Estimating past inhalation exposure to asbestos: a tool for risk attribution and disease screening

Introduction: Late presentation is common in mesothelioma. Reliable assessment of past exposure to asbestos is a necessary first step for risk attribution and for the development of a future screening programme. Such a programme could maximise access to trials of novel therapies and would pave the way for development of novel chemoprophylaxis strategies. This paper describes a method for individual exposure reconstruction along with data from a validation study. Methods: The exposure assessment method uses only descriptive information about the circumstances of the work that could be obtained from questioning the worker. The assessment is based on the tasks carried out and includes parameters for substance emission potential, activity emission potential, the effectiveness of any local control measures, passive emission, the fractional time the asbestos source is active and the efficiency of any respiratory protection worn. Results: There was a good association between the estimated and measured exposure levels. Pearson’s correlation coefficient between the log-transformed measurements and estimates from the model was 0.86, and 95% of the estimated individual values were within about a factor of ten of the associated measured value. The method described would be suitable for pre-selecting individuals at high risk of malignant pleural mesothelioma for screening using appropriate tools and/or enrolment in clinical trials of chemo-prophylaxis. Discussion: This method is of potential clinical value in developing novel treatment approaches for mesothelioma. Pilot studies to test this approach are urgently needed

Quantified HI Morphology VII: star-formation and tidal influence on local dwarf HI morphology

Scale-invariant morphology parameters applied to atomic hydrogen maps (HI) of galaxies can be used to quantify the effects of tidal interaction or star-formation on the ISM. Here we apply these parameters, Concentration, Asymmetry, Smoothness, Gini, M20, and the GM parameter, to two public surveys of nearby dwarf galaxies, the VLA-ANGST and LITTLE-THINGS survey, to explore whether tidal interaction or the ongoing or past star-formation is a dominant force shaping the HI disk of these dwarfs. Previously, HI morphological criteria were identified for ongoing spiral-spiral interactions. When we apply these to the Irregular dwarf population, they either select almost all or none of the population. We find that only the Asymmetry-based criteria can be used to identify very isolated dwarfs (i.e., these have a low tidal indication). Otherwise, there is little or no relation between the level of tidal interaction and the HI morphology. We compare the HI morphology to three star-formation rates based on either Halpha, FUV or the resolved stellar population, probing different star-formation time-scales. The HI morphology parameters that trace the inequality of the distribution, the Gini, GM, and M20 parameters, correlate weakly with all these star-formation rates. This is in line with the picture that local physics dominates the ISM appearance and not tidal effects. Finally, we compare the SDSS measures of star-formation and stellar mass to the HI morphological parameters for all four HI surveys. In the two lower-resolution HI surveys (12"), there is no relation between star-formation measures and HI morphology. The morphology of the two high-resolution HI surveys (6"), the Asymmetry, Smoothness, Gini, M20, and GM, do show a link to the total star-formation, but a weak one.Comment: 26 figures, 4 tables, two appendices. Third appendix (HI maps of all galaxies) omitted. Accepted by MNRA

Thematic Review: School Design and Learning Environments in the City of Espoo, Finland

This report presents the main findings and recommendations resulting from a review of education infrastructure investments in the city of Espoo, Finland, carried out by the CEB’s Technical Assessment & Monitoring Directorate. The objective of the review was to examine the links between school design and learning environments. The report provides Espoo officials with recommendations for enhancing the effectiveness of the education investment and identifies good practices that could be shared with other countries. The City of Espoo and the Finnish education system are internationally recognised as top performers for learning outcomes and one of the most equitable. However, rapid population growth, increasing numbers of children and foreign-language residents, and general tightening of the public budget pose challenges to service delivery just at a time when education infrastructure is expected to adapt to new learning curricula. Notwithstanding these challenges, the commitment to education remains very high on the part of all the stakeholders met in the city of Espoo. This commitment is reflected in the strategy for the City, the continuous financial support provided to the sector over the years, and the deep value and trust placed in their highly educated teachers. The eight schools visited by the review team already reflect some elements of the vision promoted by the new curriculum introduced in 2017, including the presence of differently sized learning spaces, heightened transparency and increased flexibility. The average learning space per child tends to be more generous than in other countries, given the use of spaces such as corridors and common areas for learning activities. The review team identified a series of key themes to encourage further discussion and exploration by Espoo teachers and city officials in their search for effective strategies to guide investments in the education sector. These include: • the need to find the right balance between cost-effectiveness and the promotion of effective learning environments; • the value of systematically involving the school community in the design process; • the importance of providing the necessary support for teachers to transition into new learning environments, by developing and implementing an Effective Spatial Professional Development programme. Ultimately, the effectiveness of any investment depends on how well it is used. In this regard, international research is unanimous in identifying teachers as the factor that correlates most strongly with student achievement. Thus, as part of any build, investing in teachers’ effective use of spaces must be a priority and an important component in the budgeting process

Quantified Morphology of HI Disks in the Universe

he upcoming new perspective of the high redshift Universe in the 21 cm line of atomic hydrogen opens possibilities to explore topics of spiral disk evolution, hitherto reserved for the optical regime. The growth of spiral gas disks over Cosmic time can be explored with the new generation of radio telescopes, notably the SKA, and its precursors, as accurately as with the Hubble Space Telescope for stellar disks. Since the atomic hydrogen gas is the building block of these disks, it should trace their formation accurately. Morphology of HI disks can now equally be quantified over Cosmic time. In studies of HST deep fields, the optical or UV morphology of high-redshift galaxy disks have been characterized using a few quantities: concentration (C), asymmetry (A), smoothness (S), second-order-moment (M20), the GINI coefficient (G), and Ellipticity (E). We have applied these parameters across wavelengths and compared them to the HI morphology over the THINGS sample. NGC 3184, an unperturbed disk, and NGC 5194, the canonical 3:1 interaction, serve as examples for quantified morphology. We find that morphology parameters determined in HI are as good or better a tracer of interaction compared to those in any other wavelength, notably in Asymmetry, Gini and M20. This opens the possibility of using them in the parameterization pipeline for SKA precursor catalogues to select interacting or harassed galaxies from their HI morphology. Asymmetry, Gini and M20 may be redefined for use on data-cubes rather than HI column density image.Comment: 6 pages, 3 figures, proceeding of the conference "Panoramic Radio Astronomy: Wide-field 1-2 GHz research on galaxy evolution", June 02 - 05 2009, Groningen, update after small edit

Systematic analysis of the evolution of electricity and carbon markets under deep decarbonization

The decarbonization of electricity generation presents policy makers in many countries with the delicate task of balancing initiatives for technological change with a commitment to market liberalization. Despite the theoretical attractions, it has become doubtful whether carbon markets by themselves can offer the desired solution. We address this question through an integrated modeling framework, stylized for the Great Britain (GB) power market within the EU ETS, which includes three distinct components: (a) long-term least-cost capacity planning, similar in functionality to many used in policy analysis, but innovative in providing the endogenous calculation of carbon prices; (b) short-term price risk analysis producing hourly dispatch and pricing outputs, which are used to test the annual financial performance metrics implied by the longer-term investments; and (c) agent-based computational learning to derive pricing behavior in imperfect markets. The results indicate that the risk/return profile of electricity markets may deteriorate substantially as a result of decarbonization, reducing the propensity of companies to invest in the absence of increased government support and/or more beneficial market circumstances. If allowed, markets may adjust by deferring investment until conditions improve, consolidating to increase market power, or operating in a tighter market with reduced spare capacity. To the extent that each of these “market-led” solutions may be politically unpalatable, policy design will need to sustain a delicate regulatory regime, moderating the possible increased market power of companies while maintaining low-carbon subsidies for longer than expected. This paper considers some of the modeling implications for this compromise

An exactly solvable coarse-grained model for species diversity

We present novel analytical results about ecosystem species diversity that stem from a proposed coarse grained neutral model based on birth-death processes. The relevance of the problem lies in the urgency for understanding and synthesizing both theoretical results of ecological neutral theory and empirical evidence on species diversity preservation. Neutral model of biodiversity deals with ecosystems in the same trophic level where per-capita vital rates are assumed to be species-independent. Close-form analytical solutions for neutral theory are obtained within a coarse-grained model, where the only input is the species persistence time distribution. Our results pertain: the probability distribution function of the number of species in the ecosystem both in transient and stationary states; the n-points connected time correlation function; and the survival probability, definned as the distribution of time-spans to local extinction for a species randomly sampled from the community. Analytical predictions are also tested on empirical data from a estuarine fish ecosystem. We find that emerging properties of the ecosystem are very robust and do not depend on specific details of the model, with implications on biodiversity and conservation biology.Comment: 20 pages, 4 figures. To appear in Journal of Statistichal Mechanic

Quantified HI Morphology II : Lopsidedness and Interaction in WHISP Column Density Maps

Lopsidedness of the gaseous disk of spiral galaxies is a common phenomenon in disk morphology, profile and kinematics. Simultaneously, the asymmetry of a galaxy's stellar disk, in combination with other morphological parameters, has seen extensive use as an indication of recent merger or interaction in galaxy samples. Quantified morphology of stellar spiral disks is one avenue to determine the merger rate over much of the age of the Universe. In this paper, we measure the quantitative morphology parameters for the HI column density maps from the Westerbork observations of neutral Hydrogen in Irregular and SPiral galaxies (WHISP). These are Concentration, Asymmetry, Smoothness, Gini, M20, and one addition of our own, the Gini parameter of the second order moment (GM). Our aim is to determine if lopsided or interacting disks can be identified with these parameters. Our sample of 141 HI maps have all previous classifications on their lopsidedness and interaction. We find that the Asymmetry, M20, and our new GM parameter correlate only weakly with the previous morphological lopsidedness quantification. These three parameters may be used to compute a probability that an HI disk is morphologically lopsided but not unequivocally to determine it. However, we do find that that the question whether or not an HI disk is interacting can be settled well using morphological parameters. Parameter cuts from the literature do not translate from ultraviolet to HI directly but new selection criteria using combinations of Asymmetry and M20 or Concentration and M20, work very well. We suggest that future all-sky HI surveys may use these parameters of the column density maps to determine the merger fraction and hence rate in the local Universe with a high degree of accuracy.Comment: 12 pages, 5 figures, 1 table, accepted by MNRAS, appendix not include

A nonlinear quantum model of the Friedmann universe

A discussion is given of the quantisation of a physical system with finite degrees of freedom subject to a Hamiltonian constraint by treating time as a constrained classical variable interacting with an unconstrained quantum state. This leads to a quantisation scheme that yields a Schrodinger-type equation which is in general nonlinear in evolution. Nevertheless it is compatible with a probabilistic interpretation of quantum mechanics and in particular the construction of a Hilbert space with a Euclidean norm is possible. The new scheme is applied to the quantisation of a Friedmann Universe with a massive scalar field whose dynamical behaviour is investigated numerically.Comment: 11 pages of text + 4 pages for 8 figure