Socio economic and psychological benefits of employment for people with disabilities

Pravo na rad za osobe s invaliditetom prepoznato je Konvencijom o pravima osoba s invaliditetom (UN, 2006) koju je i Republika Hrvatska (RH) ratificirala. U Republici Hrvatskoj prava osoba s invaliditetom na profesionalnu rehabilitaciju, zapošljavanje i rad propisana su Zakonom o profesionalnoj rehabilitaciji i zapošljavanju osoba s invaliditetom (NN 157/2013, 152/14, 39/18). Unatoč zakonskoj regulativi, osobe s invaliditetom se suočavaju s brojnim preprekama pri zapošljavanju. Uzroke otežanom zapošljavanju osoba s invaliditetom možemo pronaći u nižoj formalnoj razini obrazovanja, lošoj gospodarskoj situaciji, predrasudama i negativnim stavovima poslodavaca, kao i njihovoj zabrinutosti o radnoj sposobnosti osoba s invaliditetom i potrebnim prilagodbama. U prilog potrebi zapošljavanja osoba s invaliditetom svakako govore i dobrobiti koje osobe s invaliditetom pritom ostvaruju. Zaposlenost je najvažniji način održavanja prihoda, nužnih za financijsku sigurnost i punopravno sudjelovanje u društvu (Honey, 2004). Rad osigurava smislenu organizaciju vremena i prilike za razvoj novih vještina tijekom sudjelovanja u različitim aktivnostima. Obavljanje plaćenih i značajnih poslova pomoći će osobama s invaliditetom u stjecanju društveno vrednovanih uloga i izgradnji društvenog identiteta (Wolfensberger, 1972 prema Jenkins, 2002). Zaposlenost je put prema stjecanju neovisnosti i osjećaju pripadnosti (Jenkins, 2002). Rad doprinosi fizičkom i mentalnom zdravlju osobe i jačanju samopouzdanja (Wadell i Burton, 2006 prema Kulkarni i Kote, 2014). Zaposlenost nudi izazove, stimulaciju i pruža osobno zadovoljstvo (Baume i Kay, 1995; Reark Research, 1993 prema Honey, 2004). Cilj ovog diplomskog rada je dobiti uvid u perspektivu osoba s invaliditetom zaposlenih u poduzećima grupacije Calzedonia u Republici Hrvatskoj o društveno-ekonomskoj i psihološkoj dobrobiti zapošljavanja za osobe s invaliditetom. Problemska pitanja koja proizlaze iz ovog cilja su: postoje li dobrobiti zapošljavanja za osobe s invaliditetom i koje su dobrobiti koje ostvaruju. S obzirom na cilj istraživanja i postavljena istraživačka pitanja u ovom je istraživanju korišten kvalitativni pristup prikupljanja podataka. Kao tehnika prikupljanja podataka odabrana je metoda grupnog intervjuiranja ili grupne diskusije odnosno fokus grupa u kojoj je sudjelovalo šest osoba s invaliditetom različitih vrsta oštećenja. Podaci prikupljeni istraživanjem pokazuju da sudionici prepoznaju brojne dobrobiti rada: financijski doprinos rada, doprinos rada osobnom razvoju i sigurnosti, osjećaju vlastite dobrobiti i neovisnosti, doprinos rada za obitelj, ostvarivanje interakcija i međuljudske odnose. Izrazili su zadovoljstvo inkluzivnom praksom poduzeća u kojem rade te pritom dali i važne prijedloge poboljšanju vlastite kvalitete rada.The right of persons with disabilities to work is recognized by Convention on the Rights of Persons with Disabilities (UN, 2006), which is also ratificated by Republic of Croatia. Right of persons with disabilities to professional rehabilitation, employment and work are given by Act on professional rehabilitation, employment and work of persons with disabilities (NN 157/2013, 152/14, 39/18). Despite legislation, persons with disabilities still face many barriers to employment. Difficulties which persons with disabilities face are caused by lower educational level, poor economic situation, prejudice and negative attitudes of employers, as well as worries they have about working ability of people with disabilites and necessary adjustments. In favor of employing persons with disabilities go benefits which employed persons with disabilites experience. Employment is the most important way of maintaining income necessary for financial security and full participation in society (Honey, 2004). Work provides meaningful time organisation and gives opportunities to develop new skills by participating in different activities. Performing meaningful and paid work helps persons with disabilities to acquire valued social roles and build social identity (Wolfensberger, 1972 according to Jenkins, 2002). Employment is way to establish independence and feeling of belonging (Jenkins, 2002). Work contributes to physical and mental health, and builds selfconfidence (Wadell i Burton, 2006 according to Kulkarni i Kote, 2014). Employment offers challenge, stimulation and personal satisfaction (Baume i Kay, 1995; Reark Research, 1993 according to Honey, 2004). The aim of this thesis is to get insight in perspective of persons with disabilities employed in different companies of affiliation of Calzedonia in Republic of Croatia, with regard to socio-economic and psychological benefits of employment for persons with disabilities. There are two research questions: are there any benefits of employing people with disabilities and which are those. Given the aim of the research and set up research questions in this study used a qualitative approach to data collection. As data collection technique was chosen method of group interviews or group discussions and focus groups in which participated six people with disabilities with different types of disability. Data collected by the survey indicate that participants recognize many benefits of work: financial benefit, benefits of work to personal development and feelings of safety, personal benefits and independence, benefits of work for families and interpersonal relationships and interactions. They expressed their satisfaction with inclusive practice of company they work for and gave important suggestions for improvment of their own work quality

THE PERCEPTION OF UNETHICAL ISSUES IN SELECTED THAILAND TOURIST AREAS: MEASURING THE ATTITUDES OF FOREIGN TOURISM STUDENTS

The principal aim of the paper was to examine what kind of experience international exchange students, as future professionals in tourism industry, gained during their study at the Faculty of Hospitality and Tourism in Phuket, Thailand. Thus, the paper deals with how often they encountered the unethical issues in the tourism industry, and how these issues affect their perception of the image of Thailand as a tourist destination. The paper also explores how formal education in Tourism ethics affects the perception of Thailand tourism unethical practices, and as such, it is one of the first studies in this field. In addition, the paper intends to show if there is a relationship between formal education in Ethics in tourism and the respondents’ experience and perception of unethical issues. The results show that these unethical issues have the significant and very strong influence on tourism perception of Thailand with a special emphasis on exploitation of women and children in sex tourism. Also, the study indicates that respondents who have a formal education in Ethics were more aware and had a clearer picture of the negative effect of these unethical issues on the image of Thailand as a destination

Supplementary data for the article: Božić, A. R.; Bjelogrlić, S. K.; Novaković, I. T.; Filipović, N. R.; Petrović, P. M.; Marinković, A. D.; Todorović, T. R.; Cvijetić, I. N. Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models. ChemistrySelect 2018, 3 (7), 2215–2221. https://doi.org/10.1002/slct.201702691

Supplementary material for: [https://doi.org/10.1002/slct.201702691]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2094

Supplementary data for the article: Božić, A.; Marinković, A.; Bjelogrlić, S.; Todorović, T. R.; Cvijetić, I. N.; Novaković, I.; Muller, C. D.; Filipović, N. R. Quinoline Based Mono- and Bis-(Thio)Carbohydrazones: Synthesis, Anticancer Activity in 2D and 3D Cancer and Cancer Stem Cell Models. RSC Advances 2016, 6 (106), 104763–104781. https://doi.org/10.1039/c6ra23940d

Supplementary material for: [https://doi.org/10.1039/c6ra23940d]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2352

Supplementary data for the article: Božić, A. R.; Bjelogrlić, S. K.; Novaković, I. T.; Filipović, N. R.; Petrović, P. M.; Marinković, A. D.; Todorović, T. R.; Cvijetić, I. N. Antimicrobial Activity of Thiocarbohydrazones: Experimental Studies and Alignment-Independent 3D QSAR Models. ChemistrySelect 2018, 3 (7), 2215–2221. https://doi.org/10.1002/slct.201702691

Supplementary material for: [https://doi.org/10.1002/slct.201702691]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2094

Supplementary data for the article: Božić, A.; Marinković, A.; Bjelogrlić, S.; Todorović, T. R.; Cvijetić, I. N.; Novaković, I.; Muller, C. D.; Filipović, N. R. Quinoline Based Mono- and Bis-(Thio)Carbohydrazones: Synthesis, Anticancer Activity in 2D and 3D Cancer and Cancer Stem Cell Models. RSC Advances 2016, 6 (106), 104763–104781. https://doi.org/10.1039/c6ra23940d

Supplementary material for: [https://doi.org/10.1039/c6ra23940d]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2352

Supplementary data for article: Božić, A. R.; Filipović, N. R.; Verbić, T.; Milčić, M. K.; Todorović, T.; Cvijetić, I.; Klisurić, O.; Radišić, M.; Marinković, A. A Detailed Experimental and Computational Study of Monocarbohydrazones. Arabian Journal of Chemistry 2020. https://doi.org/10.1016/j.arabjc.2017.08.010

Supplementary material for: [https://www.sciencedirect.com/science/article/pii/S1878535217301661?via%3Dihub]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/318

Koštani morfogenetski proteini (BMP): Od otkrića do razvoja nove autologne koštane naprave koja se sastoji od rekombinantnog humanog BMP6 u autolognom krvnom ugrušku kao nosaču

Bone Morphogenetic Proteins (BMPs) are growth and differentiation factors within the TGFβ superfam- ily of proteins. They induce ectopic and orthotopic endochondral bone formation and are involved in the regulation of cell proliferation, differentiation, apoptosis and mesenchymal-epithelial interactions in critical morphogenetic processes of tissues beyond bone. BMP2 and BMP7 osteogenic devices have been approved for enhancing healing in patients with long bone defects and anterior spinal fusion proce- dures. However, due to a high price and various serious adverse events including heterotopic ossifica- tion, retrograde ejaculation and pain their clinical use have been limited. In this review we discuss the BMP discovery, biology and their use in clinical studies with particular reference to the newly developed BMP6 based autologous bone graft substitute (ABGS). A novel ABGS consisting of an autologous bone coagulum (ABC) carrier with dispersed BMP6 to initiate the differentiation of mesenchymal cells into endochondral bone. The ABC met the conditions for an optimal delivery system for BMP6 due to han- dling simplicity, without an immunogenic and inflammatory response at the implantation site. Addition of allograft or synthetic ceramics to ABGS demonstrated in animal models significantly increased volume and better microarchitecture of the newly formed bone. The first clinical study was conducted in patients with distal radial fractures (Phase I study) and the second in patients undergoing high tibial osteotomy (Phase I/II study) and no serious adverse events have been observed. Finally, in the ongoing OSTEO- proSPINE study ABGS enforced with allograft bone is evaluated in patients with chronic back pain due to degenerative disc diseases. The novel ABGS bone mimetic is a major breakthrough and contribution to bone biology and regenerative medicine of skeletal repair.Koštani morfogenetski proteini (BMP) čine grupu čimbenika rasta i diferencijacije unutar TGFβ nado- bitelji. Oni induciraju stvaranje ektopične i ortotopične endohondralne kosti te su uključeni u regulaciju stanične proliferacije, diferencijacije, apoptoze i mezenhimalno-epitelne interakcije u važnim tkivnim morfogenetskim procesima izvan koštanog sustava. Koštane naprave koje sadrže BMP2 i BMP7 pro- tein odobrene su za poboljšanje koštanog cijeljenja kod pacijenata s defektima dugih cjevastih kostiju i kod prednje spinalne fuzije kralježnice. Međutim, zbog visoke cijene i mnogobrojnih nuspojava koje su uključivale pojavu heterotopičnih osifikacija, retrogradnu ejakulaciju i bol, njihova je klinička prim- jena ograničena. U ovom smo preglednom radu raspravili otkriće BMP molekula, njihovu biologiju i primjenu u kliničkim studijama s posebnim osvrtom na nedavno otkrivenu novu autolognu koštanu napravu (ABGS) koja sadrži BMP6. Novi ABGS sastoji se od nosača autolognog koaguluma (ABC) s otopljenim BMP6 koji je ključan za pokretanje diferencijacije mezenhimalnih stanica u smjeru stvaranja endohondralne kosti. ABC je ispunio sve potrebne uvjete za formulaciju optimalnog nosača za BMP6 isključivo zbog jednostavnosti priprave i primjene te odsustva imunogenog i upalnog odgovora na mjestu implantacije. Uz dodatak alografta ili sintetičke keramike što je potvrđeno na životinjskim modelima došlo je do značajnog povećanja volumena te poboljšanja mikroarhitekture novonastale kosti. Prvo kliničko ispitivanje provedeno je na pacijentima s distalnim prijelomima radijusa (faza I studije), a drugo na pacijentima koji su podvrgnuti visokoj osteotomiji tibije (faza I/II studije) bez uočenih ozbiljnih nuspojava. Trenutno je u tijeku studija OSTEOproSPINE u kojoj se testira učinkovitost ABGS u kom- binaciji s koštanim alograftom u bolesnika s kroničnim bolovima u leđima uzrokovanim degenerativnim promjenama intervertebralnog diska. Nova ABGS koštana naprava značajna je prekretnica i napredak u području koštane biologije te regenerativne medicine koštanog sustava

Galectin-1 Is Part of Human Trophoblast Invasion Machinery - A Functional Study In Vitro

Interactions of glycoconjugates with endogenous galectins, have been long proposed to participate in several reproductive processes including implantation. In human placenta gal-1, gal-3, gal-8, and gal-13 proteins are known to be present. Each of them has been proposed to play multiple functions, but so far no clear picture has emerged. We hypothesized that gal-1 participates in trophoblast invasion, and conducted Matrigel invasion assay using isolated cytotrophoblast from first trimester placenta and HTR-8/SVneo cell line to test it.<0.001) by Ox-gal-1 at 1 µg/ml. Both sets of results confirmed involvement of gal-1 in trophoblast invasion. Galectin profile of isolated cytotrophoblast and HTR-8/SVneo cells was established using RT-PCR and real-time PCR and found to consist of gal-1, gal-3 and gal-8 for both cell types. Only gal-1 was located at the trophoblast cell membrane, as determined by FACS analysis, which is consistent with the results of the functional tests.These findings qualify gal-1 as a member of human trophoblast cell invasion machinery

TROŠARINE NA NAFTU I NAFTNE DERIVATE I NJIHOV FINANCIJSKI ZNAČAJ

Ovaj rad prvenstveno će obuhvatiti jedan od najstarijih poreznih oblika u Republici Hrvatskoj. Riječ je o posebnim porezima, odnosno popularno nazvanim akcizama ili trošarinama. Kako su posebni porezi u Republici Hrvatskoj jedan od izdašnijih izvora oporezivanja, tako se ova tema pokazala opravdanom kao izbor ovog završnog rada. Posebnim porezima unutar svakog modernog poreznog sustava oporezuju se najčešće alkohol, energenti i duhan, dok od države do države postoji niz drugih izvora oporezivanja posebnim porezima. Posebne poreze pojedine države uvode zbog raznih kako u prvom redu fiskalnih razloga, tako i zbog niza drugih poput socijalnih, zdravstvenih i ekoloških. Republika Hrvatska jedna je od takvih zemalja i trenutno u Republici Hrvatskoj nailazimo na široku lepezu proizvoda koji predstavljaju poreznu osnovicu pri oporezivanju ovom vrstom poreza. Jedna od značajnih prednosti za zakonodavca i njegovo opravdanje i odgovor na pitanje zašto posebni porezi leži upravo u jednostavnosti ubiranja, malom broju poreznih obveznika i ne manje bitnoj izdašnosti ovog poreznog oblika. Ako, pak posebne poreze razmatramo s aspekta Europske Unije može se spomenuti da EU pokušava uskladiti porezne sustave svojih članica, posebice u domeni trošarina, no za sada još uvijek postoje znatne razlike kako u poreznim stopama ali isto tako i u strukturi trošarina pojedinih zemalja. Stoga će cilj i svrha ovog završnog rada biti detaljnije obraditi samo jedan oblik trošarina pod nazivom trošarine na naftu i naftne derivate te pokušati precizirati njihov financijski značaj u strukturi trošarina u Republici Hrvatskoj