Identifying the factors that contribute to sustainable development of the national economy

The structural imbalance is the main problem hindering the development of the Russian national economy. It leads to significant difference in economic efficiency of various industrial sectors. Moreover, the structural imbalance adversely affects the interaction between industries and hampers to foster an enabling environment that would accelerate economic growth consistent with the principles of sustainable development. The right balance between economic sectors provides favorable conditions for a successful interaction between industries. The article suggests the methodology intended to identify the factors contributing to sustainable development of the national economy, to assess the status of the economy as well as to estimate the dynamics of economic growth. The methodology is a promising approach building a network of interactions between different industries to deepen the diversification of economic sectors. The authors propose a set of indicators - indicators of economic imbalances - that allow, based on primary statistical data, to quantitatively determine the degree of difference and the changing dynamics in economic, financial, technological and social characteristics of several economic sectors. The paper details the developed system of monitoring and multi-criteria evaluation of growth in several economic sectors. The system makes it possible to estimate key factors affecting sustainable development of the economy as well as to get the right diagnosis of economic processes that shape the sectoral structure of the Russian economy.peer-reviewe

A SINGLE DIGITAL SPACE FOR THE EFFICIENT FUNCTIONING OF INDUSTRY

The article is devoted to the development of the concept of a single digital space for the effective functioning of the industry. A new model of industrial production organisation, the platform ecosystem are analysed. The analysis of the theoretical concepts of the world economy on its structure, the system of organisation of interaction between ecosystem participants, factors affecting its dynamic development is given. It is shown that digital technologies play an essential role in the organisation of the ecosystem. At the same time, digitalisation occurs in two directions: the creation of the digital space of the enterprise participating in the ecosystem and the creation of the digital space of the ecosystem of industrial production.The analysis of the use of digital technologies in various industries is given. The rating of the use of digital technologies in industry is discussed. The analysis of the factors constraining the process of digitalisation of the industry of the Russian Federation is given. The concept of ecosystem, presented in the world literature, and its functional and organisational features are analysed.The influence of institutional conditions on the functional characteristics of the ecosystem is discussed. The ecosystem management system affects the economic and technological efficiency of each ecosystem participant. The prospects for the development of ecosystems based on platforms are shown.The ability of the Russian manufacturing industry to adapt digital technologies and the organisation of modern forms of production on their basis are analysed. It is demonstrated that the potential of modern production of complex multicomponent products is determined by the ability to scale based on industry 4.0 technologies. At the same time, most of the enterprises fulfill individual orders of consumers and do not participate in the production chains of such products.The tasks necessary for the organisation of breakthrough development of manufacturing enterprises in Russia are formulated. For modern organisational forms of the manufacturing industry a non-departmental management body is proposed. Its structure and functions are discussed

用于工业高效运作的的单一数字空间

The article is devoted to the development of the concept of a single digital space for the effective functioning of the industry. A new model of industrial production organisation, the platform ecosystem are analysed. The analysis of the theoretical concepts of the world economy on its structure, the system of organisation of interaction between ecosystem participants, factors affecting its dynamic development is given. It is shown that digital technologies play an essential role in the organisation of the ecosystem. At the same time, digitalisation occurs in two directions: the creation of the digital space of the enterprise participating in the ecosystem and the creation of the digital space of the ecosystem of industrial production.The analysis of the use of digital technologies in various industries is given. The rating of the use of digital technologies in industry is discussed. The analysis of the factors constraining the process of digitalisation of the industry of the Russian Federation is given. The concept of ecosystem, presented in the world literature, and its functional and organisational features are analysed.The influence of institutional conditions on the functional characteristics of the ecosystem is discussed. The ecosystem management system affects the economic and technological efficiency of each ecosystem participant. The prospects for the development of ecosystems based on platforms are shown.The ability of the Russian manufacturing industry to adapt digital technologies and the organisation of modern forms of production on their basis are analysed. It is demonstrated that the potential of modern production of complex multicomponent products is determined by the ability to scale based on industry 4.0 technologies. At the same time, most of the enterprises fulfill individual orders of consumers and do not participate in the production chains of such products.The tasks necessary for the organisation of breakthrough development of manufacturing enterprises in Russia are formulated. For modern organisational forms of the manufacturing industry a non-departmental management body is proposed. Its structure and functions are discussed.Статья посвящена разработке концепции единого цифрового пространства для эффективного функционирования промышленности. Анализируется новая модель организации промышленного производства – платформенная экосистема. Дан анализ теоретическим представлениям мировой экономики по ее структуре, системе организации взаимодействия между участниками экосистемы, факторам, влияющим на ее динамическое развитие. Показано, что существенную роль в организации экосистемы играют цифровые технологии. При этом цифровизация идет по двум направлениям: создание цифрового пространства предприятия участника экосистемы и создание цифрового пространства экосистемы промышленного производства.Дается анализ по использованию цифровых технологий в различных отраслях промышленности. Обсуждается рейтинг применения цифровых технологий в промышленности. Дается анализ факторов, сдерживающих процесс цифровизации промышленности РФ. Анализируются представленное в мировой литературе понятие экосистемы и ее функциональные и организационные особенности.Обсуждается влияние институциональных условий на функциональные характеристики экосистемы. Показано, что система управления экосистем воздействует на экономическую, технологическую эффективность каждого участника экосистемы. Отмечена перспективность развития экосистем на основе платформ. Проанализирована способность обрабатывающей промышленности России к адаптации цифровых технологий и организация на их основе современных форм производства. Продемонстрировано, что потенциал современного производства сложной многокомпонентной продукции определяется способностью к масштабированию на основе технологий индустрии 4.0. Показано, что большая часть предприятий машиностроения в силу своей функциональной специфики не способна к масштабированию производства.Сформулированы задачи, необходимые для организации прорывного развития предприятий обрабатывающей промышленности России. Для обрабатывающей промышленности предлагается вневедомственный орган управления; обсуждается его структура и функции.文章论述了为工业的有效运作发展单一数字空间的概念｡分析了工业生产组织的新模式 —— 平台生态系统｡作者分析了世界经济结构的理论洞察力﹐而且描述了组织生态系统参与者之间互动的系统以及影响其动态发展的因素｡数字技术已被证明在生态系统的组织中发挥了重要作用｡而数字化是在两个方面进行的：为参与生态系统的企业创建一个数字空间﹐以及为工业生产生态系统创造一个数字空间｡对数字技术在不同工业部门的应用进行了分析｡讨论了数字技术在工业中的应用水平｡对俄罗斯工业数字化的制约因素进行了分析｡对世界文献中提出的生态系统的概念及其功能和组织特征进行了分析｡讨论了制度条件对生态系统的功能特征的影响｡生态系统管理体制影响到其中每个参与者的经济﹑技术效率｡基于平台的生态系统的前景显示｡作者分析了俄罗斯加工工业采用数字技术和在其基础上组织现代生产形式的能力｡证明了﹐当今复杂的多部件生产的潜力是由基于工业4.0技术的扩展能力决定的﹐同时企业主体部分完成客户的个别订单﹐不参与此类产品的生产链｡制定了俄罗斯加工工业突破性发展的挑战｡作者建议为加工工业建立一个非部门管理机构﹐并讨论其结构和功能

PROBLEMS OF DIGITALIZATION OF THE RUSSIAN INDUSTRY

The article is devoted to the substantiation of the model of the formation of an industrial development ecosystem based on modern digital technologies in industry.The article deals with the problems of technological sovereignty of the Russian economy. It is shown that the solution of this problem is possible only on the basis of an industrial development ecosystem – a system of production chains of the most important types of industrial products, a technological development platform, interaction of subjects of industrial production with consumers of its products in the domestic and foreign markets. The necessity of concentration of industrial potential, resources of technological development, qualified personnel potential and direction to create conditions for providing the Russian economy with products corresponding to the world technological level is shown. The article analyzes the main existing and promising models of the functioning of an industrial enterprise. A detailed description of the barriers and difficulties on the way of digitalization of industrial enterprises in the Russian Federation is given.In order to form the ecosystem of industrial development of the Russian Federation, the directions of identifying and assessing the state of production and technological personnel potential, its compliance with the needs of the domestic market are formulated. Recommendations are given on the creation of an ecosystem structure, mechanisms for the interaction of its various elements, a management and coordination system based on digital technologies for creating a system of individual elements that form information and analytical centers in various functional areas of the ecosystem.A model of the ecosystem of industrial and technological development of the Russian economy based on digital technologies is proposed.A set of mechanisms that contribute to reducing the level of uncertainty is proposed, and a design method of interaction within the framework of the digital industrial enterprise technology platform model is described.The article formulates recommendations for the digitalization of an industrial enterprise in the new technological conditions of economic and social development, in the so-called new technological paradigm “Industry 4.0”, the characteristic features of which are minimal use of manual and mechanized labor, as well as a low level of transaction costs.A new approach is proposed, on the basis of which industrial enterprises will interact on the basis of shared access to information and digital resources and the ability to combine the development of innovative projects and value chains necessary to create competitive products in order to increase the operational efficiency of enterprises

Fokker-Planck type equations with Sobolev diffusion coefficients and BV drift coefficients

In this paper we give an affirmative answer to an open question mentioned in [Le Bris and Lions, Comm. Partial Differential Equations 33 (2008), 1272--1317], that is, we prove the well-posedness of the Fokker-Planck type equations with Sobolev diffusion coefficients and BV drift coefficients.Comment: 11 pages. The proof has been modifie

Correlator Bank Detection of GW chirps. False-Alarm Probability, Template Density and Thresholds: Behind and Beyond the Minimal-Match Issue

The general problem of computing the false-alarm rate vs. detection-threshold relationship for a bank of correlators is addressed, in the context of maximum-likelihood detection of gravitational waves, with specific reference to chirps from coalescing binary systems. Accurate (lower-bound) approximants for the cumulative distribution of the whole-bank supremum are deduced from a class of Bonferroni-type inequalities. The asymptotic properties of the cumulative distribution are obtained, in the limit where the number of correlators goes to infinity. The validity of numerical simulations made on small-size banks is extended to banks of any size, via a gaussian-correlation inequality. The result is used to estimate the optimum template density, yielding the best tradeoff between computational cost and detection efficiency, in terms of undetected potentially observable sources at a prescribed false-alarm level, for the simplest case of Newtonian chirps.Comment: submitted to Phys. Rev.

Myectomy versus alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy

OBJECTIVES: There is very little evidence comparing the safety and efficacy of alcohol septal ablation versus septal myectomy for a septal reduction in patients with hypertrophic obstructive cardiomyopathy. This study aimed to compare the immediate and long-term outcomes of these procedures. METHODS: Following propensity score matching, we retrospectively analysed outcomes in 105 patients who underwent myectomy and 105 who underwent septal ablation between 2011 and 2017 at 2 reference centres. RESULTS: The mean age was 51.9 ± 14.3 and 52.2 ± 14.3 years in the myectomy and ablation groups, respectively (P = 0.855), and postoperative left ventricular outflow tract gradients were 13 (10-19) mmHg vs 16 (12-26) mmHg; P = 0.025. The 1-year prevalence of the New York Heart Association class III-IV was higher in the ablation group (none vs 6.4%; P = 0.041). The 5-year overall survival rate [96.8% (86.3-99.3) after myectomy and 93.5% (85.9-97.1) after ablation; P = 0.103] and cumulative incidence of sudden cardiac death [0% and 1.9% (0.5-7.5), respectively P = 0.797] did not differ between the groups. The cumulative reoperation rate within 5 years was lower after myectomy than after ablation [2.0% (0.5-7.6) vs 14.6% (8.6-24.1); P = 0.003]. Ablation was associated with a higher reoperation risk (subdistributional hazard ratio = 5.9; 95% confidence interval 1.3-26.3, P = 0.020). At follow-up, left ventricular outflow tract gradient [16 (11-20) vs 23 (15-59) mmHg; P < 0.001] and prevalence of 2+ mitral regurgitation (1.1% vs 10.6%; P = 0.016) were lower after myectomy than after ablation. CONCLUSIONS: Both procedures improved functional capacity; however, myectomy better-resolved classes III-IV of heart failure. Septal ablation was associated with higher reoperation rates. Myectomy demonstrated benefits in gradient relief and mitral regurgitation elimination. The results suggest that decreasing rates of myectomy procedures need to be investigated and reconsidered. © The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors

O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors. These compounds were assembled in a modular fashion by photoinitiated thiol–ene conjugation of allyl-UDP and optimal acceptor peptides in which the acceptor serine was replaced with cysteine. The conjugate VTPVC­(S-propyl-UDP)­TA (<i>K</i>_i = 1.3 μM) inhibits the OGT activity in HeLa cell lysates. Linear fusions of this conjugate with cell penetrating peptides were explored as prototypes of cell-penetrant OGT inhibitors. A crystal structure of human OGT with the inhibitor revealed mimicry of the interactions seen in the pseudo-Michaelis complex. Furthermore, a fluorophore-tagged derivative of the inhibitor works as a high affinity probe in a fluorescence polarimetry hOGT assay