Somalie

Daraasaad la sameeyey 1966 oo ku saabsan sidii ay ku suurtaggeli lahayd warshadaynta dalka Soomaaliya iyo diraasaad dhaqaale oo halkaas lagu qoondaynayo mashaariic.Studio sulle possibilità di industrializzazione della Somalia effettuato nel 1966 e studio economico dei progetti in essere.A study on the possibilities of industrialization of Somalia carried out in 1966 and an economic study of the projects in place.Link:http://aei.pitt.edu/34949/1/A1100.pd

Modélisation vasculaire 3D : vers une compréhension de la texture

L'analyse de texture des images médicales est souvent réalisée selon une approche « aveugle » qui présente l'avantage d'être générique, mais ne permet pas de donner une interprétation physiologique aux caractéristiques de texture mesurées. Nous proposons une démarche plus explicative, basée sur la modélisation d'un constituant important de tout organe, et qui participe, sous certaines conditions, de façon importante à la texture de l'image: la vascularisation. La modélisation de l'acquisition des images scanner permet d'étudier les relations entre les paramètres du modèle vasculaire, liés aux propriétés physiologiques de la vascularisation, et les caractéristiques de texture, ainsi que d'essayer de comprendre l'évolution de ces caractéristiques en fonction des conditions d'acquisition des images

Quantifying Nearshore Sea Turtle Densities: Applications of Unmanned Aerial Systems for Population Assessments

Although sea turtles face significant pressure from human activities, some populations are recovering due to conservation programs, bans on the trade of turtle products, and reductions in bycatch. While these trends are encouraging, the status of many populations remains unknown and scientific monitoring is needed to inform conservation and management decisions. To address these gaps, this study presents methods for using unmanned aerial systems (UAS) to conduct population assessments. Using a fixed-wing UAS and a modified strip-transect method, we conducted aerial surveys along a three-kilometer track line at Ostional, Costa Rica during a mass-nesting event of olive ridley turtles (Lepidochelys olivacea). We visually assessed images collected during six transects for sea turtle presence, resulting in 682 certain detections. A cumulative total of 1091 certain and probable turtles were detected in the collected imagery. Using these data, we calculate estimates of sea turtle density (km-2) in nearshore waters. After adjusting for both availability and perception biases, we developed a low-end estimate of 1299 ± 458 and a high-end estimate of 2086 ± 803 turtles per km-2. This pilot study illustrates how UAS can be used to conduct robust, safe, and cost-effective population assessments of sea turtle populations in coastal marine ecosystems

Parthenogenesis In The Tropical Gekkonid Lizard, Nactus Arnouxii (Sauria: Gekkonidae)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137400/1/evo02464.pd

Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis

Megakaryocytopoiesis is a complex differentiation process driven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocytes, the giant bone marrow cells that in turn break down to form blood platelets. The Tribbles Pseudokinase 3 gene (TRIB3) encodes a pleiotropic protein increasingly implicated in the regulation of cellular differentiation programmes. Previous studies have hinted that TRIB3 could be also involved in megakaryocytopoiesis but its role in this process has so far not been investigated. Using cellular model systems of haematopoietic lineage differentiation here we demonstrate that TRIB3 is a negative modulator of megakaryocytopoiesis. We found that in primary cultures derived from human haematopoietic progenitor cells, thrombopoietin-induced megakaryocytic differentiation led to a time and dosedependent decrease in TRIB3 mRNA levels. In the haematopoietic cell line UT7/mpl, silencing of TRIB3 increased basal and thrombopoietin-stimulated megakaryocyte antigen expression, as well as basal levels of ERK1/2 phosphorylation. In primary haematopoietic cell cultures, silencing of TRIB3 facilitated megakaryocyte differentiation. In contrast, over-expression of TRIB3 in these cells inhibited the differentiation process. The in-vitro identification of TRIB3 as a negative regulator of megakaryocytopoiesis suggests that in-vivo this gene could be important for the regulation of platelet production

ANKRD26 and Its Interacting Partners TRIO, GPS2, HMMR and DIPA Regulate Adipogenesis in 3T3-L1 Cells

Partial inactivation of the Ankyrin repeat domain 26 (Ankrd26) gene causes obesity and diabetes in mice and increases spontaneous and induced adipogenesis in mouse embryonic fibroblasts. However, it is not yet known how the Ankrd26 protein carries out its biological functions. We identified by yeast two-hybrid and immunoprecipitation assays the triple functional domain protein (TRIO), the G protein pathway suppressor 2 (GPS2), the delta-interacting protein A (DIPA) and the hyaluronan-mediated motility receptor (HMMR) as ANKRD26 interacting partners. Adipogenesis of 3T3-L1 cells was increased by selective down-regulation of Ankrd26, Trio, Gps2, Hmmr and Dipa. Furthermore, GPS2 and DIPA, which are normally located in the nucleus, were translocated to the cytoplasm, when the C-terminus of ANKRD26 was introduced into these cells. These findings provide biochemical evidence that ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenisis and identify new targets for the modulation of adipogenesis

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway

In mammals, plasma amino acid concentrations are markedly affected by dietary or pathological conditions. It has been well established that amino acids are involved in the control of gene expression. Up to now, all the information concerning the molecular mechanisms involved in the regulation of gene transcription by amino acid availability has been obtained in cultured cell lines. The present study aims to investigate the mechanisms involved in transcriptional activation of the TRB3 gene following amino acid limitation in mice liver. The results show that TRB3 is up-regulated in the liver of mice fed a leucine-deficient diet and that this induction is quickly reversible. Using transient transfection and chromatin immunoprecipitation approaches in hepatoma cells, we report the characterization of a functional Amino Acid Response Element (AARE) in the TRB3 promoter and the binding of ATF4, ATF2 and C/EBPβ to this AARE sequence. We also provide evidence that only the binding of ATF4 to the AARE plays a crucial role in the amino acid-regulated transcription of TRB3. In mouse liver, we demonstrate that the GCN2/eIF2α/ATF4 pathway is essential for the induction of the TRB3 gene transcription in response to a leucine-deficient diet. Therefore, this work establishes for the first time that the molecular mechanisms involved in the regulation of gene transcription by amino acid availability are functional in mouse liver