An Amenity Assessment Model for Evaluating State Park Tourism Assets

Creative, quick and inexpensive assessment models based on sound methods that yield practical applications can be of great utility to the administrators of both public and private sector outdoor recreation resources in their decision-making tasks. This paper presents a case study on the development of a tourism amenity assessment model designed for application to state and regional parks and historic sites. The five-step process utilized in developing and applying the model is discussed. The findings yielded as a result of application of the model to state parks in southeastern Georgia (USA) are enumerated, and the recommendations made to Georgia Department of Natural Resources decision makers are presented. A concluding discussion identifies the wider managerial utility of the model

A Grateful Nation Remembers: Bulloch County\u27s World War II Roll of Honor

A list of Bulloch County natives who died in World War II, along with some of their biographies. Compiled by James D. Bigley, Jr. and Rebecca Ziegler.https://digitalcommons.georgiasouthern.edu/bchs-pubs/1002/thumbnail.jp

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

1997 Coastal Georgia Tourism Survey of Interstate 95 Travelers

Conducted for the Coastal Georgia Regional Development Center, Brunswick, GA, November 1997

Hullabaloo, Caneck, Caneck – A Texas Aggie’s Silver Star

Exhibit was evaluated as the “Best Texas Themed Exhibit” and received the OMSA “Gold Medal Exhibit Award” (two separate awards). Juried/Peer Reviewed

Have you heard this one? 101st Airborne Division Research Notes and Recent Finds

Presented in Philadelphia, PA at the 4th Annual 101st Airborne Division History Convention, July 31, 2010. A conference designed for veterans, popular historians and the general public

The Economic Impact of Institutional Members of the Georgia Association of Museums and Galleries

Presentation given at the Georgia Association of Museums and Galleries Annual Meeting