Salinity and Toxicological Studies of Waters of Rajasthan Desert

Detailed studies on quality of ground waters of Western Rajasthan have been carried out by analysing about 1500 water samples for presence of total dissolved solids (TDS) and other normal chemical constituents. 109 ground water samples were tested for presence of 8 toxic substances viz. As, Ba, Cd, Cr/sup +6/, Pb, Se, Ag, and CN and F and NO/sub 3/. About 9 percent of the waters conform to the normal standards of drinking water i.e. contain less than 500 mg/l TDS. None of the water points has been found to be contaminated with toxic substances. However, fluoride and nitrate were present in all the samples.A survey of water-borne diseases, kidney diseases and fluorosis carried out to establish the possible correlation between prevailing diseases and dissolved solids in waters indicate that 82 percent of the reported cases are due to water-borne diseases. The guinea-worm (Dracunculus medinensis) has been found in the surface waters and sulphate reducing bacteria (Desulphovibrio desulphuricans) in the brackish water

Periodic harmonic functions on lattices and points count in positive characteristic

This survey addresses pluri-periodic harmonic functions on lattices with values in a positive characteristic field. We mention, as a motivation, the game "Lights Out" following the work of Sutner, Goldwasser-Klostermeyer-Ware, Barua-Ramakrishnan-Sarkar, Hunzikel-Machiavello-Park e.a.; see also 2 previous author's preprints for a more detailed account. Our approach explores harmonic analysis and algebraic geometry over a positive characteristic field. The Fourier transform allows us to interpret pluri-periods of harmonic functions on lattices as torsion multi-orders of points on the corresponding affine algebraic variety.Comment: These are notes on 13p. based on a talk presented during the meeting "Analysis on Graphs and Fractals", the Cardiff University, 29 May-2 June 2007 (a sattelite meeting of the programme "Analysis on Graphs and its Applications" at the Isaac Newton Institute from 8 January to 29 June 2007

Multiculturalism and moderate secularism

What is sometimes talked about as the ‘post-secular’ or a ‘crisis of secularism’ is, in Western Europe, quite crucially to do with the reality of multiculturalism. By which I mean not just the fact of new ethno-religious diversity but the presence of a multiculturalist approach to this diversity, namely: the idea that equality must be extended from uniformity of treatment to include respect for difference; recognition of public/private interdependence rather than dichotomized as in classical liberalism; the public recognition and institutional accommodation of minorities; the reversal of marginalisation and a remaking of national citizenship so that all can have a sense of belonging to it. I think that equality requires that this ethno-cultural multiculturalism should be extended to include state-religion connexions in Western Europe, which I characterise as ‘moderate secularism’, based on the idea that political authority should not be subordinated to religious authority yet religion can be a public good which the state should assist in realising or utilising. I discuss here three multiculturalist approaches that contend this multiculturalising of moderate secularism is not the way forward. One excludes religious groups and secularism from the scope of multiculturalism (Kymlicka); another largely limits itself to opposing the ‘othering’ of groups such as Jews and Muslims (Jansen); and the third argues that moderate secularism is the problem not the solution (Bhargava)

Explicit Orbit Classification of Reducible Jordan Algebras and Freudenthal Triple Systems

We determine explicit orbit representatives of reducible Jordan algebras and of their corresponding Freudenthal triple systems. This work has direct application to the classification of extremal black hole solutions of N = 2, 4 locally supersymmetric theories of gravity coupled to an arbitrary number of Abelian vector multiplets in D = 4, 5 space-time dimensions.Comment: 18 pages. Updated to match published versio

Deformational temperatures across the Lesser Himalayan Sequence in eastern Bhutan and their implications for the deformation history of the Main Central Thrust

We postulate that the inverted metamorphic sequence in the Lesser Himalayan Sequence of the Himalayan orogen is a finite product of its deformation and temperature history. To explain the formation of this inverted metamorphic sequence across the Lesser Himalayan Sequence with a focus on the Main Central Thrust (MCT) in eastern Bhutan, we determined the metamorphic peak temperatures by Raman spectroscopy of carbonaceous material and established the deformation temperatures by Ti-in-quartz thermobarometry and quartz c axis textures. These data were combined with thermochronology, including new and published Ar-40/Ar-39 ages of muscovite and published apatite fission track, and apatite and zircon (U-Th)/He ages. To obtain accurate metamorphic, deformation, and closure temperatures of thermochronological systems, pressures and cooling rates for the period of interest were derived by inverse modeling of multiple thermochronological data sets, and temperatures were determined by iterative calculations. The Raman spectroscopy of carbonaceous material results indicate two temperature sequences separated by a thrust. In the external sequence, peak temperatures are constant across the structural strike, consistent with the observed hinterland-dipping duplex system. In the internal temperature sequence associated with the MCT shear zone, each geothermometer yields an apparent inverted temperature gradient although with different temperature ranges, and all temperatures appear to be retrograde. These observations are consistent with the quartz microfabrics. Further, all thermochronometers indicate upward younging across the MCT. We interpret our data as a composite peak and deformation temperature sequence that formed successively and reflects the broadening and narrowing of the MCT shear zone in which the ductile deformation lasted until similar to 11 Ma.Peer reviewe

No increased bleeding events in patients with relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma treated with idelalisib

The advent of novel B-cell receptor pathway targeting agents like ibrutinib dramatically changed management of B-cell malignancies. However, with concomitant anticoagulation (AC) and antiplatelet (AP) therapy, ibrutinib is associated with increased bleeding. This post hoc analysis aimed to determine the role of AC/AP therapy in patients with idelalisib-treated B-cell malignancies and to establish if it contributes to increased bleeding events. Data from two idelalisib trials (rituximab ± idelalisib in chronic lymphocytic leukemia [CLL] and idelalisib monotherapy in indolent non-Hodgkin lymphoma [iNHL]) were analyzed. Antithrombotic therapy was common (36%–63%), with comparable bleeding incidence across treatment groups (14%–19%; p = 0.56). Bleeding events of grade ≥3 occurred in 0.9% and 3.2% of the idelalisib-treated CLL and iNHL cohorts, respectively. Our findings demonstrate no increase in bleeding events with simultaneous AC/AP treatment and idelalisib use. Hemorrhagic risk is prevalent in these patients and an important consideration when evaluating available treatment options

Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study

<p>Abstract</p> <p>Background</p> <p>The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels.</p> <p>Methods</p> <p>This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fasting blood samples were collected from a subgroup of consented psoriasis vulgaris patients and matched controls (n = 84) for the quantification of homocysteine, vitamin B₁₂and folic acid levels.</p> <p>Results</p> <p>There was no significant increase of the MTHFR 677 C > T mutation in patients with psoriasis vulgaris compared with controls (<it>χ</it>²= 0.733, p = 0.392). No significant association between homocysteine levels and MTHFR gene polymorphism in cases and controls were observed (F = 0.91, df = 3, 80, p = 0.44). However, homocysteine levels in cases were negatively correlated with vitamin B₁₂(r = -0.173) and folic acid (r = -0.345) levels. Vitamin B₁₂and folic acid levels in cases were also negatively correlated (r = -0.164).</p> <p>Conclusions</p> <p>Our results indicate that there was no significant association between the MTHFR gene polymorphism and psoriasis vulgaris in the Malaysian population. There was no significant increase of the plasma homocysteine level in the psoriasis patients compared to the controls.</p

Titanium based cranial reconstruction using incremental sheet forming

In this paper, we report recent work in cranial plate manufacturing using incremental sheet forming (ISF) process. With a typical cranial shape, the ISF process was used to manufacture the titanium cranial shape by using different ISF tooling solutions with and without backing plates. Detailed evaluation of the ISF process including material deformation and thinning, geometric accuracy and surface finish was conducted by using a combination of experimental testing and Finite Element (FE) simulation. The results show that satisfactory cranial shape can be achieved with sufficient accuracy and surface finish by using a feature based tool path generation method and new ISF tooling design. The results also demonstrate that the ISF based cranial reconstruction has the potential to achieve considerable lead time reduction as compared to conventional methods for cranial plate manufacturing. This outcome indicates that there is a potential for the ISF process to achieve technological advances and economic benefits as well as improvement to quality of life