Light and Hydrogen Peroxide Inhibit C. elegans Feeding through Gustatory Receptor Orthologs and Pharyngeal Neurons

While gustatory sensing of the five primary flavors (sweet, salty, sour, bitter, and savory) has been extensively studied, pathways that detect non-canonical taste stimuli remain relatively unexplored. In particular, while reactive oxygen species cause generalized damage to biological systems, no gustatory mechanism to prevent ingestion of such material has been identified in any organism. We observed that light inhibits C. elegans feeding and used light as a tool to uncover molecular and neural mechanisms for gustation. Light can generate hydrogen peroxide, and we discovered that hydrogen peroxide similarly inhibits feeding. The gustatory receptor family members LITE-1 and GUR-3 are required for the inhibition of feeding by light and hydrogen peroxide. The I2 pharyngeal neurons increase calcium in response to light and hydrogen peroxide, and these responses require GUR-3 and a conserved antioxidant enzyme peroxiredoxin PRDX-2. Our results demonstrate a gustatory mechanism that mediates the detection and blocks ingestion of a noncanonical taste stimulus, hydrogen peroxide.National Science Foundation (U.S.). Graduate Research Fellowship ProgramNational Institutes of Health (U.S.) (Grant GM24663

Plant Physiology, Development and Metabolism

Water is one of the most important constituents of life. Chemically, water is the hydride of oxygen. Oxygen, being more electronegative, exerts a strong attractive pull on its electrons. This unequal attraction results in small positive charge on twohydrogenmoleculesandasmallnegativechargeontheoxygenmolecule.The two lone pairs of electrons of the oxygen molecule result in bending of water molecule. The partial charges on oxygen and hydrogen molecules result in high electric dipole moment and polarity of water molecule

Rare cause of unexplained hypertension in an oligomenorrheic adolescent girl with adnexal mass: case report and review of literature

A 17-year-old girl with oligomenorrhoea was detected to have hypertension and right adnexal solid-cystic mass, 6×8 cm on ultrasound. Hormone profile was normal, CA-125 was 132.5 U/mL, other tumour markers were in normal range; though RMI-4 and ROMA index suggested malignancy. Patient underwent exploratory laparotomy, peritoneal wash cytology, right salpingo-oophorectomy, pelvic lymphadenectomy and omental biopsy. Intraoperative frozen-section revealed ovarian steroid cell tumour. Later, steroid cell tumour-not otherwise specified (SCT-NOS) was confirmed on histopathology and immunohistochemistry. When followed three months post-surgery, patient had resumed 30-32 days menstrual-cycle, and she was normotensive without medications. This case is being reported to emphasize that imaging though not recommended for evaluation of PCOS in adolescence; and measuring blood-pressure which is often skipped in young women; proved crucial in this patient

Portland Daily Press: December 19,1888

https://digitalmaine.com/pdp_1888/1298/thumbnail.jp

HPV vaccination of immunocompromised hosts.

It is well-established that immunocompromised people are at increased risk of HPV-related disease compared with those who are immunocompetent. Prophylactic HPV sub-unit vaccines are safe and immunogenic in immunocompromised people and it is strongly recommended that vaccination occur according to national guidelines. When delivered to immunocompromised populations, HPV vaccines should be given as a 3-dose regimen

The Effect of Dimensions of the Organizational Citizenship Behavior on performance of employees in Finance Sector with special reference to Banking sector in Lucknow

The paper focuses on the effect of dimensions of organizational citizenship behavior on performance of employees in Finance sector with special reference to Banking sector in Lucknow.This paper brings out as to which dimension is present in higher proportion .The study was conducted on 400 employees of banking sector in Lucknow and it uses convenience sampling. The data was collected from both the private banks and nationalized banks. The study brings out that the conscientiousness is present to a greatest degree in the employees of banking sector. While the sportsmanship behavior is present to the least degree in the employees of banking sector. 

A study on climatological features of the Asian summer monsoon: dynamics, energetics and variability

A continuing goal in the diagnostic studies of the atmospheric general circulation is to estimate various quantities that cannot be directly observed. Evaluation of all the dynamical terms in the budget equations for kinetic energy, vorticity, heat and moisture provide estimates of kinetic energy and vorticity generation, diabatic heating and source/sinks of moisture. All these are important forcing factors to the climate system. In this paper, diagnostic aspects of the dynamics and energetics of the Asian summer monsoon and its spatial variability in terms of contrasting features of surplus and deficient summer monsoon seasons over India are studied with reanalysis data sets. The daily reanalysis data sets from the National Centre for Environmental Prediction/National Centre for Atmospheric Research (NCEP/NCAR) are used for a fifty-two year (1948-1999) period to investigate the large-scale budget of kinetic energy, vorticity, heat and moisture. The primary objectives of the study are to comprehend the climate diagnostics of the Asian summer monsoon and the role of equatorial convection of the summer monsoon activity over India.It is observed that the entrance/exit regions of the Tropical Easterly Jet (TEJ) are characterized by the production/destruction of the kinetic energy, which is essential to maintain outflow/inflow prevailing at the respective location of the TEJ. Both zonal and meridional components contribute to the production of kinetic energy over the monsoon domain, though the significant contribution to the adiabatic generation of kinetic energy originates from the meridional component over the Bay of Bengal in the upper level and over the Somali Coast in the low level. The results indicate that the entire Indian peninsula including the Bay of Bengal is quite unstable during the summer monsoon associated with the production of vorticity within the domain itself and maintain the circulation. The summer monsoon evinces strong convergence of heat and moisture over the monsoon domain. Also, considerable heat energy is generated through the action of the adiabatic process. The combined effect of these processes leads to the formation of a strong diabatic heat source in the region to maintain the monsoon circulation. The interesting aspect noted in this study is that the large-scale budgets of heat and moisture indicate excess magnitudes over the Arabian Sea and the western equatorial Indian Ocean during surplus monsoon. On the other hand, the east equatorial Indian Ocean and the Bay of Bengal region show stronger activity during deficient monsoon. This is reflected in various budget terms considered in this study

Interannual variability of onset of the summer monsoon over India and its prediction

In this article, the interannual variability of certain dynamic and thermodynamic characteristics of various sectors in the Asian summer monsoon domain was examined during the onset phase over the south Indian peninsula (Kerala Coast). Daily average (0000 and 1200 UTC) reanalysis data sets of the National Centre for Environmental Prediction/National Centre for Atmospheric Research (NCEP/NCAR) for the period 1948-1999 were used. Based on 52 years onset date of the Indian summer monsoon, we categorized the pre-onset, onset, and post-onset periods (each an average of 5 days) to investigate the interannual variability of significant budget terms over the Arabian Sea, Bay of Bengal, and the Indian peninsula. A higher difference was noticed in low-level kinetic energy (850 hPa) and the vertically integrated generation of kinetic energy over the Arabian Sea from the pre-onset, onset, and post-onset periods. Also, significant changes were noticed in the net tropospheric moisture and diabatic heating over the Arabian Sea and Indian peninsula from the pre-onset to the post-onset period. It appears that attaining the magnitude of 40 m2 s-2 and then a sharp rise in kinetic energy at 850 hPa is an appropriate time to declare the onset of the summer monsoon over India. In addition to a sufficient level of net tropospheric moisture (40 mm), a minimum strength of low-level flow is needed to trigger convective activity over the Arabian Sea and the Bay of Bengal. An attempt was also made to develop a location-specific prediction of onset dates of the summer monsoon over India based on energetics and basic meteorological parameters using multivariate statistical techniques. The regression technique was developed with the data of May and June for 42 years (1948-1989) and validated with 10 years NCEP reanalysis from 1990 to 1999. It was found that the predicted onset dates from the regression model are fairly in agreement with the observed onset dates obtained from the Indian Meteorology Department

Onset characteristics of the southwest monsoon over India

Dynamic and thermodynamic characteristics of the Asian summer monsoon during the onset phase over the Indian Peninsula (Kerala coast) and its variability are examined with reanalysis data sets. For this study, daily averaged (0000 and 1200 UTC) reanalysis data sets of National Centre for Environmental Prediction-National Centre for Atmospheric Research for the period 1948-99 are used. Based on 52 years of onset dates of the Indian summer monsoon, we categorized pre-onset, onset and post-onset periods (each averaged 5 days) to investigate the mean circulation characteristics and the large-scale energetics of the Asian summer monsoon. It is found that the strength of the low-level Somali jet and upper tropospheric tropical easterly jet increase rapidly during the time of evolution of the summer monsoon over India. Over the Bay of Bengal and the Arabian Sea, predominant changes are noticed in the large-scale balances of kinetic energy, heat and moisture from the pre-onset to the post-onset periods. Prior to the onset of the summer monsoon over India, a zone of flux convergence of heat and moisture is noticed over the eastern sector of the Bay of Bengal and this intensifies in the onset and post-onset periods. During onset of the monsoon over India, the horizontal flux convergence of heat and moisture, as well as diabatic heating, are enhanced over the Arabian Sea. These subsequently increase with the evolution and advancement of the monsoon over India. Further, the dynamics of the evolution processes (15 days before and 30 days after the onset date of the monsoon over Kerala for each annual cycle) are studied over various sectors, such as the Arabian Sea, Bay of Bengal and Indian Peninsula region. The study reveals that the low-level kinetic energy, vertically integrated generation of kinetic energy and net tropospheric moisture over Arabian Sea can be used as potential predictors for the prediction of the possible onset date of the summer monsoon over the Indian Peninsula