14 research outputs found
A novel Appendicitis TriMOdal prediction Score (ATMOS) for acute appendicitis in pregnancy: a retrospective observational study
Several scoring systems exist for the management of acute appendicitis (AA) during pregnancy. However, the systems are
based on the nonpregnant adult population. The aim of this study was to create a highly accurate scoring system that can be
applied to pregnant women and to compare it to the most commonly used scores in general population and pregnant women.
The creation and subsequent implementation of a highly accurate score system could shorten the diagnostic period and
minimize the use of (ionizing) diagnostic imaging allowing the selection of the best treatment approach in pregnant patients
with acute appendicitis. A single-center, retrospective cohort observational study was conducted at the University Hospital
Centre Zagreb, Zagreb, Croatia. Data were extracted from medical records of pregnant patients with suspected AA from
January 2010 to December 2020. A total of 59 pregnant patients diagnosed with AA during pregnancy were identifed, 41
were treated surgically, and 18 had non-surgical management. The main objective of our study was the detection of predictive
factors of AA during pregnancy. Anorexia, pain migration to the right lower quadrant, rebound pain, axillary temperature
over 37.3 °C, CRP/platelet ratio>0.0422, neutrophil/lymphocyte ratio>7.182, and ultrasonic signs of AA were scored.
Scoring in Appendicitis TriMOdal Score (ATMOS) consists of positive clinical parameter, each bringing 1 point and other
parameters mentioned above that bring 2 points each. The score ranges from 0 to 10. Our model of ATMOS yields a high
area under the receiver-operating characteristic curve of 0.963. The positive likelihood ratio is 9.97 (95% CI 2.64â38.00),
and the negative likelihood ratio is 0.1 (95% CI 0.03â0.31), meaning that 94% of cases with ATMOS>4 have AA, while
less than 13% with an ATMOSâ€4 have the diagnosis of AA. The potential of ATMOS diferentiating AA during pregnancy
was demonstrated. Future prospective, randomized trials are needed to evaluate its accuracy and whether it should be used
instead of Alvarado or Tzanakis scores in clinical decision-makin
Tick-borne encephalitis outbreak following raw goat milk consumption in a new micro-location, Croatia, June 2019.
Dentistsâ use of digital radiographic techniques: Part II â extraoral radiography: a questionnaire study of Swedish dentists
Treatment of the iatrogenic lesion of the biliary tree secondary to laparoscopic cholecystectomy: a single center experience
The Presence of Either Typical or Atypical Radiological Changes Predicts Poor COVID-19 Outcomes in HIV-Positive Patients from a Multinational Observational Study: Data from Euroguidelines in Central and Eastern Europe Network Group
HIV-positive patients may present lungs with multiple infections, which may hinder differential diagnoses and the choice of treatment in the course of COVID-19, especially in countries with limited access to high-standard healthcare. Here, we aim to investigate the association between radiological changes and poor COVID-19 outcomes among HIV-positive patients from Central and Eastern Europe. Between November 2020 and May 2021, the Euroguidelines in Central and Eastern Europe Network Group started collecting observational data on HIV and COVID-19 co-infections. In total, 16 countries from Central and Eastern European submitted data (eCRF) on 557 HIV-positive patients. The current analyses included patients who had a radiological examination performed. Logistic regression models were used to identify the factors associated with death, ICU admission, and partial recovery (poor COVID-19 outcomes). Factors that were significant in the univariate models (p < 0.1) were included in the multivariate model. Radiological data were available for 224 (40.2%) patients, 108 (48.2%) had computed tomography, and 116 (51.8%) had a chest X-ray. Of these, 211 (94.2%) were diagnosed using RT-PCR tests, 212 (94.6%) were symptomatic, 123 (55.6%) were hospitalized, 37 (16.6%) required oxygen therapy, and 28 (13.1%) either died, were admitted to ICU, or only partially recovered. From the radiologistâs description, 138 (61.6%) patients had typical radiological changes, 18 (8.0%) atypical changes, and 68 (30.4%) no changes. In the univariate models, CD4 count (OR = 0.86 [95% CI: 0.76â0.98]), having a comorbidity (2.33 [1.43â3.80]), HCV and/or HBV co-infection (3.17 [1.32â7.60]), being currently employed (0.31 [0.13â0.70]), being on antiretroviral therapy (0.22 [0.08â0.63]), and having typical (3.90 [1.12â13.65]) or atypical (10.8 [2.23â 52.5]) radiological changes were all significantly associated with poor COVID-19 outcomes. In the multivariate model, being on antiretroviral therapy (OR = 0.20 [95% CI:0.05â0.80]) decreased the odds of poor COVID-19 outcomes, while having a comorbidity (2.12 [1.20â3.72]) or either typical (4.23 [1.05â17.0]) or atypical (6.39 [1.03â39.7]) radiological changes (vs. no changes) increased the odds of poor COVID-19 outcomes. Among HIV patients diagnosed with symptomatic SARS-CoV-2 infection, the presence of either typical or atypical radiological COVID-19 changes independently predicted poorer outcomes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland
A novel QSPR model for predicting Ξ (lower critical solution temperature) in polymer solutions using molecular descriptors
European results of unrelated cord blood transplants
This report summarizes the results of unrelated cord blood transplants. Sixty-five patients were reported to Eurocord. One year survival was 29%. Factors associated with survival were diagnosis, inborn errors had a better survival than leukemia or aplastic anemia; higher number of cells infused and negative pre-transplant CMV serology were also favorable factors. Granulocyte and platelet engraftment were associated with a higher number of nucleated cells infused, GVH incidence was low especially in CMV negative patients, it was not associated with the degree of HLA disparity. These results were similar to other series reported in the USA and showed the benefit of using mismatched unrelated cord blood in clearly defined situations