An architecture for certification-aware service discovery

Service-orientation is an emerging paradigm for building complex systems based on loosely coupled components, deployed and consumed over the network. Despite the original intent of the paradigm, its current instantiations are limited to a single trust domain (e.g., a single organization). Also, some of the key promises of service-orientation - such as the dynamic orchestration of externally provided software services, using runtime service discovery and deployment - are still unachieved. One of the main reasons for this is the trust gap that normally arises when software services, offered by previously unknown providers, are to be selected at run-time, without any human intervention. To close this gap, the concept of machine-readable security certificates (called asserts) has been recently introduced, which paves the way to automated processing about security properties of services. Similarly to current security certification schemes, the assessment of the security properties of a service is delegated to an independent third party (certification authority), who issues a corresponding assert, bound to the service. In this paper, we propose an architecture, which exploits the assert concept to realise a certification-aware service discovery framework. The architecture supports the discovery of single services based on certified security properties (in additional to the usual functional properties), as well as the dynamic synthesis of service compositions, that satisfy the given security properties. The architecture is extensible, thus allowing for a range of domain specific matchmaking components, to cover dimensions related to, e.g., performance, cost and other non-functional characteristics

Arms down cone beam CT hepatic angiography: are we focusing on the wrong target?

We read with great interest the recent article by Dr. Gonzalez-Aguirre and colleagues entitled ‘‘Arms Down Cone Beam CT Hepatic Angiography Performance Assessment: Vascular Imaging Quality and Imaging Artefacts’’ [1]. One of the most important advantages of cone beam CT (CBCT) is the possibility to evaluate the lesion’s feeders assisting their identification and catheterization [2]. In this set, the patient’s arms positioning is crucial in order not to impair CBCT imaging. Dr. Gonzalez-Aguirre et al. had elegantly demonstrated that vessels’ visualization is independent from the patient’s arms position, allowing to perform the entire procedure without patient’s movements. This minimizes the risk of contamination and reduces procedural time. However, literature shows that the major pivotal strength of CBCT, either mono-phasic or possibly bi-phasic, is the ability to depict in intra-procedurally ‘‘occult lesions’’, not visible at pre-procedural second-line non-invasive imaging (MRI, MDCT) [3]. This ability is not just for show, but yield to some major clinical implications: the visualization of an occult nodule identifies a subset of population experiencing fast tumour growth, having consequences on the number of adjunctive treatments controlling tumour growth (adjunctive RFA, or TACE procedures) and prioritization for transplantation [4]. Moreover, bi-phasic CBCT, with its unique ability to intra-procedural permit nodule characterization, could help in patients’ reclassification and real-time TACE strategy modification [5]. In this light would be a crucial interest for the audience to know whether the CBCT acquisition with arms down does not alter the diagnostic performance of the modality and ability of lesion’s characterization, especially for those lesion localized peripherally, where the beam hardening artefacts have been shown to be significant. Finally, patient’s positioning is fundamental for CBCT imaging. By acquiring the scan with patient’s arm down, liver volume would not be located within the rotation isocentre. This could be a substantial limitation for lesion located within the left liver lobe, eventually hypertrophied, and for high BMI patients

Polyethylene Glycol Epirubicin-Loaded Transcatheter Arterial Chemoembolization Procedures Utilizing a Combined Approach with 100 and 200 μm Microspheres: A Promising Alternative to Current Standards

PURPOSE:To report clinical effectiveness, toxicity profile, and prognostic factors of combined 100 μm ± 25 and 200 μm ± 50 epirubicin-loaded polyethylene glycol (PEG) microsphere drug-eluting embolic transcatheter arterial chemoembolization protocol in patients with hepatocellular carcinoma. MATERIALS AND METHODS: In this prospective, single-center, single-arm study with 18 months of follow-up, 36 consecutive patients (mean age 69.9 y ± 10.8; 26 men, 10 women; 54 naïve lesions) were treated. Embolization was initiated with 100 μm ± 25 microspheres, and if stasis (10 heart beats) was not achieved, 200 μm ± 50 microspheres were administered. Each syringe (2 mL) of PEG microsphere was loaded with 50 mg of epirubicin. Results were evaluated using Modified Response Evaluation Criteria In Solid Tumors with multidetector computed tomography/magnetic resonance imaging at 1, 3-6, 9-12, and 15-18 months. Toxicity profile was assessed by laboratory testing before and after the procedure. Complications were recorded. Postembolization syndrome (PES) was defined as onset of fever/nausea/pain after the procedure. Patient/lesion characteristics and treatment results were correlated with predicted outcome using regression analysis. Child-Pugh score was A in 86.1% of patients (31/36) and B in 13.9% (5/36). RESULTS: In 10 of 21 lesions, < 2 cm in diameter (47.5%) stasis was achieved with 100 μm ± 25 microspheres only, whereas all other lesions required adjunctive treatment with 200 μm ± 50 microspheres. Reported adverse events were grade 1 acute liver bile duct injury (3/39 cases, 7.7%) and PES (grade 2; 3/39 cases, 7.7%). Complete response (CR) at 1, 3-6, 9-12, and 15-18 months was 61.1%, 65.5%, 63.63%, and 62.5%. Objective response (CR + partial response) at 1, 3-6, 9-12, and 15-18 months was 83.3%, 65.85%, 63.63%, and 62.5%. No single factor (laboratory testing, etiology, patient status, hepatic status, tumor characteristics, administration protocol) predicted outcomes except for albumin level at baseline for CR (P < .05, odds ratio = 1.09). CONCLUSIONS: The combined microsphere sizing strategy was technically feasible and yielded promising results in terms of effectiveness and toxicity

Coastal vulnerability assessment: through regional to local downscaling of wave characteristics along the Bay of Lalzit (Albania)

Coastal vulnerability is evaluated against inundation risk triggered by wave run-up through the evaluation of vulnerability levels (referred to as VLs) introduced by Bosom and Jiménez (2011). VLs are assessed through different wave climate characterizations, referring to regional (offshore wave climate) or local (nearshore wave climate) scales. The study is set along the Bay of Lalzit, a coastal area near Durrës (Albania). The analysis reveals that the results vary due to uncertainties inherent in the run-up estimation, showing that the computational procedure should be developed by taking into account detailed information about the local wave climate. Different approaches in choosing wave characteristics for run-up estimation significantly affect the estimate of shoreline vulnerability. The analysis also shows the feasibility and challenges of applying VL estimates in contexts characterized by limited data availability through targeted field measurements of the coast geomorphology and an overall understanding of the recent coastal dynamics and related controlling factors.</p

“Mura della Bastia” – Onigo di Pederobba (Treviso). Ricerche archeologiche, rilievo 3D laser scanning e anastilosi virtuale in un castello medievale del pedemonte trevigiano

The paper presents the results of the ongoing research coordinated by the Chair of Ancient Topography at the University of Padova. The work concerns the medieval site of “Mura della Bastia” in Onigo di Pederobba (Treviso), in the North-Eastern part of Italy. Historical information from written documents and results obtained from the archaeological investigation at the Onigo castle (1994-2007) are discussed. The study provided the historical reconstruction of recent collapses of the Onigo tower and allowed the virtual reconstruction of still-cohesive blocks, which had fallen down in 1989, and which were recovered during the summer of 2007. At this time, five of the ten building blocks have been positioned; the procedure was carried out by comparing the panoply of each agglomerate with the prospect of the tower, which was obtained from the photogrammetric rectification of the historical images (2D). The 3D survey of the tower and of nine blocks was performed with a Leica HDS 2500 laser scanner. The resulting point clouds were aligned with Cyclone software, also using the coordinates of some laser scanning targets, which were measured with the Leica TC 2003 total station in a local reference system. The final 3D model obtained by the co-registration of the scans was textured with the digital images acquired with a Canon EOS 1 ds Mark II camera. Subsequently, three of the five recognized blocks were positioned on the 3D model using Reconstructor software

Multidisciplinary assessment and prediction tools addressing coastal vulnerability to erosion and sea level rise. Lesson learnt from the RITMARE Project

Natural processes and human activities are strongly connected, and sometimes con icting, in the evolution of coastal and transitional environments. The strong anthropic pressure on coastal regions, together with the e ects of a changing climate, demands nowadays more pressingly for e cient tools to characterise and predict the behaviour of such systems in order to de ne appropriate response strategies. This requires a deep understanding of the connections among di erent drivers and di erent scales, a multidisciplinary challenge in which heterogeneous data, approaches and scales need to be framed within a consistent dynamical description. To this aim, a speci c research line was dedicated to \u201cCoastal Vulnerability to Erosion and Sea Level Rise\u201d within the RITMARE Project, supported by the Italian Ministry of University and Research with the purpose of integrating the Italian Marine community in shared research elds in the period 2012-2017. The activities carried out in this framework have been moving along interconnected branches tackling the themes related with sea level rise, ocean modelling, and geomorphological assessment in present conditions and in di erent climate change scenarios, with an eye on the exploitation of marine sand as a strategic resource. In this contribution we review the main outcomes of this multidisciplinary and coordinated research. Besides discussing the advances and the possibilities from state-of-the art technologies and methodologies, we point out that a coordinated use of the described tools should be promoted in the design of survey and monitoring activities, as well as in the exploitation of already collected data. Expected outcomes of this strategy include the implementation of improved policies and infrastructures for coastal protection, anked by reliable short-term forecasting systems and e cient rapid response protocols, in the framework of an integrated coastal planning at the multi-decadal scale

Surgical resection is superior to TACE in the treatment of HCC in a well selected cohort of BCLC-B elderly patients—A retrospective observational study

Simple Summary Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Liver transplantation (LT) and surgical resection (SR) are currently the primary treatments with curative intent. Nevertheless, more than two-thirds of patients are elderly and, therefore, excluded from LT; while, according to the Barcelona Clinic Liver Cancer (BCLC) system, SR should only be offered to a small group of patients with early stage HCC. The identification in stage B of an intermediate subgroup of patients that fulfill the criteria for surgery may play an important role in the implementation of potentially curative treatments. Hepatocellular carcinoma (HCC) usually develops in cirrhotic liver, with high recurrence rates. However, considering its increasing detection in non-cirrhotic liver, the choice of treatment assumes particular relevance. This study aimed to investigate outcomes of patients among BCLC stages and enrolled for surgical resection (SR) according to a more complex evaluation, to establish its safety and efficacy. A total of 186 selected HCC patients (median age 73.2 yrs), submitted to SR between January 2005 and January 2021, were retrospectively analyzed. Of which, 166 were staged 0, A, B according to the BCLC system, while 20 with a single large tumor (&gt;5 cm) were classified as stage AB. No perioperative mortality was recorded; complications occurred in 48 (25.80%) patients, and all but two were Clavien-Dindo grade I-II. Median follow-up was 9.2 years. Subsequently, 162 recurrent patients (87,1%) were selected for new treatments. Comparable overall survival rates (OS) were observed at 1, 3, 5, and 10 years in 0, A, B and AB stages (p = 0.2). Eventually, the BCLC-B group was matched to 40 BCLC-B patients treated (2015-2021) with TACE. Significant differences in baseline characteristics (p &lt;0.0001) and in OS were observed at 1 and 3 years (p &lt;0.0001); a significant difference was also observed in oncological outcomes, in terms of the absence, residual, or relapse of disease (p &lt;0.05). Surgery might be a valid treatment in HCC for patients affected by chronic liver disease in a condition of compensation, up to BCLC-B stage. Surgical indication for liver resection in case of HCC should be extensively revised

On farm agronomic and first environmental evaluation of oil crops for sustainable bioenergy chains.

Energy crops, and in particular oil crops, could be an important occasion for developing new non food production rows for a new multi-functional agriculture in Italy. In this view, the use of local biomass is a fundamental starting point for the development of a virtuous energy chain that should pursue not only agricultural profitability, but also chain sustainability and that is less dependent on the global market, characterized by instability in terms of biomass availability and price. From this perspective, particular attention must be paid to crop choice on the basis of its rusticity and of its adaptability to local growing conditions and to low input cropping systems. In this context, alike woody and herbaceous biomasses, oil crops such as sunflower and rapeseed should be able to support local agricultural bioenergy chain in Italy. In addition, in a local bioenergy chain, the role of the farmers should not be limited just to grain production; but also grain processing should be performed at farm or consortium level in oilseed extraction plants well proportioned to the cropped surface. In this way, by means of a simple power generator, farmer could thus produce its own thermal and electric energy from the oil, maximizing his profit. This objective could also be achieved through the exploitation of the total biomass, including crop residues and defatted seed meals, that may be considered as fundamental additional economic and/or environmental benefits of the chain. This paper reports some results of three-years on-farm experiments on oil crop chain carried out in the framework of "Bioenergie" project, that was focused to enhance farmers awareness of these criteria and to the feasibility at open field scale of low-input cultivation of rapeseed, sunflower and Brassica carinata in seven Italian regions. In several on-farm experiences, these crops produced more than 800 kg ha-1 of oil with good energy properties. Defatted seed meals could be interesting as organic fertilizers and, in the case of B. carinata, as a biofumigant amendment that could offer a total or partial alternative to some chemicals in agriculture. Furthermore, biomass soil incorporation could contribute to C sequestration, catching CO2 from atmosphere and sinking a part in soil as stable humus. Finally, four different open field experiences carried out again in the second year of the project, have been analysed in order to evaluate their energy and greenhouse gasses balance after cultivation phase

Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents

Venetoclax (VEN) and hypomethylating agent (HMAs) regimens are emerging as the standard of care for unfit for chemotherapy acute myeloid leukemia (AML) patients, but the safety and feasibility of a total outpatient management have not been fully investigated. Fifty-nine AML patients with active disease received VEN and HMAs. Nineteen out of 59 (32.2%) patients received the first cycle as inpatients, whereas 40/59 (67.8%) patients were treated in the outpatient setting. No significant differences were observed with regard to incidence of adverse events (AEs), including tumor lysis syndrome (TLS), and the 30-day and 60-day mortality was comparable. Notably, an infectious prophylaxis inspired to that adopted during intensive chemotherapy resulted in a low infection rate with a reduced bacterial infections incidence in out- versus hospitalized patients (p&nbsp;&lt;.0001). The overall time of hospitalization was significantly shorter in patients who received a total outpatient treatment as compared to those who received the first cycle as inpatients (5.9 vs. 39.7&nbsp;days, p&nbsp;&lt;.0001). Despite the adopted differences in treatment management, the efficacy was similar. These data indicate that a total outpatient management of VEN and HMAs is feasible in AML patients without negatively impacting on treatment efficacy and may yield pharmacoeconomic and quality-of-life benefits