Machine learning techniques for optimal worm-like motion

En un context de popularització de les tècniques d’Intel·ligència Artificial, aquest treball es proposa aplicar la versió més coneguda d’aquestes, les xarxes neuronals, per tractar comprendre la dinàmica del tipus de cuc C.elegans. Xarxes denses, convolucionals i recurrents van ser provades per tractar de predir moments de flexió a través de posicions i validar l’actual teoria sobre el moviment d’aquests cucs. La capacitat de les Xarxes Neuronals de predir moments a través de posicions sintètiques i experimentals demostrarà ser molt bona, tot i que caldria més investigació per aconseguir una resposta definitiva.En un contexto de popularización de las técnicas de Inteligencia Artificial, este trabajo se propone aplicar la versión más conocida de estas, las redes neuronales, para tratar de comprender la dinámica del tipo de gusano C.elegans. Redes densas, convolucionales y recurrentes serán probadas para tratar de predecir momentos de flexión a través de posiciones y validar la actual teoría sobre el movimiento de estos gusanos. La capacidad de las Redes Neuronales de predecir momentos a través de posiciones sintéticas demostrará ser muy buena, aunque haría falta más investigación para llegar a una respuesta definitiva.In a context of popularization of Artificial Intelligence techniques, this project apllies its most known implementation, neural networks, to try to understand the dynamics underlying the motion of the nematode C.elegans. Dense, convolutional and recurrent networks will be tried to predict moments in base of positions and validate the current theory of these worm’s motion. The capacity of Neural Networks to predict muscle activity, i.e. bending moments, from both synthetic and experimental positions will prove to be very good. However, more investigation would be needed in order to reach a definitive answer

Structural safety analysis of the aqueducts 'Coll de foix' and 'Capdevila' of the Canal of Aragon and Catalonia

The Canal of Aragon and Catalonia (CAC) is 134 km long and irrigates 105,000 ha (131 irrigation user communities) and it is owned by the River Ebro’s Water Agency. The aqueducts are located between km 67 and 71 of the canal and were designed by the civil engineer Félix de los Ríos Martín in 1907. The cross-section of both aqueducts, Coll de Foix and Capdevila, was extended within the framework of the project by Fernando Hué Herrero in 1962 in order to reach design flows of 26.1 m3/s and 25.7 m3/s, respectively. The structural performance of the aqueducts has been satisfactory; nevertheless, the hydraulic capacity has reduced over the years. As a result, the irrigation user communities have expressed the need to extend the cross-section of the aqueducts to meet the irrigation demands. Given the age of the structure and the different design considerations at the time, it is paramount to verify the structural reliability of the aqueducts in the new load configuration. Therefore, the objective of this contribution is to present the structural safety analysis conducted and to describe the new extended cross-section for both aqueducts (maintaining the original structural typology).Peer ReviewedPostprint (published version

Sustainability based-approach to determine the concrete type and reinforcement configuration of TBM tunnels linings. Case study: Extension line to Barcelona Airport T1

Fibre-reinforced concrete (FRC) is a suitable alternative to the traditional reinforced concrete used in the manufacture of precast segments used to line tunnels excavated with a tunnel boring machine (TBM). Moreover, its use as a structural material has been approved by several national codes and by the current fib Model Code (2010). The use of FRC in segmental linings confers several technical and economic advantages, evidenced by the fact that structural fibres have been used to partially or entirely replace reinforcing bars in many TBM tunnels built over the past 20 years or currently under construction. FRC could also have been used in other tunnels, which are currently in the planning stage or under construction. However, despite its technical suitability and approval in current codes, the use of FRC was not possible in some cases. The impediment has sometimes been an incomplete understanding of the structural behaviour of the material, but a more general motive has been that comparisons of materials have taken into account only direct material costs and have not considered indirect costs or social and environmental factors. The aim of the present research is to develop a method for analysing the sustainability of different concrete and reinforcement configurations for segmental linings of TBM tunnels using the MIVES method (a multi-criteria decision making approach for assessing sustainability). This MCDM method allows minimising subjectivity in decision making while integrating economic, environmental and social factors. The model has been used to assess the sustainability of different alternatives proposed for manufacturing the segmental tunnel lining for the extension of the rail line of Ferrocarrils de la Generalitat de Catalunya (FGC) to Terminal 1 of El Prat Airport in Barcelona.Peer ReviewedPostprint (author's final draft

Design and development of experiments with emotional stimulation techniques by means of image and sound to improve the individual's resilience against stress

The World Health Organization has defined stress as the "Health Epidemic of the 21st Century". Chronic stress is found to be one of the main causes of growing numbers of physical chronic diseases. Even though there are some challenges, there is a lot of evidence to support the use of sound, images and resonant breathing to combat stress. However, music and image therapy are not easily integrated in our daily lives as it is largely based on personal preferences that may also be linked to cultural sensitivity. The search for reliable stress biomarkers has established heart rate variability (HRV) as a suitable, cost-effective, non-invasive index for stress and stress vulnerability in mammals. The focus of this project will be to study how rhythmic sonic emotional stimulation techniques, rhythmic visual emotional stimulation and resonant breathing can be used to control the HRV performance with the intention of reducing and controlling stress2022/202

The AMBRE Project: Parameterisation of FGK-type stars from the ESO:HARPS archived spectra

The AMBRE project is a collaboration between the European Southern Observatory (ESO) and the Observatoire de la Cote d'Azur (OCA). It has been established to determine the stellar atmospheric parameters (effective temperature, surface gravity, global metallicities and abundance of alpha-elements over iron) of the archived spectra of four ESO spectrographs. The analysis of the ESO:HARPS archived spectra is presented. The sample being analysed (AMBRE:HARPS) covers the period from 2003 to 2010 and is comprised of 126688 scientific spectra corresponding to 17218 different stars. For the analysis of the spectral sample, the automated pipeline developed for the analysis of the AMBRE:FEROS archived spectra has been adapted to the characteristics of the HARPS spectra. Within the pipeline, the stellar parameters are determined by the MATISSE algorithm, developed at OCA for the analysis of large samples of stellar spectra in the framework of galactic archaeology. In the present application, MATISSE uses the AMBRE grid of synthetic spectra, which covers FGKM-type stars for a range of gravities and metallicities. We first determined the radial velocity and its associated error for the ~15% of the AMBRE:HARPS spectra, for which this velocity had not been derived by the ESO:HARPS reduction pipeline. The stellar atmospheric parameters and the associated chemical index [alpha/Fe] with their associated errors have then been estimated for all the spectra of the AMBRE:HARPS archived sample. Based on quality criteria, we accepted and delivered the parameterisation of ~71% of the total sample to ESO. These spectra correspond to ~10706 stars; each are observed between one and several hundred times. This automatic parameterisation of the AMBRE:HARPS spectra shows that the large majority of these stars are cool main-sequence dwarfs with metallicities greater than -0.5 dex

A bacterial acetyltransferase targets the protein kinase ZIP1, a positive regulator of plant immunity

Pseudomonas syringae is a model bacterial pathogen that penetrates the leaf to reach the plant apoplast, where it replicates causing disease. In order to do that, the pathogen must interfere and suppress a two-tiered plant defense response: PTI (PAMP-Triggered Immunity, or basal resistance) and ETI (Effector-Triggered Immunity). P. syringae uses a type III secretion system to directly deliver effector proteins inside the plant cell cytosol, many of which are known to suppress PTI, some of which are known to trigger ETI, and a handful of which are known to suppress ETI. Bacterial infection can also trigger a systemic plant defense response that protects the plant against additional pathogen attacks known as SAR (Systemic Acquired Resistance). We are particularly interested in the molecular and cellular mechanisms involved in effector-mediated defense evasion by P. syringae, in particular those involved in the suppression of ETI and SAR, and/or mediation of hormone signaling. Here we present data describing effector-mediated interference with plant immunity, by means of acetylation of a key positive regulator of local and systemic responses. Our work identifies a novel plant target for effector function, and characterizes its function. This work illustrates how analyzing the means by which a given effector interferes with its target can provide novel information regarding eukaryotic molecular mechanisms.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. MINECO BIO2015-64391R y FEDE

Influence of the type of fiber on the structural response and design of FRC slabs

Most codes for the design of fiber reinforced concrete (FRC) structures are based on the experience achieved throughout the years with steel fibers. Recent codes include the possibility of applying the same considerations for FRC structures with plastic fiber. However, the consequences of assuming identical design considerations regardless of the type of fiber is scarcely known in terms of the structural behavior of full-scale elements. The main goal of this paper is to assess the influence of the type of fiber on the performance of full-scale concrete slabs, emphasizing on the consequences of using a common design approach. For that, a comparative experimental study was conducted in order to expose differences regarding the crack pattern and load-deflection behavior. Then, finite element simulations were performed using the constitutive equations from the Model Code 2010. The results indicate distinct levels of overestimation of the structural behavior measured experimentally, confirming that specific design considerations are required depending on the type of fiber used. Based on the findings, correction factors are proposed for the design of FRC slabs with each fiber.Peer ReviewedPostprint (author's final draft

The bacterial effector HopZ1a acetylates ZIP1 kinase to suppress Arabidopsis defence responses

During the plant-pathogen interaction, disease or resistance are determined in the plant by a series of molecular events. The plant detects Pathogen-Associated Molecular Patterns (PAMPs), such as flagellin, triggering a defence response called PTI (PAMP-Triggered Immunity). Bacterial pathogens can in turn suppress such defence response through the translocation into the plant cell cytosol of virulence proteins, called effectors, via a Type Three Secretion System (T3SS). In resistant plants, intracellular receptors known as R proteins recognize these effectors, triggering a second line of defence, more specific and intense, called ETI (Effector-Triggered Immunity), which usually leads to programmed cell death known as HR (Hypersensitive Response). Pseudomonas syringae is a phytopathogenic bacterium whose virulence depends on a T3SS and its effector repertoire. Some strains include HopZ1a, an unusual effector which is able to suppress in Arabidopsis both local (PTI and ETI), and systemic (SAR, for Systemic Acquired Resistance) defences, by means of its acetyltransferase activity. In resistant Arabidopsis plants, HopZ1a acetylates the ZED1 pseudokinase, which is proposed to function as a decoy mimicking HopZ1a target in the plant: ZED1 modification activates an R-protein (ZAR1) to trigger HopZ1a-dependent ETI. None of the Arabidopsis proteins proposed to date as HopZ1a targets is a kinase, nor fully explains the effector´s defence suppression abilities. In this work we identify an Arabidopsis kinase that functions as a positive regulator of PTI, ETI and SAR, which interacts with HopZ1a and is acetylated by this effector in lysine residues essential for its kinase activity. Further, HopZ1a can specifically suppress the defence phenotypes resulting from ZIP1 expression in Arabidopsis. We propose that ZIP1 acetylation by HopZ1a interferes with its kinase activity, and consequently with positive defence signalling.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Inference of contractility evolution on planar worm locomotion

Postprint (published version