New Algorithm of the Finite Lattice Method for the High-temperature Expansion of the Ising Model in Three Dimensions

We propose a new algorithm of the finite lattice method to generate the high-temperature series for the Ising model in three dimensions. It enables us to extend the series for the free energy of the simple cubic lattice from the previous series of 26th order to 46th order in the inverse temperature. The obtained series give the estimate of the critical exponent for the specific heat in high precision.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Letter

Natural sources as potential anti-cancer agents: A review

Natural products remain an important source of new drugs, new drug leads and new chemical entities. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan), marine organisms (citarabine, aplidine and dolastatin 10) and micro-organisms (dactinomycin, bleomycin and doxorubicin). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide (allium), S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin (fenugreek), 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears, prunes), silymarin (milk thistle), anethol (anise, camphor, and fennel), catechins (green tea), eugenol (cloves), indole-3-carbinol (cruciferous vegetables), limonene (citrus fruits), beta carotene (carrots), and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action. Keywords: Cancer, vincristin, vinblastin, fruit, vegetables

Natural sources as potential anti-cancer agents: A review

Natural products remain an important source of new drugs, new drug leads and new chemical entities. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan), marine organisms (citarabine, aplidine and dolastatin 10) and micro-organisms (dactinomycin, bleomycin and doxorubicin). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide (allium), S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin (fenugreek), 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears, prunes), silymarin (milk thistle), anethol (anise, camphor, and fennel), catechins (green tea), eugenol (cloves), indole-3-carbinol (cruciferous vegetables), limonene (citrus fruits), beta carotene (carrots), and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action. Keywords: Cancer, vincristin, vinblastin, fruit, vegetables

Innovative Technique of Vascular Repair in Intra-Operative IVC Rupture During Lumbar Microdiscectomy: A Case Report

Background: Major vascular injury during a spinal surgery is a rare but most dreaded complication. Case Presentation: A 39 years old female undergoing microscopic lumbar discectomy suddenly developed severe hypotension on table. The procedure was abandoned and the patient turned supine. It was diagnosed to be a major vessel tear and the patient was taken up for immediate successful vascular repair. To best of our knowledge such a repair procedure has not been described in literature. Conclusions: Majority of such vascular injuries are dealt with primary repair of the defect by a vascular surgeon; however in our case the rent was big and placed on the undersurface making it very difficult for the vascular surgeon to approach or repair it primarily

On the large N limit, W_\infty Strings, Star products, AdS/CFT Duality, Nonlinear Sigma Models on AdS spaces and Chern-Simons p-branes

It is shown that the large $N$ limit of SU(N) YM in $curved$ $m$-dim backgrounds can be subsumed by a higher $m+n$ dimensional gravitational theory which can be identified to an $m$-dim generally invariant gauge theory of diffs $N$, where $N$ is an $n$-dim internal space (Cho, Sho, Park, Yoon). Based on these findings, a very plausible geometrical interpretation of the $AdS/CFT$ correspondence could be given. Conformally invariant sigma models in $D=2n$ dimensions with target non-compact SO(2n,1) groups are reviewed. Despite the non-compact nature of the SO(2n,1), the classical action and Hamiltonian are positive definite. Instanton field configurations are found to correspond geometrically to conformal ``stereographic'' mappings of $R^{2n}$ into the Euclidean signature $AdS_{2n}$ spaces. The relation between Self Dual branes and Chern-Simons branes, High Dimensional Knots, follows. A detailed discussion on $W_\infty$ symmetry is given and we outline the Vasiliev procedure to construct an action involving higher spin massless fields in $AdS_4$. This $AdS_4$ spacetime higher spin theory should have a one-to-one correspondence to noncritical $W_\infty$ strings propagating on $AdS_4 \times S^7$.Comment: 43 pages, Tex fil

On Statistical Modeling of Sequencing Noise in High Depth Data to Assess Tumor Evolution

© 2017, Springer Science+Business Media, LLC, part of Springer Nature. One cause of cancer mortality is tumor evolution to therapy-resistant disease. First line therapy often targets the dominant clone, and drug resistance can emerge from preexisting clones that gain fitness through therapy-induced natural selection. Such mutations may be identified using targeted sequencing assays by analysis of noise in high-depth data. Here, we develop a comprehensive, unbiased model for sequencing error background. We find that noise in sufficiently deep DNA sequencing data can be approximated by aggregating negative binomial distributions. Mutations with frequencies above noise may have prognostic value. We evaluate our model with simulated exponentially expanded populations as well as data from cell line and patient sample dilution experiments, demonstrating its utility in prognosticating tumor progression. Our results may have the potential to identify significant mutations that can cause recurrence. These results are relevant in the pretreatment clinical setting to determine appropriate therapy and prepare for potential recurrence pretreatment

Large N reduction in the continuum three dimensional Yang-Mills theory

Numerical and theoretical evidence leads us to propose the following: Three dimensional Euclidean Yang-Mills theory in the planar limit undergoes a phase transition on a torus of side $l=l_c$. For $l>l_c$ the planar limit is $l$-independent, as expected of a non-interacting string theory. We expect the situation in four dimensions to be similar.Comment: 4 pages, latex file, two figures, version to appear in Phys. Rev. Let