T-cell/Histiocyte-rich Large B-cell Lmphoma in Pediatric Patients: a Reported Case of a 16-year-old Patient in Clinical Haematology Department of the University Teaching Hospital of Yopougon (Abidjan-Ivory Coast)

T-cell/Histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare pathology, uncommon in children population and the few cases reported, had wide range clinical presentations, including advanced stage, extranodal involvement and bad prognosis. Authors report a case of a 16-year-old male patient with no medical history, who presented a single left axillary adenopathy. T-cell/Histiocyte-rich large B-cell lymphoma was diagnosed by immunohistochemistry and was classified good prognosis. A RCHOP-based chemotherapy was performed with good progress. Authors hope to contribute to the literature on THRLBCL and draw the attention of practitioners to its occurrence in the pediatric population

T-cell/Histiocyte-rich Large B-cell Lymphoma in an Adolescent from Abidjan-Ivory Coast: Case Report

T-cell/Histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare pathology, uncommon in the children population, and the few cases reported had a wide range of clinical presentations, including advanced stage, extranodal involvement, and bad prognosis. The authors report a case of a 16-year-old male patient with no medical history, who presented a single left axillary adenopathy. T-cell/Histiocyte-rich large B-cell lymphoma was diagnosed by immunohistochemistry and was classified good prognosis. RCHOP-based chemotherapy was performed with good progress. The authors hope to contribute to the literature on THRLBCL and draw the attention of practitioners to its occurrence in the pediatric population

T-cell/Histiocyte-rich Large B-cell Lmphoma in Pediatric Patients: a Reported Case of a 16-year-old Patient in Clinical Haematology Department of the University Teaching Hospital of Yopougon (Abidjan-Ivory Coast)

T-cell/Histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare pathology, uncommon in children population and the few cases reported, had wide range clinical presentations, including advanced stage, extranodal involvement and bad prognosis. Authors report a case of a 16-year-old male patient with no medical history, who presented a single left axillary adenopathy. T-cell/Histiocyte-rich large B-cell lymphoma was diagnosed by immunohistochemistry and was classified good prognosis. A RCHOP-based chemotherapy was performed with good progress. Authors hope to contribute to the literature on THRLBCL and draw the attention of practitioners to its occurrence in the pediatric population

Primary Gastric Localization of Diffuse Large Cell Lymphoma and Viral Hepatitis C. A Case Report at the Department of Clinical Hematology of University Hospital of Yopougon, Abidjan (Côte d’Ivoire)

Non-Hodgkin's lymphomas are characterized by its clinical and pathological polymorphism. In the stomach, MALT lymphomas are common and mostly associated with Helicobacter Pylori infection. We report a case of 76-year old women with a medical history of chronic stomach pain, addressed for the investigation of normochromic normocytic anemia. The clinical picture included signs of digestive hemorrhage and stomach pain. Gastrointestinal endoscopy and histology noted an unspecified ulcer-budding tumor without signs of Helibacter pylori infection. Immunohistochemistry concluded to diffuse large B cell lymphoma with CD79b +, BCL10 +/-, BCL2+, BCL6 +, MUM1+. The Ann Arbor classification was  stage IE. The serology of Helicobacter pylori was negative. Pre-treatment investigation noted a comorbity with Hepatitis C infection. This study has two interests. Firstly the rarity of the localization of this lymphoma, and secondly, the etiopathological interest because of association with hepatitis C virus

Le Syndrome des Anticorps Anti Phospholipides: Une Etiologie des Fausses Couches Laquelle on Ne Pense pas Souvent en Afrique Noire

Contexte : Le syndrome des anticorps antiphospholipides est l’une des étiologies des fausses couches rarement évoquée en première intention, sous diagnostiquée en Afrique Noire. Presentation de Cas : Les auteurs rapportent l’observation d’une femme de 36 ans, aux antécédents d’ulcère de la jambe gauche, suivie au service de gynéco-obstétrique pour des fausses couches à répétition totalisant cinq (5) épisodes. Le diagnostic initial était orienté vers les causes gynéco-obstétricales, lesquelles trois cerclages du col ont été réalisés avec échec. La survenue d’une pancytopénie qui était le motif majeur de consultation de la patiente a permis de porter le diagnostic de syndrome des anticorps antiphospholipides lupiques par un titrage significatif des anticorpsantiphospholipides et des anticorps antinucléaires de spécifié anti DNA. Le traitement avec les corticoïdes, immunosuppresseurs, l’aspirine et l’héparine a permis une évolution favorable conduisait une 6è grossesse avec succès. Conclusion : Ce travail interpelle les praticiens à rechercher systématiquement le syndrome des anticorps antiphospholipides devant toutes fausses couches spontanées en vue d’un diagnostic et prise en charge précoce. Background: The antiphospholipid antibody syndrome (APL) was rarely evoked as abortion etiology in black Africa. Case Report: The authors reported a case of a 36-year-old female with a medical history of leg ulcer who presented five episodes of recurrent abortion. The diagnosis was oriented to obstetrical etiologies, and three uterine cervix cerclages were realized with failure. As a result of pancytopenia which was the main reason of consultation, the diagnosis was made with immunology test showing a high titer of antiphospholipid antibody and lupus anticoagulant. The patient was treated with corticosteroids, immunosuppressive agents, aspirin, and heparin. The 6th pregnancy was free from complications and led to the birth of a living child. Conclusion: This case calls on practitioners to systematically search for the antiphospholipid antibody syndrome during the investigation of spontaneous miscarriages for diagnosis and early management

Evolutionary profile of patients with hemoglobin SC disease regularly followed in Côte d'Ivoire

Background: West Africa is recognized as the elective focus of hemoglobin C. The S and C combination in the same patient gives a major sickle cell syndrome. In our country, very few series dealing with the evolutionary features of this SC form have been published contrary to the homozygous SS form. The aim of this study was to describe the evolutionary profile of double heterozygous SC sickle cell patients.Methods: This was a retrospective and prospective study with descriptive and analytical purpose of 174 SC sickle cell patients.Results: The median age was 26 years with extremes of 6 years and 57 years. 96% of patients had less than 4 vaso-occlusive seizures per year. The evolutionary complications were mainly ischemic (56.30%) and infectious (39.10%). Among ischemic complications, sickle cell retinopathies and aseptic osteonecrosis are the most common with 59.20% and 31.63% respectively. Infectious complications were dominated by ENT (36.76%) and osteoarticular (35.29%) infections. Only age had an influence on the occurrence of ischemic complications (p = 0.0001). The probability of survival at 5 years was 99.38% and that at 20 years was 91.57%. The overall survival was not influenced by evolutionary complications.Conclusions: Infectious and ischemic evolutionary complications show the importance of vaccination and an early screening program

Un Cas de Lupus Erythemateux Dissemine (LED) Revele par une Anemie Chronique au Service d’hematologie Clinique du CHU de Yopougon

The authors report one case of systemic lupus erythematosus revealed by chronic anemia. This was a 29-year-old patient with long-term fever, chronic skin and joint lesions with isolated hypochrome microcytic haemolytic anemia on the hemogram. The diagnosis of SLE was made three years after the onset of symptomatology based on seven of the American Rheumatology Association's (ARA) criteria out of 11, including positive immunological status (antinuclear antibodies and native DNA). This observation shows the interest of evoking SLE, while looking for signs in a young woman with multiple and varied symptoms with signs of skin, kidney, osteoarticular and hematological disorders.Les auteurs rapportent un cas de lupus érythémateux disséminé révélé par une anémie chronique. IL s’agissait d’une patiente de 29 ans présentant une fièvre au long cours, des lésions cutanées et articulaires d’évolution chronique avec à l’hémogramme une anémie hémolytique isolée hypochrome microcytaire. Le diagnostic de LED a été retenu trois années après le début de la symptomatologie devant sept critères sur 11 de L’American Rheumatology Association (ARA) dont le bilan immunologique positif (anticorps antinucléaires et DNA natif). Cette observation montre l’intérêt d’évoquer le LED, tout en recherchant les signes chez une femme jeune présentant une symptomatologie multiple et variée avec les signes d’atteintes cutanée, rénale, ostéo-articulaire et hématologique

Imatinib Mesylate Effectiveness in Chronic Myeloid Leukemia with Additional Cytogenetic Abnormalities at Diagnosis among Black Africans

Imatinib mesylate provides good results in the treatment of CML in general. But what about the results of this treatment in CML associated with additional cytogenetic abnormalities at diagnosis among black Africans? For this, we retrospectively studied 27 cases of CML associated with additional cytogenetic abnormalities, diagnosed in the department of clinical hematology of the University Hospital of Yopougon in Côte d'Ivoire, from May 2005 to October 2011. The age of patients ranged from 13 to 68 years, with a mean age of 38 years and a sex ratio of 2. Patients were severely symptomatic with a high Sokal score of 67%. CML in chronic phase accounted for 67%. The prevalence of additional cytogenetic abnormalities was 29.7%. There were variants of the Philadelphia chromosome (18.5%), trisomy 8 (14.8%), complex cytogenetic abnormalities (18.5%), second Philadelphia chromosome (14.8%), and minor cytogenetic abnormalities (44.4%). Complete hematologic remission was achieved in 59%, with 52% of major cytogenetic remission. The outcome was fatal in 37% of patients. Death was related in 40% to hematologic toxicity and in 30% to acutisation. The median survival was 40 months

Characteristics and Results of the Treatment of Multiple Myeloma in the Subject under the Age of 65 at the University Hospital of Yopougon in Abidjan, Côte d’Ivoire

We retrospectively studied 30 cases of multiple myeloma in patients under the age of 65, diagnosed from 1991 to 2005 in the clinical hematology department of the University Hospital of Yopougon that is a hospital incidence of 2.9 cases/year. The age of patients ranged from 34 to 64 years, with a mean age of 49 years and a sex ratio of 1.73. The professional activity was variable with 3% of radiographers and 10% of farmers. Clinically, the dominant sign was bone pain in 83% of cases. Myeloma was secretory in 93% of cases. It was Ig G-type in 86%, kappa-type in 66% of cases. 86% of patients were anemic, 20% had creatinine >20 mg/L, and 10% had serum calcium >120 mg/L. Geodes were found in 80% of cases. 53% were at stage III of DURIE and SALMON. Complications were infectious (33%), renal (20%), and hemorrhagic (7%). Chemotherapy regimens were VAD (10%), VMCP (30%), and VMCP/VBAP (60%) with 47% of partial responses, 33% of stable disease, and 7% of very good quality partial responses. The outcome developed towards death in 37% and causes of death were renal in 46% of cases. The median survival was only 5.1 months