688 research outputs found

    An investigation of the intention to share files over P2P Networks

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    In this research we take a comprehensive view of file-sharing over peer-to-peer (P2P) networks in order to develop a model of the intention to share files. P2P file-sharing once consisted largely of music files which, when downloaded, were an infringement of copyrights. For this reason models of file-sharing intentions often included factors and constructs representing ethical concerns. However, these models did not produce a broad agreement about whether or not those ethical concerns had significant effects on intentions. Furthermore, files now shared over P2P networks represent a significant portion of both legitimate and non-infringing files. The model we propose applies to P2P file-sharing of all files, regardless of media type, and regardless of whether they are shared legally or illegally. Lastly we present the factors from the model that were suggested to be significant from an initial pilot study

    The Impact of the Massive Young Star GL 2591 on its Circumstellar Material: Temperature, Density and Velocity Structure

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    The temperature, density and kinematics of the gas and dust surrounding the luminous young stellar object GL~2591 are investigated on scales as small as 100 AU, probed by 4.7 micron absorption spectroscopy, to over 60,000 AU, probed by single-dish submillimeter spectroscopy. These two scales are connected by interferometric 86-226 GHz images of size 60,000 AU and resolution 2000 AU in continuum and molecular lines. The data are used to constrain the physical structure of the envelope and investigate the influence of the young star on its immediate surroundings.Comment: To be published in The Astrophysical Journal, Vol. 522 No. 2 (1999 Sep 10). 45 pages including 11 figure

    Count Models Based on Weibull Interarrival Times

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    The widespread popularity and use of both the Poisson and the negative binomial models for count data arise, in part, from their derivation as the number of arrivals in a given time period assuming exponentially distributed interarrival times (without and with heterogeneity in the underlying base rates, respectively). However, with that clean theory come some limitations including limited flexibility in the assumed underlying arrival rate distribution and the inability to model underdispersed counts (variance less than the mean). Although extant research has addressed some of these issues, there still remain numerous valuable extensions. In this research, we present a model that, due to computational tractability, was previously thought to be infeasible. In particular, we introduce here a generalized model for count data based upon an assumed Weibull interarrival process that nests the Poisson and negative binomial models as special cases. The computational intractability is overcome by deriving the Weibull count model using a polynomial expansion which then allows for closed-form inference (integration term-by-term) when incorporating heterogeneity due to the conjugacy of the expansion and a commonly employed gamma distribution. In addition, we demonstrate that this new Weibull count model can (1) model both over- and underdispersed count data, (2) allow covariates to be introduced in a straightforward manner through the hazard function, and (3) be computed in standard software

    Hydrodynamic attraction of swimming microorganisms by surfaces

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    Cells swimming in confined environments are attracted by surfaces. We measure the steady-state distribution of smooth-swimming bacteria (Escherichia coli) between two glass plates. In agreement with earlier studies, we find a strong increase of the cell concentration at the boundaries. We demonstrate theoretically that hydrodynamic interactions of the swimming cells with solid surfaces lead to their re-orientation in the direction parallel to the surfaces, as well as their attraction by the closest wall. A model is derived for the steady-state distribution of swimming cells, which compares favorably with our measurements. We exploit our data to estimate the flagellar propulsive force in swimming E. coli

    Determining the Hubble Constant without the Sound Horizon: A 3.6%3.6\% Constraint on H0H_0 from Galaxy Surveys, CMB Lensing and Supernovae

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    Many theoretical resolutions to the so-called "Hubble tension" rely on modifying the sound horizon at recombination, rsr_s, and thus the acoustic scale used as a standard ruler in the cosmic microwave background (CMB) and large scale structure (LSS) datasets. As shown in a number of recent works, these observables can also be used to compute rsr_s-independent constraints on H0H_0 by making use of the horizon scale at matter-radiation equality, keqk_{\rm eq}, which has different sensitivity to high redshift physics than rsr_s. In this work, we present the tightest keqk_{\rm eq}-based constraints on the expansion rate from current data, finding H0=64.8−2.5+2.2H_0=64.8^{+2.2}_{-2.5} at 68%\% CL from a combination of BOSS galaxy power spectra, Planck CMB lensing, and the newly released Pantheon+ supernova constraints, as well as physical priors on the baryon density, neutrino mass, and spectral index (in km s−1Mpc−1\mathrm{km}\,\mathrm{s}^{-1}\mathrm{Mpc}^{-1} units). The BOSS and Planck measurements have different degeneracy directions, leading to the improved combined constraints, with a bound of H0=67.1−2.9+2.5H_0 = 67.1^{+2.5}_{-2.9} (63.6−3.6+2.963.6^{+2.9}_{-3.6}) from BOSS (Planck) alone. The results show some dependence on the neutrino mass bounds, with the constraint broadening to H0=68.0−3.2+2.9H_0 = 68.0^{+2.9}_{-3.2} if we instead impose a weak prior on ∑mν\sum m_\nu from terrestrial experiments rather than assuming ∑mν<0.26 eV\sum m_\nu<0.26\,\mathrm{eV}, or shifting to H0=64.6±2.4H_0 = 64.6\pm2.4 if the neutrino mass is fixed to its minimal value. Even without any dependence on the sound horizon, our results are in ≈3σ\approx 3\sigma tension with those obtained from the Cepheid-calibrated distance ladder, providing evidence against new physics models that vary H0H_0 by changing acoustic physics or the expansion history immediately prior to recombination.Comment: 11 pages, 3 figures, submitted to Phys. Rev.

    Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

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    Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses. Here we show by using T7 RNA polymerase mediated production of PV genomic RNA, PV polymerase-catalyzed primer extension and cell-free PV synthesis that a pyrimidine ribonucleoside triphosphate analogue (rPTP) with ambiguous basepairing capacity is an efficient mutagen of the PV genome. The in vitro incorporation properties of rPTP are superior to ribavirin triphosphate. We observed a log-linear relationship between virus titer reduction and the number of rPMP molecules incorporated. A PV genome encoding a high-fidelity polymerase was more sensitive to rPMP incorporation, consistent with diminished mutational robustness of high-fidelity PV. The nucleoside (rP) did not exhibit antiviral activity in cell culture owing to the inability of rP to be converted to rPMP by cellular nucleotide kinases. rP was also a poor substrate for herpes simplex virus thymidine kinase. The block to nucleoside phosphorylation could be bypassed by treatment with the P nucleobase, which exhibited both antiviral activity and mutagenesis, presumably a reflection of rP nucleotide formation by a nucleotide salvage pathway. These studies provide additional support for lethal mutagenesis as an antiviral strategy, suggest that rPMP prodrugs may be highly efficacious antiviral agents, and provide a new tool to determine the sensitivity of RNA virus genomes to mutagenesis as well as interrogation of the impact of mutational load on the population dynamics of these viruses
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