Personality Differences in Perception: The role of Incongruity Intolerance and Mental Schemata on Aesthetic Preferences.

ries of classic and modern artistic paintings was examined. The study uses pictures that trigger in the observer the amodal completion, which involves the application and confirmation of already consolidated mental schemata, or the perceptual contradiction, which highlights their non-confirmation, generating incongruity experience. As in a first preliminary study conducted by Bonaiuto, Biasi, Giannini, & Chiodetti (2001) with advertising images, incongruity intolerance levels were assessed with the Building Inclination Test (BIT). Also in this new study, we apply the BIT tool in order to select sixty young adults, divided into three subgroups: 20 very incongruity intolerant participants, 20 very incongruity tolerant ones, and 20 intermediate participants, both genders equally subdivided. Moreover, we selected eighteen colour laser reproductions of classical and modern artistic paintings on A4 paper sheets: six show the predominant completion phenomena, other six are based on clear incongruous situations and the last six show completion phenomena mixed with incongruity. Each participant individually evaluated each illustration on aesthetic and physiognomic aspects, using 11-point scales. Double-blind experimental conditions were assured. The results show that very incongruity intolerant participants highly aesthetically appreciate the completion pictures, but they do not like the incongruent pictures. Differently the very incongruity tolerant participants are able to appreciate all three types of images presented, and attribute positive aesthetic scores also to the incongruent and thus conflictual pictures. The third group of participants is characterized by intermediate level of incongruity intolerance and obtain intermediate scores. Collected data confirm our research paradigm based on the theoretical model of overloading of conflict, and stress the role of the individual level of intolerance of incongruity in the dynamics of aesthetic preferences. This survey also allows to obtain an effect of generalization of the theoretical model through the empirical verification with different types of images

The Effectiveness of Clinical Colloquium Established by the “Drawing Recall” Technique in University Counselling Services for Student Mental Health

An experimental assessment of the effectiveness of university counselling was conducted through the “Stress Drawing Recall” Technique applied before and after a clinical colloquium with 70 uni- versity students of both genders, aged 18 - 35 years, who had requested this service. Another 70 students waiting to undergo the colloquium were interviewed as a control group. Two parallel se- ries of drawings depicting personal stress situations were collected and, after evaluation by three expert judges in “double-blind” conditions, led to establishing five forms of development of the graphic language from the first to second drawing, defined as follows: a) distension, with a reduc- tion in stress indicators and increase in comfort indicators; b) explicit representation of conflict resolution; c) appearance of new elements, with persisting conflict; d) increase in stress indicators; e) invariant or equivalent repetition of the stress drawing. Results showed that students who un- derwent the clinical colloquium (experimental group) changed their stress drawings mainly in the direction of distension and conflict resolution, while the control group had more invariant or equivalent repetition of the stress situation ( X42 = 62.77; p < 0.001). The events depicted in the stress drawings were divided into three categories: a) limited short-term stressful situations due to mainly external agents; b) externally induced stressful situations with intense emotional reso- nance; c) wide-ranging long-lasting stressful situations with great involvement of the self. The participants were divided into: a) very anxious subjects; b) averagely anxious subjects; c) not very anxious subjects, on the basis of their scores on two questionnaires: the MPI (1959) and the STAI (1970). There is a correspondence between the subjects’ level of conflict and extension of the de- picted stress. This confirms the usefulness of the Stress Drawing Recall Technique in psychological counsellin

Loss of function NFKB1 variants are the most common monogenic cause of CVID in Europeans

BACKGROUND: The genetic etiology of primary immunodeficiency disease (PID) carries prognostic information. OBJECTIVE: We conducted a whole-genome sequencing study assessing a large proportion of the NIHR-BioResource - Rare Disease cohort. METHODS: In the predominantly European study population of principally sporadic unrelated PID cases (n=846), a novel Bayesian method identified NFKB1 as one most strongly associated with PID, and the association was explained by 16 novel heterozygous truncating, missense and gene deletion variants. This accounted for 4% of common variable immunodeficiency (CVID) cases (n=390) in the cohort. Amino-acid substitutions predicted to be pathogenic were assessed by analysis of structural protein data. Immunophenotyping, immunoblotting and ex vivo stimulation of lymphocytes determined the functional effects of these variants. Detailed clinical and pedigree information was collected for genotype-phenotype co-segregation analyses. RESULTS: Both sporadic and familial cases demonstrated evidence of the non-infective complications of CVID, including massive lymphadenopathy (24%), unexplained splenomegaly (48%) and autoimmune disease (48%), features prior studies correlate with worse clinical prognosis. Although partial penetrance of clinical symptoms was noted in certain pedigrees, all carriers have a deficiency in B lymphocyte differentiation. Detailed assessment of B lymphocyte numbers, phenotype and function identifies the presence of a raised CD21lowB cell population: combined with identification of the disease-causing variant, this distinguishes between healthy individuals, asymptomatic carriers and clinically affected cases. CONCLUSION: We show that heterozygous loss-of-function variants in NFKB1 are the most common known monogenic cause of CVID that results in a temporally progressive defect in the formation of immunoglobulin-producing B cells

Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Background: In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine. Methods: Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published. Results: The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm. Conclusions: We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research

ANCA-associated vasculitis.

The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders involving severe, systemic, small-vessel vasculitis and are characterized by the development of autoantibodies to the neutrophil proteins leukocyte proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA). The three AAV subgroups, namely granulomatosis with polyangiitis (GPA), microscopic polyangiitis and eosinophilic GPA (EGPA), are defined according to clinical features. However, genetic and other clinical findings suggest that these clinical syndromes may be better classified as PR3-positive AAV (PR3-AAV), MPO-positive AAV (MPO-AAV) and, for EGPA, by the presence or absence of ANCA (ANCA+ or ANCA-, respectively). Although any tissue can be involved in AAV, the upper and lower respiratory tract and kidneys are most commonly and severely affected. AAVs have a complex and unique pathogenesis, with evidence for a loss of tolerance to neutrophil proteins, which leads to ANCA-mediated neutrophil activation, recruitment and injury, with effector T cells also involved. Without therapy, prognosis is poor but treatments, typically immunosuppressants, have improved survival, albeit with considerable morbidity from glucocorticoids and other immunosuppressive medications. Current challenges include improving the measures of disease activity and risk of relapse, uncertainty about optimal therapy duration and a need for targeted therapies with fewer adverse effects. Meeting these challenges requires a more detailed knowledge of the fundamental biology of AAV as well as cooperative international research and clinical trials with meaningful input from patients

Loss of function NFKB1 variants are the most common monogenic cause of CVID in Europeans.

BACKGROUND: The genetic etiology of primary immunodeficiency disease (PID) carries prognostic information. OBJECTIVE: We conducted a whole-genome sequencing study assessing a large proportion of the NIHR-BioResource - Rare Disease cohort. METHODS: In the predominantly European study population of principally sporadic unrelated PID cases (n=846), a novel Bayesian method identified NFKB1 as one most strongly associated with PID, and the association was explained by 16 novel heterozygous truncating, missense and gene deletion variants. This accounted for 4% of common variable immunodeficiency (CVID) cases (n=390) in the cohort. Amino-acid substitutions predicted to be pathogenic were assessed by analysis of structural protein data. Immunophenotyping, immunoblotting and ex vivo stimulation of lymphocytes determined the functional effects of these variants. Detailed clinical and pedigree information was collected for genotype-phenotype co-segregation analyses. RESULTS: Both sporadic and familial cases demonstrated evidence of the non-infective complications of CVID, including massive lymphadenopathy (24%), unexplained splenomegaly (48%) and autoimmune disease (48%), features prior studies correlate with worse clinical prognosis. Although partial penetrance of clinical symptoms was noted in certain pedigrees, all carriers have a deficiency in B lymphocyte differentiation. Detailed assessment of B lymphocyte numbers, phenotype and function identifies the presence of a raised CD21lowB cell population: combined with identification of the disease-causing variant, this distinguishes between healthy individuals, asymptomatic carriers and clinically affected cases. CONCLUSION: We show that heterozygous loss-of-function variants in NFKB1 are the most common known monogenic cause of CVID that results in a temporally progressive defect in the formation of immunoglobulin-producing B cells.This study was supported by The National Institute for Health Research England (grant number RG65966), and by the Center of Immunodeficiencies Amsterdam (CIDA). JET is supported by an MRC Clinician Scientist Fellowship (MR/L006197/1). AJT is supported by both the Wellcome Trust (104807/Z/14/Z) and by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London. EO receives personal fees from CSL Behring and MSD

Le condotte “magiche” secondo la Psicologia generale. Come e perché gli esseri umani ricorrono alla magia

PUBBL. IN: E. BARONE (A CURA DI), PROGRAMMA E SINTESI DI RELAZIONI DEL I CONGRESSO NAZIONALE “MEDICINA E PSICOLOGIA TRA TERAPIA A MANIPOLAZIONE. I LINGUAGGI MANIPOLATIVI NELL’INFORMAZIONE MEDICA E PSICOLOGICA IN TV E SU INTERNET”, E.U.R., ROM

The Attribution of Meaning and Causal Informations for Processing Psychological Conflicts

Our investigation is based on experimental and control groups, each containing adults examined individually, equated as regards age (18-38 y.), cultural background and gender. The recearch design include two conflict situations: one open conflict (incongruent object) and one latent conflict (masked figure). Participants evaluate the perceived incongruity, anxiety-arousing power, self-perceived state anxiety with seven point bipolar scales. For each conflict situations: a) a group of participants receive a written causal explanation, b) a different group of participants do not receive any explanation. Then all the participants re-assessed the conflict situation and their own emotional state. Results show that in case of open conflict, after the attribution of causal informations, the level of perceived conflict and tension is reduced. On the contrary, in case of latent situation, there is an increase of perceived conflict. Collected data underline the role of the attribution of meaning for processing different type of psychological conflict