Internal kinematics of modelled interacting disc galaxies

We present an investigation of galaxy-galaxy interactions and their effects on the velocity fields of disc galaxies in combined N-body/hydrodynamic simulations, which include cooling, star formation with feedback, and galactic winds. Rotation curves (RCs) of the gas are extracted from these simulations in a way that follows the procedure applied to observations of distant, small, and faint galaxies as closely as possible. We show that galaxy-galaxy mergers and fly-bys disturb the velocity fields significantly and hence the RCs of the interacting galaxies, leading to asymmetries and distortions in the RCs. Typical features of disturbed kinematics are significantly rising or falling profiles in the direction of the companion galaxy and pronounced bumps in the RCs. In addition, tidal tails can leave strong imprints on the rotation curve. All these features are observable for intermediate redshift galaxies, on which we focus our investigations. We use a quantitative measure for the asymmetry of rotation curves to show that the appearance of these distortions strongly depends on the viewing angle. We also find in this way that the velocity fields settle back into relatively undisturbed equilibrium states after unequal mass mergers and fly-bys. About 1 Gyr after the first encounter, the RCs show no severe distortions anymore. These results are consistent with previous theoretical and observational studies. As an illustration of our results, we compare our simulated velocity fields and direct images with rotation curves from VLT/FORS spectroscopy and ACS images of a cluster at z=0.53 and find remarkable similarities.Comment: 13 pages, 14 figures, accepted for publication in A&A, some improvements and changes, main conclusions are unaffecte

The ultraviolet spectrum of HH 24A and its relation to optical spectra

The spectrum of the brightest part (HH 24A) of the complex Herbig-Haro object HH 24 in the short wavelength UV range was studied. The object is of special interest since it is known that in the optical range the continuum is due to dust scattered light originating in a young stellar object while the shock excited emission lines are formed in HH 24A itself. The spectrum shows only a continuum or a quasi-continuum and is not comparable to that of the typical high excitation object like HH1 or HH2 nor to that of a low excitation object like HH3 or HH47

Rotational and intrinsic levels in Tm169 and Lu175

Nuclear levels in Tm169 excited by electron capture of Yb169, and levels in Lu175 excited by both beta decay of Yb175 and electron capture of Hf175 have been studied by using the curved-crystal gamma-ray spectrometer and the ring-focusing beta-ray spectrometer, as well as a semicircular beta-ray spectrometer for low energies. From the precision energies and the multipolarity determinations, the levels in Tm169 have the following energies in kev, and spin and parity assignments: A (ground state) (½+), B 8.42 (3/2+), C 118.20 (5/2+), D 138.95 (7/2+), E 316.19 (7/2+), F 379.31 (7/2-), G 472.91 (9/2-). Levels A, B, C, and D are members of a rotational band whose characteristic constants are given. Levels E and F are interpreted as particle excitations and level G as a rotational level based on the state F. The Lu175 excited states have the following energies in kev, spins, and parities: A (ground state) (7/2+), B 113.81 (9/2+), C 251.46 (11/2+), D 343.40 (5/2+), E 396.31 (9/2-), F 432.76 (7/2+), G 504.7 (1/2+). A, B, and C form a rotational band for which the characteristic constants are given. Some features of the levels and transition probabilities are discussed and compared with the unified model. A brief survey of second-order rotational energy constants and of intrinsic excitation levels is given

The role of saliva in oral processing: Reconsidering the breakdown path paradigm

We discuss food oral processing research over the last two decades and consider strategies for quantifying the food breakdown model, originally conceptualised by Hutchings and Lillford . The key innovation in their seminal 1988 paper was shifting the focus from intact food properties, measured in the lab, towards strategies to capture the dynamic nature of eating. This has stimulated great progress in the field, but a key aspect missing in oral processing research is the conversion of the Hutchings and Lillford breakdown path conceptual model into quantifiable parameters considered in the context of physiological factors such as saliva and oral movements. To address these short comings, we propose the following analysis: Hutchings’s and Lillford’s definitions of “Structure” and “Lubrication” are incomplete and they comprise many and varied physicochemical properties. We offer, here, a deeper analysis of each parameter, and propose strategies for researchers to consider in their quantification as an update of the Hutchings and Lillford Breakdown path

lnfluence of grape variety, climate and soil on grape composition and on the composition and quality of table wines

The influence of grape variety, soil type, climatic area and year of vintage on grape composition and wine quality was studied over a six-year period with three grape varieties in a eo-operative investigation. The wines were made under carefully controlled conditions to eliminate, as far as possible, any effect of winemaking technique. All viticultural and oenological treatments were replicated so that the data could be analysed statistically. When grapes from different viticultural areas were made into table wines, the quality of the wines was most closely related to grape variety, followed by climatic area and least of all by soil type.Reproducible differences in grape and wine composition were found for the grape varieties studied. For fhe same sugar content Riesling grapes and wine contained more acidity and a higher tartaric acid/malic acid ratio than Clare Riesling grapes and wine. They also contained less nitrogen, phosphorus and potassium. Shiraz grapes were relatively high in malic acid.The year of vintage strongly influenced the tartaric acid/malic acid ratio, particularly for Riesling and Clare Riesling, and also certain other constituents. Certain years could be designated as either high or low malic acid years for a particular grape variety.The soil type influenced the amounts of certain of the constituents of grapes and wine, but had no significant effects on the wine quality. Wines from the same varieties grown on two widely different soils in the same area could not be differentiated in replicated taste tests. The soil depth, drainage and waterholding capacity appeared to be more important than composition per se.Wines made from irrigated vineyards in the warm River Murray viticultural region, contained similar amounts of tartaric and malic acids, but were higher in pH, than wines made from the same grape varieties in the cooler non-irrigated Barossa Valley. Wines from irrigated grapes were generally of somewhat lower quality than those made from grapes of the same variety grown without irrigation in a cooler area. The time of harvesting irrigated grapes appeared to be critical to achieve the necessary balance between sugar, acid and flavour. Shiraz grapes grown under irrigation contained considerably less colour than grapes of the same variety grown without irrigation.Aroma was correlated with flavour in assessing wine quality, but numerical values ascribed to these parameters did not correlate generally with the wine constituents measured. A positive correlation existed between high tasting scores and high Ball/acid ratio

Gamow-Teller transitions and deformation in the proton-neutron random phase approximation

We investigate reliability of Gamow-Teller transition strengths computed in the proton-neutron random phase approximation, comparing with exact results from diagonalization in full $0\hbar\omega$ shell-model spaces. By allowing the Hartree-Fock state to be deformed, we obtain good results for a wide variety of nuclides, even though we do not project onto good angular momentum. We suggest that deformation is as important or more so than pairing for Gamow-Teller transitions.Comment: 8 pages, 5 figures; added references, clarified discussion with regards to stabilit

Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus

Aims/hypothesis: The molecular mechanisms of obesity-related insulin resistance are incompletely understood. Macrophages accumulate in adipose tissue of obese individuals. In obesity, monocyte chemoattractant protein-1 (MCP-1), a key chemokine in the process of macrophage accumulation, is overexpressed in adipose tissue. MCP-1 is an insulin-responsive gene that continues to respond to exogenous insulin in insulin-resistant adipocytes and mice. MCP-1 decreases insulin-stimulated glucose uptake into adipocytes. The A-2518G polymorphism in the distal regulatory region of MCP-1 may regulate gene expression. The aim of this study was to investigate the impact of this gene polymorphism on insulin resistance. Methods: We genotyped the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort (n=3307). Insulin resistance, estimated by homeostasis model assessment, and Type 2 diabetes were diagnosed in 803 and 635 patients respectively. Results: Univariate analysis revealed that plasma MCP-1 levels were significantly and positively correlated with WHR (p=0.011), insulin resistance (p=0.0097) and diabetes (p<0.0001). Presence of the MCP-1 G-2518 allele was associated with decreased plasma MCP-1 (p=0.017), a decreased prevalence of insulin resistance (odds ratio [OR]=0.82, 95% CI: 0.70-0.97, p=0.021) and a decreased prevalence of diabetes (OR=0.80, 95% CI: 0.67-0.96, p=0.014). In multivariate analysis, the G allele retained statistical significance as a negative predictor of insulin resistance (OR=0.78, 95% CI: 0.65-0.93, p=0.0060) and diabetes (OR=0.80, 95% CI: 0.66-0.96, p=0.018). Conclusions/interpretation: In a large cohort of Caucasians, the MCP-1 G-2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes. These results add to recent evidence supporting a role for MCP-1 in pathologies associated with hyperinsulinaemi

PAMELA and FERMI-LAT limits on the neutralino-chargino mass degeneracy

Searches for Dark Matter (DM) particles with indirect detection techniques have reached important milestones with the precise measurements of the anti-proton and gamma-ray spectra, notably by the PAMELA and FERMI-LAT experiments. While the gamma-ray results have been used to test the thermal Dark Matter hypothesis and constrain the Dark Matter annihilation cross section into Standard Model (SM) particles, the anti-proton flux measured by the PAMELA experiment remains relatively unexploited. Here we show that the latter can be used to set a constraint on the neutralino-chargino mass difference. To illustrate our point we use a Supersymmetric model in which the gauginos are light, the sfermions are heavy and the Lightest Supersymmetric Particle (LSP) is the neutralino. In this framework the W^+ W^- production is expected to be significant, thus leading to large anti-proton and gamma-ray fluxes. After determining a generic limit on the Dark Matter pair annihilation cross section into W^+ W^- from the anti-proton data only, we show that one can constrain scenarios in which the neutralino-chargino mass difference is as large as ~ 20 GeV for a mixed neutralino (and intermediate choices of the anti-proton propagation scheme). This result is consistent with the limit obtained by using the FERMI-LAT data. As a result, we can safely rule out the pure wino neutralino hypothesis if it is lighter than 450 GeV and constitutes all the Dark Matter.Comment: 22page

Restrictions on dilatonic brane-world models

We consider dilatonic brane-world models with a non-minimal coupling between a dilaton and usual matter on a brane. We demonstrate that variation of the fundamental constants on the brane due to such interaction leads to strong restrictions on parameters of models. In particular, the experimental bounds on variation of the fine structure constant rule out non-minimal dilatonic models with a Liouville-type coupling potential f(varphi) = exp (b varphi) where b is order of 1.Comment: MiKTeX2-LaTeX2e, 10 pages, minor changes, improved references, to appear in IJMP

Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II

By using an immunoprecipitation assay, we analysed reactivity of autoantibodies to human recombinant GAD65 and GAD67 in sera from patients with autoimmune polyendocrine syndrome Type II (APS II) with and without Type 1 (insulin-dependent) diabetes mellitus (IDDM) compared to patients with organ-specific autoimmunity. Overall antibodies to GAD65 were correlated with IDDM in all study groups, whereas GAD67 antibodies were associated with IDDM when APS II coexists. Antibodies to GAD65 and GAD67 were detected in 13 (44.8%) and 7 (24.1%) out of 29 APS II patients with IDDM, but in only 4 (13.8%) and 2 (6.9%) out of 29 APS II patients without IDDM, respectively (p < 0.05). In short-standing IDDM (< 1 year), antibodies to GAD67 were significantly more frequent in patients with APS II (5 of 9 [55.6%] subjects) compared to matched diabetic patients without coexisting polyendocrinopathy (1 of 18 [5.6%] subjects) (p < 0.02). The levels of GAD65 (142 ± 90 AU) and GAD67 antibodies (178 ± 95 AU) were significantly higher in patients with polyglandular disease than in patients with isolated IDDM (91 ± 85 AU and 93 ± 57 AU) (p < 0.02). Interestingly, all 11 GAD67 antibody positive subjects also had GAD65 antibodies (p < 0.0001), and in 10 of 11 anti-GAD67 positive sera the GAD67 antibodies could be blocked by either GAD67 or GAD65, suggesting the presence of cross-reactive autoantibodies. No correlation was observed between GAD antibodies and age, sex or any particular associated autoimmune disease, besides IDDM. GAD antibodies were present in only 1 of 6 (16.7%) patients with APS Type I, in 1 of 26 (3.9%) patients with autoimmune thyroid disease but in none of the patients with Addison's disease (n = 16), pernicious anaemia (n = 7) or normal controls (n = 50). Our data suggest distinct antibody specificities reactive to GAD isoforms in APS II and IDDM, which might reflect different mechanisms of autoimmune response in IDDM with coexisting autoimmune polyendocrine autoimmunity