665 research outputs found
Paternity Test: Finding a Director’s Voice for Father
The following thesis is a brief view of the production process of Theatre UNO’s Spring 2014 production of the Tennessee William’s New Orleans Literary Festival One-Act play competition 2013 winner, Father. This thesis will include analysis, production book, documentation from the production, and an evaluation of the process of putting this production on stage. The play was performed in New Orleans, Louisiana at the University of New Orleans, Performing Arts Center Robert E Nims Lab Theatre on February 11th- 16th, 2014
Performances of Herschel/PACS bolometer arrays and future developments at CEA
The European Space Agency is building a space telescope to observe the Universe in the Far-IR and sub-millimeter regime of the electromagnetic spectrum. The scientific payload is composed of three instruments. One of them, PACS, is equipped with a novel type of bolometer arrays developed by CEA in the late 90's. We briefly present the PACS Photometer and the architecture of CEA filled bolometer arrays. We accessed the physics of the detectors and thoroughly measured their performances by developing a pragmatic calibration procedure. The Photometer is now calibrated and integrated on the focal plane of the observatory. The launch is scheduled for April 2009. Meanwhile, CEA is working on adapting PACS bolometers to longer wavelength for wide-field ground-based telescopes, and for the future cold-telescope space mission SPICA
CEA Bolometer Arrays: the First Year in Space
The CEA/LETI and CEA/SAp started the development of far-infrared filled bolometer arrays for space applications
over a decade ago. The unique design of these detectors makes possible the assembling of large focal planes
comprising thousands of bolometers running at 300 mK with very low power dissipation. Ten arrays of 16x16
pixels were thoroughly tested on the ground, and integrated in the Herschel/PACS instrument before launch in
May 2009. These detectors have been successfully commissioned and are now operating in their nominal environment
at the second Lagrangian point of the Earth-Sun system. In this paper we briefly explain the functioning
of CEA bolometer arrays, and we present the properties of the detectors focusing on their noise characteristics,
the effect of cosmic rays on the signal, the repeatability of the measurements, and the stability of the system
Adaptive designs in critical care trials: a simulation study
BACKGROUND: Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care trials remains limited. A better understanding of the relative benefits of various adaptive designs may increase their use and interpretation. METHODS: Using two large critical care trials (ADRENAL. CLINICALTRIALS: gov number, NCT01448109. Updated 12-12-2017; NICE-SUGAR. CLINICALTRIALS: gov number, NCT00220987. Updated 01-29-2009), we assessed the performance of three frequentist and two bayesian adaptive approaches. We retrospectively re-analysed the trials with one, two, four, and nine equally spaced interims. Using the original hypotheses, we conducted 10,000 simulations to derive error rates, probabilities of making an early correct and incorrect decision, expected sample size and treatment effect estimates under the null scenario (no treatment effect) and alternative scenario (a positive treatment effect). We used a logistic regression model with 90-day mortality as the outcome and the treatment arm as the covariate. The null hypothesis was tested using a two-sided significance level (α) at 0.05. RESULTS: Across all approaches, increasing the number of interims led to a decreased expected sample size. Under the null scenario, group sequential approaches provided good control of the type-I error rate; however, the type I error rate inflation was an issue for the Bayesian approaches. The Bayesian Predictive Probability and O'Brien-Fleming approaches showed the highest probability of correctly stopping the trials (around 95%). Under the alternative scenario, the Bayesian approaches showed the highest overall probability of correctly stopping the ADRENAL trial for efficacy (around 91%), whereas the Haybittle-Peto approach achieved the greatest power for the NICE-SUGAR trial. Treatment effect estimates became increasingly underestimated as the number of interims increased. CONCLUSIONS: This study confirms the right adaptive design can reach the same conclusion as a fixed design with a much-reduced sample size. The efficiency gain associated with an increased number of interims is highly relevant to late-phase critical care trials with large sample sizes and short follow-up times. Systematically exploring adaptive methods at the trial design stage will aid the choice of the most appropriate method
HOPS 383: An Outbursting Class 0 Protostar in Orion
We report the dramatic mid-infrared brightening between 2004 and 2006 of HOPS
383, a deeply embedded protostar adjacent to NGC 1977 in Orion. By 2008, the
source became a factor of 35 brighter at 24 microns with a brightness increase
also apparent at 4.5 microns. The outburst is also detected in the
submillimeter by comparing APEX/SABOCA to SCUBA data, and a scattered-light
nebula appeared in NEWFIRM K_s imaging. The post-outburst spectral energy
distribution indicates a Class 0 source with a dense envelope and a luminosity
between 6 and 14 L_sun. Post-outburst time-series mid- and far-infrared
photometry shows no long-term fading and variability at the 18% level between
2009 and 2012. HOPS 383 is the first outbursting Class 0 object discovered,
pointing to the importance of episodic accretion at early stages in the star
formation process. Its dramatic rise and lack of fading over a six-year period
hint that it may be similar to FU Ori outbursts, although the luminosity
appears to be significantly smaller than the canonical luminosities of such
objects.Comment: Accepted by ApJ Letters, 6 pages, 4 figures; v2 has an updated email
address for the lead autho
Star formation triggered by HII regions in our Galaxy: First results for N49 from the Herschel infrared survey of the Galactic plane
It has been shown that by means of different physical mechanisms the
expansion of HII regions can trigger the formation of new stars of all masses.
This process may be important to the formation of massive stars but has never
been quantified in the Galaxy. We use Herschel-PACS and -SPIRE images from the
Herschel Infrared survey of the Galactic plane, Hi-GAL, to perform this study.
We combine the Spitzer-GLIMPSE and -MIPSGAL, radio-continuum and sub-millimeter
surveys such as ATLASGAL with Hi-GAL to study Young Stellar Objects (YSOs)
observed towards Galactic HII regions. We select a representative HII region,
N49, located in the field centered on l=30 degr observed as part of the Hi-GAL
Science Demonstration Phase, to demonstrate the importance Hi-GAL will have to
this field of research. Hi-GAL PACS and SPIRE images reveal a new population of
embedded young stars, coincident with bright ATLASGAL condensations. The Hi-GAL
images also allow us, for the first time, to constrain the physical properties
of the newly formed stars by means of fits to their spectral energy
distribution. Massive young stellar objects are observed at the borders of the
N49 region and represent second generation massive stars whose formation has
been triggered by the expansion of the ionized region. Hi-GAL enables us to
detect a population of young stars at different evolutionary stages, cold
condensations only being detected in the SPIRE wavelength range. The far IR
coverage of Hi-GAL strongly constrains the physical properties of the YSOs. The
large and unbiased spatial coverage of this survey offers us a unique
opportunity to lead, for the first time, a global study of star formation
triggered by HII regions in our Galaxy.Comment: 4 pages, 2 figures, accepted by A&A (Special issue on Herschel first
results
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