Flower-like supramolecular self-assembly of phosphonic acid appended naphthalene diimide and melamine

Diverse supramolecular assemblies ranging from nanometres to micrometers of small aromatic π-conjugated functional molecules have attracted enormous research interest in light of their applications in optoelectronics, chemosensors, nanotechnology, biotechnology and biomedicines. Here we study the mechanism of the formation of a flower-shaped supramolecular structure of phosphonic acid appended naphthalene diimide with melamine. The flower-shaped assembly formation was visualised by scanning electron microscope (SEM) and transmission electron microscopy (TEM) imaging, furthermore, XRD and DLS used to determined mode of aggregation. Characteristically, phosphonic acid-substituted at imide position of NDIs possess two important properties resulting in the formation of controlled flower-like nanostructures: (i) the aromatic core of the NDI which is designed to optimize the dispersive interactions (π-π stacking and van der Waals interactions) between the cores within a construct and (ii) phosphonic acid of NDI interact with malamine through molecular recognition i.e. strong hydrogen-bonding (H-bonding). We believe such arrangements prevent crystallization and favour the directional growth of flower-like nanostructure in 3D fashion. These works demonstrate that complex self-assembly can indeed be attained through hierarchical non-covalent interactions of two components. Furthermore, flower-like structures built from molecular recognition by these molecules indicate their potential in other fields if combined with other chemical entities

Data Compression Algorithm for Wireless Sensor Network

In use of wireless sensor network technology for environmental monitoring, the two main fundamental activities of wireless sensor network is data acquisition and data transmission. However, transmitting or receiving data are power consuming task. Wireless sensor network consists of a set of sensor nodes. The processing capacity varies with each node. Sensors in it have storage capacity which is limited. The main challenge today in this field is to improvise the power and energy management of sensor network. Different techniques have been introduced by various researchers. In order to reduce power consumption during transmission, we introduce data compression by processing information locally.             This paper presents the simulation results for RLE method for data compression. The MATLAB GUI model is employed to simulate the RLE method. The simulation result shows that the RLE method can effectively compress the data with minimum power consumption

Comparison of postoperative analgesic efficacy and safety of parecoxib and ketorolac in patients of inguinal hernia

Background: The present study was conducted to compare postoperative analgesic efficacy and safety profile of intravenous parecoxib with intravenous ketorolac in patients operated for inguinal hernia.Methods: It was six months, prospective, randomized parallel group, open label study in patients operated for inguinal hernia. Each patient was randomly assigned the analgesic drug treatment and was grouped as control group (ketorolac treated) and study group (parecoxib treated).Results: The present study has shown that parecoxib has similar analgesic efficacy as that of ketorolac, with parecoxib having significant longer duration of analgesic action. Parecoxib sodium was well tolerated in all patients and most of patients rated parecoxib as well as ketorolac as either good or excellent. Conclusions: The study demonstrated that parecoxib compares favorably with ketorolac and parecoxib can be recommended as a useful component of postoperative pain control in hernia surgery

FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE

Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to develop an orally disintegrating tablet of chlorpheneramine maleate with an increase in bioavailability and patient compliance. Methods: The sublimation technique was used to prepare orally disintegrating tablets. Porous tablet prepared after sublimation of camphor at 60 °C in a hot air oven for 60 min. In the research work, 32full factorial design used to find out the effect of two variables like the amount of Crospovidone and Croscarmellose sodium. Results: All prepared formulations were analyzed for various parameters. DSC of pure drug and optimized formulation A (9) showed purity of sample and compatibility of all ingredients with each other. In FTIR study of pure drug and optimized formulation A (9) no major shifts were seen. An optimized formulation (A9) was found to have good hardness (3.2 kg/cm2), friability (<1%), disintegration time (26 s), % drug release (99.77 %) within 6 min. Conclusion: The result obtained showed that orally disintegrating tablet of chlorpheneramine maleate enhances dissolution rate, improves bioavailability which will improve patient compliance

Fixed drug eruptions to ciprofloxacin - a case report

Fixed drug eruptions (FDE) are common adverse drug reactions and they recur at the same site with each exposure to a particular drug. Drugs inducing FDE are usually those taken intermittently. Most common drugs causing fixed drug eruptions are antibiotics and analgesics. Here, we report a case of FDE to ciprofloxacin which was used in treatment of upper respiratory tract infection

Review of Supercapacitive Performance of Metal Oxide Thin Film Synthesized by Chemical Route

Objective of this paper is synthesis of metal-oxide supported on conducting substrate by electrochemical deposition. According to this study analysis of metal oxide thin film were done for physico-chemical properties like pH, current density, specific capacitance Vs voltage, surface area, cycle stability and coulombic efficiency. In order to get efficient metal-oxide thin film for various metal-oxide. Finally, higher energy density materials with better stability in an actual operating condition can be obtained by chemical route

Review of Metal Oxide Thin Film Based Supercapacitors

Metal oxide thin films based supercapacitors known for several decades and are those used as for storing the potential energy.Presently research had done on energy storage methods namely redox electrochemical capacitors, the electrochemical double layer capacitor,metal oxides and conducting polymers. Recently, many chemically deposited metal oxide thin film electrodes including MnO2, Co3O4, NiO, Fe3O4 etc. have been tested in supercapacitors. From this review data of metal oxide thin films proposed to play a major role in supercapacitor technolog

Coagulation Markers as Predictive and Prognostic Factors in Carcinoma Breast Patients with Lymph Node Metastasis

  Objective: The purpose of this prospective observational study was to evaluate the predictive and prognostic value of coagulation markers in patients with lymph node metastases and cancer of the breast, as well as their associations with important histopathologic criteria. Methods: Between December 2020 and July 2022, 100 patients from the surgery department of a tertiary hospital were enrolled in the study. D-dimer, fibrinogen, and prothrombin time were assessed as coagulation indicators. Documented histopathologic characteristics included tumor grade, size, lymph node involvement, and estrogen receptor status. Chi-square tests, t-tests, Kaplan-Meier survival curves, and log-rank tests were all used in the statistical study. Results: Elevated D-dimer levels were significantly associated with higher tumor grade (p < 0.05) and lymph node involvement (p < 0.01). Elevated fibrinogen levels were linked to larger tumor size (p < 0.05). Abnormal coagulation markers were correlated with reduced disease-free survival (p < 0.001). Conclusion: In breast cancer patients with lymph node metastases, coagulation indicators have the potential to predict disease severity and prognoses. Together with established parameters, their clinical utility may result in more precise care and better patient outcome

Role of Neoadjuvant Paclitaxel Chemotherapy in Carcinoma Breast: A Prospective Study

  Objective: The purpose of this prospective study was to assess the value of neoadjuvant chemotherapy with paclitaxel in the treatment of breast cancer. Methods: There were 88 diagnosed breast cancer patients altogether, 44 in each of the two groups (paclitaxel group and control group). To verify eligibility, thorough clinical, radiological, and laboratory evaluations were made. The reduction of tumor size, pathological reactions, and safety profiles were evaluated. To compare results between groups, statistical tests were used during data processing. Results: At 12 and 24 weeks, the paclitaxel group showed significantly smaller tumor sizes than the control group. In the paclitaxel group, complete pathological responses were more common, indicating efficient tumor regression. The side effects of paclitaxel therapy were generally well-tolerated and controllable. Conclusion: In conclusion, patients with breast cancer showed encouraging improvements in histological responses and tumor size after neoadjuvant paclitaxel treatment. These results suggest the potential advantages of using paclitaxel in neoadjuvant therapy protocols, perhaps making breast-conserving surgery more feasible. In order to provide more individualized treatments, future research should investigate long-term outcomes and biomarkers indicative of paclitaxel sensitivit