Rural soldiers continue to account for disproportionately high share of U.S. casualties in Iraq and Afghanistan

When the nation goes to war, all Americans are expected to make sacrifices. Today\u27s rural Americans, however, have fewer job opportunities within their communities, and are joining the military at higher rates. In turn, rural communities are facing military losses in disproportionate numbers to their urban counterparts

U.S. rural soldiers account for a disproportionately high share of casualties in Iraq and Afghanistan

A study by the Carsey Institute found that among U.S. soldiers serving in Iraq and Afghanistan, those who are from rural America are dying at a higher rate than those soldiers who are from cities and suburbs. According to U.S. Department of Defense records, rural youth enlist in the military at a higher rate than urban and suburban youth and in all but eight states, soldiers from rural areas make up a disproportionately high share of the casualties

Rural Soldiers Continue to Account for a Disproportionately High Share of U.S. Casualties in Iraq and Afghanistan

When the country goes to war, all Americans are expected to make sacrifices and rural Americans have always stepped forward to do their part in past wars and national emergencies. However, as the data presented here attests, today's rural Americans are making the ultimate sacrifice in disproportionately high numbers. Examination of deaths based on hometown in the Department of Defense records shows soldiers from rural America are dying at a higher rate than soldiers from big cities and suburbs. In most states, soldiers from rural areas make up a disproportionately high share of casualties

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.

The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding. This activity is thought to promote dissociation of RAD51 from heteroduplex DNA following strand exchange during homologous recombination. In addition, previous experiments in budding yeast have shown that the same activity of Rad54 removes Rad51 from undamaged sites on chromosomes; mutants lacking Rad54 accumulate nonrepair-associated complexes that can block growth and lead to chromosome loss. Here, we show that human RAD54 also promotes the dissociation of RAD51 from dsDNA and not ssDNA. We also show that translocase depletion in tumor cell lines leads to the accumulation of RAD51 on chromosomes, forming complexes that are not associated with markers of DNA damage. We further show that combined depletion of RAD54L and RAD54B and/or artificial induction of RAD51 overexpression blocks replication and promotes chromosome segregation defects. These results support a model in which RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells. Thus, in addition to having genome-stabilizing DNA repair activity, human RAD51 has genome-destabilizing activity when expressed at high levels, as is the case in many human tumors

Control and Non-Payload Communications (CNPC) Prototype Radio Verification Test Report

This report provides an overview and results from the verification of the specifications that defines the operational capabilities of the airborne and ground, L Band and C Band, Command and Non-Payload Communications radio link system. An overview of system verification is provided along with an overview of the operation of the radio. Measurement results are presented for verification of the radios operation

Setting Priorities for Space Research: Opportunities and Imperatives

This report represents the first phase of a study by a task group convened by the Space Studies Board to ascertain whether it should attempt to develop a methodology for recommending priorities among the various initiatives in space research (that is, scientific activities concerned with phenomena in space or utilizing observations from space). The report argues that such priority statements by the space research community are both necessary and desirable and would contribute to the formulation and implementation of public policy. The report advocates the establishment of priorities to enhance effective management of the nation's scientific research program in space. It argues that scientific objectives and purposes should determine how and under what circumstances scientific research should be done. The report does not take a position on the controversy between advocates of manned space exploration and those who favor the exclusive use of unmanned space vehicles. Nor does the report address questions about the value or appropriateness of Space Station Freedom or proposals to establish a permanent manned Moon base or to undertake a manned mission to Mars. These issues lie beyond the charge to the task group

Pattern and Outcome of Chest Injuries at Bugando Medical Centre in Northwestern Tanzania.

Chest injuries constitute a continuing challenge to the trauma or general surgeon practicing in developing countries. This study was conducted to outline the etiological spectrum, injury patterns and short term outcome of these injuries in our setting. This was a prospective study involving chest injury patients admitted to Bugando Medical Centre over a six-month period from November 2009 to April 2010 inclusive. A total of 150 chest injury patients were studied. Males outnumbered females by a ratio of 3.8:1. Their ages ranged from 1 to 80 years (mean = 32.17 years). The majority of patients (72.7%) sustained blunt injuries. Road traffic crush was the most common cause of injuries affecting 50.7% of patients. Chest wall wounds, hemothorax and rib fractures were the most common type of injuries accounting for 30.0%, 21.3% and 20.7% respectively. Associated injuries were noted in 56.0% of patients and head/neck (33.3%) and musculoskeletal regions (26.7%) were commonly affected. The majority of patients (55.3%) were treated successfully with non-operative approach. Underwater seal drainage was performed in 39 patients (19.3%). One patient (0.7%) underwent thoracotomy due to hemopericardium. Thirty nine patients (26.0%) had complications of which wound sepsis (14.7%) and complications of long bone fractures (12.0%) were the most common complications. The mean LOS was 13.17 days and mortality rate was 3.3%. Using multivariate logistic regression analysis, associated injuries, the type of injury, trauma scores (ISS, RTS and PTS) were found to be significant predictors of the LOS (P < 0.001), whereas mortality was significantly associated with pre-morbid illness, associated injuries, trauma scores (ISS, RTS and PTS), the need for ICU admission and the presence of complications (P < 0.001). Chest injuries resulting from RTCs remain a major public health problem in this part of Tanzania. Urgent preventive measures targeting at reducing the occurrence of RTCs is necessary to reduce the incidence of chest injuries in this region

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22

A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI)-high tumors, or no evidence of linkage to MMR genes). Families were ascertained via the Colon Cancer Family Registry multi-site NCI-supported consortium (Colon CFR), the City of Hope Comprehensive Cancer Center, and Memorial University of Newfoundland. A total of 1,612 individuals (average 5.0 per family including 2.2 affected) were genotyped using genome-wide single nucleotide polymorphism linkage arrays; parametric and non-parametric linkage analysis used MERLIN in a priori-defined family groups. Five lod scores greater than 3.0 were observed assuming heterogeneity. The greatest were among families with mean age of diagnosis less than 50 years at 4q21.1 (dominant HLOD = 4.51, α = 0.84, 145.40 cM, rs10518142) and among all families at 12q24.32 (dominant HLOD = 3.60, α = 0.48, 285.15 cM, rs952093). Among families with four or more affected individuals and among clinic-based families, a common peak was observed at 15q22.31 (101.40 cM, rs1477798; dominant HLOD = 3.07, α = 0.29; dominant HLOD = 3.03, α = 0.32, respectively). Analysis of families with only two affected individuals yielded a peak at 8q13.2 (recessive HLOD = 3.02, α = 0.51, 132.52 cM, rs1319036). These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated. © 2012 Cicek et al

The imposition of Cauchy data to the Teukolsky equation II: Numerical comparison with the Zerilli-Moncrief approach to black hole perturbations

We revisit the question of the imposition of initial data representing astrophysical gravitational perturbations of black holes. We study their dynamics for the case of nonrotating black holes by numerically evolving the Teukolsky equation in the time domain. In order to express the Teukolsky function Psi explicitly in terms of hypersurface quantities, we relate it to the Moncrief waveform phi_M through a Chandrasekhar transformation in the case of a nonrotating black hole. This relation between Psi and phi_M holds for any constant time hypersurface and allows us to compare the computation of the evolution of Schwarzschild perturbations by the Teukolsky and by the Zerilli and Regge-Wheeler equations. We explicitly perform this comparison for the Misner initial data in the close limit approach. We evolve numerically both, the Teukolsky (with the recent code of Ref. [1]) and the Zerilli equations, finding complete agreement in resulting waveforms within numerical error. The consistency of these results further supports the correctness of the numerical code for evolving the Teukolsky equation as well as the analytic expressions for Psi in terms only of the three-metric and the extrinsic curvature.Comment: 14 pages, 7 Postscript figures, to appear in Phys. Rev.