354 research outputs found
A social geography of urban fringe housing estates
The thesis explores three themes for each of which hypotheses are put forward based upon existing research. They are; first, that there are recognisable socio-geographic subdivisions within any community of neighbourhood unit size; second, that design and layout are important determinants of the social pattern; and third, that attitudes to place are the product of environmental as well as individual characteristics. Two urban-fringe council housing estates, broadly similar in age, size, and location, are chosen for study - North Kenton on Tyneside, and the G.L.C. out-county estate at Sheerwater, Woking, Surrey. The research is based on existing data, observation, and direct enquiry of a sampled population by means of a schedule. The environmental and demographic features of the estates are described. Analysis of workplace, shopping, entertainment, and visiting patterns reveals the interaction between each estate and the wider community. While both have attained a degree of functional self-sufficiency, Sheerwater, more isolated from the former homes of its residents, has achieved more social integration than North Kenton. The North Kenton survey emphasises the impact of the built environment which has resulted in the socio-geographic characteristic of the estate. Certain problems, affecting old people and young children especially, have arisen from failures in layout and design. At Sheerwater attitudes to place and spatial perception are examined and the role of individual experience and aspiration, and personal mobility are among the factors considered. Beyond the estate perceptual clarity diminishes though it is clearly influenced by the main lines of communication. In conclusion, the inter-relationship of the major themes is demonstrated and the validity of the initial hypotheses upheld. The research area is a broad one and suggests lines of future enquiry. In particular the theme of spatial perception offers considerable scope for all forms of geographical study
Symbolic power: the future of nuclear energy in Lithuania
EU accession states may have thrown off their Soviet past in political terms, but abandoning some of the Soviet era technologies is proving to be harder. Civil nuclear power is on the way out in most of Europe, but for some ex-Soviet countries this may present serious problems of economic, social and cultural transformation -- especially in countries like Lithuania, where nuclear power supplies the bulk of the electricity.
The issue has come to a head given the EU's insistence that several ex-Soviet states must agree to close their nuclear plant as a condition of EU entry. Lithuania is the accession country most wedded to and certainly most reliant on nuclear power. It has a nuclear plant which uses a technology (the RBMK, Chernobyl-type reactor) which the EU has insisted should be closed rapidly on safety grounds. This has proved an unpopular requirement in Lithuania for a variety of reasons. There are problem with ensuring continued energy supplies and replacing the lost employment and earning power.
However Lithuania also has a more general commitment to this technology as a symbol of national prowess and independence. During and immediately after the struggle for national independence in 1991, the country had a mass anti-nuclear movement. This has been analysed as a covert expression of nationalist and anti-Soviet feeling, given that most opposition to nuclear power evaporated after independence (Dawson 1996). Subsequently the EU ruled that Lithuania's Ignalina nuclear plant should be closed. Yet now it is widely seen as a national asset, a view reinforced by resentment about the EU apparently imposing an unwarranted closure policy.
This article will analyse how public and policy views on nuclear power have changed over time in Lithuania and how its symbolic meaning has changed during different phases of transformation of the Lithuanian society
Spatial trends on an ungrazed West Cumbrian saltmarsh of surface contamination by selected radionuclides over a 25 year period
Long term spatial and temporal variations in radionuclide activity have been measured in a contaminated ungrazed saltmarsh near Ravenglass, Cumbria. Over a twenty–five year period there has been a decrease in activity concentration with 106Ru and 137Cs showing the highest rate of change followed by Pu alpha and 241Am. A number of factors contribute to the reduction with time; including radiological half lives, discharge and remobilisation. For 241Am the lower reduction rate is partially due to ingrowth from 241Pu and partially as a result of transport of sediment from the offshore Irish Sea mud patch. Considerable spatial variation for the different radionuclides was observed, which with time became less defined. The highest activity concentrations of long-lived radionuclides were in low energy areas, typically where higher rates of sedimentation and vegetation occurred. The trend was reversed for the shorter lived radionuclide, 106Ru, with higher activity concentrations observed in high energy areas where there was frequent tidal inundation. Surface scrape samples provide a pragmatic, practical method of measuring sediment contamination over large areas and is a sampling approach adopted by most routine environmental monitoring programs, but it does not allow for interpretation of the effect of variation in sedimentation rates. This paper proposes a method for calculating indicative sedimentation rates across the saltmarsh using surface scrape data, which produces results consistent with values experimentally obtained
Birmingham’s Eastside story: making steps towards sustainability?
Sustainability has come to play a dominant discursive role in the UK planning system, particularly relating to urban regeneration. The purpose of this paper is to evaluate the role that sustainability plays in a major regeneration
programme, known as Eastside, currently underway in Birmingham, the UK. That this £6 billion redevelopment is now widely talked about by such key players as Birmingham City Council and the Regional Development Agency, Advantage West Midlands, as having a central sustainability agenda points to the growing importance of the ideal of sustainability in planning and regeneration agendas. In this paper, we investigate in detail how and why sustainability has become part of the planning discourse for Eastside and critically evaluate what impact, if any, this is having on public policy decision-making
CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of Cardiovascular death
An increased risk of cardiovascular death in Cytomegalovirus (CMV)-infected individuals remains unexplained, although it might partly result from the fact that CMV infection is closely associated with the accumulation of CD28null T-cells, in particular CD28null CD4 T-cells. These cells can directly damage endothelium and precipitate cardiovascular events. However, the current paradigm holds that the accumulation of CD28null T-cells is a normal consequence of aging, whereas the link between these T-cell populations and CMV infection is explained by the increased prevalence of this infection in older people. Resolving whether CMV infection or aging triggers CD28null T-cell expansions is of critical importance because, unlike aging, CMV infection can be treated.
Methods: We used multi-color flow-cytometry, antigen-specific activation assays, and HLA-typing to dissect the contributions of CMV infection and aging to the accumulation of CD28null CD4 and CD8 T-cells in CMV+ and CMV− individuals aged 19 to 94 years. Linear/logistic regression was used to test the effect of sex, age, CMV infection, and HLA-type on CD28null T-cell frequencies.
Results: The median frequencies of CD28null CD4 T-cells and CD28null CD8 T-cells were >12-fold (p=0.000) but only approximately 2-fold higher (p=0.000), respectively, in CMV+ (n=136) compared with CMV− individuals (n=106). The effect of CMV infection on these T-cell subsets was confirmed by linear regression. Unexpectedly, aging contributed only marginally to an increase in CD28null T-cell frequencies, and only in CMV+ individuals. Interestingly, the presence of HLA-DRB1*0301 led to an approximately 9-fold reduction of the risk of having CD28null CD4 T-cell expansions (OR=0.108, p=0.003). Over 75% of CMV-reactive CD4 T-cells were CD28null.
Conclusion: CMV infection and HLA type are major risk factors for CD28null CD4 T-cell-associated cardiovascular pathology. Increased numbers of CD28null CD8 T-cells are also associated with CMV infection, but to a lesser extent. Aging, however, makes only a negligible contribution to the expansion of these T-cell subsets, and only in the presence of CMV infection. Our results open up new avenues for risk assessment, prevention, and treatment
Recommended from our members
Magnet reliability in the Fermilab Main Injector and implications for the ILC
The International Linear Collider reference design requires over 13000 magnets, of approximately 135 styles, which must operate with very high reliability. The Fermilab Main Injector represents a modern machine with many conventional magnet styles, each of significant quantity, that has now accumulated many hundreds of magnet-years of operation. We review here the performance of the magnets built for this machine, assess their reliability and categorize the failure modes, and discuss implications for reliability of similar magnet styles expected to be used at the ILC
Comparing nuclear power trajectories in Germany and the UK: from ‘regimes' to ‘democracies’ in sociotechnical transitions and Discontinuities
This paper focuses on arguably the single most striking contrast in contemporary major energy politics in Europe (and even the developed world as a whole): the starkly differing civil nuclear policies of Germany and the UK. Germany is seeking entirely to phase out nuclear power by 2022. Yet the UK advocates a ‘nuclear renaissance’, promoting the most ambitious new nuclear construction programme in Western Europe.Here,this paper poses a simple yet quite fundamental question: what are the particular divergent conditions most strongly implicated in the contrasting developments in these two countries. With nuclear playing such an iconic role in historical discussions over technological continuity and transformation, answering this may assist in wider understandings of sociotechnical incumbency and discontinuity in the burgeoning field of‘sustainability transitions’. To this end, an ‘abductive’ approach is taken: deploying nine potentially relevant criteria for understanding the different directions pursued in Germany and the UK. Together constituted by 30 parameters spanning literatures related to socio-technical regimes in general as well as nuclear technology in particular, the criteria are divided into those that are ‘internal’ and ‘external’ to the ‘focal regime configuration’ of nuclear power and associated ‘challenger technologies’ like renewables.
It is ‘internal’ criteria that are emphasised in conventional sociotechnical regime theory, with ‘external’ criteria relatively less well explored. Asking under each criterion whether attempted discontinuation of nuclear power would be more likely in Germany or the UK, a clear picture emerges. ‘Internal’ criteria suggest attempted nuclear discontinuation should be more likely in the UK than in Germany– the reverse of what is occurring.
‘External’ criteria are more aligned with observed dynamics –especially those relating to military nuclear commitments and broader ‘qualities of democracy’. Despite many differences of framing concerning exactly what constitutes ‘democracy’, a rich political science literature on this point is unanimous in characterising Germany more positively than the UK. Although based only on a single case,a potentially important question is nonetheless raised as to whether sociotechnical regime theory might usefully give greater attention to the general importance of various aspects of democracy in constituting conditions for significant technological discontinuities and transformations. If so, the policy implications are significant. A number of important areas are identified for future research, including the roles of diverse understandings and specific aspects of democracy and the particular relevance of military nuclear commitments– whose under-discussion in civil nuclear policy literatures raises its own questions of democratic accountability
Dual fast-cycling superconducting synchrotron at Fermilab and a possible path to the future of high energy particle physics
We briefly outline shorter and longer term physics motivation for
constructing a dual, fast-cycling superconducting synchrotron accelerator
(DSFMR - Dual Super-Ferric Main Ring) in the Tevatron tunnel at Fermilab. We
discuss using this accelerator as a high-intensity dual neutrino beam source
for the long-baseline neutrino oscillation search experiments, and also as a
fast, dual pre-injector accelerator for the VLHC (Very Large Hadron Collider)
- …