Rapid Particle Size Measurements Used as a Proxy to Control Instant Whole Milk Powder Dispersibility

Characterising the dispersion of instant whole milk powder (IWMP) into water is a complex dissolution measurement that is both manual and laborious so is normally carried out post production at industrial dryers. However, this means there is no immediate feedback so the functional quality cannot be controlled in real-time. This work proposes the idea of applying a simpler, surrogate measurement that can be implemented in the plant in order to have useful real-time information regarding the quality of the product being produced. This we term is a proxy measurement. The functional property dispersibility was used as a case study, with particle size being investigated as a proxy at an industrial IWMP plant. It was found that particle sizing could be used to provide useful information regarding the powder, with the proxy measurement being able to predict in-specification powder 97% of the time. Although the test was not as effective for predicting out-of-specification results, with an false-positive rate of 50%, the fact that out-of-specification events are rare in the industry setting means that the overall proxy measurement is still between 78—87 % accurate, and thus useful for predicting the dispersibility quality of the IWMP. Furthermore, these proxy measurements can then be combined with on-line plant information using multivariate techniques to further improve their accuracy and understand how the quality can be controlled by changing the plant processing conditions

The Significance of Powder Breakdown During Conveying Within Industrial Milk Powder Plants

Instant whole milk powder (IWMP) is designed to rapidly dissolve in water, which depends on the particle size distribution (PSD). The fragile milk powder exiting the dryer has to be conveyed for packing, which can break down the particles, worsening the dissolution properties. This work investigated the importance of in-plant conveying in determining the nal functional properties at the industrial scale. IWMP breakdown was compared between two plants with di erent transport systems; a pneumatic system and bucket elevator. It was expected that the plant with the bucket elevator consistently produced powder with superior dissolution due to lower breakdown during transport. This was evaluated using the change in PSD. It was found that both plants had a similar decrease in the median particle size, and powder with an initially larger particle size showed more breakdown. However, it was not enough to compensate for the initially larger size. Thus powder that started out larger still had a larger particle size after transport. When quanti ed using the change in bulk density, a low initial bulk density compensated for large breakdown during conveying and ameliorated the impact on the functional properties. Thus in order to produce IWMP with the desired functionalities the focus should be on improving the initial agglomeration, as oppose to reducing transport breakdown.

Полиморфизм гена μ1-опиоидного рецептора (OPRM1) может иметь значение в генезе злокачественных новообразований почки

Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of μ1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm.Цель исследования – оценить распределение аллелей однонуклеотидного полиморфизма 118A>G гена опиоидного μ1-рецептора (OPRM1) у пациентов со злокачественными новообразованиями и доброкачественными заболеваниями почек.Материалы и методы. Проанализированы данные 100 пациентов, перенесших операции на почке. Пациенты были ретроспективно разделены на группы злокачественных новообразований (n = 29) и доброкачественных заболеваний (n = 71) почек.Результаты. Частота злокачественных новообразований почек была выше в группе гомозиготных носителей 118АА по сравнению с группой AG + GG (36,4 % против 14,7 %; р = 0,035).Заключение. Однонуклеотидный полиморфизм 118A>G гена OPRM1 может иметь значение в генезе злокачественных новообразований почки

Study of charmonium and charmonium-like contributions in B+ → J/ψηK+ decays

A study of B+→ J/ψηK+ decays, followed by J/ψ → μ+μ− and η → γγ, is performed using a dataset collected with the LHCb detector in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The J/ψη mass spectrum is investigated for contributions from charmonia and charmonium-like states. Evidence is found for the B+→ (ψ2(3823) → J/ψη)K+ and B+→ (ψ(4040) → J/ψη)K+ decays with significance of 3.4 and 4.7 standard deviations, respectively. This constitutes the first evidence for the ψ2(3823) → J/ψη decay

Search for new intermediate resonances in a three-body B-meson decays with charmonium in the final state at the LHCb experiment

This research aims to study $B^\pm\rightarrow J/\psi\eta (\eta\rightarrow \gamma\gamma) K^{\pm}$ decay and investigate ${J/\psi\eta}$ invariant mass spectrum. This state is also sensitive to the conventional states $\psi$(4040) and $\psi$(4160). The corresponded study was conducted by Belle Collaboration. The analysis is based on a data sample collected by the LHCb experiment in proton-proton collisions corresponding to 9 $\text{fb}^{-1}$ of integrated luminosity at centre-of-mass energies of 7, 8 and 13 TeV

THE RISK OF SEVERE PAIN AFTER THE SURGERY DEPENDS ON THE PREOPERATIVE PSYCHOLOGICAL CONDITION OF PATIENTS

Background Good pain control after surgeries is important to prevent different negative outcomes. Despite the overwhelming rationale for the effective postoperative pain control, the clinical reality is still far from satisfactory. However, many factors must be considered before deciding on the type of pain therapy to be provided to the surgical patient. Thus, many clinical researches confirm the interrelation between psychological status and the level of postoperative pain syndrome. Nevertheless, the prognostic value of psychological scales relative to the severe pain after the surgery has not been evaluated yet and new researches in this direction can be of significant scientific and practical importance. AIM The aim of this study was to evaluate the predictive value of scales, characterising the preoperative psychological condition of patient relative to the intensity of pain after the surgery. Materials and Methods The observational study has been conducted, which included 100 consecutive patients undergoing major urological surgeries with lumbotomic access. The level of preoperative anxiety and depression was assessed using the HADS and PHQ-9 scales. Pain after the surgery was assessed using a questionnaire in which patients were asked to mark the worst pain within the first 24 hours after the surgery (0-10 score). Relative risk (RR), Odds Ratio (OR), Likelihood Ratio (LR) and Positive predictive value (PPV) for each scale and scales combinations have been calculated. Differences in patients groups were considered statistically significant at p <0.05. Results and Discussion Out of 100 patients, 62 (62%) experienced severe pain after the surgery. It has been determined, that the risk of severe pain after the surgery was increased in patients with clinical manifestations of anxiety and depression according to HADS scale (OR = 1,91; 95% CI 1,40-2,61 and OR = 1,57; 95% CI 1,18-2,07 respectively) and depression according to PHQ-9 scale (OR = 2,01; 95% CI 1,30-3,11) compared with groups of patients without psychological disorders (p<0,01). The PHQ-9 had the highest sensitivity – 77,5% and scale combinations – HADSanxiety and HADSdepression had the highest specificity – 93,3%. The maximal PPV was observed in scales combinations HADSanxiety and PHQ-9 – 87,6% (95% CI 72,0–94,1); HADSanxiety and HADSdepression – 92,5% (95% CI 73,2–97,6). Conclusions The risk of severe pain occurrence increased in patients with high level of preoperative anxiety and depression. In order to improve the effectiveness of postoperative analgesia, it is advisable to continue the search of other factors, affecting individual pain perception

«Изучение трехчастичных распадов В-мезонов в эксперименте Большого адронного коллайдера, посвященном исследованию прелестных адронов

The corresponded study was conducted by Belle Collaboration. This research aims to obtain \ $B^{\pm}\to J/\psi\eta (\eta \to \gamma\gamma)K^{\pm}$ signal yield as well as $J/\psi\eta$ invariant mass spectrum. The analysis is based on a data sample collected by the LHCb experiment in proton-proton collisions corresponding to 9 $\text{fb}^{-1}$ of integrated luminosity at centre-of-mass energies of 7, 8 and 13 TeV