1,438 research outputs found

    Family and peer modeling of alcohol use in African American college students [abstract]

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    Abstract only availableFamily influences on alcohol consumption have received considerable research attention. However relatively little research has examined this aspect of the alcoholism risk process for African Americans. This study tested whether familial influences on participant drinking differed as a function of socioeconomic status. The study sample consisted of 141 African American college students (mean age = 21.89, SD = 1.24; 41% male). The association between participant report of family drinking (father, mother, sibling), peer drinking and personal drinking levels were tested. Next, tests were ran to determine whether these associations differed by socioeconomic status. Results indicated that mother, sibling, and peer drinking were associated with participant drinking, but father drinking and socioeconomic status were not. There was evidence for moderation, with socioeconomic status having a greater impact on participant drinking for those reporting high maternal drinking. These results highlight the need for more complex models to test the effect of contextual factors, such as family drinking and socioeconomic status on alcohol use

    A rare case of lactation anaphylaxis

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    Lactation anaphylaxis (LA) is an extremely rare condition with only five other cases having been previously reported in the literature. Patients will exhibit cutaneous symptoms, respiratory symptoms, gastrointestinal symptoms, and/or cardiovascular symptoms. Post-partum, the drop in hormones is thought to facilitate an exaggerated histamine response. An elevated serum tryptase level performed between 15 minutes to three hours of onset of symptoms will confirm a true anaphylactic reaction. It is important to be aware of this extremely rare medical condition and its management with antihistamines. Better awareness and education of medical staff on this very rare phenomenon can help to better manage these patients

    Investigating toxic aluminium levels in haemodialysis patients after “Day Zero” drought in Cape Town, South Africa

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    Introduction: Aluminium is the most abundant metallic element in the earth’s crust and can be consumed through water, medications, and by using metallic cooking utensils. Aluminium levels become a concern when they are above biological exposure limits and can present with multiple clinical complications. When patients have chronic kidney disease and are on haemodialysis, impaired aluminium excretion can lead to its accumulation. Significantly elevated serum aluminium levels were noted in patients with chronic kidney disease (stage 5) on haemodialysis at Groote Schuur Hospital, Cape Town, South Africa. This coincided with one of the worst water crises ever experienced in this metropolitan area, with extreme water restrictions being imposed and alternative water sources being accessed.Method: A multidisciplinary task force performed a systematic evaluation of aluminium concentrations throughout the dialysis water system. Additionally, a thorough investigation was performed to assess the quality of the laboratory results.Results: Possible areas of contamination and potential sources of exposure were excluded. The laboratory results were verified, and potential sources of error were excluded. The investigation verified that aluminium was truly elevated in the serum of patients, and concluded that dialysis was not the cause. Subsequently, patients’ results have declined to baseline, making it possible that there was increased environmental exposure during the drought.Conclusion: This report serves as a reminder to clinicians of acceptable serum aluminium levels in people on dialysis, and in the water system. Furthermore, it highlights the importance of a multidisciplinary collaborative team approach for the investigation of unexpected results or changes in trends

    Social network analysis of a landscape-scale conservation initiative in South Africa

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    Assessment of social relations, including social network analysis, is central to understanding collaborative processes for environmental decision-making and action. The capacity of network role players to learn and adapt appropriately to uncertainty and change is a critical determinant of the resilience of social-ecological systems. Poor social network structure can predispose failure. In this study, we used social network analysis to explore learning capacity and network resilience in a multi-authority conservation initiative on the West Coast of South Africa (Dassenberg Coastal Catchment Partnership). Our analysis focused on structural variables for network learning and resilience, namely connectivity, heterogeneity, and centrality. The governance network was found to be structurally connected, with the interaction between heterogeneous organisations and sectors, and centralised around a core group of actors. The network had good structural features to enable learning. However, the high level of centrality, and dependence on a small number of core actors, rendered the network potentially vulnerable to dealing with complex challenges. We recommend that core actors (1) reflect on their core functions and whether the network can absorb these functions if they were to leave and (2) tap into the knowledge potential of actors on the network periphery or invite new actors to the network when dealing with complex challenges. This may require the network to diverge into decentralised subgroups to deal with complex issues. We further suggest that the Dassenberg Coastal Catchment Partnership network incorporate social network research with qualitative monitoring into a long-term plan to monitor the movement and influence of actors as the initiative evolves. Significance: This study illustrates how social network analysis can help researchers, public-sector organisations, and donor agencies to monitor the structural features of governance networks that enable or disable learning and resilience within landscape-scale conservation initiatives. Our results illustrate how social network analysis can assist public-sector actors to reflect on their roles and whether there is redundant competency within the network to maintain its resilience

    Health-related quality of life in a PD-First programme in South Africa

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    Groote Schuur Hospital in Cape Town, South Africa, offers a PD-First policy as a result of haemodialysis (HD) restrictions and resource limitations. This study aimed to compare health-related quality of life (HRQOL) between HD and peritoneal dialysis (PD) patients, given the lack of autonomy in modality choice and the socio-economic challenges. This single-centre, cross-sectional study was performed between July 2015 and December 2016. Demographic, socio-economic variables and perceptions of safety were collected. HRQOL was assessed using the Kidney Disease Quality of Life-Short Form (KDQOL-SFTM) version 1.3. All data were compared between the two dialysis modalities; 77 HD and 33 PD patients were included in the study and there were no significant differences in demographics. Median age was 42.5 years (IQR: 32.4–48.6) and 57.3% were female. HD patients had less pain (P = 0.036), better emotional well-being (P = 0.020) and a better energy/fatigue score (P = 0.015). Both cohorts experienced role-limitations due to physical health with PD being more affected overall (P = 0.05). The only significant symptom in the kidney domain was that PD patients experienced more shortness of breath (P < 0.001). Patients in both groups had very poor socio-economic circumstances, and safety within their communities was a major concern. The patients in our dialysis service have very challenging social circumstances. Those on PD scored worse in four HRQOL domains, possibly due to a lack of autonomy in dialysis modality choice and less frequent contact with dialysis staff. Additional psychological and social support needs to be instituted to help improve our patients’ well-being on PD

    ACCase cross-resistance in Italian ryegrass (Lolium multiflorum) sub-populations from Oregon, US

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    ACCase-resistant Italian ryegrass (Lolium multiflorum) is one of the most troublesome weeds in US wheat production systems. This study had the objective of determining the resistance pattern of three subpopulations selected from a winter wheat field with history of ACCase-inhibitor herbicides applications in Oregon. A greenhouse experiment was conducted to test four ACCase-inhibitor herbicides for the control of the three sub-populations: Pinoxaden, clethodim, sethoxydim and clodinafop. All three sub-populations were cross-resistant to the commercial dose of at least two herbicides. One sub-population was cross-resistant to all herbicides tested. This resistance pattern highlights the need of studying different ACCase herbicides for crossresistance, as well as herbicides with different modes of action for multiple-resistance to control these subpopulations.Keywords: Acetyl-coA carboxylase, aryloxyphenoxypropionate, cyclohexanodione, herbicide resistanceACCase-Kreuzresistenz bei Subpopulationen des Italienischen Weidelgrases (Lolium multiflorum) in Oregon, USAACCase-resistentes Italienisches Weidelgras (Lolium multiflorum) ist eines der problematischsten Ungräser in nordamerikanischen Weizenanbausystemen. Ziel dieser Arbeit ist die Bestimmung des Resistenzmusters dreier Subpopulationen, die aus einem Winterweizenfeld mit einer ausgeprägten Historie von Herbizidapplikationen mit ACCase-Inhibitoren stammten. Ein Gewächshausversuch wurde durchgeführt um die Bekämpfung der drei Subpopulationen mit vier ACCase-Inhibitoren zu untersuchen: Pinoxaden, Clethodim, Sethoxydim und Clodinafop. Alle drei Subpopulationen zeigten bei einer Applikation mit der empfohlenen Aufwandmenge Kreuzresistenzen gegen mindestens zwei der getesteten Wirkstoffe. Eine Subpopulation erwies sich als kreuzresistent gegen alle vier getesteten Wirkstoffe. Die beobachteten Resistenzmuster unterstreichen die dringende Notwendigkeit der Erforschung verschiedener ACCase-Inhibitoren bezüglich ihrer Kreuzungsresistenzmuster, sowie die Untersuchung von Herbiziden mit unterschiedlichen Wirkungsweisen auf vorhandene multiple Resistenzen mit dem Ziel der Bekämpfung dieser Subpopulationen. Stichwörter: Acetyl-coA-carboxylase, Aryloxyphenoxypropionate, Cyclohexanodione, Herbizidresisten

    Sports Bra Preferences by Age and Impact of Breast Size on Physical Activity among American Females

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    For many females, sports bras are an essential piece of equipment for participation in sports and physical activity. Breast pain or discomfort from lack of support may be a contributing factor to the noted gender disparity in physical activity of females compared to males. Our objective was to evaluate sports bra usage and characterize sports bra preferences of an active female cohort. This multicenter cross-sectional survey study was conducted at five geographically distinct academic centers. Our measure was administered during outpatient sports medicine clinic visits to females aged 11–64 years old. Chi-square tests were used to compare characteristics across subgroups. Our analysis consisted of 438 respondents, with a mean age of 22 ± 12.2 years. More than a quarter (27.4%) reported lack of breast support prevented them from being active or exercising. Age (p = 0.03), breast size (p < 0.0001), and household income (p = 0.01) were significantly associated with greater frequency of physical activity being limited by lack of breast support. Lack of breast support may be an important barrier for young females of specific populations to meeting physical activity recommendations. Further research is needed to improve the understanding of this important piece of sporting equipment for women

    CD4 Effectors Need to Recognize Antigen Locally to Become Cytotoxic CD4 and Follicular Helper T Cells [preprint]

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    T follicular helper (TFH) and Cytotoxic CD4 (ThCTL) are tissue-restricted CD4 effector subsets, functionally specialized to mediate optimal Ab production and cytotoxicity of infected cells. Influenza infection generates robust CD4 responses, including lung ThCTL and SLO TFH, that protect against reinfection by variant strains. Antigen (Ag) presentation after infection, lasts through the effector phase of the response. Here, we show that this effector phase Ag presentation, well after priming, is required to drive CD4 effectors to ThCTL and TFH. Using in vivo influenza models, we varied Ag presentation to effectors acutely, just at the effector phase. Ag presentation was required in the tissue of effector residence. We suggest these requirements contain unnecessary or potentially pathogenic CD4 responses, only allowing them if infection is uncleared. The results imply that providing effector phase Ag, would lead to stronger humoral and CD4 tissue immunity and thus can be applied to improve vaccine design
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