The AMS-02 Anticoincidence Counter

The AMS-02 detector will measure cosmic rays on the International Space Station. This contribution will cover production, testing, space qualification and integration of the AMS-02 anticoincidence counter. The anticoincidence counter is needed to to assure a clean track reconstruction for the charge determination and to reduce the trigger rate during periods of high flux.Comment: IPRD08 conference proceeding. Will be published in Nuclear Physics B (Proceedings Supplement

Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

Tumor necrosis factor (TNF) has various effects on phosphorylation-mediated cellular signaling. Combining phosphoproteomics, subcellular localization analyses and kinase inhibitor assays, the authors provide systems level insights into TNF signaling and identify modulators of TNF-induced cell death. Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies against inflammatory diseases. However, blocking this well studied and pleiotropic ligand can cause dramatic side-effects. Here, we reason that a systems-level proteomic analysis of TNF signaling could dissect its diverse functions and offer a base for developing more targeted therapies. Therefore, we combine phosphoproteomics time course experiments with subcellular localization and kinase inhibitor analysis to identify functional modules of protein phosphorylation. The majority of regulated phosphorylation events can be assigned to an upstream kinase by inhibiting master kinases. Spatial proteomics reveals phosphorylation-dependent translocations of hundreds of proteins upon TNF stimulation. Phosphoproteome analysis of TNF-induced apoptosis and necroptosis uncovers a key role for transcriptional cyclin-dependent kinase activity to promote cytokine production and prevent excessive cell death downstream of the TNF signaling receptor. This resource of TNF-induced pathways and sites can be explored at

Structural analyses of ordered rubidium phases on Ru(0001) using low-energy electron diffraction

The adsorption geometries of the p(2×2) and (√3×√3)R30° Rb/Ru(0001) phases at coverages of 0.25 and 0.33, respectively, were investigated using low-energy electron diffraction. The structure analyses revealed that Rb resides in the threefold fcc site in the p(2×2) phase while for the (√3×√3)R30° phase the hcp site is favored. The effective radius of Rb does not change with the Rb coverage within the error bars of this analysis. The concept of ‘‘split positions’’ has been used in order to take the enhanced motion of the adsorbate atoms parallel to the surface properly into account

Intensive Cultural Resources Survey of the Proposed Galveston County Project, Texas City, Galveston County, Texas

On behalf of Florida Gas Transmission Company, LLC (FGT), EDGE Engineering and Science, LLC (EDGE) has selected Horizon Environmental Services, Inc. (Horizon) to conduct a cultural resources survey and assessment for the proposed Galveston County Project. The project includes a proposed pipeline that will allow the delivery of natural gas to a new delivery point off the FGT mainline. The facilities to be installed include approximately 4.0 kilometers ([km] 2.5 miles) of 30.5-centimeter ([cm]12.0-inch) and 50.8-cm (20.0-inch) lateral piping as well as a measurement and regulation (M&R) station located at the southwest end of the new pipeline, referred to as the Attwater-Topaz M&R station. This portion of the proposed project is located approximately 2.9 km (1.8 miles) northwest of Texas City and crosses State Highway (SH) 146 in Galveston County, Texas. As part of the Galveston County Project, FGT will also be uprating a unit at their existing CS 4 compressor station in Matagorda County, Texas to maintain a sufficient delivery pressure to the proposed Attwater-Topaz M&R station. In accordance with Section 7(b) of the Natural Gas Act, the project requires Prior Notice authorization to the Federal Energy Regulatory Commission (FERC), which will serve as the lead federal agency for the undertaking. Because the undertaking is regulated by FERC, the undertaking falls under the regulations of Section 106 of the National Historic Preservation Act (NHPA) of 1966, as amended. The Antiquities Code of Texas (ACT) governs proposed undertakings by political subdivisions of the State of Texas and/or projects located on publicly owned lands. Approximately 11.3 hectares (27.8 acres) of the project area are owned by the Gulf Coast Water Authority (GCWA). Since the GCWA is a public entity, this portion of the project falls under the jurisdiction of the ACT. Survey of the GCWA property was carried out under Antiquities Permit No. 9449. Less than 0.1 hectare (0.2 acres) of additional temporary workspace (ATWS) falls within the State Highway (SH) 146 ROW, which is controlled by the Texas Department of Transportation (TxDOT). Since TxDOT is a State agency, survey of this area would also require an Antiquities Permit. However, this area has already been disturbed from road construction and underground utilities. Horizon therefore recommends no additional survey or shovel testing in this ATWS. Horizon sent a letter with this recommendation to the Texas Historical Commission (THC) on June 30, 2020. Originally, FGT did not define the actual limits of the proposed right-of-way (ROW) for the project. Rather, they elected to wait until after the environmental assessments on larger overall parcels were complete in order to select a route with the least amount of environmental impacts. As such, the cultural resources survey initially consisted of 100% survey of the entire 203.2 hectares (502.0 acres) that comprise the parcels traversed by the proposed pipeline. After FGT selected a proposed route, Horizon archeologists conducted additional fieldwork to ensure adequate survey coverage within the proposed ROW. From May 12 to 15, and June 17, 2020, Horizon archeologists Charles E. Bludau, Jr. and Luis Gonzales performed an intensive cultural resources survey of the project area to locate any cultural resources that would potentially be impacted by the proposed undertaking. Horizon’s archeologists traversed the project area on foot and thoroughly inspected the modern ground surface for aboriginal and historic-age cultural resources. The project area consists of an extensive, largely featureless coastal flat. An existing FGT pipeline corridor passes from northeast to southwest through the northern portion of the project area. In addition to pedestrian walkover, the recently revised 2020 Texas State Minimum Archeological Survey Standards (TSMASS) require at least 50 shovel tests for the first 10.1 hectares (25.0 acres) of a project plus at least one shovel test for every 2.0 hectares (5.0 acres) over the original 10.1 hectares (25.0 acres). This equates to a minimum of 145 shovel tests within the original 203.2-hectare (502.0-acre) project area. Horizon excavated156 shovel tests within this area, thereby exceeding the TSMASS for a project area of this size. The TSMASS require a minimum of 16 shovel tests per mile for projects measuring 30.0 m (98.4 feet) or less in width; this equates to a minimum of 40 shovel tests within the proposed ROW. Horizon exceeded this minimum by excavating 46 shovel tests within the proposed ROW. Shovel testing typically revealed shallow deposits of hydric, dark gray clay extending from the modern ground surface to depths ranging from 5.0 to 60.0 cm (2.0 to 23.6 inches) below surface, though most shovel tests were terminated at depths of 30.0 to 50.0 cm (11.8 to 19.7 inches) below surface. Shovel testing was capable of penetrating Holocene-age soils with the potential to contain subsurface archeological resources. No archeological sites or historic-aged structures were recorded within the project area during the survey. A modern cattle corral, constructed with modern lumber, is present in the northeast corner of the project area, south of Skyline Drive. The corral does not appear on any historical topographic maps. It is first visible in a 1981 aerial image, which indicates the corral is not of historic age. Based on the results of the survey-level investigations documented in this report, no significant cultural resources would be affected by the proposed undertaking. In accordance with 36 CFR 800.4, Horizon has made a reasonable and good faith effort to identify historic properties within the project area. No cultural resources were identified within the project area that meet the criteria for inclusion in the National Register of Historic Places (NRHP) under 36 CFR 60.4. Horizon recommends a finding of “no historic properties affected,” and no further archeological work is recommended in connection with the proposed undertaking. However, human burials, both prehistoric and historic, are protected under the Texas Health and Safety Code. In the event that any human remains or burial objects are inadvertently discovered at any point during construction, use, or ongoing maintenance in the project area, even in previously surveyed areas, all work should cease immediately in the vicinity of the inadvertent discovery, and the THC should be notified immediately

Multilayer adsorption and desorption: Cs and Li on Ru(0001)

We use a multilayer lattice gas model for adsorption and desorption to analyze and simulate desorption data for Li and Cs on Ru(0001) extracting surface binding energies and lateral interactions. The latter are repulsive for the first layer and attractive for subsequent ones

Coverage-dependent adsorption sites in the K/Ru(0001) system: a low-energy electron-diffraction analysis

The two ordered phases p(2 × 2) at a coverage θ = 0.25 and (√3 × √3)R30° at θ = 0.33 of potassium adsorbed on Ru(0001) were analyzed by use of low-energy electron-diffraction (LEED). In the (√3 × √3)R30° phase, the K atoms occupy threefold hcp sites, while in the p(2 × 2) phase the fcc site is favoured. In both phases, the K hard-sphere radii are nearly the same and close to the covalent Pauling radius

Effect of aging on esophageal motility in patients with and without GERD

Background/Aims: The impact of aging on esophageal motility is not completely understood. This study aims at assessing 1) whether degeneration of esophageal body motility occurs with age and 2) whether this development is influenced by gastroesophageal reflux disease (GERD)

Effect of aging on esophageal motility in patients with and without GERD

Background/Aims: The impact of aging on esophageal motility is not completely understood. This study aims at assessing 1) whether degeneration of esophageal body motility occurs with age and 2) whether this development is influenced by gastroesophageal reflux disease (GERD)

Oxygen adsorption on the Ru (10 bar 1 0) surface: Anomalous coverage dependence

Oxygen adsorption onto Ru (10 bar 1 0) results in the formation of two ordered overlayers, i.e. a c(2 times 4)-2O and a (2 times 1)pg-2O phase, which were analyzed by low-energy electron diffraction (LEED) and density functional theory (DFT) calculation. In addition, the vibrational properties of these overlayers were studied by high-resolution electron loss spectroscopy. In both phases, oxygen occupies the threefold coordinated hcp site along the densely packed rows on an otherwise unreconstructed surface, i.e. the O atoms are attached to two atoms in the first Ru layer Ru(1) and to one Ru atom in the second layer Ru(2), forming zigzag chains along the troughs. While in the low-coverage c(2 times 4)-O phase, the bond lengths of O to Ru(1) and Ru(2) are 2.08 A and 2.03 A, respectively, corresponding bond lengths in the high-coverage (2 times 1)-2O phase are 2.01 A and 2.04 A (LEED). Although the adsorption energy decreases by 220 meV with O coverage (DFT calculations), we observe experimentally a shortening of the Ru(1)-O bond length with O coverage. This effect could not be reconciled with the present DFT-GGA calculations. The nu(Ru-O) stretch mode is found at 67 meV [c(2 times 4)-2O] and 64 meV [(2 times 1)pg-2O].Comment: 10 pages, figures are available as hardcopies on request by mailing [email protected], submitted to Phys. Rev. B (8. Aug. 97), other related publications can be found at http://www.rz-berlin.mpg.de/th/paper.htm

Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear

Social interactions are critical for mammalian survival and evolution. Dysregulation of social behavior often leads to psychopathologies such as social anxiety disorder, denoted by intense fear and avoidance of social situations. Using the social fear conditioning (SFC) paradigm, we analyzed expression levels of miR-132-3p and miR-124-3p within the septum, a brain region essential for social preference and avoidance behavior, after acquisition and extinction of social fear. Here, we found that SFC dynamically altered both microRNAs. Functional in vivo approaches using pharmacological strategies, inhibition of miR-132-3p, viral overexpression of miR-132-3p, and shRNA-mediated knockdown of miR-132-3p specifically within oxytocin receptor-positive neurons confirmed septal miR-132-3p to be critically involved not only in social fear extinction, but also in oxytocin-induced reversal of social fear. Moreover, Argonaute-RNA-co-immunoprecipitation-microarray analysis and further in vitro and in vivo quantification of target mRNA and protein, revealed growth differentiation factor-5 (Gdf-5) as a target of miR-132-3p. Septal application of GDF-5 impaired social fear extinction suggesting its functional involvement in the reversal of social fear. In summary, we show that septal miR-132-3p and its downstream target Gdf-5 regulate social fear expression and potentially mediate oxytocin-induced reversal of social fear