The impact of former mining activity on soils and plants in the vicinity of an old mercury mine (Vallalta, Belluno, NE Italy)

Exploitation of ore minerals (cinnabar, chalcopyrite, sphalerite) from the old mine in Vallalta (Belluno, NE Italy) has resulted in serious environmental impacts, including the acidification of water, and the contamination of soils and plants. Forty-eight soil samples and four wild plants were examined at four sites in the vicinity of the mine ( Micronutrients Cu, Zn, Fe and Mn showed translocation factors (TFs) of between 0.5 and 1, suggesting that these elements are taken up to a critical concentration and are then arrested in the roots. Iron is less mobile, particularly in C. hirsutum, with the lowest TF of 0.38. The TF for Mn and Hg is >1 in S. nemorum and C. hirsutum; a TF of Soil contamination is confined to the proximity

Does the EU Directive on non-financial information influence the value relevance of ESG disclosure? Italian evidence

The implementation of the EU Directive on non-financial information determines the transition from a voluntary to a mandatory disclosure setting. This paper is a first attempt to investigate if this transition influences the value relevance of non-financial information, which relates to the environmental, social and governance disclosure (ESG) requirements of the Directive. Italy provides an interesting setting as non-financial information was generally voluntary before the Directive, which was implemented with the Italian Legislative Decree 254/2016. To this extent, we examine the non-financial, environmental and social disclosure practices of 231 Italian listed firms in the pre- (2016) and post- (2017) Legislative Decree application. Our results do not show any relevant increase of such disclosures after the Decree application, as Italian listed firms limit such disclosure to a minimum requirement. Further, this finding is confirmed also for those firms voluntarily providing a non-financial report (sustainability or integrated report) before the Decree application. Our regression analysis shows that accounting numbers are associated with share prices, while non-financial, environmental and social information are not value-relevant with reference to the pre- and post-Legislative Decree application. This means that the nonfinancial, environmental and social information beyond the financial accounting information do not explain any incremental value-relevant information to investors in the new non-financial mandatory disclosure setting required by the new regulation. Our results enrich previous evidence concerning the value relevance of non-financial and ESG disclosure mainly focused on Anglo-Saxon contexts

Business Model and Non-Financial Key Performance Indicator Disclosure

Business model disclosure is proposed as a communication tool for companies to increase the effectiveness of non-financial key performance indicator (NFKPI) disclosure. First, business model enables the identification of indicators that are aligned with strategic objectives. Moreover, it acts as an integrated framework, showing how different capitals are combined to create value

Do Non-Aromatic Labiatae Produce Essential Oil? The Case Study of Prasium Majus L

Prasium majus L. (Labiatae, Lamioideae) is considered a typical non-aromatic plant. In this work we examined the glandular trichomes present on leaves and inflorescences and the essential oils of plants growing along the Tuscan coast of Italy. The micromorphological study evidenced different types of trichomes responsible for the essential oil production. The essential oil compositions of leaves and flowers were analyzed by GC/MS and are here reported

Business Model Reporting: Why the Perception of Preparers and Users Matters

The aim of this work is to investigate the alignment of preparers’ and users’ perceptions of the BM and its constitutive elements. Results show that, while both categories assign great importance to this concept, different conceptions of the purpose and the components of a BM emerge

The Impact of the Weight Status on Cardiovascular Parameters Related to Physical Effort in Young Athletes

Excess weight leads to an impaired cardiovascular response to physical exertion even at a young age. Sports training during youth promotes cardiovascular adaptations. The aim of the study is to verify the impact of weight status on cardiovascular parameters related to physical effort in young people who engage in competitive sports. A retrospective study was conducted on 8307 young athletes (5578 males and 2729 females) aged 6–18 years (mean age 13.9 ± 2.2 years). The data concerning graded exercise tests of young athletes in normal weight and overweight were compared. Approximately, 13.4% of the sample had excess weight. Young overweight athletes show a higher resting heart rate as well as systolic and diastolic pressure than young normal weight athletes. Excess weight condition leads to a reduction in the duration of the graded exercise test, reaching higher blood pressure values at the end of the test compared to those with normal weight. After four min from the end of the test, heart rate and systolic/diastolic blood pressure remained higher in the young overweight athletes. Excess weight affects cardiovascular parameters both at rest and in response to physical exertion during youth; however, competitive sport seems to be able to keep these parameters within the normal range even in young overweight athletes

Multi-Omics Integrative Approach of Extracellular Vesicles: A Future Challenging Milestone

In the era of multi-omic sciences, dogma on singular cause-effect in physio-pathological processes is overcome and system biology approaches have been providing new perspectives to see through. In this context, extracellular vesicles (EVs) are offering a new level of complexity, given their role in cellular communication and their activity as mediators of specific signals to target cells or tissues. Indeed, their heterogeneity in terms of content, function, origin and potentiality contribute to the cross-interaction of almost every molecular process occurring in a complex system. Such features make EVs proper biological systems being, therefore, optimal targets of omic sciences. Currently, most studies focus on dissecting EVs content in order to either characterize it or to explore its role in various pathogenic processes at transcriptomic, proteomic, metabolomic, lipidomic and genomic levels. Despite valuable results being provided by individual omic studies, the categorization of EVs biological data might represent a limit to be overcome. For this reason, a multi-omic integrative approach might contribute to explore EVs function, their tissue-specific origin and their potentiality. This review summarizes the state-of-the-art of EVs omic studies, addressing recent research on the integration of EVs multi-level biological data and challenging developments in EVs origin

Neurodegenerative Disorder Risk in Krabbe Disease Carriers

Krabbe disease (KD) is a rare autosomal recessive disorder caused by mutations in the galactocerebrosidase gene (GALC). Defective GALC causes aberrant metabolism of galactolipids present almost exclusively in myelin, with consequent demyelinization and neurodegeneration of the central and peripheral nervous system (NS). KD shares some similar features with other neuropathies and heterozygous carriers of GALC mutations are emerging with an increased risk in developing NS disorders. In this work, we set out to identify possible variations in the proteomic profile of KD-carrier brain to identify altered pathways that may imbalance its homeostasis and that may be associated with neurological disorders. The differential analysis performed on whole brains from 33-day-old twitcher (galc (-/-)), heterozygous (galc (+/-)), and wild-type mice highlighted the dysregulation of several multifunctional factors in both heterozygous and twitcher mice. Notably, the KD-carrier mouse, despite its normal phenotype, presents the deregulation of vimentin, receptor of activated protein C kinase 1 (RACK1), myelin basic protein (MBP), 2 ',3 '-cyclic-nucleotide 3 '-phosphodiesterase (CNP), transitional endoplasmic reticulum ATPase (VCP), and N-myc downstream regulated gene 1 protein (NDRG1) as well as changes in the ubiquitinated-protein pattern. Our findings suggest the carrier may be affected by dysfunctions classically associated with neurodegeneration: (i) alteration of (mechano) signaling and intracellular trafficking, (ii) a generalized affection of proteostasis and lipid metabolism, with possible defects in myelin composition and turnover, and (iii) mitochondrion and energy supply dysfunctions

The exosome and human ribosome biogenesis

Exoribonucleases have many important functions in the cell including RNA processing, turnover and quality control. One of the key 3’-5’ exonucleases is the exosome, a multiprotein complex that has been extensively characterised in yeast. Many substrates that undergo maturation and/or degradation involving the yeast exosome have been identified and these include tRNAs, mRNAs, snRNAs, snoRNAs and rRNAs. By comparison, the human exosome is poorly understood and it is not clear whether functions of the yeast exosome are conserved in higher eukaryotes. We show that the human exosome has degradation functions including the turnover, but not the processing, of snoRNAs and the recycling of excised pre-rRNA fragments. We and others have shown that the human exosome also participates in pre-rRNA processing to form the mature 3’ end of 5.8S rRNA. Here we identify a novel role for the exosome in the processing of the pre-rRNA internal transcribed spacer 1 (ITS1). The small (18S) and large (5.8S and 28S) subunit rRNAs are co-transcribed as a single precursor. Processing of ITS1 is a key step in ribosome biogenesis as it separates 18S from the large subunit rRNAs and in higher eukaryotes it involves an additional processing step compared to yeast. We define alternative ITS1 processing pathways in human cells. In the major pathway, following an endonucleolytic cleavage to separate the small and large subunit rRNAs, the exosome, which is not involved in ITS1 processing in yeast, processes to within 25 nucleotides of the 3’ end of 18S. Our data highlight significant differences between the nucleases involved in ITS1 processing in yeast and humans. However, it appears that the roles of several yeast biogenesis factors are conserved in higher eukaryotes. Further, we have investigated mechanisms by which exonucleolytic processing of ITS1 may be regulated and suggest how this could be coordinated with the final maturation steps of the pre-40S complex.EThOS - Electronic Theses Online ServiceBBSRCWellcome TrustGBUnited Kingdo