Antibacterial activity of nano goldparticles synthesized by Bacillus Sps.

The synthesis and bioactivity of gold nanoparticles has been extensively studied. However, the antibacterial activity of gold nano particles individually or in combination with different antibiotics has not been demonstrated. In the present study the effect of gold nano particles on the antibacterial activity of different antibiotics was evaluated against Staphylococcus aureus, k.pnemonea, P.aureginosa, E.coli. Disk diffusion method was used to determine the antibacterial activity of various antibiotics in the absence and presence of sub inhibitory concentration of gold nano particles. A clinical isolates of S. aureus, k.pnemonea, p.aureginosa,E.coli.  were used as the test strains. In the presence of sub-inhibitory concentration of gold nano particles the antibacterial activities of all antibiotics have . Increased from minimum 2 mm to a maximum of 8 mm. The highest increase was observed for ceftazidime followed by genthamycin. These results signify that the gold nano particles potentiate the antimicrobial action of cephalosporins and amino glycosides, suggesting a possible utilization of nano compounds in combination therapy against S. aureus, k.pnemonea, p.aureginosa,E.coli

Study of maternal and fetal outcome in pregnancy beyond 40 weeks: a prospective observational study at a tertiary institute

Background: Prolonged pregnancy is one that exceeds 42 0/7weeks. Management of prolonged pregnancy is very challenging in modern obstetrics.Methods: It is prospective observational study in department of Obstetrics and Gynecology, Shri B.M Patil medical college and Research center, deemed to be University, Vijayapur, North karnataka. Study period was from January 2018 to January 2019.Results: Total of 186 pregnant women were included in the study. Results in terms of age, gravidity, gestational age, time of induction, mode of delivery, neonatal outcome and maternal complications.Conclusion: Pregnancies beyond 40 weeks require early detection, effective fetal monitoring and proper planning of labour. In pregnancies beyond 40 weeks, decision of induction should be taken cautiously as early induction leads to failure of induction and increased rates of lower (uterine) segment Caesarean section (LSCS), while delayed induction leads to increased fetal complications

Outcome of Anterior Wall Acetabulum and Pelvis Fracture through a Modified Stoppa Approach: A Prospective Cohort Study

Introduction: Acetabular fractures are becoming more common these days. The treatment of complicated acetabular fractures is challenging due to their location and associated injuries. Since the development of the Stoppa approach, it has been used as an alternative to the conventional ilioinguinal strategy. Aim: To assess the postoperative outcomes based on clinical and radiographic results in patients with fractures of the pelvis and acetabulum treated using the Modified Stoppa method. Materials and Methods: This prospective cohort study was conducted at Shri BM Patil Medical College, Hospital and Research Centre in Vijayapura, Karnataka, India, from January 2021 to May 2022. The study included 30 patients with acetabular fractures. Fracture reduction was achieved using a modified Stoppa technique. The patients were followed up for six months, and postoperative function was assessed using the Merle D’Aubigne Score and postoperative X-rays. Frequency distribution was used to analyse the frequency and percentage of study variables. The Chi-square test was used to determine the association between outcomes and radiographic results. Pearson’s correlation coefficient test was used to compare the follow-up time of the patients and the Merle D score. Results: Out of the 30 cases operated on using the modified Stoppa approach, 86.67% achieved anatomical reduction, with 53.33% showing a good outcome and 33.33% achieving an excellent outcome post-surgery. The results were subjected to statistical analysis. Frequency distribution was used to analyse the frequency and percentage of study variables. The Chi-square test was used to determine the association between outcomes and radiographic results. Pearson’s correlation coefficient test was used to compare the follow-up time of the patients and the Merle D score. There was a statistically significant correlation (r-value of 0.007) between the patient’s outcome and the radiographic results post-surgery. Conclusion: The use of less invasive techniques has simplified surgery and reduced complications in the treatment of difficult acetabular fractures. With improved surgical skills and early intervention, this innovative technique for anterior exposure of the acetabulum can be used effectively

Functional Outcome of Acute Minimally Displaced Scaphoid Waist Fractures Treated with Percutaneous Headless Compression Screw Fixation: A Prospective Cohort Study

Introduction: Scaphoid fracture incidence has increased recently due to increased participation of people in sports and increased road traffic accidents and easy availability of diagnostic tools like Computed Tomography (CT), which help in easily diagnosing scaphoid fractures, and may be missed on routine radiographs. Aim: To evaluate the functional outcome of surgical intervention with percutaneous headless compression screw fixation for acute minimally displaced scaphoid fractures. Materials and Methods: The present study was a prospective cohort study in which patients with acute fractures of scaphoid bone managed with percutaneous headless compression screw fixation were included between January 2020 to December 2022 and were evaluated using the Modified Mayo Wrist Score (MMWS) and Disabilities of Arm, Shoulder and Hand (DASH) score. The data obtained was entered into a Microsoft Excel sheet, and statistical analysis was performed using a Statistical Package for the Social Sciences (SPSS) version 20.0. Results: The study included 55 patients with a mean age of 32.9 years, out of which 43 were males and 12 were females. Road traffic accident injuries were in 19 patients, 17 were sports injuries and 19 were due to direct trauma. All patients were managed by percutaneous headless compression screw fixation. Among these, 27 patients showed excellent outcomes, 24 showed good outcomes, and four showed fair outcomes. Conclusion: This study shows that percutaneous fixation of minimally displaced scaphoid fractures results in early symptomatic relief and functional recovery. It shows that percutaneous fixation using a headless compression screw has similar functional outcomes and less hospital stay and patient scarring than in open fixation methods. Functional recovery is faster with percutaneous fixation than in non operative and open fixation