800 research outputs found

    Singularités des surfaces paramétrées : courbures et isolignes uv serrées

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    Considering a CAD surface (resulting from a Computer-Aided Design system) defined by a planar domain parametrization, the first objective is to evaluate numerically the principal curvatures and directions at a given point of these surface and more particularly at the neighborhood of singular points (where partial derivatives are null or collinear). Secondly, the phenomenon of tight \textit{uv} isolines will be presented, which has for principal effect to transform a regular geometrical pattern in the parameters domain into a degenerated element in the Euclidian space, which is harmful for surface mesh generation.Etant donnĂ©e une surface CAO (issue de la Conception AssistĂ©e par Ordinateur) dĂ©finie via une paramĂ©trisation d'un domaine plan, le premier objectif est d'Ă©valuer numĂ©riquement les courbures et les directions principales en un point quelconque de cette surface et plus particuliĂšrement au voisinage des points singuliers (oĂč les dĂ©rivĂ©es partielles sont nulles ou colinĂ©aires). Dans un second temps, il s'agira de mettre en Ă©vidence le phĂ©nomĂšne dit des isolignes uv serrĂ©es, qui a pour principal effet de transformer une forme gĂ©omĂ©trique rĂ©guliĂšre dans le domaine des paramĂštres en un Ă©lĂ©ment dĂ©gĂ©nĂ©rĂ© dans l'espace euclidien, ce qui est nĂ©faste dans le cadre de la gĂ©nĂ©ration de maillages surfaciques

    Je tremble et Cercles/Fictions : l’utopie thĂ©Ăątrale de JoĂ«l Pommerat, une politique de l’imaginaire

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    Les deux derniers spectacles de JoĂ«l Pommerat, dont la signification apparaĂźt au premier abord Ă©nigmatique, sont susceptibles d’une lecture politique. Une telle lecture, qui permettrait d’en dĂ©gager le caractĂšre utopique, n’est cependant possible qu’à condition de comprendre le rapport spĂ©cifique du rĂ©el et de l’imaginaire qu’ils mettent en Ɠuvre. Ce rapport complexe se rĂ©vĂšle en effet plus fĂ©cond que leur opposition franche mise en avant par Sartre Ă  travers sa thĂ©orie de la libertĂ© et de l’imaginaire, laquelle, en dĂ©pit de sa clartĂ© apparente, dĂ©bouche en rĂ©alitĂ© sur des contradictions insurmontables. Par contraste, l’art thĂ©Ăątral de Pommerat rĂ©vĂšle Ă  l’analyse une proximitĂ© avec les rĂ©flexions de Foucault sur la fiction et les « hĂ©tĂ©rotopies ». Le thĂ©Ăątre, pour Pommerat, se dĂ©voile alors, non tant comme un moyen au service d’une fin politique, que comme une modalitĂ© mĂȘme de la politique, pourvu qu’on envisage celle-ci, par-delĂ  les jugements et les prises de position qui la mettent en Ɠuvre, comme une interrogation partagĂ©e sur une commune prĂ©sence au monde

    La preuve Ă  l'Ă©preuve. Origines et modalitĂ©s de l'enquĂȘte pĂ©nale selon Michel Foucault

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    Duguit, e depois? Direito, propriedade e relaçÔes sociais

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    In this paper, we present the famous Duguist critique of property based on its sociological foundations. We thus return to the difficulties encountered by Duguit in defending his thesis that property would be a "social function": the demand for solidarity on which the law is supposed to be based turns out to be not so much an objective fact as a demand axiological, for which Duguit finds himself faced with the difficulty of precisely defining the articulation between facts and values, which is at the base of his project of re-founding the law. We show that the interest of the Duguist action lies, however, in this unfinished attempt to re-inscribe the notion of private property in its social framework, which constitutes a critique of the power relations inherent to the market society. Duguit's originality lies then, even today, in his attempt to incorporate public institutions into the effective critique of such a society.Presentamos aquĂ­ la famosa crĂ­tica duguista de la propiedad a partir de sus fundamentos sociolĂłgicos. Volvemos asĂ­ sobre las dificultades con que se topĂł Duguit para defender su tesis segĂșn la cual la propiedad serĂ­a una «funciĂłn social»: la exigencia de solidaridad sobre la que se supone que se funda el derecho resulta ser no tanto un hecho objetivo como una exigencia axiolĂłgica, por lo que Duguit se encuentra ante la dificultad de definir con precisiĂłn la articulaciĂłn entre los hechos y los valores, que se encuentra en la base de su proyecto de refundaciĂłn del derecho. Demostramos que el interĂ©s de la acciĂłn duguista reside, sin embargo, en este intento inacabado de reinscribir la nociĂłn de propiedad privada en su marco social, lo que constituye una crĂ­tica de las relaciones de poder propias de la sociedad de mercado. La originalidad de Duguit reside entonces, aĂșn hoy, en su intento de incorporar las instituciones pĂșblicas en la crĂ­tica eficaz de tal sociedad.Nous prĂ©sentons ici la fameuse critique duguiste de la pro­priĂ©tĂ© basĂ©e sur ses fondements sociologiques. On revient ainsi sur les difficultĂ©s rencontrĂ©es par Duguit pour dĂ©fendre sa thĂšse selon laquelle la propriĂ©tĂ© serait une «fonction sociale»: l’exigence de soli­daritĂ© sur laquelle le droit est censĂ© se fonder s’avĂšre ĂȘtre moins un fait objectif qu’une exigence axiologique, pour lequel Duguit se trouve confrontĂ© Ă  la difficultĂ© de dĂ©finir prĂ©cisĂ©ment l’articulation entre faits et valeurs, qui est Ă  la base de son projet de refondation du droit. Nous montrons que l’intĂ©rĂȘt de l’action duguiste rĂ©side cependant dans cette tentative inachevĂ©e de rĂ©inscrire la notion de propriĂ©tĂ© privĂ©e dans son contexte social, qui constitue une critique des rapports de force inhé­rents Ă  la sociĂ©tĂ© de marchĂ©. L’originalitĂ© de Duguit rĂ©side alors, encore aujourd’hui, dans sa tentative d’incorporer les institutions publiques dans la critique effective d’une telle sociĂ©tĂ©.Apresentamos aqui a famosa crĂ­tica duguista da propriedade a partir de seus fundamentos sociolĂłgicos. Voltamos assim sobre as dificuldades encontradas por Duguit para defender sua tese de acordo com a qual a propriedade seria uma “função social”: a exigĂȘncia de solidariedade em que o direitoi supostamente se deve basear revela-se nĂŁo tanto um facto objectivo mas uma exigĂȘncia axiolĂłgica, de modo que Duguit encontra-se com a dificuldade de definir com precisĂŁo a articulação entre factos e valores, que estĂĄ na base de seu projecto de refundação do direito. Demonstramos que o interesse da acção de duguista reside, no entanto, nesta tentativa inacabada de reinscrever a noção de propriedade privada em seu quadro social, o que constitui uma crĂ­tica das relaçÔes de poder tĂ­picas da sociedade de mercado. A originalidade de Duguit reside entĂŁo, ainda hoje, em sua tentativa de incorporar as instituiçÔes pĂșblicas na crĂ­tica efectiva de tal sociedade

    Duguit, e depois? Direito, propriedade e relaçÔes sociais

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    Presentamos aquĂ­ la famosa crĂ­tica duguista de la propiedad a partir de sus fundamentos sociolĂłgicos. Volvemos asĂ­ sobre las dificultades con que se topĂł Duguit para defender su tesis segĂșn la cual la propiedad serĂ­a una «funciĂłn social»: la exigencia de solidaridad sobre la que se supone que se funda el derecho resulta ser no tanto un hecho objetivo como una exigencia axiolĂłgica, por lo que Duguit se encuentra ante la dificultad de definir con precisiĂłn la articulaciĂłn entre los hechos y los valores, que se encuentra en la base de su proyecto de refundaciĂłn del derecho. Demostramos que el interĂ©s de la acciĂłn duguista reside, sin embargo, en este intento inacabado de reinscribir la nociĂłn de propiedad privada en su marco social, lo que constituye una crĂ­tica de las relaciones de poder propias de la sociedad de mercado. La originalidad de Duguit reside entonces, aĂșn hoy, en su intento de incorporar las instituciones pĂșblicas en la crĂ­tica eficaz de tal sociedad.Apresentamos aqui a famosa crĂ­tica duguista da propriedade a partir de seus fundamentos sociolĂłgicos. Voltamos assim sobre as dificuldades encontradas por Duguit para defender sua tese de acordo com a qual a propriedade seria uma “função social”: a exigĂȘncia de solidariedade em que o direitoi supostamente se deve basear revela-se nĂŁo tanto um facto objectivo mas uma exigĂȘncia axiolĂłgica, de modo que Duguit encontra-se com a dificuldade de definir com precisĂŁo a articulação entre factos e valores, que estĂĄ na base de seu projecto de refundação do direito. Demonstramos que o interesse da acção de duguista reside, no entanto, nesta tentativa inacabada de reinscrever a noção de propriedade privada em seu quadro social, o que constitui uma crĂ­tica das relaçÔes de poder tĂ­picas da sociedade de mercado. A originalidade de Duguit reside entĂŁo, ainda hoje, em sua tentativa de incorporar as instituiçÔes pĂșblicas na crĂ­tica efectiva de tal sociedade.In this paper, we present the famous Duguist critique of property based on its sociological foundations. We thus return to the difficulties encountered by Duguit in defending his thesis that property would be a “social function”: the demand for solidarity on which the law is supposed to be based turns out to be not so much an objective fact as a demand axiological, for which Duguit finds himself faced with the difficulty of precisely defining the articulation between facts and values, which is at the base of his project of re-founding the law. We show that the interest of the Duguist action lies, however, in this unfi-nished attempt to re-inscribe the notion of private property in its social framework, which constitutes a critique of the power relations inherent to the market society. Duguit’s originality lies then, even today, in his attempt to incorporate public institutions into the effective critique of such a society.Facultad de Ciencias JurĂ­dicas y Sociale

    Diagnosis and Treatment of Bradykinin-Mediated Angioedema: Outcomes from an Angioedema Expert Consensus Meeting

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    Several types of angioedema exist beyond hereditary angioedema (HAE) types I/II; however, the diagnostic and treatment needs of these conditions are not well understood. Noticeably, there are no licensed treatments available for other forms of angioedema beyond HAE types I/II, and similarly they are unresponsive to conventional antihistamine/glucocorticoid treatment. A group of angioedema experts met in Budapest in May 2013 to discuss such issues, presenting their experience, reviewing available literature and identifying unmet diagnostic and treatment needs in three different angioedema types: HAE with normal C1-inhibitor (C1-INH; previously referred to as type III HAE); nonallergic angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEI-AAE), and acquired angioedema due to C1-INH deficiency (C1-INH-AAE). The group identified unmet diagnostic and treatment needs in HAE-nC1-INH, C1-INH-AAE and ACEI-AAE, explored remedies and made recommendations on how to diagnose and treat these forms of angioedema. The group discussed the difficulties associated with using diagnostic markers, such as the level and function of C1-INH, C1q and C4 to reliably diagnose the angioedema type, and considered the use of genetic testing to identify mutations in FXII or XPNPEP2 that have been associated with HAE-nC1-INH and ACEI-AAE, respectively. Due to the lack of approved treatments for HAE-nC1-INH, ACEI-AAE and C1-INH-AAE, the group presented several case studies in which therapies approved for treatment of HAE types I/II, such as icatibant, ecallantide and pasteurized, nanofiltered C1-INH, were successful. It was uniformly agreed that further studies are needed to improve the diagnosis and treatment of angioedema other than HAE types I/II. (c) 2014 S. Karger AG, Basel

    Reactivity of a Functionalized Trisamido Ligand with Zr(NMe2)4 and GaMe3

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    NMR study of the reactivity of multifunctional ligand cis,cis-C6H9(NHCH2C6H4-o-PPh2)3 (1) with GaMe3 and Zr(NMe2)4 was carried out, yielding [cis,cis-(ÎșN-NHCH2C6H4-o-PPh2)(ÎșN-NCH2C6H4-o-PPh2)2C6H9]GaMe (2) and [cis,cis-(NCH2C6H4-o-PPh2)3C6H9]Ga2Me3 (3), and [cis,cis-(NCH2C6H4-o-PPh2)3C6H9]Zr(NMe2) (4), respectively. The spectral properties of 2 and 3 are very similar to that observed for the equivalent aluminum species already reported, but form at a much slower rate which allows for the observation of a GaMe3⋅1 adduct. Species 4 undergoes coordination/displacement of one of the phosphine arms, which was observed using both NMR spectroscopy and DFT analyses

    Short-term pretreatment with a dual 5α-reductase inhibitor before bipolar transurethral resection of the prostate (b-turp): evaluation of prostate vascularity and decreased surgical blood loss in large prostates

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    Objective: To investigate if short-term treatment with dutasteride (8 weeks) before bipolar transurethral resection of the prostate (B-TURP) can reduce intraoperative bleeding, as dutasteride a dual 5α-reductase inhibitor (5-ARI) blocks the conversion of testosterone into its active form dihydrotestosterone (DHT), and reduces prostate volume and prostate-specific antigen (PSA) levels, while increasing urinary flow rate. Patients and Methods: In all, 259 patients were enrolled and randomised to two groups: Group A, receiving placebo and Group B, receiving dutasteride (0.5mg daily for 8 weeks). Blood samples were taken before and after B-TURP for serum chemistry evaluation. In particular we evaluated blood parameters associated with blood loss [haemoglobin (Hb) and haematocrit (Ht)] and prostate vascularity [vascular endothelial growth factor (VEGF) immunoreactivity and microvessel density (MVD) using cluster of differentiation 34 (CD34) immunoreactivity]. Results: Total testosterone, DHT, PSA level and prostate volume were evaluated and with the exception of DHT and PSA level there was no statistically significant differences between the groups. When comparing changes in Hb and Ht between Group A and Group B before and after B-TURP, there was a statistically significant difference only in patients with large prostates of ≄50mL (ΔHb 3.86 vs 2.05g/dL and ΔHt 4.98 vs 2.64%, in Groups A and B, respectively). There was no significant difference in MVD and VEGF index in prostates of <50mL, conversely in large prostates the difference become statistically significant. Conclusions: Dutasteride was able to reduce operative and perioperative bleeding only in patients with large prostates (≄50mL) that underwent B-TURP. Our findings are confirmed by Hb and Ht values reported before and after the B-TURP and reductions in the molecular markers for VEGF and CD34 in the dutasteride-treated specimens

    La promotion de la santé mentale des pÚres durant la période périnatale: travail de Bachelor

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    Introduction: Depuis 2015, l’Organisation mondiale de la santĂ© [OMS] appelle les Sages-femmes* Ă  inclure les pĂšres dans les services de pĂ©rinatalitĂ© pour amĂ©liorer la santĂ© des mĂšres et des enfants. Cependant, selon les recherches rĂ©centes prĂšs d’un pĂšre sur dix souffrirait de dĂ©pression pĂ©rinatale [DPN] avec des rĂ©percussions nĂ©gatives sur toute la famille notamment le dĂ©veloppement des enfants. Objectif : Explorer les facteurs protecteurs de la santĂ© mentale des pĂšres et le rĂŽle que pourraient avoir les sages-femmes auprĂšs des pĂšres. MĂ©thode : Ce travail est une revue de la littĂ©rature scientifique limitĂ©e Ă  5 articles recueillis dans les bases de donnĂ©es Medline, PsycINFO, CINAHL, MIDIRS et le moteur de recherche Google Scholar grĂące Ă  des mots6clĂ©s tels que « fathers », « mental health » et « midwives » avec un filtre incluant les publications du 1.01.2004 au 15.01.2018. RĂ©sultats : Selon les Ă©tudes, les pĂšres ont besoin de soutien Ă©motionnel et informatif pour assurer leur bien6ĂȘtre psychique durant la pĂ©riode pĂ©rinatale. Le bien-ĂȘtre de la partenaire, la satisfaction dans le couple, le sentiment de cohĂ©rence familiale et le sentiment d’auto6efficacitĂ© parentale seraient des facteurs protecteurs de la DPN. Les pĂšres expriment un sentiment d’exclusion des services de pĂ©rinatalitĂ© et un manque de reconnaissance dans leur rĂŽle de coparent. Ils questionnent leur lĂ©gitimitĂ© Ă  y ĂȘtre inclus craignant le regard de la sociĂ©tĂ© et d’îter des ressources Ă  la mĂšre et l’enfant. Les sages6femmes ont besoin de formations complĂ©mentaires et ne semblent pas ĂȘtre l’interlocuteur privilĂ©giĂ©, cependant elles peuvent avoir un impact favorable. Les pĂšres se disent intĂ©ressĂ©s par de l’information sur diffĂ©rents supports et des services de pĂ©rinatalitĂ© plus flexibles. Limites : La santĂ© mentale des pĂšres est un objet de recherche rĂ©cent et les publications peu nombreuses limitent la comparaison des rĂ©sultats. De plus, la paternitĂ© Ă©voluant rapidement socialement, cette revue de la littĂ©rature devrait ĂȘtre mise Ă  jour rĂ©guliĂšrement. Conclusion : Ces rĂ©sultats invitent les sages-femmes Ă  rĂ©flĂ©chir Ă  la place accordĂ©e aux pĂšres dans les services de pĂ©rinatalitĂ©, la formation des sages6 femmes et les programmes Ă  destination des parents. Des interventions favorisant le bien ĂȘtre des partenaires, la qualitĂ© de la relation de couple, le sentiment de cohĂ©rence familial et le sentiment d’auto-efficacitĂ© parentale des pĂšres pourraient ĂȘtre mises en place. *Bien qu'il s'entende aussi au masculin, le terme sage-femme est employĂ© au fĂ©minin par mesure de simplification

    Shoot regeneration and genetic transformation by Agrobacterium tumefaciens of Hydrangea macrophylla Ser. leaf discs

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    A reproducible procedure was developed for genetic transformation of Hydrangea macrophylla Ser. cv. Blaumeise by Agrobacterium tumefaciens following the development of an efficient regeneration system using leaf discs excised from 12 to 15 weeks old meristem-derived vitroplants. Explants were cultivated on solid B5 medium complemented with maltose 110 mM, BAP 10 ÎŒM and NAA 0.5 ÎŒM. A low light regime of 17 ÎŒmol m−2 s−1 improved regeneration frequency up to 86%. For transformation, leaf discs were inoculated and co-cultivated with two disarmed A. tumefaciens strains, EHA 101 and LBA 4404, both carrying the binary vector pFAJ3000 which contained the nptII selectable gene and the GUS reporter gene. A pre-culture period of 3 days and a short co-cultivation duration (1 day) improved the efficiency of transformation. Inoculation of only 10 min with agitation including (or not) vacuum infiltration was sufficient. If selection on kanamycin containing medium was applied after a 2 weeks culture period on shoot regeneration medium, the percentage of explants forming kanamycin-resistant shoots increased from 3.3 to 13.3%. Integration and expression of the introduced transgene were confirmed by histochemical GUS assay, PCR and Southern blot analysis. Flowering of transgenic plants in glasshouse occurred 10 months after acclimatization
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