(E)-2-[(3-Fluoro­phen­yl)imino­meth­yl]-4-(trifluoro­meth­oxy)phenol

The title compound, C14H9F4NO2, is a Schiff base which adopts the phenol–imine tautomeric form in the solid state. The H atom is located on the hydr­oxy O atom rather than on the N atom. This H atom is involved in a strong intra­molecular O—H⋯N hydrogen bond. The mol­ecule is almost planar, the angle between the benzene rings being 2.14 (13)°

1-[(E)-(2-Methyl-3-nitro­phen­yl)imino­meth­yl]-2-naphthol

The title Schiff base compound, C18H14N2O3, has an inter­mediate state between NH and OH tautomers. The mol­ecular structure is stabilized by an O—H⋯N hydrogen bond. The dihedral angle between the naphthalene ring system and the benzene ring is 37.44 (5)°

Angioedema and Urticaria Associated with Fluoxetine in a Preadolescent Boy

Angioedema is defined as increased permeability and dilatation of the capillaries in the deep dermis or subcutaneous or submucosal tissues leading to localized swelling, often affecting the upper respiratory and gastrointestinal tracts. It can also be observed as a rare adverse effect of selective serotonin reuptake inhibitors, as is the case with many other drugs. Here, we report a 10-year-old boy who had urticaria with fluoxetine use, showed recovery after cessation of the drug, and manifested with urticaria and angioedema after re-prescription. In the literature, there are two previous case reports of angioedema with fluoxetine. One case of angioedema accompanied by urticaria and showed a flu-like presentation 2 days after ingestion of high-dose fluoxetine. The other case, reporting angioedema with 10 mg/day, was without urticaria and thought to be a pseudoallergic reaction. We assume that our case is unique in this respect for that angioedema developed with therapeutic doses and thought to be allergic

Characteristics of food allergy in children: National multicenter study

Conference: Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) Location: Lisbon, PORTUGAL Date: JUN 01-05, 2019Background : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.European Academy of Allergy and Clinical Immunolog

Results of Screening in Schools for Visually Impaired Children

Objectives: The aim of this study was to identify the causes of visual impairment in children attending schools for students with visual impairment and to identify children suitable for treatment and rehabilitation. Materials and Methods: All students were examined in our department by a pediatric ophthalmologist and an ophthalmologist experienced in low vision and visual rehabilitation. The children’s medical histories were recorded. All children underwent ophthalmological examination including visual acuity measurement, anterior segment and dilated fundus evaluation, retinoscopy with cycloplegia, and intraocular pressure measurement. The causes of visual impairment were grouped as avoidable and unavoidable. Children with residual visual acuity better than 20/1250 were included in the low vision rehabilitation programme. Results: A total of 120 patients were evaluated and 79.2% were legally blind (visual acuity less than 0.05), 18.4% had low vision (visual acuity between 0.05 and 0.3), and 0.8% had normal vision (>0.3). The main causes of visual impairment were retinal dystrophies (24.2%) and retinopathy of prematurity (17.5%). Of all diseases related to visual impairment, 27.6% were avoidable. Improvement in visual acuity was achieved with low vision aids in 57.5% of all patients. Conclusion: The incidence of visual impairment due to avoidable causes can be decreased by ophthalmic screening. Treatment of these children in the early stages of visual development can improve visual acuity. Even in cases with delayed diagnosis, low vision aids are important for visual and neurobehavioral development, and these programmes may improve quality of life and education in these children

Diagnostic Dilemma in Allergy and Coronary Syndromes: Kounis Syndrome or Adrenaline Effect?

Management of anaphylaxis includes adrenaline, a life-saving drug, however appropriate dosing and administration are of crucial importance due to serious side effects. We present a 15-year-old female with anaphylactic reaction manifesting as acute coronary syndrome and pulmonary edema following the administration of adrenaline as an intravenous bolus. Focusing on anaphylaxis, adrenaline and coronary symptoms, this report discussed the interactions between three intertwining entities: Kounis syndrome, Takotsubo cardiomyopathy, and adrenaline-induced coronary vasospasm, and challenges in differential diagnosis. Brugada syndrome (cardiac autonomic dysfunction) and clinical manifestation of the patient was also evaluated. Early consideration of adrenaline at the appropriate dose and administration route is essential in anaphylaxis management. Kounis syndrome should be considered in those presenting with allergy symptoms and chest pain and adrenaline should be used carefully due to possible risks of worsening coronary symptoms in patients with Kounis syndrome. This report also highlights a very rare side effect of adrenaline; the drug, which constitutes the cornerstone of anaphylaxis management, has a potential to trigger allergy itself due to metabisulfite-containing preservative

Kıyı ve deniz mühendisliğinde entellektüel tasarım

Kıyı yerleşimlerinin en değerli hazinesi doğal yapıları ve görsel özellikleridir. Denizlere uyumlu olarak yaşamak için kıyılarda inşa edilen yapıların denizlerimizin ve kıyı alanlarının görsel özelliği olan güzel manzaralarını bozmadan tasarlanması önemlidir. Kıyı ve Deniz Mühendisliğinin tarihsel geçmişinde, kıyı problemlerinin çözümleri için teknik yaklaşımlar ve tasarım yöntemlerinde de değişimler olmaktadır. Önceleri dayanıklı, sağlam ve dengeli kıyı yapıları tasarlanması tercih edilmekte iken, sonraları yapıların performanslarının devamlılığı ön plana alınmıştır. Bunların yanında bölgede yaşayanlar tarafından kıyı yapılarında estetik ve sürdürülebilir kullanım konusunda talepler artmaktadır Ergin, (2018). Bu çalışma kıyı mühendisliğinde yapılan tasarımlarda dikkate alınması gerekli yeni bir kavram olan entelektüel tasarım kavramını değerlendirmekte, yapılacak kıyı yapıları tasarımlarında özellikle kentsel mekânda kalite, estetik ve sürdürebilirlik kavramlarının önemi ve nasıl ele alınacağı tartışılarak öneriler sunulmuştur

Current Trends in Tolerance Induction in Cow's Milk Allergy: From Passive to Proactive Strategies.

This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to support the efficacy of food allergen avoidance in infancy and the concept of the dual-allergen-exposure hypothesis, which suggests that allergen exposure through the skin leads to sensitization, whereas early oral consumption of allergenic food protein induces oral tolerance. The new approach is based on the likelihood of early introduction of allergenic foods to the infant's diet to reduce the development of food allergies through oral tolerance induction. The latest treatment guidelines recommend the continuation of breast feeding and the elimination of cow's milk and products from the maternal diet in exclusively breast-fed infants with CMPA, the use of an extensively hydrolyzed infant formula (eHF) with proven efficacy in CMPA as the first elimination diet in formula-fed infants with CMPA and the use of amino acid-based formula (AAF) in severe cases, such as anaphylaxis, enteropathy, eosinophilic esophagitis, and food protein-induced enterocolitis syndrome (FPIES), as well as cases of multiple system involvement, multiple food allergies, and intolerance to extensively hydrolyzed formula (eHF). In conclusion, this paper presents the current knowledge on tolerance development in infants and children with CMPA to increase the awareness of the clinicians concerning the new approaches in CMPA treatment Tolerance development is considered a relatively new concept in CMPA, inducing a shift in interventions in CMPA from a passive (avoidance of responsible allergen) toward a proactive (tolerance induction) strategy

Epidemiology of pertussis in adolescents and adults in Turkey

Two hundred and fourteen patients who had a cough illness lasting at least 2 weeks were studied to investigate Bordetella pertussis as a cause of prolonged cough in adolescents and adults. Medical history and nasopharyngeal swab specimens for culture and polymerase chain reaction (PCR) were obtained at presentation. Three (1.4%) patients were B. pertussis culture-positive; 15 (7%) were B. pertussis PCR-positive (including the culture-positive patients) and 11 (5.1%) were Bordetella spp. PCR-positive. Symptom combinations were significantly high both in patients with pertussis and patients with indeterminate results (P < 0.05). We conclude that B. pertussis should be considered among differential diagnoses of prolonged cough in adolescents and adults and PCR and culture should be used to detect these cases and facilitate public health response