Supplementary information "Model-based analysis of the dynamic capacity ramp-up of closed-loop supply chains for lithium-ion batteries in Japan and Germany"

Mathematical formulation of a capacity planning model for the proceedings paper for the EcoDesign 2023 conference in Japan

Extending the Life Cycle of EEE - Findings from a Repair Study in Germany: Repair Challenges and Recommendations for Action

The increasing amount of waste from electrical and electronic equipment and the resulting environmental issues are challenging, since product life cycles are too short, and companies continue to rely on linear (business) models. The Circular Economy is an approach to meet these challenges by extending the product lifetime. One way to extend the product lifetime is to repair them. However, since there has been no detailed research on the repair sector yet, this article aims at conducting a repair study in Germany to understand the repair process and get insights into typical failure patterns. Therefore, we analyze the repair sector’s current barriers from different perspectives, especially of customers and businesses. We discuss the results of the repair study, where 382 repair attempts were conducted, with a total success rate of 55%. Moreover, the participants were interviewed to understand their barriers and motivation for repair. Based on the study’s interim findings, recommendations for action are given to make the repair services more attractive for the repairer and customer. Based on the findings, an interdisciplinary approach to improve repair processes by using a digital repair portal is derived

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease

Disease-modifying therapies to treat Alzheimer's disease (AD) are of fundamental interest for aging humans, societies, and health care systems. Predictable disease progression in transgenic AD models favors preclinical studies employing a preventive study design with an early pre-symptomatic treatment start, instead of assessing a truly curative approach with treatment starting after diagnosed disease onset. The aim of this study was to investigate the pharmacokinetic profile and efficacy of RD2 to enhance short-term memory and cognition in cognitively impaired aged Beagle dogs - a non-transgenic model of truly sporadic AD. RD2 has previously demonstrated pharmacodynamic efficacy in three different transgenic AD mouse models in three different laboratories. Here, we demonstrate that oral treatment with RD2 significantly reduced cognitive deficits in cognitively impaired aged Beagle dogs even beyond the treatment end, which suggests in combination with the treatment dependent CSF tau oligomer decrease a disease-modifying effect of RD2 treatment