Seal Hunters, Fishermen and Sea-voyagers: Late Middle Neolithic (2600–2400 cal BC) Maritime Hunter-Gatherers in the Baltic Sea Archipelago at Tråsättra, Sweden

Large scale excavations of Neolithic settlements and cemeteries along the Swedish east coast and on the islands of Gotland and Öland in the Baltic Sea during the last 30 years have produced a large amount of new information concerning the Funnel Beaker Culture, the Pitted Ware Culture and the Battle Axe Culture. Excavations of large areas in a number of sites have given us a much deeper understanding of how these societies were organized, how people made their living and how they buried their dead. Large scale studies of palaeoecological remains, lipids in ceramics and isotopes in animal and human bones have given us new information concerning differences in diet and economy, and studies of genetic material have produced new essential knowledge of ethnic and cultural affiliations. The excavation at Tråsättra covered the whole area of a permanent hunter-gatherer settlement that can be related to the late Pitted Ware Culture, ca. 2600– 2400calBC. This gave us the opportunity to study the organization of the settlement, economy and diet, craftsmanship and ritual activities in detail. Also, finds of a large number of anthropomorphic and zoomorphic clay figurines, a cult building with ritual deposits and a small cemetery made a unique analysis of religious and ideological aspects of the hunter-gatherers in the archipelago of the eastern middle part of Sweden during the late Middle Neolithic B possible

Maritime Hunter-Gatherers Adopt Cultivation at the Farming extreme of Northern Europe 5000 Years Ago

The dynamics of the origins and spread of farming are globally debated in anthropology and archaeology. Lately, numerous aDNA studies have turned the tide in favour of migrations, leaving only a few cases in Neolithic Europe where hunter-gatherers might have adopted agriculture. It is thus widely accepted that agriculture was expanding to its northern extreme in Sweden c. 4000 BC by migrating Funnel Beaker Culture (FBC) farmers. This was followed by intense contacts with local hunter-gatherers, leading to the development of the Pitted Ware Culture (PWC), who nonetheless relied on maritime prey. Here, we present archaeobotanical remains from Sweden and the Aland archipelago (Finland) showing that PWC used free-threshing barley and hulled and free-threshing wheat from c. 3300 BC. We suggest that these hunter-gatherers adopted cultivation from FBC farmers and brought it to islands beyond the 60th parallel north. Based on directly dated grains, land areas suitable for cultivation, and absence of signs of exchange with FBC in Sweden, we argue that PWC cultivated crops in Aland. While we have isotopic and lipid-biomarker proof that their main subsistence was still hunting/fishing/gathering, we argue small-scale cereal use was intended for ritual feasts, when cereal products could have been consumed with pork.Peer reviewe

Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E-deficient mice

Objective Metformin is associated with a reduced incidence and growth of abdominal aortic aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of metformin on AAA development and possible underlying mechanisms in experimentally induced AAAs in mice, along with the possible synergistic effects of metformin and imatinib. Methods Angiotensin II was used to induce AAAs in apolipoprotein E knockout (ApoE−/−) mice for 28 days. The mice were treated with metformin (n = 11), metformin combined with imatinib (n = 7), or vehicle (n = 12), starting 3 days before angiotensin II infusion. Ultrasound examination was used to analyze aneurysm formation. Cholesterol and blood pressure levels were measured at the start and end of the study. Gene array and quantitative polymerase chain reaction were used to analyze the changes in gene expression in the aorta. Wire myography was used to study vascular function. Results Metformin (n = 11) suppressed the formation and progression of AAAs by 50% compared with the vehicle controls (n = 12), with no further effects from imatinib (n = 7). Metformin reduced total cholesterol and mRNA expression of SPP1 (encoding osteopontin), MMP12, and the glycoprotein genes Gpnmb and Clec7a. Furthermore, metformin inhibited blood pressure increases and reduced vascular contractions, as determined by wire myography, and restored the anticontractile function of perivascular adipose tissue. Conclusion Metformin inhibited aneurysm formation and progression and normalized vascular function in ApoE−/− mice with no additional effect of imatinib. This might be mediated by the protective effects on vascular endothelial function and perivascular adipose tissue via reduced expression of genes promoting inflammation, including SPP1, MMP12, Gpnmb, and Clec7a.Funding agencies: The present study was supported by grants from the Swedish Research Council (grants 2019-01673 to D.W. and K2013-64X-20406-07-3 to A.W.), Swedish Heart-Lung Foundation (grants 20190556 to D.W., and 2012-0353 and 1015-0596 to A.W.), Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse (to A.W.), and the Lions Research Foundation (to A.K.). </p

Risk factors for subarachnoid haemorrhage : a nationwide cohort of 950 000 adults

BACKGROUND: Subarachnoid haemorrhage (SAH) is a devastating disease, with high mortality rate and substantial disability among survivors. Its causes are poorly understood. We aimed to investigate risk factors for SAH using a novel nationwide cohort consortium. METHODS: We obtained individual participant data of 949 683 persons (330 334 women) between 25 and 90 years old, with no history of SAH at baseline, from 21 population-based cohorts. Outcomes were obtained from the Swedish Patient and Causes of Death Registries. RESULTS: During 13 704 959 person-years of follow-up, 2659 cases of first-ever fatal or non-fatal SAH occurred, with an age-standardized incidence rate of 9.0 [95% confidence interval (CI) (7.4-10.6)/100 000 person-years] in men and 13.8 [(11.4-16.2)/100 000 person-years] in women. The incidence rate increased exponentially with higher age. In multivariable-adjusted Poisson models, marked sex interactions for current smoking and body mass index (BMI) were observed. Current smoking conferred a rate ratio (RR) of 2.24 (95% CI 1.95-2.57) in women and 1.62 (1.47-1.79) in men. One standard deviation higher BMI was associated with an RR of 0.86 (0.81-0.92) in women and 1.02 (0.96-1.08) in men. Higher blood pressure and lower education level were also associated with higher risk of SAH. CONCLUSIONS: The risk of SAH is 45% higher in women than in men, with substantial sex differences in risk factor strengths. In particular, a markedly stronger adverse effect of smoking in women may motivate targeted public health initiatives