Analysis of Laser ARPES from Bi2_2Sr2_2CaCu2_2O8+δ_{8+\delta} in superconductive state: angle resolved self-energy and fluctuation spectrum

We analyze the ultra high resolution laser angle resolved photo-emission spectroscopy (ARPES) intensity from the slightly underdoped Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ in the superconductive (SC) state. The momentum distribution curves (MDC) were fitted at each energy \w employing the SC Green's function along several cuts perpendicular to the Fermi surface with the tilt angle $\theta$ with respect to the nodal cut. The clear observation of particle-hole mixing was utilized such that the complex self-energy as a function of $\omega$ is directly obtained from the fitting. The obtained angle resolved self-energy is then used to deduce the Eliashberg function \alpha^2 F^{(+)}(\th,\w) in the diagonal channel by inverting the d-wave Eliashberg equation using the maximum entropy method. Besides a broad featureless spectrum up to the cutoff energy $\omega_c$, the deduced $\alpha^2 F$ exhibits two peaks around 0.05 eV and 0.015 eV. The former and the broad feature are already present in the normal state, while the latter emerges only below $T_c$. Both peaks become enhanced as $T$ is lowered or the angle $\th$ moves away from the nodal direction. The implication of these findings are discussed.Comment: 7 pages, 5 figures, summited to PR

Secondary Metabolic Gene Cluster Silencing in Aspergillus Nidulans

In contrast to most primary metabolism genes, the genes involved in secondary metabolism and certain nutrient utilization pathways are clustered in fungi. Recently a nuclear protein, LaeA, was found to be required for the transcription of several secondary metabolite gene clusters in Aspergillus nidulans. Here we show that LaeA regulation does not extend to nutrient utilization or the spoC1 sporulation clusters. One of the secondary metabolite clusters regulated by LaeA contains the positive regulatory (i.e. aflR) and biosynthetic genes required for biosynthesis of sterigmatocystin (ST), a carcinogenic toxin. Analysis of ST gene cluster expression indicates LaeA regulation of the cluster is location specific as transcription of genes bordering the ST cluster are unaffected in a ΔlaeA mutant and placement of a primary metabolic gene, argB, in the ST cluster resulted in argB silencing in the ΔlaeA background. ST cluster gene expression was remediated when an additional copy of aflR was placed outside of the cluster but not when placed in the cluster. Site-specific mutation of an s-adenosyl methionine (AdoMet) binding site in LaeA generated a ΔlaeA phenotype suggesting the protein to be a methyltransferase

Analysis of two pairing-based three-party password authenticated key exchange protocols

Password-Authenticated Key Exchange (PAKE) protocols allow parties to share secret keys in an authentic manner based on an easily memorizable password. Recently, Nam et al. showed that a provably secure three-party password-based authenticated key exchange protocol using Weil pairing by Wen et al. is vulnerable to a man-in-the-middle attack. In doing so, Nam et al. showed the flaws in the proof of Wen et al. and described how to fix the problem so that their attack no longer works. In this paper, we show that both Wen et al. and Nam et al. variants fall to key compromise impersonation by any adversary. Our results underline the fact that although the provable security approach is necessary to designing PAKEs, gaps still exist between what can be proven and what are really secure in practice

The velocity distribution of nearby stars from Hipparcos data II. The nature of the low-velocity moving groups

The velocity distribution of nearby stars contains many "moving groups" that are inconsistent with the standard assumption of an axisymmetric, time-independent, and steady-state Galaxy. We study the age and metallicity properties of the low-velocity moving groups based on the reconstruction of the local velocity distribution in Paper I of this series. We perform stringent, conservative hypothesis testing to establish for each of these moving groups whether it could conceivably consist of a coeval population of stars. We conclude that they do not: the moving groups are not trivially associated with their eponymous open clusters nor with any other inhomogeneous star formation event. Concerning a possible dynamical origin of the moving groups, we test whether any of the moving groups has a higher or lower metallicity than the background population of thin disk stars, as would generically be the case if the moving groups are associated with resonances of the bar or spiral structure. We find clear evidence that the Hyades moving group has higher than average metallicity and weak evidence that the Sirius moving group has lower than average metallicity, which could indicate that these two groups are related to the inner Lindblad resonance of the spiral structure. Further we find weak evidence that the Hercules moving group has higher than average metallicity, as would be the case if it is associated with the bar's outer Lindblad resonance. The Pleiades moving group shows no clear metallicity anomaly, arguing against a common dynamical origin for the Hyades and Pleiades groups. Overall, however, the moving groups are barely distinguishable from the background population of stars, raising the likelihood that the moving groups are associated with transient perturbations. [abridged

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.

BackgroundHyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate of metabolism through glycolytic pathways in human prostate cancer. Heretofore this imaging modality has been successfully utilized in prostate cancer only in localized disease. This pilot clinical study investigated the feasibility and imaging performance of HP 13C-pyruvate MR metabolic imaging in prostate cancer patients with metastases to the bone and/or viscera.MethodsSix patients who had metastatic castration-resistant prostate cancer were recruited. Carbon-13 MR examination were conducted on a clinical 3T MRI following injection of 250 mM hyperpolarized 13C-pyruvate, where pyruvate-to-lactate conversion rate (kPL) was calculated. Paired metastatic tumor biopsy was performed with histopathological and RNA-seq analyses.ResultsWe observed a high rate of glycolytic metabolism in prostate cancer metastases, with a mean kPL value of 0.020 ± 0.006 (s-1) and 0.026 ± 0.000 (s-1) in bone (N = 4) and liver (N = 2) metastases, respectively. Overall, high kPL showed concordance with biopsy-confirmed high-grade prostate cancer including neuroendocrine differentiation in one case. Interval decrease of kPL from 0.026 at baseline to 0.015 (s-1) was observed in a liver metastasis 2 months after the initiation of taxane plus platinum chemotherapy. RNA-seq found higher levels of the lactate dehydrogenase isoform A (Ldha,15.7 ± 0.7) expression relative to the dominant isoform of pyruvate dehydrogenase (Pdha1, 12.8 ± 0.9).ConclusionsHP 13C-pyruvate MRI can detect real-time glycolytic metabolism within prostate cancer metastases, and can measure changes in quantitative kPL values following treatment response at early time points. This first feasibility study supports future clinical studies of HP 13C-pyruvate MRI in the setting of advanced prostate cancer

Behavioural evidence for polychromatic ultraviolet sensitivity in mantis shrimp

Stomatopod crustaceans are renowned for their elaborate visual systems. Their eyes contain a plethora of photoreceptors specialized for chromatic and polarization detection, including several that are sensitive to varying wavelength ranges and angles of polarization within the ultraviolet (UV) range (less than 400 nm). Behavioural experiments have previously suggested that UV photoreception plays a role in stomatopod communication, but these experiments have only manipulated the entire UV range. Here, using a behavioural approach, we examine UV vision in the stomatopod Haptosquilla trispinosa Using binary trained choice assays as well as innate burrow-choice experiments, we assessed the ability of H. trispinosa to detect and respond to narrow-band LED stimuli peaking near 314 nm (UVB) versus 379 nm (UVA) in wavelength. We find that H. trispinosa can discriminate these stimuli and appears to display an aversive reaction to UVB light, suggesting segregated behavioural responses to stimuli within the UV range. Furthermore, we find that H. trispinosa can discriminate stimuli peaking near 379 nm versus 351 nm in wavelength, suggesting that their wavelength discrimination in the UV is comparable to their performance in the human-visible range