Renal albumin absorption in physiology and pathology

Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by supporting the oncotic pressure and volume of the blood. The presence of albumin in urine is considered to be the result of the balance between glomerular filtration and tubular reabsorption. Albuminuria has been accepted as an independent risk factor and a marker for renal as well as cardiovascular disease, and during the past decade, evidence has suggested that albumin itself may cause progression of renal disease. Thus, the reduction of proteinuria and, in particular, albuminuria has become a target in itself to prevent deterioration of renal function. Studies have shown albumin and its ligands to induce expression of inflammatory and fibrogenic mediators, and it has been hypothesized that increased filtration of albumin causes excessive tubular reabsorption, resulting in inflammation and fibrosis, resulting in the loss of renal function. In addition, it is known that tubular dysfunction in itself may cause albuminuria owing to decreased reabsorption of filtered albumin, and, recently, it has been suggested that significant amounts of albumin fragments are excreted in the urine as a result of tubular degradation. Thus, although both tubular and glomerular dysfunction influences renal handling of albumin, it appears that tubular reabsorption plays a central role in mediating the effects of albumin on renal function. The present paper will review the mechanisms for tubular albumin uptake and the possible implications for the development of renal disease

Magnetotail structures in a simulated Earth's magnetosphere

The structure of the magnetotail is investigated in a laboratory simulated magnetosphere. Particular emphasis is placed on the region of distant magnetotail where the closed field line region of the plasma sheet terminates and the process of reconnection takes place. Our study builds upon the previous investigation of the magnetotail where the main results were based on the magnetic field measurements in the tail region of the simulated magnetosphere. In this paper, more elaborate measurements of plasma flow and electric field are presented. Besides these measurements, this region of distant magnetotail is also explored by high resolution imaging with a gated optical imager (GOI) and by digital image analysis. These images clearly reveal a Y-type magnetic neutral line for the northward 'interplanetary' field (IMF) and a usual X-type for the southward IMF that confirms our previous results deduced from the magnetic field measurements. In the neighborhood of these neutral points a strong component of dawn to dusk electric field (E(sub y)) and a counterstreaming plasma flow is also observed. Plasma flow is measured by using a double sided Faraday cup which is also used to measure the y-component of tail current (J(sub y)) at different locations. These measurements reveal that the tail current is not carried by ions as previously thought, rather it is carried by electrons alone

A case report of hereditary apolipoprotein A-I amyloidosis associated with a novel APOA1 mutation and variable phenotype

Apolipoprotein A-I (apo A-I) amyloidosis is a non-AL, non-AA, and non-transthyretin type of amyloidosis associated with mutations in the APOA1 gene inherited in an autosomal dominant fashion. It is a form of systemic amyloidosis, but at presentation, can also mimic localized amyloidosis. The renal presentation generally involves interstitial and medullary deposition of apo A-I amyloid protein. We describe the identification of apo A-I amyloidosis by mass spectrometry in a 52-year old male, with no family history of amyloidosis, presenting with nephrotic syndrome and associated with heterozygosity for a novel APOA1 mutation (c.220 T > A) which encodes the known amyloidogenic Trp50Arg variant. Renal amyloid deposits in this case were confined to the glomeruli alone, and the patient developed progressive renal impairment. One year after diagnosis, the patient had a successful kidney transplant from an unrelated donor. Pathogenic mutations in the APOA1 gene are generally associated with symptoms of amyloidosis. In this family however, genotyping of family members identified several unaffected carriers suggesting a variable disease penetrance, which has not been described before in this form of amyloidosis and has implications when counselling those with APOA1 mutations

On the mean field dynamo with Hall effect

We study in the present paper how Hall effect modifies the quenching process of the electromotive force (e.m.f.) in Mean Field Dynamo (MFD) theories. We write down the evolution equations for the e.m.f. and for the large and small scale magnetic helicity, treat Hall effect as a perturbation and integrate the resulting equations assuming boundary conditions such that the total divergencies vanish. For force-free large scale magnetic fields, Hall effect acts by coupling the small scale velocity and magnetic fields. For the range of parameters considered, the overall effect is a stronger quenching of the e.m.f. than in standard MHD and a damping of the inverse cascade of magnetic helicity. In astrophysical environments characterized by the parameters considered here, Hall effect would produce an earlier quenching of the e.m.f. and consequently a weaker large scale magnetic field.Comment: 8 pages, 4 figures. Accepted by A&

New Insights into Dissipation in the Electron Layer During Magnetic Reconnection

Detailed comparisons are reported between laboratory observations of electron-scale dissipation layers near a reconnecting X-line and direct two-dimensional full-particle simulations. Many experimental features of the electron layers, such as insensitivity to the ion mass, are reproduced by the simulations; the layer thickness, however, is about 3-5 times larger than the predictions. Consequently, the leading candidate 2D mechanism based on collisionless electron nongyrotropic pressure is insufficient to explain the observed reconnection rates. These results suggest that, in addition to the residual collisions, 3D effects play an important role in electron-scale dissipation during fast reconnection.Comment: 17 pages, 4 figure

Conditions for fast magnetic reconnection in astrophysical plasmas

We investigate favourable circumstances for fast magnetic reconnection in astrophysical plasmas based on recent results by Rogers et al. (2001). Given that a critical magnetic field structure with antiparallel field lines exists, our analysis demonstrates that a sufficient condition for fast reconnection is that the ratio of the thermal pressure to the magnetic field pressure $\beta$ should be significantly larger than $2 m_e/m_p$ (twice the ratio of electron mass to proton mass). Using several examples (like the different components of the interstellar medium, the intergalactic medium, active galactic nuclei and jets) we show that in almost all astrophysical plasmas, magnetic reconnection proceeds fast i.e. independent of the resistivity, with a few percent of the Alfv{\'e}n speed. Only for special cases like neutron stars and white dwarfs is $\beta$ smaller than $2 m_e/ m_p$

Imaging Spectroscopy of a White-Light Solar Flare

We report observations of a white-light solar flare (SOL2010-06-12T00:57, M2.0) observed by the Helioseismic Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO) and the Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI). The HMI data give us the first space-based high-resolution imaging spectroscopy of a white-light flare, including continuum, Doppler, and magnetic signatures for the photospheric FeI line at 6173.34{\AA} and its neighboring continuum. In the impulsive phase of the flare, a bright white-light kernel appears in each of the two magnetic footpoints. When the flare occurred, the spectral coverage of the HMI filtergrams (six equidistant samples spanning \pm172m{\AA} around nominal line center) encompassed the line core and the blue continuum sufficiently far from the core to eliminate significant Doppler crosstalk in the latter, which is otherwise a possibility for the extreme conditions in a white-light flare. RHESSI obtained complete hard X-ray and \Upsilon-ray spectra (this was the first \Upsilon-ray flare of Cycle 24). The FeI line appears to be shifted to the blue during the flare but does not go into emission; the contrast is nearly constant across the line profile. We did not detect a seismic wave from this event. The HMI data suggest stepwise changes of the line-of-sight magnetic field in the white-light footpoints.Comment: 14 pages, 7 figures, Accepted by Solar Physic

Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function-A follow-up of the CONTEXT study

BACKGROUND: Ischaemia-reperfusion injury in kidney transplantation leads to delayed graft function (DGF), which is associated with reduced long term graft function. Remote ischaemic conditioning (RIC) improved early kidney graft function in a porcine model of donation after brain death and was associated with improved long-term cardiac outcome after myocardial ischaemia. This randomised, double-blinded trial evaluated the effect of RIC on kidney graft outcome in the first year, and examined the predictive value of a new measure of initial kidney graft function, i.e. the estimated time to a 50% reduction in plasma creatinine post-transplantation (tCr50). METHODS: A total of 225 patients undergoing deceased donor kidney transplantation were randomised to RIC or a sham procedure performed prior to kidney reperfusion. Up to four repetitive cycles of five minutes of leg ischaemia and five minutes of reperfusion were given. GFR, plasma creatinine, cystatin C and neutrophil gelatinase associated lipocalin (NGAL) were measured at three and twelve months and estimated GFR was calculated using four different equations. Other secondary outcomes were identified from patient files. RESULTS: RIC did not affect GFR or other outcomes when compared to the sham procedure at three or twelve months. tCr50 correlated with one year graft function (p<0.0001 for both mGFR and eGFR estimates). In contrast, DGF i.e. "need of dialysis the first week" did not correlate significantly with one year GFR. CONCLUSION: RIC during deceased donor kidney transplantation did not improve one year outcome. However, t