Investigation of the Teachers’ Restraint and Satisfaction Perceptions in their Free Times

In this study it was intended to investigate the Boredom and satisfaction perceptions of the teachers who participate / do not participate in recreational activities during their leisure time in Konya. The screening model was used in the study. 330 questionnaire forms were distributed to the participants. As the result of the review, 300 of the questionnaires were found to be worth for analyzing after excluding those which were invalid due to the following reasons marking the same options or leaving the questionnaire incomplete. The information of 300 participants (46,7% male n=140, 53,3% female n=160) were taken into consideration. The Leisure Boredom Scale whose Turkish adaptation was made by Kara, Gürbüz and Öncü was used as data collection tool in the research. The boredom and satisfaction perceptions of the participants in their leisure time were evaluated in terms of the age, gender, income level and the frequency of participation. In the study significant difference was observed at the significance level in the leisure boredom perception according to variables age, gender and the frequency of participation. In terms of these variables significant difference was not observed in the satisfaction perceptions. On the contrary, in terms of the income level variable while significant difference wasn’t observed in the leisure boredom perception, in the satisfaction perception significant difference was observed. At the participation point of the educational administrators and teachers in leisure time activities contribution can be ensured to the satisfaction perception against the boredom with the necessary planning and implementing possibilities

BCL-2 gene study in septic patients with acute renal injury

YÖK Tez No: 634581Giriş: Sepsis, enfeksiyona karşı disregüle konak yanıtına bağlı organ disfonksiyonun gelişmesidir. Sepsis tanısında gerekli olan organ disfonksiyonu için, Sofa skorunda iki veya daha üstü puan almak gerekmektedir. Sepsis tanısı olan hastaların %15-20'sinde sepsise bağlı akut böbrek hasarı (ABH) görülmektedir. Sepsisin şiddeti arttıkça ABH görülme sıklığı da artmaktadır. Ayrıca ABH yalnızca sepsisin seyrini kötüleştirmez, aynı zamanda ABH'da enfeksiyonlara yatkınlık nedeniyle tekrarlayan sepsis gelişiminde predispozan bir faktördür. Bu sebeple sepsiste ABH'ın erken tanınması ve patogenezinin anlaşılması önem arz etmektedir. Sepsiste ABH gelişimi için önceden tanımlanan risk faktörleri olan yaş, cinsiyet, komorbiditeler ve enfeksiyon odakları sepsis ilişkili ABH gelişimini güvenilir şekilde açıklayamamıştır. Dolayısıyla bireyler arasındaki genetik değişkenliğin ABH gelişiminin önemli bir bölümünü oluşturduğu düşünülmektedir. Çalışmamızda hücre ölümünde ana modülatör olan BCL-2 genetik varyasyonunun sepsisli hastalarda ABH gelişne riskini arttırıp arttırmadığını araştırmayı planladık. Gereç ve Yöntem: Düzce Üniversitesi Etik Kurulunun 2019/177 karar numaralı izni alınan, Bilimsel Araştırma Projeleri tarafından 2019.04.03.1037 proje numarası ile desteklenenen ve Helsinki Deklerasyonu prensiplerine uygun olarak gerçekleştirilen bu çalışma, 01.10.2019-15.01.2020 tarihleri arasında Düzce Üniversitesi Tıp Fakültesi Araştırma ve Uygulama Hastanesi Dahiliye Yoğun Bakım Ünitesi'nde yatan 49 hasta alınmıştır. Çalışmaya yoğun bakıma sepsis tanısıyla yatırılan, 18 yaş ve üzerinde olan, çalışmayı kabul eden ve son dönem böbrek yetmezliği olmayan hastalar dahil edilmiştir. Hastalar sepsis tanısı olup ABH gelişenler (n=25) ve ABH gelişmeyenler (n=24) olmak üzere iki gruba ayrılmıştır. Her iki gruptaki hastalarda BCL-2 genetik varyasyonu değerlendirilmiştir. Bulgular: Yaş ve cinsiyet açısından gruplar homojen dağılırken, vücut ağırlığı, antihipertansif ve antitrombotik ilaç kullanım öyküsü ile koroner arter hastalığı, kalp yetmezliği ve kronik böbrek hastalığı (KBY) oranları ABH grubunda daha yüksek saptanmıştır. Ardışık Organ Yetmezliği Değerlendirme Skoru (Sequential Organ Failure Assesment, [SOFA]), Akut Fizyoloji ve Kronik Sağlık Değerlendirmesi Skoru (Acute Physiology and Chronic Health Evaluation II, [APACHE II]), kreatinin değerleri ve laktat değerlerinin yüksekliği ABH olan grupta istatistiksel olarak belirgin yüksek bulunmuştur. ABH grubunda bikarbonat seviyesi anlamlı derecede düşük bulundu. Her iki grupta ana yatış nedeni pnömoni (n=42, [%85]; kontrol grupta, n=13, [%54.2]; hasta grupta, n=14, [%56.0]) olup, en sık üreyen mikroorganizmalar sırasıyla Klebsiella (n=11, [%22]), Asinetobakter (n=10, [%20]), Pseudomonas (n=8, [%16]) ve S.aureus'tur (n=6 [%12]). ABH gelişen grupta yoğun bakım, hastane ve uzun dönem (6 ve 12 aylık) mortalite oranlarının ABH gelişmeyen gruba göre istatistiksel olarak anlamlı derecede fazla olduğu saptanmıştır. BCL-2'nin rs1801018 ve rs4987711 olmak üzere iki genetik varyasyonu tespit edilmiştir. ABH hasarı olan grupta rs1801018 varyasyonu daha fazla saptanmış olup (kontrol grupta, n=6, [%25]; hasta grupta, n=16, [%64]; p=0.003), rs4987711 genetik varyasyonu ise sadece ABH olan grupta saptanmıştır (kontrol grupta, n=0, [%0]; hasta grupta, n=2, [%8]; p=0.003). BCL-2 genetik varyasyonu saptanan hastalarda ABH gelişme riski 7.71 kat, KBY gelişme riski ise 4.73 kat daha fazla bulunmuştur. Mortalite durumuna bakıldığında BCL-2 genetik varyasyonu taşıyanlarda 6 ve 12 aylık mortalite oranları sırasıyla 8.94 ve 7.26 kat artmış olarak saptanmıştır. Sonuç: BCL-2 genetik varyasyonu yoğun bakımda sepsise bağlı ABH gelişen hastalarda anlamlı yüksek tespit edilmiştir. BCL-2 genetik polimorfizmi olan hastalarda ABH yatkınlığı 7.71 kat yüksek saptandı. Ayrıca genetik varyasyona sahip hastalarda 3 ve 6 aylık mortalite oranının daha yüksek olduğu görüldü. Bu sebeple BCL-2 genetik varyasonunun ABH gelişimi için risk faktörü olarak kabul edilebileceği düşünülmüştür.Introduction: Sepsis is the development of organ dysfunction due to dysregulated host response to infection. For organ dysfunction, which is required in the diagnosis of sepsis, it is necessary to get a score of two or more in the Sofa score. Acute kidney injury (AKI) due to sepsis is seen in 15-20% of patients diagnosed with sepsis. As the severity of sepsis increases, the incidence of AKI also increases. In addition, AKI not only worsens the course of sepsis, but is also a predisposing factor in the development of recurrent sepsis due to susceptibility to infections in AKI. For this reason, it is important to recognize AKI early and understand its pathogenesis in sepsis. Age, gender, comorbidities and foci of infection, which are predefined risk factors for the development of AKI in sepsis, could not reliably explain the development of sepsis-related AKI. Therefore, genetic variability between individuals is thought to constitute an important part of AKI development. In our study, we planned to investigate whether BCL-2 genetic variation, which is the main modulator of cell death, increases the risk of developing AKI in patients with sepsis. Materials and Methods: This study, which was approved by the Düzce University Ethics Committee with decision number 2019/177, supported by the Scientific Research Projects with the project number 2019.04.03.1037 and carried out in accordance with the principles of the Helsinki Declaration, was carried out between 01.10.2019-15.01.2020. 49 patients hospitalized in Duzce University Research and Application Hospital Internal Medicine Intensive Care Unit were included. Patients who were hospitalized in the intensive care unit with a diagnosis of sepsis, who were 18 years of age or older, who accepted the study and who did not have end-stage renal failure were included in the study. Patients with a diagnosis of sepsis were divided into two groups as those with AKI (n=25) and those without AKI (n=24). BCL-2 genetic variation was evaluated in patients in both groups. Results: While the groups were homogeneously distributed in terms of age and gender; body weight, rates of antihypertensive and antithrombotic drug use, coronary artery disease, heart failure, and chronic kidney disease (CRF) were higher in the AKI group. Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II), creatinine values and high lactate values were statistically significantly higher in the group with AKI. The bicarbonate level was found to be significantly lower in the AKI group. The main reason for hospitalization in both groups was pneumonia (n=42, [85%]; n=13, [54.2%] in the control group; n=14, [56.0%] in the patient group) and the most common microorganisms were Klebsiella (n=11, [22%]), Acinetobacter (n=10, [20%]), Pseudomonas (n=8, [16%]) and S. aureus (n=6 [12%]), respectively. It was found that intensive care, hospital and long-term (6 and 12 months) mortality rates in the group with AKI were statistically significantly higher than the group without AKI. Two genetic variations of BCL-2 have been identified as "rs1801018" and "rs4987711". The rs1801018 variation was higher in the group with AKI (n=6, [25%] in the control group; n=16, [64%] in the patient group; p=0.003), while the genetic variation of rs4987711 was found only in the group with AKI (n=0, [0%] in the control group; n=2, [8%] in the patient group; p=0.003). In patients with BCL-2 genetic variation, the risk of developing AKI was 7.71 times higher and the risk of developing CRF was 4.73 times higher. In terms of mortality, the 6 and 12-month mortality rates were found to be 8.94 and 7.26 times higher, respectively, in those carrying BCL-2 genetic variation. Conclusion: BCL-2 genetic variation was found to be significantly higher in patients with AKI due to sepsis in the intensive care unit. Patients with BCL-2 genetic polymorphism were found to be 7.71 times more susceptible to AKI. In addition, it was observed that the 3 and 6 month mortality rate was higher in patients with genetic variation. Therefore, it is thought that the BCL-2 genetic variation can be considered as a risk factor for the development of AKI

The Relationship Between Acute Pancreatitis Severity of Platelet Lymphocyte Ratio, Neutrophil Lymphocyte Ratio, Erythrocyte Distribution Width and Mean Platelet Volume

WOS: 000464326000004Amaç: Bu çalışmada sistemik inflamasyon ile ilişkili bir marker olduğu gösterilen; Nötrofillenfosit oranı (NLR), platelet-lenfosit oranı (PLR), ortalama trombosit hacmi (MPV) ve Eritrosit dağılım hacmi (RDW) ile akut pankreatitin (AP) başvuru anındaki ciddiyetini gösteren Ranson kriteri ile aralarındaki ilişkinin gösterilmesi amaçlanmıştır. Gereç ve Yöntem: Ocak 2017 ile Kasım 2018 tarihleri arasında AP tanısı ile takip eden hastaların verilerine retrospektif olarak ulaşıldı. 82 biliyer ve 15 nonbiliyer olmak üzere toplam 139 hasta çalışmaya alındı. Hastaların ilk başvuru anında bakılan hemogram ve biyokimyasal parametreleri, yaşları, cinsiyetleri, ko-morbiditeleri ve yatış süreleri kaydedildi. İlk başvuru anında bakılan Ranson Kriterlerine göre skoru < 3 ve skoru ≥ 3 pozitif olanlar olmak üzere 2 gruba ayrıldı ve bu gruplar karşılaştırıldı. Bulgular: AP tanısı ile takip edilen 139 hastanın 75 (%54)’i erkek, 64 (%46)’ü kadındı. Hastaların 113’ü Ranson kriterlerine göre 3’ün altında 26’sı ise 3 ve üzerindeydi. Ortalama yaş hafif AP grubunda 61±20 yıl, şiddetli AP grubunda ise 70±13 yıldı. MPV (P< 0.001) ve NLR (P< 0.001) değerleri gruplar arasında anlamlı olarak farklı saptandı. Korelasyon analizinde; NLR ile ranson skoru arasında pozitif korelasyon saptandı (r= 0,253 p<0,01). Yapılan Lineer Regresyon analizi sonucunda, NLR ve PLR’nin AP şiddetini göstermede bağımsız prediktör oldukları bulundu. Sonuç: Sistemik inflamasyonu gösteren çalıştığımız parametrelerden NLR, AP’nin şiddetini belirlemede basit ve güvenilir bir gösterge olarak kullanılabilir.Objective: In this study we have shown that there is a marker associated with systemic inflammation; The aim of this study was to determine the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), mean platelet volume (MPV) and Erythrocyte distribution volume (RDW) and Ranson Criteria showing the severity of acute pancreatitis (AP) at the time of presentation. Methods: The data of the patients who were diagnosed with AP between January 2017 and November 2018 were retrospectively obtained. A total of 139 patients (82 biliary and 15 nonbiliary) were included in the study. Hemogram and biochemical parameters, age, gender, co-morbidities and duration of hospitalization were recorded. According to the Ranson Criteria used at the time of admission score = 3 positive and these groups were compared. Results: Of the 139 patients diagnosed with AP, 75 (54%) were male and 64 (46%) were female. 113 of the patients were divided into two groups according to the Ranson criteria. The mean age was 61 +/- 20 years in the mild AP group and 70 +/- 13 years in the severe AP group. MPV (P <0.001), NLR (P <0.001) values were significantly different between the groups. In the correlation analysis; there was a positive correlation between NLR and ranson score (r = 0.253 p <0.01). Linear regression analysis showed that, NLR and PLR were independent predictors of acute pancreatitis. Conclusion: NLR can be used as a simple and reliable indicator in determining the severity of AP

Empirical bolometric correction coefficients for nearby main-sequence stars in the Gaia era

Nearby detached double-lined eclipsing binaries with most accurate data were studied and 290 systems were found with at least one main-sequence component having a metallicity of 0.008 10 000 K, while the quadratic relation is valid for T-eff < 10 000 K; that is, both are valid in the same temperature range in which the BC-Teff relation is valid. New BCs computed from Teff and other astrophysical parameters are tabulated, as well

Prevalence Of Childhood Obesity And Related Parental Factors Across Socioeconomic Strata In Ankara, Turkey

Background: Among low- and middle-income nations, the highest prevalence of child overweight and associated metabolic disorders has been found in Middle Eastern and Eastern European countries. Obesity has been on the rise in Turkey and past research has shown regional variations among adults. However, the prevalence of childhood obesity in different socioeconomic groups in the largest metropolitan areas in the country has not been reported. Aims: This study aimed to investigate the prevalence of child obesity with a population-representative, SES-stratified random sample with objective measures of body mass index (BMI) in the capital city of Turkey. Methods: Weight status was measured by the WHO growth curve and analyzed by socioeconomic status (SES), sex, and parental factors in a population-representative sample of 2066 parent-child dyads. Chi-square and logistic regression were conducted. Results: Rates of overweight and obesity were 21.2% and 14.6% (35.8% combined) but significantly higher in high (24.5% and 18.9%) vs. low SES (20.1% and 13.8%) (P = 0.02). Boys were at higher risk for obesity than girls, especially in high vs. low SES (Odds Ratio [OR] = 3.o [95% CI: 1.4-6.5] vs. 1.7 [95% CI: 1.2-2.5]). Having both parents being overweight or obese increased the risk for obesity, particularly in medium and high SES (OR = 5.8 [95% CI: 2.3-14.1]) and 6.3 (95% CI: 1.5-26.2). Conclusions: Higher maternal education was a risk factor in low-to-medium but not high SES. In Ankara, child overweight and obesity appears to be 1.5 times more prevalent than national estimates. Higher SES may signify greater exposure to an obesogenic environment and greater obesity risk.WoSScopu

Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis

Macroautophagy/autophagy is an evolutionarily conserved cellular stress response mechanism. Autophagy induction in the tumor microenvironment (stroma) has been shown to support tumor metabolism. However, cancer cell-derived secreted factors that initiate communication with surrounding cells and stimulate autophagy in the tumor microenvironment are not fully documented. We identified CTF1/CT-1 (cardiotrophin 1) as an activator of autophagy in fibroblasts and breast cancer-derived carcinoma-associated fibroblasts (CAFs). We showed that CTF1 stimulated phosphorylation and nuclear translocation of STAT3, initiating transcriptional activation of key autophagy proteins. Additionally, following CTF1 treatment, AMPK and ULK1 activation was observed. We provided evidence that autophagy was important for CTF1-dependent ACTA2/alpha-SMA accumulation, stress fiber formation and fibroblast activation. Moreover, promotion of breast cancer cell migration and invasion by activated fibroblasts depended on CTF1 and autophagy. Analysis of the expression levels of CTF1 in patient-derived breast cancer samples led us to establish a correlation between CTF1 expression and autophagy in the tumor stroma. In line with our in vitro data on cancer migration and invasion, higher levels of CTF1 expression in breast tumors was significantly associated with lymph node metastasis in patients. Therefore, CTF1 is an important mediator of tumor-stroma interactions, fibroblast activation and cancer metastasis, and autophagy plays a key role in all these cancer-related events

Ekolojik Kampus: ODTÜ Erdemli Kampusu Biyolojik Çeşitliliği

Artan insan nüfusu ve endüstrileşme ile ekosistemler ve barındırdıkları yaban hayat hızlı bir yok oluşa sürüklenmektedir. Anthropocene olarak adlandırılan bu yeni çağda insanların ve doğal canlıların bir arada kentsel ve kırsal alanlarda var olmasını sağlayacak çözüm arayışları başlamıştır. Dünyanın önde gelen üniversiteleri bu arayışları ‘ekolojik kampus’ yaklaşımı ile kendi kampuslarında uyguluyor; doğru ve yenilikçi yönetim ilkeleri ile hem insan hem de yaban hayatın sürdürülebilir olarak var olabileceği çözümler üretiyorlar. Bu çözümlerin geliştirilebilmesi için ise öncelikle kampusu kullanan biyolojik çeşitliliğin bilinmesi gereklidir. Bu amaçla, projemiz ODTÜ Erdemli Kampusunun barındırdığı biyolojik çeşitliliği anlamak için bir senelik yoğun bir saha araştırması programı önermektedir. Hem ODTÜ Ankara ve Erdemli Kampusundan hem de diğer üniversitelerden 20’den fazla uzman odak grup olarak seçilen bitki, eklem bacaklı, balık, amfibi ve sürüngen, kuş ve memeli canlı gruplarının çeşitliliğini, yaygınlığını ve bolluklarını ortaya çıkararak ileriki yıllarda yapılacak ekolojik kampus yönetimi stratejilerinin belirlenmesi için gerekli kapasiteyi oluşturacaklar. Aynı zamanda ileride yapılacak çalışmalarla çevresel değişimlerin ve kullanım politikalarının kampus yaban hayatı üzerine etkilerinin anlaşılması mümkün olacak. Bu çalışma ile ODTÜ kendi kampusunda var olan biyolojik çeşitliliği bilen ve bu bilgiyi yenilikçi yaklaşımlarda kullanabilen bir üniversite olacaktır

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy

Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a fatal syndrome consisting of severe autoinflammation and progredient leukoencephalopathy with recurrent seizures; 12 of these subjects, whose DNA was available, segregated homozygous loss-of-function C2orf69 variants. C2ORF69 bears homology to esterase enzymes, and orthologs can be found in most eukaryotic genomes, including that of unicellular phytoplankton. We found that endogenous C2ORF69 (1) is loosely bound to mitochondria, (2) affects mitochondrial membrane potential and oxidative respiration in cultured neurons, and (3) controls the levels of the glycogen branching enzyme 1 (GBE1) consistent with a glycogen-storage-associated mitochondriopathy. We show that CRISPR-Cas9-mediated inactivation of zebrafish C2orf69 results in lethality by 8 months of age due to spontaneous epileptic seizures, which is preceded by persistent brain inflammation. Collectively, our results delineate an autoinflammatory Mendelian disorder of C2orf69 deficiency that disrupts the development/homeostasis of the immune and central nervous systems