbearing only if they are stated by women. Finally, having a cohabiting relationship is a pre-condition for the realization of childbearing intentions for both men and women. The findings provide a new interpretation of the gap between intended and actual fertility and a new explanation of the fact that birth intentions remain often unrealised

The Heterogeneity of Disability Trajectories in Later Life: Dynamics of Activities of Daily Living Performance Among Nursing Home Residents.

Objective: This study investigated the variability in activities of daily living (ADL) trajectories among 6,155 nursing home residents using unique and rich observational data. Method: The impairment in ADL performance was considered as a dynamic process in a multi-state framework. Using an innovative mixture model, such states were not defined a priori but inferred from the data. Results: The process of change in functional health differed among residents. We identified four latent regimes: stability or slight deterioration, relevant change, variability, and recovery. Impaired body functions and poor physical performance were main risk factors associated with degradation in functional health. Discussion: The evolution of disability in later life is not completely gradual or homogeneous. Steep deterioration in functional health can be followed by periods of stability or even recovery. The current condition can be used to successfully predict the evolution of ADL allowing to set and target different care priorities and practices