Ferromagnetic Ligand Holes in Cobalt Perovskite Electrocatalysts as Essential Factor for High Activity Towards Oxygen Evolution

The definition of the interplay between chemical composition, electro-magnetic configuration and catalytic activity requires a rational study of the orbital physics behind active materials. Apart from Coulomb forces, quantum spin exchange interactions (QSEI) are part of the potentials that differentiate the activity of magnetic oxides, strongly correlated electrocatalysts, in electron transfer reactions. Ferromagnetic (FM) cobalt oxides can show low overpotentials for the oxygen evolution reaction (OER) and the La1XSrXCoO3d (0 r X r 1) family of perovskites is good ground to gain understanding of the electronic interactions in strongly correlated catalysts. In this case, Sr-doping raises the OER activity and the conductivity and increases FM spin moments. The efficiency of electrocatalysts based on Earth-abundant 3d-transition metals correlates with the interrelated factors: mild-bonding energies, the reduction of the electronic repulsions because of the QSEI in the open-shells, and enhanced spin delocalization in FM ordering. The reason for the outstanding OER activity of SrCoO3d is the accumulation of FM holes in the 3d–2p bonds, including the ligand orbitals, thus facilitating spinselected charge transport and production of triplet O2 moieties from the oxidation of diamagnetic precursors. Spin-polarized oxygen atoms in the lattice can participate in O–O coupling and release of O2 in a Mars–Van Krevelen mechanistic fashion. We show that the stabilizing FM QSEI decrease the adsorption and activation energies during oxygen evolution and spin-dependent potentials are one of the factors that govern the catalytic activity of magnetic compositions: spintro-catalysis

Avaliação do teste imunológico da gravides em pacientes do sexo masculino e do sexo feminino fora do ciclo grávido-puerperal.

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Tocoginecologia, Curso de Medicina, Florianópolis, 197

ACIDENTE VASCULAR ENCEFÁLICO COMO FATOR DE RISCO PARA INCONTINÊNCIA URINÁRIA EM IDOSOS INSTITUCIONALIZADOS

TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Estudo com objetivo de analisar os fatores de risco (faixa etária, gênero, comorbidades/hábitos de vida, potencial de deambulação, presença de declínio cognitivo e ocorrência de acidente vascular encefálico) para a incontinência urinária nos idosos institucionalizados. Pesquisa descritiva e transversal, incluídos 76 idosos institucionalizados. Ocorrência da incontinência urinária determinada através do Incontinence Questionnaire e do acidente vascular encefálico pela avaliação clínica/parecer médico. Análise do perfil por meio dos prontuários, cognição e funcionalidade pelo Mini-Exame do Estado Mental e Índice de Barthel, estado funcional após acidente vascular encefálico pela escala de Rankin modificada. Presença de incontinência urinária foi de 37,10%, sendo mais prevalente nos idosos com acidente vascular encefálico (p=0,002). Deambulação (p=0,000), cognição (p=0,003) e ocorrência do acidente vascular encefálico (p=0,002) foram associados com a presença de incontinência urinária. Conclui-se que o potencial de deambulação reduzido associa-se fortemente com o desenvolvimento da incontinência urinária em idosos institucionalizados com acidente vascular encefálico

Dor de origem endodôntica: eventos agudos na atenção básica

Este objeto começa destacando que a abordagem da dor endodôntica é de grande relevância na prática da Atenção Básica e lembra que a situação é preocupante uma vez que, caso o usuário não receba o devido tratamento, a doença poderá evoluir a ponto de gerar lesões mais complexas, que produzam inflamações pulpares. Enfoca a prevenção, indicando que as dores pulpares podem ser causadas por agentes biológicos, agentes físicos e agentes químicos, explicando cada um deles. Conceitua a dor endodôntica como aquela que se origina na polpa dentária, em decorrência de cárie ou de trauma dental, que pode acometer os tecidos periodontais apicais. Especifica como são classificadas as situações de dor endodôntica e define cada caso, abordando detalhes sobre as alterações pulpares (pulpagia hiper-reativa, pulpite sintomática, pulpite assintomática) e as alterações periapicais (pericementite apical, abscesso periapical agudo, abscesso periapical crônico agudizado – abscesso Fênix). Em seguida, orienta sobre a importância da avaliação diagnóstica correta do estado pulpar e periapical, salientando que a interpretação de testes deve estar aliada às informações obtidas na anamnese, pois são fatores que indicam ao profissional o estado de saúde pulpar e periapical do usuário, e apontam, assim, as possibilidades de tratamento a serem executadas, detalhando cada classificação. Ressalta a importância do método sistemático de eliminação, conhecido como diagnóstico diferencial, que conduz o dentista a um diagnóstico definitivo, apresentando um quadro sobre diagnóstico diferencial das alterações pulpares e outro sobre alterações periapicais. Indica que, na abordagem inicial, o principal objetivo é a eliminação do agente agressor e a medicação inicial para posterior atendimento sequencial, e orienta sobre as medidas a serem tomadas para cada um dos casos. Em relação ao atendimento sequencial, aborda que nem sempre será possível resolver a situação com somente um atendimento ao usuário, e repassa orientações sobre o tema tanto para alterações pulpares quanto para alterações periapicais. Finaliza observando que o encaminhamento do usuário para o Centro de Especialidades Odontológicas (CEO) será necessário sempre que o tratamento definitivo for a endodontia e que, em todos os casos de encaminhamentos, há necessidade de que o cirurgião-dentista da Atenção Básica faça o acompanhamento do usuário enquanto este aguarda atendimento no CEO.1.0Ministério da Saúde/OPAS/OM

Long-term radiographic and clinical-functional outcomes of isolated, displaced, closed talar neck and body fractures treated by ORIF: the timing of surgical management

Background: The main purpose of this retrospective case series study was to evaluate long-term radiographic and clinical outcomes of a consecutive series of patients diagnosed with isolated, displaced, closed talar neck or body fractures treated by open reduction and internal fixation (ORIF). Secondly, the aim was to verify the influence of the location of talar fractures on the outcomes, the prognostic value of the Hawkins sign, whether operative delays promote avascular necrosis (AVN) and if the fractures require emergent surgical management. Methods: From January 2007 to December 2012, at our institution, 31 patients underwent ORIF through the use of screws. On the basis of Inokuchi criteria, the injuries were divided between neck and body fractures, which were classified according to Hawkins and Sneppen, respectively. The patients included were divided into two groups in relation to fracture location and complexity. Radiographic assessment focused on reduction quality, bone healing, the Hawkins sign and post-traumatic arthritis (PTA) development. For the clinical evaluation, clinical-functional scores (AOFAS Ankle-Hindfoot Score; MFS; FFI-17; SF-36) and VAS were determined, and statistical analysis was performed. Results: 27 patients, 19 males and 8 females, mean age 38.3 years, were included with an average follow-up period of 83.2 months (range 49\u2013119). There were 9 neck and 19 body fractures; their reduction was anatomical or nearly anatomical in 22 cases, and all reached radiographic consolidation after a mean period of 3.4 months (range 1.7\u20137). The Hawkins sign was observed in 9 cases, in which necrosis did not develop. With a 0\u201311 day surgical timing interval, more than 60% of the patients obtained good or fair results with different scores, while 18 (66.7%) were completely satisfied (VAS: 9\u201310). The early complications included malunions (21.4%) and wound problems (25%); the late complications involved AVN (25%) and PTA (78.6%). Conclusions: Despite a high rate of long-term complications, satisfactory clinical results were achieved. Talar fracture location did not influence the outcomes, the Hawkins sign was confirmed as a positive prognostic factor, and operation timing did not influence AVN development. Hence, these injuries do not require emergent surgical management by ORIF

Genetical stability and osteogenic ability of mesenchimal stem cells on demineralized bone matrices

Journal of Osseointegration Volume 7, Issue 1, 1 March 2015, Pages 2-7 Open Access Genetical stability and osteogenic ability of mesenchimal stem cells on demineralized bone matrices (Article) Pozzuoli, A.a, Gardin, C.b, Aldegheri, R.a, Bressan, E.c, Isola, M.d, Calvo-Guirado, J.L.e, Biz, C.a, Arrigoni, P.a, Feroni, L.b, Zavan, B.b a Department of Surgical,Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy b Department of Biomedical Sciences, University of Padua, Padua, Italy c Department of Neurosciences, University of Padua, Padua, Italy d Department of Animal Medicine, Production and Health (MAPS), Italy e Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain Hide additional affiliations View references (44) Abstract Aim: Tissue engineering is a rapidly expanding field with regard to the use of biomaterials and stem cells in the orthopedic surgery. Many experimental studies have been done to understand the best characteristics of cells, materials and laboratory methods for safe clinical applications. The aim of this study was to compare the ability of 2 different human demineralized bone matrices (DBMs), the one enriched and the other not enriched with hyaluronic acid, to stimulate in vitro the proliferation and the osteogenic differentiation of human adipose-derived stem cells (ADSCs) seeded onto an osteoconductive scaffold. Materials and Methods: ADSCs were isolated, by enzymatic digestion, from abdominal adipose tissue of 5 patients undergoing cosmetic lipoaspiration surgery. ADSCs were then seeded onto a 3D scaffold in the presence of the two different osteoinductive matrices of human demineralized bone and evaluated for proliferation and osteogenic differentiation. The safety of the methods was verified using array-Comparative Genomic Hybridization (array-CGH). Results: ADSCs were able to differentiate in osteogenic sense. Both DBMs showed the ability to induce osteogenic differentiation of the cells. Conclusion: array-CGH showed no changes at genome level, thus confirming the safety of materials and method

Medium-Long-Term Radiographic and Clinical Outcomes after Surgical Treatment of Intra-Articular Tibial Pilon Fractures by Three Different Techniques

The goal of this retrospective, observational, case series study was to evaluate the medium-long-term clinical and radiographic results of the three most common surgical osteosynthesis techniques used for the treatment of articular tibial pilon fractures: ORIF, MIPO, and EF. Materials and Methods. A consecutive series of patients with articular pilon fractures who underwent surgery at our institution were enrolled in this study. Fractures were classified according to the M\ufcller AO classification system. Overall outcomes took the following into account: radiographic quality of reduction, evaluated using Ovadia and Beals\u2019 criteria; clinical assessment, evaluated using the AOFAS questionnaire; and general health, evaluated with the SF36-v2 Health Survey. Results. A total of 94 articular pilon fractures (34 type 43-B and 60 43-C) were evaluated with a mean follow-up of 56.34 months (range 33\u2013101). The techniques used were ORIF, MIPO, and EF in 63 (67%), 17 (18.9%), and 14 cases (14.1%), respectively. According to Ovadia and Beals\u2019 criteria, good, fair, and poor results were reported in 61 (64.89%), 26 (27.66%), and 7 (7.45%) cases, respectively. The mean AOFAS score was 82.41 for MIPO, 79.83 for ORIF, and 50.57 for EF, respectively. Thirty-nine patients (41.49%) presented early and/or late complications. Conclusion. Satisfactory outcomes using the three different techniques were reported. In particular, the radiographic outcomes were inversely proportional to the fracture comminutions and statistically different between internal and external osteosynthesis, but comparable between ORIF and MIPO techniques. On the other hand, the clinical outcomes were closely related to the soft tissue conditions and the anatomical reconstruction of the joint

Medium-Long-Term Clinical and Radiographic Outcomes of Minimally Invasive Distal Metatarsal Metaphyseal Osteotomy (DMMO) for Central Primary Metatarsalgia: Do Maestro Criteria Have a Predictive Value in the Preoperative Planning for This Percutaneous Technique?

The purpose of this prospective study was first to evaluate the safety and effectiveness of Minimally Invasive Distal Metatarsal Metaphyseal Osteotomy (DMMO) in treating central metatarsalgia, identifying possible contraindications. The second objective was to verify the potential of DMMO to restore a harmonious forefoot morphotype according to Maestro criteria. Methods. A consecutive series of patients with metatarsalgia was consecutively enrolled and treated by DMMO. According to Maestro criteria, preoperative planning was carried out by both clinical and radiological assessment. Patient demographic data, AOFAS scores, 17-FFI, MOXFQ, SF-36, VAS, and complications were recorded. Maestro parameters, relative morphotypes, and bone callus formation were assessed. Statistical analysis was carried out (p<0.05). Results. Ninety-three patients (93 feet) with a mean age of 62.4 (31-87) years were evaluated. At mean follow-up of 58.7 (36-96) months, all of the clinical scores improved significantly (p<0.0001). Most of the osteotomies (76.3%) had healed by 3-month follow-up, while ideal harmonious morphotype was restored only in a few feet (3.2%). Clinical and radiological outcomes were not different based on principal demographic parameters. Long-term complications were recorded in 12 cases (12.9%). Conclusion. DMMO is a safe and effective method for the treatment of metatarsalgia. Although Maestro criteria were useful to calculate the metatarsal bones to be shortened and a significant clinical improvement of all scores was achieved, the ideal harmonious morphotype was restored only in a few feet. Hence, our data show that Maestro criteria did not have a predictive value in clinical outcomes of DMM

Isolation and Expansion of Muscle Precursor Cells from Human Skeletal Muscle Biopsies

One of the major issues concerning human skeletal muscle progenitor cells is represented by the efficient isolation and in vitro expansion of cells retaining the ability to proliferate, migrate and differentiate once transplanted. Here we describe a method (1) effective in obtaining human muscle precursor cells both from fresh and frozen biopsies coming from different muscles, (2) selective to yield cells uniformly positive for CD56 and negative for CD34 without FACS sorting, (3) reliable in maintaining proliferative and in vitro differentiative capacity up to passage 10

Eventos agudos em saúde bucal

O módulo aborda temas relevantes para a prática odontológica na Atenção Básica, tais como as dores de origem endodôntica e de origem periodontal, bem como traumas dental e de face. Na unidade sobre dor de origem endodôntica são abordados subsídios para as práticas diagnósticas e terapêuticas no cuidado a pessoas portadoras deste tipo de dor. A unidade sobre dor de origem periodontal e de mucosa enfoca este evento comum do cotidiano do profissional dentista, ressaltando a importância de diagnosticar e promover a conduta necessária para sua prevenção e tratamento. A unidade sobre trauma dental inicia destacando que as situações de traumatismo dental são eventos agudos cada vez mais frequentes na clínica odontológica da Atenção Básica, e aponta as principais intervenções e ações preventivas, que podem ser realizadas tanto no âmbito individual quanto no coletivo. A unidade sobre trauma de face destaca a importância do treinamento de cirurgiões-dentistas para o atendimento inicial desse trauma, orienta sobre tipos de trauma de face, fraturas do complexo naso-orbitoetmoidal, do complexo zigomático-maxilar e do arco zigomático, além de abordar procedimentos terapêuticos pertinentes.1.0UNA-SUSMinistério da Saúd