Predicting Stock Market using Regression Technique

We use two and half year data set of 50 companies of Nifty along with Nifty from 1st Jan 2009 to 28th June 2011 and apply multivariate technique for data reduction, namely Factor Analysis. Using Factor analysis we reduce these 50 companies’ data (50 variables) into the most significant 4 FACTORS. These four significant factors are then used to predict the Nifty using Multiple linear regression. We observed that the model is good fitted and it explained 90 % of the total variance. Keywords: Nifty, Factor Analysis, Multiple Linear Regression, Data reduction

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men