MOLINO PALOMBA - DEGRADATION AND POSSIBLE STATIC RECOVERY OF A DISUSED INDUSTRIAL BUILDING

The aim of this paper is to propose an intervention methodology for the restoration of an industrial archeology building starting from the analysis of the state of the art with a view to sustainability and resilient thinking. The building in object is an ancient masonry mill called "ex Molino Palomba" that has, in the writers 'opinion, historical-monumental relevance both as a symbol of ancient work technologies, that because is situated in a territory strictly interconnected with the "Caserta Palace" (UNESCO site). Today the building presents a visible state of decay and structural instability, but a preliminary analysis of the overall framework and the bibliographical research, have however allowed to outline a proposal of a resilient approach

Degradation of concrete resistance: analysis of a homogeneous area. The city of Caserta

The concept that concrete degrades over time has now been acquired and this leads to a reduction of the resistance. In the case under consideration, an attempt is made to establish a relationship between the time elapsed from construction to the test date with the same environmental conditions, as all samples from the same geographical area were examined. A few dozen results are analyzed, in terms of compressive strength and an attempt is made to draw a relationship between time and reduction of resistance. Where the level of carbonation penetration is also available, an attempt is also made to find a correlation between carbonatation and reduction of resistance in the time. Resistance is measured on samples from the extraction of cores from existing public and private buildings and built over different periods of time. The investigations were carried out in the time interval between 2009 and today for various purposes requested by the owners at the TecnoLab laboratory in Naples which allowed us to access their archive, not disclosing personal customer data. The resistance was assessed both through the direct crushing of the extracted samples and through evaluations with non-destructive methods such as the combined SonReb tests

Strenght Tests of Two Reinforced Concrete Plinths of the Former Saint Gobain Factory in Caserta Dating Back to the 1960s

The article highlights the current status and the physical conditions in which they pour two reinforced concrete plinths, belonging to the foundations of the former glass factory Saint Gobain of Caserta (Italy). They are about half a century old and, thanks to the destructive and non-destructive analyzes carried out on the plinths, followed by structural tests in the laboratory, it was possible to establish how resistant the structural elements were and how much they affected environment and degradation factors on quality and relative durability of the same. The old structure is incorporated into the new one on the south side. The two examples of plinths: they are identical in constitution and material but the physical and chemical state in which they are found today is different. The old structure is often clearly visible, although it is based on in more than disastrous situations; the second, a few meters away, has always been left at the mercy of the passing of years, exposed to atmospheric and related agents, surrounded by rubble. The tests performed are: Pacometric; Sclerometric; Ultrasonic; No. 2 samples of cylindrical sample (coring); Test on compression on the extracted carrots. Furthermore, the sclerometric and ultrasonic tests were processed with the SONREB method, to obtain a more reliable estimate of the strength of the concrete on site. Comparing the values obtained and given the passage of time and the advanced age of the materials, it can be said that the result was surprising and unexpected

Pathologic response and residual tumor cellularity after neo-adjuvant chemotherapy predict prognosis in breast cancer patients

Introduction: Residual tumor cellularity (RTC) and pathologic complete response (pCR) after neo-adjuvant chemotherapy (NAC) are prognostic factors associated with improved outcomes in breast cancer (BC). However, the majority of patients achieve partial pathologic response (pPR) and no clear correlation between RTC patterns and outcomes was described. Our aims were to define predictive factors for pCR and compare different outcomes of patients with pCR or pPR and with different RTC patterns. Materials and methods: Baseline and post-NAC demographics, clinicopathological characteristics, post-operative data, survival and recurrence status were recorded from our institutional database. A multivariable analysis was performed using a logistic regression model to identify independent predictors of pCR. Disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS) analyses were performed using the Kaplan-Meier method. Results: Overall, of the 495 patients analyzed, 148 (29.9%) achieved pCR, 347 (70.1%) had pPR, and the median RTC was 40%. Multivariable analysis identified 3 independent factors predictive of pCR: tumor stage before NAC (cT1-2 84.5% versus cT3-4 15.5%), BC sub-type (HER2-positive 54.7% versus triple-negative 29.8% versus luminal-like 15.5%), and vascular invasion (absence 98.0% versus presence 2.0%). We found statistically significant longer DFS, DDFS, and OS in patients with pCR and with RTC <40%; no difference was observed in terms of OS between RTC <40% and RTC ≥40% groups. Conclusions: Tumor stage before NAC, BC sub-type, and vascular invasion are significant and independent factors associated with pCR. Patients with pCR and with RTC <40% have longer DFS, DDFS, and OS compared with patients with pPR

Myofibroblastoma of the breast: two case reports and literature review

Myofibroblastoma (MFB) is a relatively rare tumor of the breast parenchyma, which belongs to the family of the 'benign stromal tumor of the breast'. Two cases of MFB of the breast are described. Radiological imaging is nonspecific in MFB, and pathological examination of needle biopsy or surgically resected specimen is necessary for the diagnosis. Surgery is recommended and considered curative without additional treatment; however, patients should be followed-up

Manuale di Chirurgia Generale

Dal continuo lavoro del corpo docenti dell’Accademia Italiana Medici Specializzandi (AIMS) nasce questa sesta edizione del Manuale di Chirurgia Generale - Sesta Edizione 2020. Si tratta di un testo specificamente pensato per la preparazione del laureato in Medicina e Chirurgia affinché possa affrontare efficacemente il nuovo Concorso delle Scuole di Specializzazione Mediche: è una risorsa schematica, sintetica e aggiornata in base alle più recenti linee guida che consente uno studio rapido della disciplina. La trattazione semplice ma, al tempo stesso, rigorosa, stimola la capacità di ragionamento clinico del giovane medico che ne affronta lo studio e rende quest’opera un strumento valido, unico nel suo genere e complementare alla preparazione del corso di preparazione AIMS. L’intera Opera è corredata da una grande varietà di immagini e schemi, pensati per facilitare la comprensione e la memorizzazione degli argomenti trattati

Nipple sparing mastectomy with prepectoral immediate prosthetic reconstruction without acellular dermal matrices: a single center experience

Background: Nipple-sparing mastectomy (NSM) with immediate prosthetic breast reconstruction (IPBR) is an oncologically accepted technique that allows to improve aesthetic results and patient quality of life. Traditionally, implant for reconstruction have been placed in a submuscolar (SM) plane, beneath the pectoralis major muscle (PMM). Recently, prepectoral (PP) placement of prosthesis is increasingly used in order to avoid morbidities related to manipulation of PMM. The aim of the present study was to report our experience with 209 NSMs and IPBR using a prepectoral approach and polyurethane-coated implant without acellular dermal matrices (ADMs). Methods: A retrospective review of breast cancer patients who underwent NSM followed by PP - IPBR from January 2018 to April 2021 was performed. Data were recorded in order to evaluate operative details, major complications and oncological outcomes. Aesthetic results and patient quality of life were measured by a specific "QOL assessment PRO" survey. Results: Two hundred and nine patients (269 breasts) with PP - IPBR after NSM were included. Mean age was 47 (25-73) years and median follow-up was 14 (1-40) months. A simultaneous contralateral implant-based mammoplasty of symmetrization after unilateral NSM was carried out in six of 149 (4%) patients. Implant loss was observed in three of 209 patient (1.44%); two of 209 (0.96%) patients developed a full-thickness NAC necrosis that required excision. During follow-up one local relapse (0.48%) and two regional nodes recurrences (0,96%) was observed. Patient satisfaction, assessed using a personalized QOL Assessment PRO survey, in term of aesthetic results, chronic pain, shoulder dysfunction, sports activity, sexual and relationship life and skin sensibility, was excellent. Conclusions: Our experience shows that PP-IPBR using polyurethane-coated implant after NSM is a safe, reliable and effective alternative to traditional IPBR with excellent aesthetic outcomes and high patient quality of life; it is easy to perform, minimizes complications related to manipulation of PPM and reduces operative time while resulting also in a cost-effective technique