Effects of abdominal and vaginal hysterectomy on anorectal functions along with quality of life of the patient

Objectives and background:Hysterectomy is the most commonly performed major gynecological operation for both benign and malign gynecologic conditions. After hysterectomy, although some investigators have declared an increased incidence of urinary and anorectal dysfunction, some others could not show any connection. Methods: The voluntary patients were divided in two groups: abdominal hysterectomy (Group 1) and vaginal hysterectomy (Group 2). Anal manometry and all the other examinations of the patients were performed at the Department of General Surgery Endoscopy Unit of Ankara University, Faculty of Medicine. Results: When the quality of life of the patients was assessed before the operation and on the 12 th post-operative month via the SF-36 form; it can be seen that body pain parameters of the patients in Group 1 had significantly improved and there is no statistical difference in other parameters. When the effect of hysterectomy on the quality of life of the patients was evaluated by the “Cleveland Clinic Global Quality of Life” form, the statistically significant improvement in the quality of life of the patients in Group 2 was observed. Conclusion: If the type of operation (vaginal or abdominal) is performed due to benign causes, it does not affect the urinary and anorectal functions of the patients. Depending on the decrease of complaints of the patients, it has a positive effect on the quality of life. © 2018 Birsen et al

Effects of laparoscopic sleeve gastrectomy on serum lncRNA levels in obese patients

Obesity is a disease associated with excessive fat accumulation in the body, which body mass index (BMI) is greater than 30 kg/m. Bariatric surgery technique is one of the most common treatment options for obesity with the advantage of faster weight loss in a short time. lncRNAs play a role in adipogenesis and metabolic diseases, including obesity, type 2 diabetes, cardiovascular disease (CVD), osteoarthritis, and hypertension, so they are significant targets for therapeutic options. In this study, we aimed to determine lncRNAs and specific parameters that show different expressions in the plasma of patients with obesity. We included fifteen patients with BMI greater than 30 kg/m2 before and less than 30 kg/m2 after laparoscopic sleeve gastrectomy (LSG) in the study. Total RNAs, including lncRNAs and other non-coding RNAs, were isolated from plasma samples of patients, and eight lncRNAs (H19, Neat1, HOTAIR, ANRIL,  MALAT1, ATB, SNGH5, UCA1) were quantified by real-time PCR. Gene Ontology, KEGG, and relation of obesity analysis were utilized. Unpaired Student's t-test Pearson correlation analysis was used for statistical analysis. We observed a statistically significant increase in the expression levels of all lncRNAs in the patients with the post-operative BMI change. We have added a new dimension to the biomarker studies related to obesity and the clinical follow-up of patients undergoing LSG surgery. Further studies are required for enlighting the molecular mechanisms

Effects of abdominal and vaginal hysterectomy on anorectal functions along with quality of life of the patient

Objectives and background: Hysterectomy is the most commonly performed major gynecological operation for both benign and malign gynecologic conditions. After hysterectomy, although some investigators have declared an increased incidence of urinary and anorectal dysfunction, some others could not show any connection. Methods: The voluntary patients were divided in two groups: abdominal hysterectomy (Group 1) and vaginal hysterectomy (Group 2). Anal manometry and all the other examinations of the patients were performed at the Department of General Surgery Endoscopy Unit of Ankara University, Faculty of Medicine. Results: When the quality of life of the patients was assessed before the operation and on the 12th post-operative month via the SF-36 form; it can be seen that body pain parameters of the patients in Group 1 had significantly improved and there is no statistical difference in other parameters. When the effect of hysterectomy on the quality of life of the patients was evaluated by the \u201cCleveland Clinic Global Quality of Life\u201d form, the statistically significant improvement in the quality of life of the patients in Group 2 was observed. Conclusion: If the type of operation (vaginal or abdominal) is performed due to benign causes, it does not affect the urinary and anorectal functions of the patients. Depending on the decrease of complaints of the patients, it has a positive effect on the quality of life

Böbrek nakli alıcısında splenik arter anevrizması

In this article, we present the first case of SAA (Splenic Artery Aneurysm) in a kidney transplantation recipient, which was incidentally detected during the preparation of the transplantation and successfully treated. A 25-mm SAA was detected at kidney transplant recipient during the preparation examination by abdominal ultrasonography. Splenic artery ligation and aneurysmectomy was performed before the transplantation. Intraoperative Doppler ultrasonography revealed that there were no abnormalities of the spleen blood supply. During the first month of follow-up, the patient remained asymptomatic and laboratory investigations revealed no abnormalities. Selective ligation and resection of SAAs combined with spleen preservation is a safe treatment modality for selected cases with favorable short and long-term results, allowing the permanent treatment of the SAA, while preserving the splenic function.Bu yazıda, böbrek nakli alıcısında, nakil hazırlığı sırasında tesadüfen tespit edilen ve başarıyla tedavi edilen ilk SAA (Splenik Arter Anevrizması) vakasını sunuyoruz. Karın ultrasonografi ile yapılan hazırlık incelemesinde böbrek nakli alıcılarında 25 mm SAA saptandı. Nakil öncesi splenik arter ligasyonu ve anevrizmektomi yapıldı. İntraoperatif Doppler ultrasonografi ile dalak kan akışında herhangi bir anormallik olmadığı gösterildi. Takibin ilk ayında hasta asemptomatik kaldı ve laboratuvar incelemelerinde herhangi bir anormallik görülmedi. Dalak korunarak SAA'ların seçici ligasyonu ve rezeksiyonu, splenik fonksiyonu korurken SAA'nın kalıcı tedavisine izin veren, olumlu kısa ve uzun vadeli sonuçları olan seçilmiş vakalar için güvenli bir tedavi yöntemidir

Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy

Radiotherapy (RT) may result in platelet activation and thrombosis development. To the best of our knowledge, the potential effect of volumetric-modulated arc therapy (VMAT), a novel radiotherapy technique, on platelet function and microRNA (miRNA/miR) expression has not been previously investigated. The present study aimed to determine the effect of VMAT on the alterations in platelet function parameters and miRNA expression levels. A total of 25 patients with prostate cancer and 25 healthy subjects were included in the present study. Blood samples were collected from the patient group on the day prior to RT (pre-RT), the day RT was completed (post-RT day 0), and 40 days following the end of therapy (post-RT day 40). Platelet count, mean platelet volume (MPV) value, platelet aggregation, plasma P-selectin, thrombospondin-1, platelet factor 4, plasma miR-223 and miR-126 expression levels were measured. A significant decrease in platelet count in the post-RT day 0 group was measured in comparison with the pre-RT and the post-RT day 40 groups. Pre-RT MPV values were higher than those of the post-RT day 0 and the post-RT day 40 groups. No significant differences were observed in the levels of platelet activation markers or miR-223 and miR-126 expression levels between the RT groups. Although RT may result in a reduction in platelet and MPV counts, the results of the present study indicate that platelet activation markers are not affected by VMAT. Therefore, it is possible that no platelet activation occurs during VMAT, owing to the conformal dose distributions, improved target volume coverage and the sparing of normal tissues from undesired radiation

Four Hydatid Cysts in One Family: Is Family Screening Necessary?

Hydatid cyst is a parasitic infection mostly caused by Echinococcus granulosus. As transmission occurs from infected dogs, it is endemic in animal husbandry regions. Here four patients within the same family are presented. The first patient is a 10 year-old girl admitted with nausea, vomiting, and fever. On her physical examination, there were decreased respiratory sounds in the right lung, rales, and hepatomegaly. In the radiological examination, cysts were seen in both her lung and liver. After the confirmation of the diagnosis with a serological examination, surgical resection was performed, and albendazole treatment was given. On family screening, cysts were detected in the liver and spleen in her asymptomatic 6-year-old brother; in the lung, liver, spleen, and right kidney in her 33-year-old mother who had repeating abdominal pain; and in the liver and left kidney in her 33-year-old asymptomatic father. Hydatid cyst infection was serologically confirmed in all patients, and they were given albendazole and were surgically treated. In this case report, four patients in the same family and diagnosed as having hydatid cysts were presented. It was emphasized that once a hydatid cyst was diagnosed, family screening became important, in endemic regions in particular

Premenopausal female with bilateral mucinous cancer of the breast: The first case in literature

Few reports exist in the clinical literature characterizing a synchronous bilateral mucinous carcinoma of the breast however this is the first case of premenopausal woman with bilateral mucinous breast cancer in the literature. We report a case of bilateral mucinous carcinoma of the breast which is seen very rarely

DIVERSITY AND BATHYMETRIC DISTRIBUTION OF DECAPOD CRUSTACEANS ATTRACTED TO BAITED TRAPS FROM THE MIDDLE SLOPE OF THE NORTHERN AEGEAN SEA

We sampled the decapod crustaceans inhabiting the depth zone between 500 and 1500 m off Gokceada Island (northern Aegean Sea) from May 2010 to November 2011. The deep-slope decapod fauna of the northern Aegean Sea was sampled with baited traps. A total of 23 species of decapods have been identified at 32 stations. The results were analysed in terms of composition and distribution of benthic and benthopelagic bait-attracted species between regions. In addition, they were compared between stations in relation to the depth gradient. The results are discussed in relation to previous studies carried out in the eastern and western Mediterranean. Also, the use of traps is commented for different regions and the effects of the sampler on benthic species are discussed. The most common species was the penaeid shrimp, Parapenaeus longirostris in samples taken between 500 and 600 m. It is followed by Polycheles typhlops and the pandalid shrimp Plesionika martia martia. These species constitute more than 50% of all decapods. Differences among the strata at 500-1500 m depth were tentatively explained using the Shannon-Weaver diversity index (H'). The highest H' value was found for the 800-1000 m depth strata. The lowest number of species was observed between 1000 and 1500 m, which lowered the diversity index values (H'). The results of similarity percentage analysis (SIMPER) showed a change in the decapod fauna below 1000 m depth. The present results are preliminary; further data collection and analysis will be required to evaluate the role of palaeoecolgical conditions and trophic factors, and how these could be supposed to interact

Tuberculous valvular endocarditis with brain abscesses a case report and literature review

WOS: 000391847300008Tuberculous endocarditis (TBE) is a rare clinical entity, usually encountered during the course of miliary tuberculosis. Brain abscess is a very rare complication of TBE. Here, we report a case of valvular TBE presenting with meningoencephalitis due to septic embolization. The literature on well-documented cases of valvular TBE was also reviewed. Early diagnosis, an appropriate treatment strategy, surgical intervention, and close follow-up may lead to favorable outcomes in TBE. Surgical intervention (valve replacement and repair) may be required in 70% of TBE cases