The causal relationship between gut microbiota and lymphoma: a two-sample Mendelian randomization study

BackgroundPrevious studies have indicated a potential link between the gut microbiota and lymphoma. However, the exact causal interplay between the two remains an area of ambiguity.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to elucidate the causal relationship between gut microbiota and five types of lymphoma. The research drew upon microbiome data from a research project of 14,306 participants and lymphoma data encompassing 324,650 cases. Single-nucleotide polymorphisms were meticulously chosen as instrumental variables according to multiple stringent criteria. Five MR methodologies, including the inverse variance weighted approach, were utilized to assess the direct causal impact between the microbial exposures and lymphoma outcomes. Moreover, sensitivity analyses were carried out to robustly scrutinize and validate the potential presence of heterogeneity and pleiotropy, thereby ensuring the reliability and accuracy.ResultsWe discerned 38 potential causal associations linking genetic predispositions within the gut microbiome to the development of lymphoma. A few of the more significant results are as follows: Genus Coprobacter (OR = 0.619, 95% CI 0.438–0.873, P = 0.006) demonstrated a potentially protective effect against Hodgkin’s lymphoma (HL). Genus Alistipes (OR = 0.473, 95% CI 0.278–0.807, P = 0.006) was a protective factor for diffuse large B-cell lymphoma. Genus Ruminococcaceae (OR = 0.541, 95% CI 0.341–0.857, P = 0.009) exhibited suggestive protective effects against follicular lymphoma. Genus LachnospiraceaeUCG001 (OR = 0.354, 95% CI 0.198–0.631, P = 0.0004) showed protective properties against T/NK cell lymphoma. The Q test indicated an absence of heterogeneity, and the MR-Egger test did not show significant horizontal polytropy. Furthermore, the leave-one-out analysis failed to identify any SNP that exerted a substantial influence on the overall results.ConclusionOur study elucidates a definitive causal link between gut microbiota and lymphoma development, pinpointing specific microbial taxa with potential causative roles in lymphomagenesis, as well as identifying probiotic candidates that may impact disease progression, which provide new ideas for possible therapeutic approaches to lymphoma and clues to the pathogenesis of lymphoma

Вихретоковый анизотропный термоэлектрический первичный преобразователь лучистого потока

Представлена оригинальная конструкция первичного преобразователя лучистого потока, который может служить основой для создания приемника неселективного излучения с повышенной чувствительностью

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

The Impact of China’s Grain for Green Program on Rural Economy and Precipitation: A Case Study of Yan River Basin in the Loess Plateau

Large-scale deforestation and abandoned planting will bring about the destruction of the ecological environment and the deterioration of the climate. In 1999, China initiated its “Grain for Green” Program (GGP) to improve the ecological environment, control soil erosion, and adjust the agricultural industrial structure to promote the sustainable development of the rural economy. In this paper, economic statistics, rainfall, and remote sensing data are used to analyze the impact of the GGP on agricultural and rural economic development and regional precipitation in the hilly and gully regions of the Loess Plateau. The results show that since the implementation of the program, the employment structure of the labor force has changed and the regional economic growth and farmers’ income have increased. From 2000 to 2016, the total gross domestic product (GDP) and per capita GDP of the Yan River Basin increased. The conversion of large-scale sloping farmland to forestry and grassland resulted in the decrease of farmland area and the increase of forestry area. The maximum, minimum, and mean value of vegetation coverage increased year by year. With the increase of vegetation coverage, the surface roughness, soil water content, and evapotranspiration improved and annual average precipitation grew significantly after the implementation of the program (2000 to 2018). From 1970 to the implementation of the project (1999), the annual average rainfall decreased at the trough from 1988 to 1999, and there was an overall upward trend from 1970 to 2018. The GGP has an important impact on the economy and people’s income in the Yan River Basin, and the vegetation change caused by the variation of land use types has a certain impact on regional rainfall. Under the background of global and regional climate change, it is of great significance to fully understand the impacts of vegetation conversion on climate and its mechanism for objective assessment of driving factors in regional and global climate, as well as for scientific planning of future land use

An Urban Water Pollution Model for Wuhu City

An in-depth study of the temporal and spatial distribution of pollution loads can assist in the development of water pollution remediation. The research scope of this paper was the highly developed Wuhu City located south of the Yangtze River. Chemical oxygen demand (COD), NH3-H, and total phosphorus (TP) were chosen as the pollutant research objects of this study. Then, by combining the natural and social conditions within the scope of the study, a balanced system of pollution load generation and migration was described. A pollution load model of Wuhu City based on Load Calculator, MIKE 11, and ArcGIS was established. The results indicate that, in terms of the time distribution, the changes in the influx of the different pollutants were consistent. In terms of the spatial distribution, the major contributions to the annual pollution load were domestic pollution, urban surface runoff pollution, and poultry breeding pollution. The major contributors to the annual pollution load into the river were domestic pollution, urban surface runoff pollution, and sewage plant tail water pollution. This analysis provides references for the comprehensive management of local water environments