3,825 research outputs found

    Alien Registration- Black, George W. (Milo, Piscataquis County)

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    https://digitalmaine.com/alien_docs/8412/thumbnail.jp

    Centerscope

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    Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.

    Special Legislation in West Virginia

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    Behavioral clusters and coronary heart disease risk

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    The purpose of the present study was to empirically identify individuals who differed in their patterns of components derived from the structured interview (SI), and to evaluate whether individuals characterized by the different patterns varied in terms of their risk for coronary heart disease (CHD). The present study represents a reanalysis of data from the Western Collaborative Group Study in which components of Type A were individually related to risk for CHD. Subgroups of individuals who differed in the patterns of their component scores were identified by means of cluster analytic techniques and were found to vary in their risk of CHD. As expected, a pattern of characteristics in which hostility was salient was found to be predictive of CHD. Moreover, another pattern of characteristics that appears to reflect pressured, controlling, socially dominant behavior in which hostility was not salient also was found to be predictive of CHD. Further, two patterns of characteristics were identified that were unrelated to CHD risk. Finally, two patterns of characteristics were identified that were related to reduced risk of CHD. Overall, these results suggest that future research should investigate variables in addition to hostility in regard to risk for and protection from CHD

    How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

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    Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme

    Investigating interfacial electron transfer in dye-sensitized NiO using vibrational spectroscopy

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    Understanding what influences the formation and lifetime of charge-separated states is key to developing photoelectrochemical devices. This paper describes the use of time-resolved infrared absorption spectroscopy (TRIR) to determine the structure and lifetime of the intermediates formed on photoexcitation of two organic donor–π–acceptor dyes adsorbed to the surface of NiO. The donor and π-linker of both dyes is triphenylamine and thiophene but the acceptors differ, maleonitrile (1) and bodipy (2). Despite their structural similarities, dye 1 outperforms 2 significantly in devices. Strong transient bands in the fingerprint region (1 and 2) and nitrile region (2300–2000 cm−1) for 1 enabled us to monitor the structure of the excited states in solution or adsorbed on NiO (in the absence and presence of electrolyte) and the corresponding kinetics, which are on a ps–ns timescale. The results are consistent with rapid (<1 ps) charge-transfer from NiO to the excited dye (1) to give exclusively the charge-separated state on the timescale of our measurements. Conversely, the TRIR experiments revealed that multiple species are present shortly after excitation of the bodipy chromophore in 2, which is electronically decoupled from the thiophene linker. In solution, excitation first populates the bodipy singlet excited state, followed by charge transfer from the triphenylamine to the bodipy. The presence and short lifetime (τ ≈ 30 ps) of the charge-transfer excited state when 2 is adsorbed on NiO (2|NiO) suggests that charge separation is slower and/or less efficient in 2|NiO than in 1|NiO. This is consistent with the difference in performance between the two dyes in dye-sensitized solar cells and photoelectrochemical water splitting devices. Compared to n-type materials such as TiO2, less is understood regarding electron transfer between dyes and p-type metal oxides such as NiO, but it is evident that fast charge-recombination presents a limit to the performance of photocathodes. This is also a major challenge to photocatalytic systems based on a “Z-scheme”, where the catalysis takes place on a µs–s timescale

    Occasional Publications of the Bounds Law Library, Number Five: Commonplace Books of Law: A Selection of Law-Related Notebooks

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    Occasional Publications of the Bounds Law Library, Number Five contains the transcriptions of five notebooks, one ledger, and one diary as well as critical introductions to each piece and an essay on notebooks in legal culture. Primary sources include: a seventeenth century notebook authored by multiple anonymous persons likely to have been students in the Inns of Courts, Alexander Dorcas\u27 ledger used from 1785 to 1817, George Josiah Sturges Walker\u27s 1826 Litchfield Law School notebook, Thomas K. Jackson\u27s 1871 diary, James Thomas Kirk\u27s notebook used from 1891 to 1916, Jerome T. Fuller\u27s notebook used from 1925 to 1935, and Hugo L. Black\u27s notebook used from 1938 to 1940.https://scholarship.law.ua.edu/occasional_publications/1004/thumbnail.jp

    Comment on Intrinsic and dynamically generated scalar meson states

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    The scalar-meson assignments of Shakin and Wang in a generalized Nambu--Jona-Lasinio model are contradicted by recent experimental information. Also the strict distinction made by these authors between ``intrinsic'' and ``dynamically generated'' states is contested, as well as a number of other statements.Comment: 7 pages, (v2 cosmetics, v3 corrections in one reference), to be published in Phys.Rev.
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