47 research outputs found
Nanocomposite Materials for Cell Growth
We propose a development of carbon nanotube (CNT)/albumin nanocomposite for 2D and 3D tissue organization by cell growth. The adhesion and proliferation for neuroblastoma and fibroblast cells have been investigated on films based on CNT/bovine serum albumin (BSA) nanocomposite. Single-walled car-bon nanotube (SWNT)/BSA composites can be used as a substrate for cell growth of different kind. The layers of nanocomposite properties growing method based on laser radiation action. Investigations of sta-bility, an adhesion and internal structure of layers were performed. Stabilizing properties of the described laser method of manufacture (laser nanoforming) of layers may be associated with the ability to obtain nanotube frame work in composite structure under action of electric field of directed laser radiation. The presence of a such frame creates the conditions for self-assembly of biomedical tissues.
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Molecular doping of single-walled carbon nanotube transistors: optoelectronic study
Single-walled carbon nanotubes (SWCNT) are a promising material for future optoelectronic applications, including flexible electrodes and field-effect transistors. Molecular doping of carbon nanotube surface can be an effective way to control the electronic structure and charge dynamics of these material systems. Herein, two organic semiconductors with different energy level alignment in respect to SWCNT are used to dope the channel of the SWCNT-based transistor. The effects of doping on the device performance are studied with a set of optoelectronic measurements. For the studied system, we observed an opposite change in photo-resistance, depending on the type (electron donor vs electron acceptor) of the dopants. We attribute this effect to interplay between two effects: (i) the change in the carrier concentration and (ii) the formation of trapping states at the SWCNT surface. We also observed a modest ~4 pA photocurrent generation in the doped systems, which indicates that the studied system could be used as a platform for multi-pulse optoelectronic experiments with photocurrent detection.JZ wants to thank China Scholarship Council for supporting PhD studies. AVE and IIB acknowledge Russian Science Foundation under grant №14-19-01308 for kindly support
Femtomolar detection of the heart failure biomarker NT-proBNP in artificial saliva using an immersible liquid-gated aptasensor with reduced graphene oxide
Measuring NT-proBNP biomarker is recommended for preliminary diagnostics of
the heart failure. Recent studies suggest a possibility of early screening of
biomarkers in saliva for non-invasive identification of cardiac diseases at the
point-of-care. However, NT-proBNP concentrations in saliva can be thousand time
lower than in blood plasma, going down to pg/mL level. To reach this level, we
developed a label-free aptasensor based on a liquid-gated field effect
transistor using a film of reduced graphene oxide monolayer (rGO-FET) with
immobilized NT-proBNP specific aptamer. We found that, depending on ionic
strength of tested solutions, there were different levels of correlation in
responses of electrical parameters of the rGO-FET aptasensor, namely, the Dirac
point shift and transconductance change. The correlation in response to
NT-proBNP was high for 1.6 mM phosphate-buffered saline (PBS) and zero for 16
mM PBS in a wide range of analyte concentrations, varied from 1 fg/mL to 10
ng/mL. The effects of transconductance and Dirac point shift in PBS solutions
of different concentrations are discussed. The biosensor exhibited a high
sensitivity for both transconductance (2 uS/decade) and Dirac point shift (2.3
mV/decade) in diluted PBS with the linear range from 10 fg/mL to 1 pg/mL. The
aptasensor performance has been also demonstrated in undiluted artificial
saliva with the achieved limit of detection down to 41 fg/mL (~4.6 fM)
Photothermoelectric response in asymmetric carbon nanotube devices exposed to sub-terahertz radiation
Laser modification of graphene oxide layers
The effect of linearly polarized laser irradiation with various energy densities was successfully used for reduction of graphene oxide (GO). The ion beam analytical methods (RBS, ERDA) were used to follow the elemental composition which is expected as the consequence of GO reduction. The chemical composition analysis was accompanied by structural study showing changed functionalities in the irradiated GO foils using spectroscopy techniques including XPS, FTIR and Raman spectroscopy. The AFM was employed to identify the surface morphology and electric properties evolution were subsequently studied using standard two point method measurement. The used analytical methods report on reduction of irradiated graphene oxide on the surface and the decrease of surface resistivity as a growing function of the laser beam energy density
Graphene-Based Sensing Platform for On-Chip Ochratoxin A Detection
In this work, we report an on-chip aptasensor for ochratoxin A (OTA) toxin detection that is based on a graphene field-effect transistor (GFET). Graphene-based devices are fabricated via large-scale technology, allowing for upscaling the sensor fabrication and lowering the device cost. The sensor assembly was performed through covalent bonding of graphene’s surface with an aptamer specifically sensitive towards OTA. The results demonstrate fast (within 5 min) response to OTA exposure with a linear range of detection between 4 ng/mL and 10 pg/mL, with a detection limit of 4 pg/mL. The regeneration time constant of the sensor was found to be rather small, only 5.6 s, meaning fast sensor regeneration for multiple usages. The high reproducibility of the sensing response was demonstrated via using several recycling procedures as well as various GFETs. The applicability of the aptasensor to real samples was demonstrated for spiked red wine samples with recovery of about 105% for a 100 pM OTA concentration; the selectivity of the sensor was also confirmed via addition of another toxin, zearalenone. The developed platform opens the way for multiplex sensing of different toxins using an on-chip array of graphene sensors
Photo-Induced Doping in a Graphene Field-Effect Transistor with Inkjet-Printed Organic Semiconducting Molecules
In this work, we report a novel method of maskless doping of a graphene channel in a field-effect transistor configuration by local inkjet printing of organic semiconducting molecules. The graphene-based transistor was fabricated via large-scale technology, allowing for upscaling electronic device fabrication and lowering the device’s cost. The altering of the functionalization of graphene was performed through local inkjet printing of N,N′-Dihexyl-3,4,9,10-perylenedicarboximide (PDI-C6) semiconducting molecules’ ink. We demonstrated the high resolution (about 50 µm) and accurate printing of organic ink on bare chemical vapor deposited (CVD) graphene. PDI-C6 forms nanocrystals onto the graphene’s surface and transfers charges via π–π stacking to graphene. While the doping from organic molecules was compensated by oxygen molecules under normal conditions, we demonstrated the photoinduced current generation at the PDI-C6/graphene junction with ambient light, a 470 nm diode, and 532 nm laser sources. The local (in the scale of 1 µm) photoresponse of 0.5 A/W was demonstrated at a low laser power density. The methods we developed open the way for local functionalization of an on-chip array of graphene by inkjet printing of different semiconducting organic molecules for photonics and electronics
Alleviating Distortion and Improving the Young’s Modulus in Two-Photon Polymerization Fabrications
Advances in nanomaterials-based electrochemical biosensors for foodborne pathogen detection
Electrochemical biosensors utilizing nanomaterials have received widespread attention in pathogen detection and monitoring. Here, the potential of different nanomaterials and electrochemical technologies is reviewed for the development of novel diagnostic devices for the detection of foodborne pathogens and their biomarkers. The overview covers basic electrochemical methods and means for electrode functionalization, utilization of nanomaterials that include quantum dots, gold, silver and magnetic nanoparticles, carbon nanomaterials (carbon and graphene quantum dots, carbon nanotubes, graphene and reduced graphene oxide, graphene nanoplatelets, laser-induced gra-phene), metal oxides (nanoparticles, 2D and 3D nanostructures) and other 2D nanomaterials. More-over, the current and future landscape of synergic effects of nanocomposites combining different nanomaterials is provided to illustrate how the limitations of traditional technologies can be over-come to design rapid, ultrasensitive, specific and affordable biosensors
Two-Photon Polymerization of Albumin Hydrogel Nanowires Strengthened with Graphene Oxide
Multifunctional biomaterials can pave a way to novel types of micro- and nanoelectromechanical systems providing benefits in mimicking of biological functions in implantable, wearable structures. The production of biocomposites that hold both superior electrical and mechanical properties is still a challenging task. In this study, we aim to fabricate 3D printed hydrogel from a biocomposite of bovine serum albumin with graphene oxide (BSA@GO) using femtosecond laser processing. We have developed the method for functional BSA@GO composite nanostructuring based on both two-photon polymerization of nanofilaments and direct laser writing. The atomic-force microscopy was used to probe local electrical and mechanical properties of hydrogel BSA@GO nanowires. The improved local mechanical properties demonstrate synergistic effect in interaction of femtosecond laser pulses and novel composite structure