Tear levels of IL-16 in vernal keratoconjunctivitis

Objective: Vernal keratoconjunctivitis is more common inchildren and young adults having an atopic background.The aim of the present study was to determine the interleukin-16 (IL-16) levels in tear fluids of patients withvernal keratoconjunctivitis (VKC).Methods: Tear fluid samples were collected from 20patients with VKC and 10 healthy subjects. Tear fluidsamples were collected with microcapillary tubes for hematocritat the lateral canthus of patients in the supineposition without any anesthesia. Tear levels of IL-16 weremeasured by ELISA kit.Results: The mean levels of IL-16 among the patients(514±135 pg/ml) was significantly higher than amongcontrols (358±139 pg/ml) (p=0.04).Conclusions: These results considered that IL-16 havesignificant effect on the pathogenetic process of vernalkeratoconjunctivitis.Key words: Interleukin-16, vernal keratoconjunctivitis,enzyme-linked immunosorbent assa

The Effect of Different Antihypertensive Treatment Methods on Endothelial Functions in Patients With Chronic Renal Failure on Hemodialysis

Kronik böbrek yetmezliğinde hipertansiyon, hipervolemi ve üremik toksinler endotel disfonksiyonunaneden olarak hızlanmış ateroskleroza yol açmaktadır. Renal replasman tedavisi almakta olan kronikböbrek yetmezlikli hastaların büyük çoğunluğu hipertansif ve hipervolemiktir. Bu iki risk faktörü enönemli mortalite nedeni olarak kabul edilmektedir. Antihipertansif ilaç alarak normotansif hale gelenhastalarda beş yıllık yaşam beklentisi %40-50’lerde iken, sıkı volüm kontrolüyle normotansiyonsağlananlarda ise on yıllık yaşam beklentisi %70’lere çıkmaktadır.GEREÇ ve yöntem: Çalışma grupları, kontrol grubu (n=30), hemodiyalize giren ve sıkı volümkontrolü uygulanarak normotansif olan hasta grubu (HDvk) (n=30) ve hemodiyalize giren veantihipertansif ilaç kullanarak normotansif olan hasta grubu (HDilaç) (n=30) şeklinde oluşturuldu. Tümgruplarda, von Willebrand factor (VWF), D-Dimer, nitrik oksit (NO), homosistein ve rutin biyokimyaparametrelerine bakıldı.Bulgular: HDilaç grubunun iki diyaliz arası kilo alımı, HDvk uygulanan gruba göre anlamlıolarak yüksek olmasına rağmen (p&lt;0,001), HDilaç’ın tansiyonu kabul edilebilir değerler içindeydi.Ancak, vWf düzeyi ve D-dimer düzeyleri HDvk uygulanan hemodiyaliz hastalarında, HDilaç uygulananhastalara göre düşük düzeydeydi.Sonuç: Sonuç olarak, diyaliz hastalarında yüksek kan basıncını antihipertansif ilaçlarla tedavietmeye çalışmak, bozuk olan endotel fonksiyonlarını düzeltmemektedir. Sıkı volüm kontrolüyle,hastaların hipertansiyonları daha iyi kontrol altına alınabilirken, endotel fonksiyonları da oldukça iyikorunabilmektedir.&nbsp;Hypervolemia and uremic toxins result in accelerated atherosclerosis in chronic renal failure bycausing endothelial dysfunction hypertension. The vast majority of patients undergoing renalreplacement therapy are hypertensive and hypervolemic. It is accepted that these two risk factorsare the most important causes of mortality. While five-year survival in hemodialysis patients usingantihypertensive drugs is 40-50%, ten-year survival in hemodialysis patients applied strict volumecontrol is 70%.MATERIAL and Method: The study was composed of three groups as follows: control group(n=30), hemodialysis patients (normotensive with hypotensive drugs HDdrug, n=30), hemodialysispatients (normotensive with strict volume control HDvc, n=30). von Willebrand factor (vWF), D-dimer,nitric oxide (NO), homocysteine and routine biochemical parameters were studied in all groups.Results: Although the interdialytic weight gain of the hemodialysis patients using antihypertensivedrugs was higher than hemodialysis patients applied strict volume control (p&lt;0.001), the bloodpressure of the drug users was within the acceptable levels. However, the levels of vWF, and, D–dimerin patients applied volume control were lower than that of HDdrug.Conclusion: In conclusion, although antihypertensive drugs can decrease elevated blood pressureto a limited extent in dialysis patients, they cannot improve the endothelial dysfunction. Elevatedblood pressure and endothelial dysfunction are controlled effectively with volume control.Key words: Chronic renal failure, Endothelium, Volume control, Antihypertensives</p

Determination of urinary N-acetyl-β-D glucosaminidase (NAG) levels in experimental blunt renal trauma

BACKGROUN

Determination of urinary N-acetyl-beta-D glucosaminidase (NAG) levels in experimental blunt renal trauma

BACKGROUN

İnvajine Meckel Divertikülü: Bir Genç Kızda Tekrarlayan Karın Ağrısının Nadir Bir Nedeni

Meckel divertikülünün invajnasyonu, ergen ve erişkinlerde karın ağrısının çok nadir bir nedenidir. İntussepsiyonun klasik klinik bulguları olan karın ağrısı, ele gelen bir sosis şeklinde kitle ve kanlı dışkı seyrek görülür. Tanıda, ultrasonografi ve bilgisayarlı tomografini önemli bir yere sahiptir ve hedef işareti ya da sosis görünümü ile karakteristik bulgular görülür. Bu yazıda, tekrarlayan karın ağrısına neden invajine Meckel divertikülü olgusu sunulmaktadır.The invagination of Meckel's diverticulum is a very rare cause of abdominal pain in adolescents and adults. The classic clinical triad of the intussusception consisting abdominal pain, a palpable sausage-shaped mass, and bloody stools is seen infrequently. At the diagnosis, ultrasonography and computed tomography has a significant role with characteristic findings that include the “target” sign and sausage- shaped appearance. In this paper, we report a case of invagination of Meckel’s diverticulum which causes recurrent abdominal pain in a young adolescent

Intravenous alfacalcidol improves insulin resistance in hemodialysis patients

We have examined the effect of a four-week intravenous treatment with 1 alpha-hydroxyvitamin D-3 on insulin sensitivity in 14 patients on chronic hemodialysis compared with 10 healthy control subjects by the insulin tolerance test. Compared to controls, the uremic patients have featured increased levels of parathyroid hormone (1085.0 +/- 822.1 vs 74.2 +/- 8.7 pg/ml, p 0.05) and C-peptide concentrations increased from 6.0 +/- 2.1 to 7.5 +/- 2.5 ng/ml (p <0.02). In summary, uremic patients with secondary hyperparathyroidism developed insulin resistance and hyperinsulinemia. Intravenous 1 alpha-hydroxyvitamin D-3 treatment has improved insulin sensitivity directly or by reducing secondary hyperparathyroidism in uremic patients on chronic hemodialysis