Hybrid 5G optical-wireless SDN-based networks, challenges and open issues

The fifth-generation (5G) mobile networks are expected to bring higher capacity, higher density of mobile devices, lower battery consumption and improved coverage. 5G entails the convergence of wireless and wired communications in a unified and efficient architecture. Mobile nodes, as defined in fourth-generation era, are transformed in heterogeneous networks to make the front-haul wireless domains flexible and intelligent. This work highlights a set of critical challenges in advancing 5G networks, fuelled by the utilisation of the network function virtualisation, the software defined radio and the software defined networks techniques. Furthermore, a novel conceptual model is presented in terms of control and management planes, where the inner architectural components are introduced in detail

RETURNEES: WHO ARE THEY, WHY ARE THEY (NOT) COMING BACK AND HOW SHOULD WE DEAL WITH THEM? Assessing Policies on Returning Foreign Terrorist Fighters in Belgium, Germany and the Netherlands. Egmont Paper 101, February 2018

Some 5000 men, women and children have travelled from Europe to Syria and Iraq since 2012. An estimated 1500 of these foreign terrorist fighters (FTF) have returned so far. Belgium, Germany and the Netherlands represent a third of European FTF and returnees. This report looks into the evolution of policies on returning foreign fighters in these three countries, comparing responses with regard to fighters that are still in the conflict zone, policies to deal with returnees in prison and attitudes towards the children of foreign fighters. It is the very first systematic and in-depth study into national approaches and policies vis-à-vis returnees. Its added value lies in the wealth of data, including data that has not been published before, and in the comparative angle

UAV IoT frameworks views and challenges : towards protecting drones as "things"

Unmanned aerial vehicles (UAVs) have enormous potential in enabling new applications in various areas, ranging from military, security, medicine, and surveillance to traffic-monitoring applications. Lately, there has been heavy investment in the development of UAVs and multi-UAVs systems that can collaborate and complete missions more efficiently and economically. Emerging technologies such as 4G/5G networks have significant potential on UAVs equipped with cameras, sensors, and GPS receivers in delivering Internet of Things (IoT) services from great heights, creating an airborne domain of the IoT. However, there are many issues to be resolved before the effective use of UAVs can be made, including security, privacy, and management. As such, in this paper we review new UAV application areas enabled by the IoT and 5G technologies, analyze the sensor requirements, and overview solutions for fleet management over aerial-networking, privacy, and security challenges. Finally, we propose a framework that supports and enables these technologies on UAVs. The introduced framework provisions a holistic IoT architecture that enables the protection of UAVs as "flying" things in a collaborative networked environment

Countering Calcium Blooming With Personalized Contrast Media Injection Protocols: The 1-2-3 Rule for Photon-Counting Detector CCTA

OBJECTIVE Photon-counting detector computed tomography (PCD-CT) enables spectral data acquisition of CT angiographies allowing for reconstruction of virtual monoenergetic images (VMIs) in routine practice. Specifically, it has potential to reduce the blooming artifacts associated with densely calcified plaques. However, calcium blooming and iodine attenuation are inversely affected by energy level (keV) of the VMIs, creating a challenge for contrast media (CM) injection protocol optimization. A pragmatic and simple rule for calcium-dependent CM injection protocols is investigated and proposed for VMI-based coronary CT angiography with PCD-CT. MATERIALS AND METHODS A physiological circulation phantom with coronary vessels including calcified lesions (maximum CT value >700 HU) with a 50% diameter stenosis was injected into at iodine delivery rates (IDRs) of 0.3, 0.5, 0.7, 1.0, 1.5, 2.0, 2.5, and 3.0 g I/s. Images were acquired using a first-generation dual-source PCD-CT and reconstructed at various VMI levels (between 45 and 190 keV). Iodine attenuation in the coronaries was measured at each IDR for each keV, and blooming artifacts from the calcified lesions were assessed including stenosis grading error (as % overestimation vs true lumen). The IDR to achieve 300 HU at each VMI level was then calculated and compared with stenosis grading accuracy to establish a general rule for CM injection protocols. RESULTS Plaque blooming artifacts and intraluminal iodine attenuation decreased with increasing keV. Fixed windowing (representing absolute worst case) resulted in stenosis overestimation from 77% ± 4% at 45 keV to 5% ± 2% at 190 keV, whereas optimized windowing resulted in overestimation from 29% ± 3% at 45 keV to 4% ± 1% at 190 keV. The required IDR to achieve 300 HU showed a strong linear correlation to VMI energy (R2 = 0.98). Comparison of this linear plot versus stenosis grading error and blooming artifact demonstrated that multipliers of 1, 2, and 3 times the reference IDR for theoretical clinical regimes of no, moderate, and severe calcification density, respectively, can be proposed as a general rule. CONCLUSIONS This study provides a proof-of-concept in an anthropomorphic phantom for a simple pragmatic adaptation of CM injection protocols in coronary CT angiography with PCD-CT. The 1-2-3 rule demonstrates the potential for reducing the effects of calcium blooming artifacts on overall image quality

Mio-Pliocene Faunal Exchanges and African Biogeography: The Record of Fossil Bovids

The development of the Ethiopian biogeographic realm since the late Miocene is here explored with the presentation and review of fossil evidence from eastern Africa. Prostrepsiceros cf. vinayaki and an unknown species of possible caprin affinity are described from the hominid-bearing Asa Koma and Kuseralee Members (∼5.7 and ∼5.2 Ma) of the Middle Awash, Ethiopia. The Middle Awash Prostrepsiceros cf. vinayaki constitutes the first record of this taxon from Africa, previously known from the Siwaliks and Arabia. The possible caprin joins a number of isolated records of caprin or caprin-like taxa recorded, but poorly understood, from the late Neogene of Africa. The identification of these two taxa from the Middle Awash prompts an overdue review of fossil bovids from the sub-Saharan African record that demonstrate Eurasian affinities, including the reduncin Kobus porrecticornis, and species of Tragoportax. The fossil bovid record provides evidence for greater biological continuity between Africa and Eurasia in the late Miocene and earliest Pliocene than is found later in time. In contrast, the early Pliocene (after 5 Ma) saw the loss of any significant proportions of Eurasian-related taxa, and the continental dominance of African-endemic taxa and lineages, a pattern that continues today

Randomised controlled trial of the effect of Tai Chi on postural balance of people with dementia

Purpose: To investigate the effect of Tai Chi exercise on postural balance among people with dementia (PWD) and the feasibility of a definitive trial on falls prevention. Patients and methods: Dyads, comprising community-dwelling PWD and their informal carer (N=85), were randomised to usual care (n=43) or usual care plus weekly Tai Chi classes and home practice for 20 weeks (n=42). The primary outcome was the timed up and go test. All outcomes for PWD and their carers were assessed six months post-baseline, except for falls, which were collected prospectively over the six-month follow-up period. Results: For PWD, there was no significant difference at follow-up on the timed up and go test (mean difference [MD] = 0.82, 95% confidence interval [CI] = -2.17, 3.81). At follow-up, PWD in the Tai Chi group had significantly higher quality of life (MD = 0.051, 95% CI = 0.002, 0.100, standardised effect size [ES] = 0.51) and a significantly lower rate of falls (rate ratio = 0.35, 95% CI =0.15, 0.81), which was no longer significant when an outlier was removed. Carers in the Tai Chi group at follow-up were significantly worse on the timed up and go test (MD = 1.83, 95% CI = 0.12, 3.53, ES = 0.61). The remaining secondary outcomes were not significant. No serious adverse events were related to participation in Tai Chi. Conclusion: With refinement, this Tai Chi intervention has potential to reduce the incidence of falls and improve quality of life among community-dwelling PWD [Trial registration: NCT02864056]

Pseudomyxoma peritonei – two novel orthotopic mouse models portray the PMCA-I histopathologic subtype

<p>Abstract</p> <p>Background</p> <p>Pseudomyxoma peritonei (PMP) is a rare malignant disease, most commonly originating from appendiceal lesions and characterized by accumulation of mucinous tumor tissue in the peritoneal cavity. Since the disease is infrequent, the task of carrying out studies of treatment efficacy and disease biology in the clinical setting is challenging, warranting the development of relevant <it>in vitro </it>and <it>in vivo </it>PMP models.</p> <p>Methods</p> <p>Human tumor tissue was implanted in the peritoneal cavity of nude mice to establish two orthotopic models exhibiting noninvasive intraperitoneal growth without metastasis development.</p> <p>Results</p> <p>Xenograft tissues have retained essential properties of the original human tumors, such as macro- and microscopic growth patterns, mucin production as well as expression of carcinoembryonal antigen, cytokeratins 20 and 7 and the proliferation marker pKi67. Upon microscopic examination, the human tumors were categorized as the PMCA-I (peritoneal mucinous carcinomatosis of intermediate features) subtype, which was conserved through 14 examined passages in mice, for the first time modeling this particular histopathologic category.</p> <p>Conclusion</p> <p>In conclusion, two novel orthotopic models of human PMP have been established that consistently portray a distinct histopathologic subtype and reflect essential human tumor properties. Xenografts can easily and reproducibly be transferred to new generations of mice with acceptable passage periods, rendering the models as attractive tools for further studies of PMP biology and treatment.</p

A new humanized in vivo model of KIT D816V+ advanced systemic mastocytosis monitored using a secreted luciferase

Systemic mastocytosis are rare neoplasms characterized by accumulation of mast cells in at least one internal organ. The majority of systemic mastocytosis patients carry KIT D816V mutation, which activates constitutively the KIT receptor. Patient with advanced forms of systemic mastocytosis, such as aggressive systemic mastocytosis or mast cell leukemia, are poorly treated to date. Unfortunately, the lack of in vivo models reflecting KIT D816V+ advanced disease hampers pathophysiological studies and preclinical development of new therapies for such patients. Here, we describe a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc mast cell line in NOD-SCID IL-2R g−/− mice, using Gaussia princeps luciferase as a reporter. Intravenous injection of ROSAKIT D816V-Gluc cells led, in 4 weeks, to engraftment in all injected primary recipient mice. Engrafted cells were found at high levels in bone marrow, and at lower levels in spleen, liver and peripheral blood. Disease progression was easily monitored by repeated quantification of Gaussia princeps luciferase activity in peripheral blood. This quantification evidenced a linear relationship between the number of cells injected and the neoplastic mast cell burden in mice. Interestingly, the secondary transplantation of ROSAKIT D816V-Gluc cells increased their engraftment capability. To conclude, this new in vivo model mimics at the best the features of human KIT D816V+ advanced systemic mastocytosis. In addition, it is a unique and convenient tool to study the kinetics of the disease and the potential in vivo activity of new drugs targeting neoplastic mast cells

Predicting glacio-hydrologic change in the headwaters of the Zongo River, Cordillera Real, Bolivia

In many partially glacierized watersheds glacier recession driven by a warming climate could lead to complex patterns of streamflow response over time, often marked with rapid increases followed by sharp declines, depending on initial glacier ice cover and rate of climate change. Capturing such “phases” of hydrologic response is critical in regions where communities rely on glacier meltwater, particularly during low flows. In this paper, we investigate glacio-hydrologic response in the headwaters of the Zongo River, Bolivia, under climate change using a distributed glacio-hydrological model over the period of 1987–2100. Model predictions are evaluated through comparisons with satellite-derived glacier extent estimates, glacier surface velocity, in situ glacier mass balance, surface energy flux, and stream discharge measurements. Historically (1987–2010) modeled glacier melt accounts for 27% of annual runoff, and 61% of dry season (JJA) runoff on average. During this period the relative glacier cover was observed to decline from 35 to 21% of the watershed. In the future, annual and dry season discharge is projected to decrease by 4% and 27% by midcentury and 25% and 57% by the end of the century, respectively, following the loss of 81% of the ice in the watershed. Modeled runoff patterns evolve through the interplay of positive and negative trends in glacier melt and increased evapotranspiration as the climate warms. Sensitivity analyses demonstrate that the selection of model surface energy balance parameters greatly influences the trajectory of hydrological change projected during the first half of the 21st century. These model results underscore the importance of coupled glacio-hydrology modeling.This is the publisher’s final pdf. The article is copyrighted by American Geophysical Union and published by John Wiley & Sons, Inc. It can be found at: http://sites.agu.org/The Modern Era Retrospective-analysis for Research and Applications (MERRA) reanalysis meteorological data can be downloaded from the Goddard Earth Sciences Data and Information Services Center (GES-DISC, http://disc.sci.gsfc.nasa.gov). Most of the glaciological and meteorological data measured in the watershed that were utilized in this study can be downloaded from the Glacioclim database (http://www-lgge.ujfgrenoble.fr/ServiceObs/). Nonpublic glaciological and meteorological data can be obtained with agreement from the Institute of Research for Development (IRD). The CMIP5 general circulation model output can be downloaded from the World Climate Research Program (WCRP, http://cmippcmdi.llnl.gov/cmip5/). The Landsat Thematic Mapper scenes can be downloaded from the United States Geological Survey (USGS, http://earthexplorer.usgs.gov/). All glacio-hydrological model data presented in this manuscript are available by request through the corresponding author ([email protected]). Surface energy balance observations were provided by Jean Emmanuel Sicart ([email protected])

Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels

Methodological and technological advances in EPR spectroscopy have enabled novel insight into the structural and dynamic aspects of integral membrane proteins. In addition to an extensive toolkit of EPR methods, multiple spin labels have been developed and utilized, among them Gd(III)-chelates which offer high sensitivity at high magnetic fields. Here, we applied a dual labeling approach, employing nitroxide and Gd(III) spin labels, in conjunction with Q-band and W-band double electron-electron resonance (DEER) measurements to characterize the solution structure of the detergent-solubilized multidrug transporter MdfA from E. coli. Our results identify highly flexible regions of MdfA, which may play an important role in its functional dynamics. Comparison of distance distribution of spin label pairs on the periplasm with those calculated using inward- and outward-facing crystal structures of MdfA, show that in detergent micelles, the protein adopts a predominantly outward-facing conformation, although more closed than the crystal structure. The cytoplasmic pairs suggest a small preference to the outward-facing crystal structure, with a somewhat more open conformation than the crystal structure. Parallel DEER measurements with the two types of labels led to similar distance distributions, demonstrating the feasibility of using W-band spectroscopy with a Gd(III) label for investigation of the structural dynamics of membrane proteins.This work was supported by the German-Israeli Foundation for Scientific Research and Development to E.B. (GIF, Grant Number I-1202-248.9/2012), the Clore Center of Biological Physics at the Weizmann Institute of Science to D.G. and E.B., by a grant from the United States - Israel Binational Science Foundation (BSF), Jerusalem, Israel to H.S.M. and E.B., and by a grant from the Minerva Foundation to D.G. E.H.Y is the recipient of a Professor Rahamimoff Travel Grant from the United States - Israel Binational Science Foundation. T.B. acknowledges financial support from the Minerva Foundation. The authors would like to thank Dr. Akiva Feintuch for his support with Gd(III) AWG-DEER measurements