L’Europa centrale fra le culture politiche nazionali tradizionali ed una nuova identità europea = Central Europe between traditional national political culture and a new European identity. ZEI Discussion Paper: 2004, C 132

No abstract

ETHOS -- An effective parametrization and classification for structure formation: the non-linear regime at z≳5z\gtrsim5

We propose two effective parameters that fully characterise galactic-scale structure formation at high redshifts ($z\gtrsim5$) for a variety of dark matter (DM) models that have a primordial cutoff in the matter power spectrum. Our description is within the recently proposed ETHOS framework and includes standard thermal Warm DM (WDM) and models with dark acoustic oscillations (DAOs). To define and explore this parameter space, we use high-redshift zoom-in simulations that cover a wide range of non-linear scales from those where DM should behave as CDM ($k\sim10\,h\,{\rm Mpc}^{-1}$), down to those characterised by the onset of galaxy formation ($k\sim500\,h\,{\rm Mpc}^{-1}$). We show that the two physically motivated parameters $h_{\rm peak}$ and $k_{\rm peak}$, the amplitude and scale of the first DAO peak, respectively, are sufficient to parametrize the linear matter power spectrum and classify the DM models as belonging to effective non-linear structure formation regions. These are defined by their relative departure from Cold DM ($k_{\rm peak}\rightarrow\infty$) and WDM ($h_{\rm peak}=0$) according to the non-linear matter power spectrum and halo mass function. We identify a region where the DAOs still leave a distinct signature from WDM down to $z=5$, while a large part of the DAO parameter space is shown to be degenerate with WDM. Our framework can then be used to seamlessly connect a broad class of particle DM models to their structure formation properties at high redshift without the need of additional $N$-body simulations.Comment: 19 pages, 17 figures; Updated version accepted for publication in MNRA

Interference in the resonance fluorescence of two incoherently coupled transitions

The fluorescence light emitted by a 4-level system in $J=1/2$ to $J=1/2$ configuration driven by a monochromatic laser field and in an external magnetic field is studied. We show that the spectrum of resonance fluorescence emitted on the $\pi$ transitions shows a signature of spontaneously generated interference effects. The degree of interference in the fluorescence spectrum can be controlled by means of the external magnetic field, provided that the Land\'e g-factors of the excited and the ground state doublet are different. For a suitably chosen magnetic field strength, the relative weight of the Rayleigh line can be completely suppressed, even for low intensities of the coherent driving field. The incoherent fluorescence spectrum emitted on the $\pi$ transitions exhibits a very narrow peak whose width and weight depends on the magnetic field strength. We demonstrate that the spectrum of resonance fluorescence emitted on the $\sigma$ transitions show an indirect signature of interference. A measurement of the relative peak heights in the spectrum from the $\sigma$ transitions allows to determine the branching ratio of the spontaneous decay of each excited state into the $\sigma$ channel

ETHOS - an Effective Theory of Structure Formation: detecting dark matter interactions through the Lyman-α\alpha forest

We perform a series of cosmological hydrodynamic simulations to investigate the effects of non-gravitational dark matter (DM) interactions on the intergalactic medium (IGM). In particular, we use the ETHOS framework (Cyr-Racine et al. 2016; Vogelsberger et al. 2016) to compare statistics of the Lyman-$\alpha$ forest in cold dark matter (CDM) with an alternative model in which the DM couples strongly with a relativistic species in the early universe. These models are characterised by a cutoff in the linear power spectrum, followed by a series of 'dark acoustic oscillations' (DAOs) on sub-dwarf scales. While the primordial cutoff delays the formation of the first galaxies, structure builds-up more rapidly in the interacting DM model compared to CDM. We show that although DAOs are quickly washed away in the non-linear clustering of DM at $z\lesssim10$, their signature can be imprinted prominently in the Lyman-$\alpha$ flux power spectrum at $z>5$. On scales larger than the cutoff ($k\sim0.08$ s/km for the specific model considered here), the relative difference to CDM is reminiscent of a warm dark matter (WDM) model with a similar initial cutoff; however, the redshift evolution on smaller scales is distinctly different. The appearance and disappearance of DAOs in the Lyman-$\alpha$ flux spectrum provides a powerful way to distinguish interacting DM models from WDM and, indeed, variations in the thermal history of the IGM that may also induce a small-scale cutoff.Comment: 15 pages, 12 figures, 1 table. Updated version accepted for publication in MNRA

Collectively enhanced Ramsey readout by cavity sub- to superradiant transition

When an inverted ensemble of atoms is tightly packed on the scale of its emission wavelength or when the atoms are collectively strongly coupled to a single cavity mode, their dipoles will align and decay rapidly via a superradiant burst. However, a spread-out dipole phase distribution theory predicts a required minimum threshold of atomic excitation for superradiance to occur. Here we experimentally confirm this predicted threshold for superradiant emission on a narrow optical transition when exciting the atoms transversely and show how to take advantage of the resulting sub- to superradiant transition. A $\pi/2$-pulse places the atoms in a subradiant state, protected from collective cavity decay, which we exploit during the free evolution period in a corresponding Ramsey pulse sequence. The final excited state population is read out via superradiant emission from the inverted atomic ensemble after a second $\pi/2$-pulse, and with minimal heating this allows for multiple Ramsey sequences within one experimental cycle. Our scheme is a fundamentally new approach to atomic state readout characterized by its speed, simplicity, and high sensitivity. It demonstrates the potential of sensors using collective effects in cavity-coupled quantum emitters

SRT1720 improves survival and healthspan of obese mice

Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1α-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals

Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting.

Abstract Background Though the Expanded Disability Status Scale (EDSS) is commonly used to assess disability level in relapsing-remitting multiple sclerosis (RRMS), the criteria defining disability progression are used for patients with a wide range of baseline levels of disability in relatively short-term trials. As a result, not all EDSS changes carry the same weight in terms of future disability, and treatment benefits such as decreased risk of reaching particular disability milestones may not be reliably captured. The objectives of this analysis are to assess the probability of confirmed disability worsening to specific EDSS milestones (i.e., EDSS scores ≥3.0, ≥4.0, or ≥6.0) at 288 weeks in the Tysabri Observational Program (TOP) and to examine the impact of relapses occurring during natalizumab therapy in TOP patients who had received natalizumab for ≥24 months. Methods TOP is an ongoing, open-label, observational, prospective study of patients with RRMS in clinical practice. Enrolled patients were naive to natalizumab at treatment initiation or had received ≤3 doses at the time of enrollment. Intravenous natalizumab (300 mg) infusions were given every 4 weeks, and the EDSS was assessed at baseline and every 24 weeks during treatment. Results Of the 4161 patients enrolled in TOP with follow-up of at least 24 months, 3253 patients with available baseline EDSS scores had continued natalizumab treatment and 908 had discontinued (5.4% due to a reported lack of efficacy and 16.4% for other reasons) at the 24-month time point. Those who discontinued due to lack of efficacy had higher baseline EDSS scores (median 4.5 vs. 3.5), higher on-treatment relapse rates (0.82 vs. 0.23), and higher cumulative probabilities of EDSS worsening (16% vs. 9%) at 24 months than those completing therapy. Among 24-month completers, after approximately 5.5 years of natalizumab treatment, the cumulative probabilities of confirmed EDSS worsening by 1.0 and 2.0 points were 18.5% and 7.9%, respectively (24-week confirmation), and 13.5% and 5.3%, respectively (48-week confirmation). The risks of 24- and 48-week confirmed EDSS worsening were significantly higher in patients with on-treatment relapses than in those without relapses. An analysis of time to specific EDSS milestones showed that the probabilities of 48-week confirmed transition from EDSS scores of 0.0–2.0 to ≥3.0, 2.0–3.0 to ≥4.0, and 4.0–5.0 to ≥6.0 at week 288 in TOP were 11.1%, 11.8%, and 9.5%, respectively, with lower probabilities observed among patients without on-treatment relapses (8.1%, 8.4%, and 5.7%, respectively). Conclusions In TOP patients with a median (range) baseline EDSS score of 3.5 (0.0–9.5) who completed 24 months of natalizumab treatment, the rate of 48-week confirmed disability worsening events was below 15%; after approximately 5.5 years of natalizumab treatment, 86.5% and 94.7% of patients did not have EDSS score increases of ≥1.0 or ≥2.0 points, respectively. The presence of relapses was associated with higher rates of overall disability worsening. These results were confirmed by assessing transition to EDSS milestones. Lower rates of overall 48-week confirmed EDSS worsening and of transitioning from EDSS score 4.0–5.0 to ≥6.0 in the absence of relapses suggest that relapses remain a significant driver of disability worsening and that on-treatment relapses in natalizumab-treated patients are of prognostic importance

SRT1720 improves survival and healthspan of obese mice

Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate Sirt1 in vitro, extends both mean and maximum lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by health benefits including reduced liver steatosis, increased insulin sensitivity, enhanced locomotor activity and normalization of gene expression profiles and markers of inflammation and apoptosis, all in the absence of any observable toxicity. Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1a-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals