Вихретоковый анизотропный термоэлектрический первичный преобразователь лучистого потока

Представлена оригинальная конструкция первичного преобразователя лучистого потока, который может служить основой для создания приемника неселективного излучения с повышенной чувствительностью

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction  = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

The Impact of China’s Grain for Green Program on Rural Economy and Precipitation: A Case Study of Yan River Basin in the Loess Plateau

Large-scale deforestation and abandoned planting will bring about the destruction of the ecological environment and the deterioration of the climate. In 1999, China initiated its “Grain for Green” Program (GGP) to improve the ecological environment, control soil erosion, and adjust the agricultural industrial structure to promote the sustainable development of the rural economy. In this paper, economic statistics, rainfall, and remote sensing data are used to analyze the impact of the GGP on agricultural and rural economic development and regional precipitation in the hilly and gully regions of the Loess Plateau. The results show that since the implementation of the program, the employment structure of the labor force has changed and the regional economic growth and farmers’ income have increased. From 2000 to 2016, the total gross domestic product (GDP) and per capita GDP of the Yan River Basin increased. The conversion of large-scale sloping farmland to forestry and grassland resulted in the decrease of farmland area and the increase of forestry area. The maximum, minimum, and mean value of vegetation coverage increased year by year. With the increase of vegetation coverage, the surface roughness, soil water content, and evapotranspiration improved and annual average precipitation grew significantly after the implementation of the program (2000 to 2018). From 1970 to the implementation of the project (1999), the annual average rainfall decreased at the trough from 1988 to 1999, and there was an overall upward trend from 1970 to 2018. The GGP has an important impact on the economy and people’s income in the Yan River Basin, and the vegetation change caused by the variation of land use types has a certain impact on regional rainfall. Under the background of global and regional climate change, it is of great significance to fully understand the impacts of vegetation conversion on climate and its mechanism for objective assessment of driving factors in regional and global climate, as well as for scientific planning of future land use

An Urban Water Pollution Model for Wuhu City

An in-depth study of the temporal and spatial distribution of pollution loads can assist in the development of water pollution remediation. The research scope of this paper was the highly developed Wuhu City located south of the Yangtze River. Chemical oxygen demand (COD), NH3-H, and total phosphorus (TP) were chosen as the pollutant research objects of this study. Then, by combining the natural and social conditions within the scope of the study, a balanced system of pollution load generation and migration was described. A pollution load model of Wuhu City based on Load Calculator, MIKE 11, and ArcGIS was established. The results indicate that, in terms of the time distribution, the changes in the influx of the different pollutants were consistent. In terms of the spatial distribution, the major contributions to the annual pollution load were domestic pollution, urban surface runoff pollution, and poultry breeding pollution. The major contributors to the annual pollution load into the river were domestic pollution, urban surface runoff pollution, and sewage plant tail water pollution. This analysis provides references for the comprehensive management of local water environments

Intra-annual Dynamics of Xylem Formation in Liquidambar formosana Subjected to Canopy and Understory N Addition

Increasing N deposition caused by intensive anthropogenic activities is expected to affect forest growth. However, the effects of N deposition on trees are still controversial due to the wide variability in results and experimental methods used. We conducted an experiment involving both canopy and understory N addition to investigate the effects of N-addition on intra-annual xylem formation of Chinese sweetgum (Liquidambar formosana) in a warm-temperate forest of Central China. Since 2013, 50 kg N ha-1 year-1 (2.5 times the current natural N deposition) was applied monthly from April to December. In 2014 and 2015, the timing and dynamics of xylem formation were monitored weekly during March–December by microcoring the stems of control and treated trees. Similar dynamics of wood formation were observed between canopy and understory N addition. Xylem formation of all the experimental trees started in March and lasted for 119–292 days. Compared to the control, no change was observed in the timing and dynamics of wood formation in N-treated trees. Tree ring-width ranged between 1701 and 4774 μm, with a rate of xylem production of 10.52–26.64 μm day-1. The radial growth of trees was not modified by the treatments. Our findings suggest that short-term N addition is unable to affect the dynamics of xylem formation in Chinese sweetgum in Central China. The effects of N on tree growth observed in previous studies might be related to the duration of the experiment or the imbalance between the amount of natural deposition and N added during treatments