10-31-74 Preliminary Memorandum

The opinion seems fine, except that it does not make the point that you considered significant with respect to the effects of counsel\u27s tactics on his client. Whether a footnote (possibly an addition to n.6) would be appropriate, I don\u27t know. It might read: Petitioner\u27s claims, whatever their merit, might have been vindicated more speedily if he had sought habeas relief in the state courts rather than following the federal route.But the wisdom of that choice, whether made by him or his counsel, is not part of this case. I would recommend against including it, however

Rotating pressure measurement system using an on board calibration standard

A computer-controlled multichannel pressure measurement system was developed to acquire detailed flow field measurements on board the Large Low Speed Centrifugal Compressor Research Facility at the NASA Lewis Research Center. A pneumatic slip ring seal assembly is used to transfer calibration pressures to a reference standard transducer on board the compressor rotor in order to measure very low differential pressures with the high accuracy required. A unique data acquisition system was designed and built to convert the analog signal from the reference transducer to the variable frequency required by the multichannel pressure measurement system and also to provide an output for temperature control of the reference transducer. The system also monitors changes in test cell barometric pressure and rotating seal leakage and provides an on screen warning to the operator if limits are exceeded. The methods used for the selection and testing of the the reference transducer are discussed, and the data acquisition system hardware and software design are described. The calculated and experimental data for the system measurement accuracy are also presented

Variations in Cholesterol Management Practices of U.S. Physicians

AbstractObjectives. This study sought to evaluate national cholesterol management practices of U.S. physicians.Background. Past studies show that nonclinical factors affect physician practices. We tested the hypothesis that physician and patient characteristics influence cholesterol management.Methods. We used a stratified, random sample of 2,332 office-based physicians providing 56,215 visits to adults in the 1991–1992 National Ambulatory Medical Care Surveys. We investigated physicians’ reporting of cholesterol-related screening, counseling or medications during office visits and used multiple logistic regression to assess independent predictors.Results. An estimated 1.12 billion adult office visits occurred in 1991 and 1992 (95% confidence interval 1.06 to 1.18 billion). For the 1.03 billion visits by patients without reported hyperlipidemia, cholesterol screening (2.8% of visits) and counseling (1.2%) were not frequent. The likelihood of screening increased with older age, cardiovascular disease risk factors, white race and private insurance. We estimate that only 1 in 12 adults received cholesterol screening annually. In the 85 million visits by patients with hyperlipidemia, cholesterol testing was reported in 22.9%, cholesterol counseling in 34.4% and lipid-lowering medications in 23.1%. Testing was more likely in diabetic and nonobese patients. Counseling was more likely with younger age, cardiovascular disease and private insurance. Medications use was associated with cardiovascular disease, Northeast region of the United States, nonobese patients and visits to internists. Physician practices did not differ by patient gender.Conclusions. Although clinical conditions strongly influence cholesterol management, the appropriateness of variations noted by payment source, geographic region and physician specialty deserve further evaluation. These variations and the low estimated volume of services suggest that physicians have not fully adopted recommended cholesterol management practices.(J Am Coll Cardiol 1997;29:139–46)

Perceived Versus Calculated HIV Risk: Implications for Pre-exposure Prophylaxis Uptake in a Randomized Trial of Men Who Have Sex With Men.

BackgroundInaccurate HIV risk perception by men who have sex with men is a barrier to HIV prevention. Providing information about objective HIV risk could improve pre-exposure prophylaxis (PrEP) uptake.MethodsPrEP Accessibility Research & Evaluation 2 (PrEPARE2) was a randomized controlled trial of men who have sex with men to determine whether an objective risk score affects future PrEP uptake. Participants completed a baseline survey to assess demographics, risk behaviors, and HIV self-perceived risk (SPR). The survey generated a calculated HIV risk (CalcR) score, estimating HIV risk based on reported condomless anal intercourse and sexually transmitted infections, and was provided to individuals in the intervention arm. Participants were contacted 8 weeks later to determine whether they initiated PrEP.ResultsOf 171 participants (median age 32 years; 37% Hispanic or non-Hispanic Black; median 5 sexual partners in the past 6 months), 81% had heard of PrEP, and 57% believed they were good PrEP candidates. SPR had poor agreement with CalcR (kappa = 0.176) with 38% underestimating their HIV risk. At week 8, only 14 of 135 participants had initiated PrEP with no difference between arms (CalcR 11%, control 10%, P > 0.99). The most common reason for not starting PrEP was low HIV risk perception. There was a relative decrease in SPR over time (P = 0.06) but no difference between arms (P = 0.29).ConclusionProviding an objective HIV risk score alone did not increase PrEP uptake. HIV testing performed at testing sites may be a crucial time to correct misperceptions about risk and initiate same-day PrEP, given enthusiasm for PrEP on the testing day to facilitate greater uptake

Computational Investigation of a Boundary-Layer Ingesting Propulsion System for the Common Research Model

The present paper examines potential propulsive and aerodynamic benefits of integrating a Boundary-Layer Ingestion (BLI) propulsion system into a typical commercial aircraft using the Common Research Model (CRM) geometry and the NASA Tetrahedral Unstructured Software System (TetrUSS). The Numerical Propulsion System Simulation (NPSS) environment is used to generate engine conditions for CFD analysis. Improvements to the BLI geometry are made using the Constrained Direct Iterative Surface Curvature (CDISC) design method. Previous studies have shown reductions of up to 25% in terms of propulsive power required for cruise for other axisymmetric geometries using the BLI concept. An analysis of engine power requirements, drag, and lift coefficients using the baseline and BLI geometries coupled with the NPSS model are shown. Potential benefits of the BLI system relating to cruise propulsive power are quantified using a power balance method, and a comparison to the baseline case is made. Iterations of the BLI geometric design are shown and any improvements between subsequent BLI designs presented. Simulations are conducted for a cruise flight condition of Mach 0.85 at an altitude of 38,500 feet and an angle of attack of 2 deg for all geometries. A comparison between available wind tunnel data, previous computational results, and the original CRM model is presented for model verification purposes along with full results for BLI power savings. Results indicate a 14.4% reduction in engine power requirements at cruise for the BLI configuration over the baseline geometry. Minor shaping of the aft portion of the fuselage using CDISC has been shown to increase the benefit from Boundary-Layer Ingestion further, resulting in a 15.6% reduction in power requirements for cruise as well as a drag reduction of eighteen counts over the baseline geometry

Learning with Music: Early Childhood Program Associated with Advantage in Self-Regulation

Purpose School success depends on the ability to regulate emotions, behavior, and attention in the service of learning. This study examines the impact of MacPhail’s Learning with Music Program on the development of self-regulatory skills for young children at risk via economic hardship. Design In Learning with Music, MacPhail music teachers visit partner preschool classrooms and model music integration for early childhood educators. We used a two-year, quasi-experimental waitlist control design to examine the impact of Learning with Music on children’s development of self-regulatory skills. In Year 1, both participating preschool programs received their preschool programming as usual, and in Year 2, both participating preschool programs additionally received Learning with Music. Method Ethical standards were followed, and all procedures were approved by the appropriate institutional review boards. The study included 234 preschool children, 104 of whom received Learning with Music and 130 of whom did not. All children were from families facing economic hardship, with income-to-needs ratios less than 2X the federal poverty threshold. Measures included a parent demographic interview and standardized child assessments of the inhibitory control aspect of self-regulation completed at the start, middle, and end of the year. Results Analyses involved latent growth curve modeling to examine initial status and growth in child inhibitory control as a function of receipt of the music program. Learning with Music was associated with greater growth in inhibitory control. The study highlights opportunities for using music to ameliorate negative effects of poverty and promote self-regulatory skill development for young children

Computational Investigation of a Boundary-Layer-Ingestion Propulsion System

The present paper examines potential propulsive and aerodynamic benefits of integrating a Boundary-Layer Ingestion (BLI) propulsion system into the Common Research Model (CRM) geometry and the NASA Tetrahedral Unstructured Software System (TetrUSS). The Numerical Propulsion System Simulation (NPSS) environment is used to generate engine conditions for Computational Fluid Dynamics (CFD) analyses. Improvements to the BLI geometry are made using the Constrained Direct Iterative Surface Curvature (CDISC) design method. Potential benefits of the BLI system relating to cruise propulsive power are quantified using a power balance method, and a comparison to the baseline case is made. Iterations of the BLI geometric design are shown, and improvements between subsequent BLI designs are presented. Simulations are conducted for a cruise flight condition of Mach 0.85 at an altitude of 38,500 feet, with Reynolds number of 40 million based on mean aerodynamic chord and an angle of attack of 2 for all geometries. Results indicate an 8% reduction in engine power requirements at cruise for the BLI configuration compared to the baseline geometry. Small geometric alterations of the aft portion of the fuselage using CDISC has been shown to marginally increase the benefit from boundary-layer ingestion further, resulting in an 8.7% reduction in power requirements for cruise, as well as a drag reduction of approximately twelve counts over the baseline geometry

Genes in the postgenomic era

We outline three very different concepts of the gene - 'instrumental', 'nominal', and 'postgenomic'. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide range of fields grounded in well-defined sequences of nucleotides, but this concept does not embody major theoretical insights into genome structure or function. The post-genomic gene embodies the continuing project of understanding how genome structure supports genome function, but with a deflationary picture of the gene as a structural unit. This final concept of the gene poses a significant challenge to conventional assumptions about the relationship between genome structure and function, and between genotype and phenotype

The triarchic model of psychopathy and antisocial behavior: results from an offender population with personality disorder

The triarchic model posits that psychopathy is a combination of phenotypes related to boldness, meanness, and disinhibition. We examined how each of these phenotypes of psychopathy related to past violence and antisocial behavior and to behavior within the prison. The sample consisted of men (n = 108) with a history of serious offending and a diagnosis of personality disorder at the point of admission to a prison serving as a therapeutic community. We took four indices of violence and antisocial behavior, (a) self-report of lifetime proactive and reaction aggression, (b) criminal convictions prior to admission to the prison, (c) exclusion from the prison within 12 months due to rule breaking, and (d) behavior within the first 12 months of admission to the unit. The constructs of the triarchic model, as assessed by the triarchic psychopathy measure (TriPM), were strong predictors of self-reported aggression, with disinhibition being related to both proactive and reactive aggression, whereas boldness was related to proactive aggression alone. Past criminal convictions were also associated with disinhibition, except for convictions for violent behavior. Both meanness and disinhibition were predictive of exclusion from the prison within 12 months for rule-breaking behavior and of aggressive behavior within the prison. The triarchic model of psychopathy is associated with past antisocial behavior and is predictive of antisocial behaviors within the prison, and the different constructs of the triarchic model are associated with different manifestations of antisocial behavior. The TriPM holds great promise for improved assessment and enhanced understanding of psychopathic personality within institutions and can facilitate offender management via improved phenotypic analysis of boldness, meanness, and disinhibition