A Comparative Study of Contrasting Machine Learning Frameworks Applied to RANS Modeling of Jets in Crossflow

Classical RANS turbulence models have known deficiencies when applied to jets in crossflow. Identifying the linear Boussinesq stress-strain hypothesis as a major contribution to erroneous prediction, we consider and contrast two machine learning frameworks for turbulence model development. Gene Expression Programming, an evolutionary algorithm that employs a survival of the fittest analogy, and a Deep Neural Network, based on neurological processing, add non-linear terms to the stress-strain relationship. The results are Explicit Algebraic Stress Model-like closures. High fidelity data from an inline jet in crossflow study is used to regress new closures. These models are then tested on a skewed jet to ascertain their predictive efficacy. For both methodologies, a vast improvement over the linear relationship is observed

Age-Depth Stratigraphy of Pine Island Glacier Inferred from Airborne Radar and Ice-Core Chronology

Understanding the contribution of the West Antarctic Ice Sheet (WAIS) to past and future sea level has been a major scientific priority over the last three decades. In recent years, observed thinning and ice‐flow acceleration of the marine‐based Pine Island Glacier has highlighted that understanding dynamic changes is critical to predicting the long‐term stability of the WAIS. However, relatively little is known about the evolution of the catchment during the Holocene. Internal Reflecting Horizons (IRHs) provide a cumulative record of accumulation, basal melt and ice dynamics that, if dated, can be used to constrain ice‐flow models. Here, we use airborne radars to trace four spatially‐extensive IRHs deposited in the late Quaternary across the Pine Island Glacier catchment. We use the WAIS Divide ice‐core chronology to assign ages to three IRHs: 4.72 ± 0.28, 6.94 ± 0.31, and 16.50 ± 0.79 ka. We use a 1‐D model, constrained by observational and modelled accumulation rates, to produce an independent validation of our ice‐core‐derived ages and provide an age estimate for our shallowest IRH (2.31‐2.92 ka). We find that our upper three IRHs correspond to three large peaks in sulphate concentrations in the WAIS Divide ice‐core record and hypothesise that the origin of these spatially‐extensive IRHs is from past volcanic activity. The clear correspondence between our IRHs and the ones previously identified over the Weddell Sea Sector, altogether representing ∼20% of the WAIS, indicates that a unique set of stratigraphic markers spanning the Holocene exists over a large part of West Antarctica

Necessary Optimality Conditions for a Dead Oil Isotherm Optimal Control Problem

We study a system of nonlinear partial differential equations resulting from the traditional modelling of oil engineering within the framework of the mechanics of a continuous medium. Recent results on the problem provide existence, uniqueness and regularity of the optimal solution. Here we obtain the first necessary optimality conditions.Comment: 9 page

First use of Timepix3 hybrid pixel detectors in ultra-high vacuum for beam profile measurements

A transverse beam gas ionization profile monitor is currently under development for the CERN Proton Synchrotron (PS) to provide non-destructive continuous measurements during a beam cycle. The implementation is exploring a novel use of the Timepix3 hybrid pixel detector mounted inside the ultra-high vacuum of the accelerator beam pipe to provide direct detection of ionization electrons. In early 2017, a prototype monitor was installed and has been used successfully to measure the transverse beam profile. The evolution of the transverse beam profile throughout the beam cycle has been measured and specific time windows within a beam cycle have been studied, for example the transition crossing. A radiation tolerant readout system for the Timepix3 detectors has been implemented which enables the connection of up to four detectors located in a highly radioactive environment. The first version of the readout was installed together with the prototype monitor in 2017 and a new version of the readout is currently under development which will enable the full speed data rate of the pixel detectors. Use of the radiation tolerant readout system can be envisioned for other beam instrumentation applications, which could provide new insight to beam diagnostics

A Dynamical Model of Oocyte Maturation Unveils Precisely Orchestrated Meiotic Decisions

Maturation of vertebrate oocytes into haploid gametes relies on two consecutive meioses without intervening DNA replication. The temporal sequence of cellular transitions driving eggs from G2 arrest to meiosis I (MI) and then to meiosis II (MII) is controlled by the interplay between cyclin-dependent and mitogen-activated protein kinases. In this paper, we propose a dynamical model of the molecular network that orchestrates maturation of Xenopus laevis oocytes. Our model reproduces the core features of maturation progression, including the characteristic non-monotonous time course of cyclin-Cdks, and unveils the network design principles underlying a precise sequence of meiotic decisions, as captured by bifurcation and sensitivity analyses. Firstly, a coherent and sharp meiotic resumption is triggered by the concerted action of positive feedback loops post-translationally activating cyclin-Cdks. Secondly, meiotic transition is driven by the dynamic antagonism between positive and negative feedback loops controlling cyclin turnover. Our findings reveal a highly modular network in which the coordination of distinct regulatory schemes ensures both reliable and flexible cell-cycle decisions

What’s in a Relationship: An Ontological Analysis

Abstract. In a series of publications, we have proposed a foundational system of ontological categories which has been successfully used to evaluate and im-prove the quality of conceptual modeling grammars and models. In this article, we continue this work by using this foundational ontology to provide real-world semantics and sound modeling guidelines for one of the most fundamental (and yet one of the most problematic) constructs in conceptual modeling, namely, the relationship type. In addition, we systematically compare our approach with a classical ontological treatment of this construct in the literature, provided by the BWW framework.

Installation and Hardware commissioning of the Multi-Turn extraction at the CERN proton synchrotron

The implementation of the new Multi-Turn Extraction (MTE) at the CERN Proton Synchrotron required major hardware changes for the nearly 50-year old accelerator. The installation of new Pulse Forming Networks (PFN) and refurbished kicker magnets for the extraction, new sextupole and octupole magnets, new power converters, together with an in-depth review of the machine aperture leading to the design of new vacuum chambers was required. As a result, a heavy programme of interventions had to be scheduled during the winter shut-down 2007-8. The newly installed hardware and its commissioning is presented and discussed in details

Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

BACKGROUND:Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved in many biological processes, such as platelet biology, angiogenesis and in the aetiopathology of atherosclerosis and cardiovascular diseases. Toll-like receptors (TLRs) are one of the most important receptors of the innate immune system. Their main function is the recognition of conserved structure of microorganisms. This recognition triggers signaling pathways that activate transcription of cytokines and co-stimulatory molecules which participate in the generation of an immune response against microbes. In particular, TLR2 has been shown to recognize a broad range of ligands. Recently, we showed that CD36 serves as a co-receptor for TLR2 and enhances recognition of specific diacylglycerides derived from bacteria. METHODOLOGY/ PRINCIPAL FINDINGS:Here, we investigate the mechanism by which CD36 contributes to ligand recognition and activation of TLR2 signaling pathway. We show that the ectodomain of murine CD36 (mCD36ED) directly interacts with negatively charged diacylglycerol ligands, which explains the specificity and selectivity of CD36 as a TLR2 co-receptor. We also show that mCD36ED amplifies the pro-inflammatory response to lipoteichoic acid in macrophages of wild-type mice and restores the pro-inflammatory response of macrophages from mice deficient in CD36 (oblivious), but not from mice deficient in cluster of differentiation 14 (CD14) (heedless). CONCLUSION/ SIGNIFICANCE: These data indicate that the CD36 ectodomain is the only relevant domain for activation of TLR2 signaling pathway and that CD36 and CD14 have a non-redundant role for loading ligands onto TLR2 in the plasma-membrane. The pro-inflammatory role of soluble CD36 can be relevant in the activation of the immune response against pathogens, as well as in the progression of chronic diseases. Therefore, an increased level of soluble forms of CD36, which has been reported to be increased in type II diabetic patients, could accelerate atherosclerosis by increasing the pro-inflammatory response to diacylglycerol ligands

Can gold be used as a hedge against the risks of Sharia-compliant securities? Application for Islamic portfolio management

In this paper, we investigate whether gold hedges Sharia-compliant stocks and Sukuk during the period from September 2005 to October 2017. The inference is taken by using both the DCC-GARCH model and the wavelet coherence analysis. On the whole, our finding suggests that gold is not effective in hedging the fluctuations of Sharia-compliant securities. However, we find that combining gold with stocks (and Sukuk) is useful in diversification and portfolio optimization. These results imply that, while gold is an excellent hedge for plain vanilla securities, it is not for Islamic exposures. This is important in light of the increasing amount of assets that are managed according to Islamic screening