Terra Nullius: The Effects of Australia’s Colonial History on Sense of Place

Australia’s history of colonization of Aboriginal communities continues to affect not only the indigenous population of Australia, but also non-Aboriginal Australians. This study focuses on how Australia’s complex history of colonization and its lasting effects influence the ability of Non-Aboriginal Australians to connect to place. One potential effect of colonization is “settler-guilt” or the complex feelings of guilt, remorse, and shame felt by “settlers” at their privilege derived from the racist, violent, and genocidal treatment of indigenous people and communities due to the colonization of indigenous lands and the legacy of colonization. This study asks whether settler-guilt exists in Australia, and if it does, how it might impact connection to place and the environment. The ultimate goal of this study is to better understand the ways in which colonization affects non-Aboriginal sense of place in order to create a post-colonial environmental and nature connection movement. I collected 69 online survey responses via distribution in environmental and sense of place Facebook groups as well as conducted 13 in-depth interviews from participants who had already completed the survey. No participants were of Aboriginal or Torres Strait Islander descent as this study focused on the effects of colonization on Non-Aboriginal Australians. Additionally, as invasion occurred differently in different locations of Australia this study compares how effects of colonization differ across three locations as surveys were collected in Northern Rivers, New South Wales, Hobart, Tasmania, and Melbourne, Victoria. A strong majority of participants reported feeling complex emotions such as guilt, shame, anger, and grief (emotions which we categorize as “settler-guilt”) when thinking about colonization. Additionally, a majority of participants agreed that, although they felt a strong connection to place, they felt that colonization affected, and in some cases presented a barrier to, their connection to place. Participants noted that in order to decolonize the environmental and nature connection movements they hoped to learn more about local indigenous communities and form personal connections with Aboriginal people. Additionally, participants placed a strong emphasis on hoping to create space for Aboriginal leadership within the environmental and nature connection movements. Although there does appear to be a connection between differing colonial effects and location in Australia, more data is needed to fully understand why differences occur. Overall, this data suggests that settler-guilt among non-Aboriginal Australians is not only present but also influences the connection to place of non-Aboriginal Australians. Looking forward, the environmental movement needs to integrate more Aboriginal leadership and create spaces and support for non-Aboriginal Australians to question their own role in the settler-colonial framework

Implementation of a Si/SiC Hybrid Optically Controlled High-Power Switching Device

The ever-increasing performance and economy of operation requirements placed on commercial and military transport aircraft are resulting in very complex systems. As a result, the use of fiber optic component technology has lead to high data throughput, immunity to EMI, reduced certification and maintenance costs and reduced weight features. In particular, in avionic systems, data integrity and high data rates are necessary for stable flight control. Fly-by-Light systems that use optical signals to actuate the flight control surfaces of an aircraft have been suggested as a solution to the EMI problem in avionic systems. Current fly-by-light systems are limited by the lack of optically activated high-power switching devices. The challenge has been the development of an optoelectronic switching technology that can withstand the high power and harsh environmental conditions common in a flight surface actuation system. Wide bandgap semiconductors such as Silicon Carbide offer the potential to overcome both the temperature and voltage blocking limitations that inhibit the use of Silicon. Unfortunately, SiC is not optically active at the near IR wavelengths where communications grade light sources are readily available. Thus, we have proposed a hybrid device that combines a silicon based photoreceiver model with a SiC power transistor. When illuminated with the 5mW optical control signal the silicon chip produces a 15mA drive current for a SiC Darlington pair. The SiC Darlington pair then produces a 150 A current that is suitable for driving an electric motor with sufficient horsepower to actuate the control surfaces on an aircraft. Further, when the optical signal is turned off, the SiC is capable of holding off a 270 V potential to insure that the motor drive current is completely off. We present in this paper the design and initial tests from a prototype device that has recently been fabricated

The Spectral Ocean Color Imager (SPOC) – An Adjustable Multispectral Imager

SPOC (SPectral Ocean Color) is a 3U small satellite mission that will use an adjustable multispectral imager to map sensitive coastal regions and off coast water quality of Georgia and beyond. SPOC is being developed by the University of Georgia’s (UGA) Small Satellite Research Laboratory (SSRL) through NASA’s Undergraduate Student Instrument Project (USIP). UGA is working with Cloudland Instruments to develop a small scale (\u3c 1000 \u3ecm3) multispectral imager, ranging from 400-850nm, for Earth science applications which will fly as part of the NASA CubeSat Launch Initiative. The project is UGA’s first satellite mission and is built by a team of undergraduates from a wide range of backgrounds and supervised by a multidisciplinary team of graduate students and faculty. Development, assembly, testing, and validation of the multispectral imager, as well integrating it into the satellite are all being done in house. At an orbit of 400 km the resulting images will be 90 km x 100 km in size, with a default spatial resolution and spectral resolution of 130 m and 4 nm, respectively

Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered

<p>Abstract</p> <p>Background</p> <p>High dose of corticosteroids has been previously shown to protect against controlled mechanical ventilation (CMV)-induced diaphragmatic dysfunction while inhibiting calpain activation. Because literature suggests that the calpain inhibiting effect of corticosteroid depends on the dose administered, we determined whether lower doses of corticosteroids would also provide protection of the diaphragm during CMV. This may be important for patients undergoing mechanical ventilation and receiving corticosteroids.</p> <p>Methods</p> <p>Rats were assigned to controls or to 24 hours of CMV while being treated at the start of mechanical ventilation with a single intramuscular administration of either saline, or 5 mg/kg (low MP) or 30 mg/kg (high MP) of methylprednisolone.</p> <p>Results</p> <p>Diaphragmatic force was decreased after CMV and this was exacerbated in the low MP group while high MP rescued this diaphragmatic dysfunction. Atrophy was more severe in the low MP group than after CMV while no atrophy was observed in the high MP group. A significant and similar increase in calpain activity was observed in both the low MP and CMV groups whereas the high dose prevented calpain activation. Expression of calpastatin, the endogenous inhibitor of calpain, was decreased in the CMV and low MP groups but its level was preserved to controls in the high MP group. Caspase-3 activity increased in all CMV groups but to a lesser extent in the low and high MP groups. The 20S proteasome activity was increased in CMV only.</p> <p>Conclusions</p> <p>Administration of 30 mg/kg methylprednisolone during CMV protected against CMV-induced diaphragm dysfunction while 5 mg/kg was more deleterious. The protective effect is due mainly to an inhibition of the calpain system through preservation of calpastatin levels and to a lesser extent to a caspase-3 inhibition.</p

MDL28170, a Calpain Inhibitor, Affects Trypanosoma cruzi Metacyclogenesis, Ultrastructure and Attachment to Rhodnius prolixus Midgut

BACKGROUND: Trypanosoma cruzi is the etiological agent of Chagas' disease. During the parasite life cycle, many molecules are involved in the differentiation process and infectivity. Peptidases are relevant for crucial steps of T. cruzi life cycle; as such, it is conceivable that they may participate in the metacyclogenesis and interaction with the invertebrate host. METHODOLOGY/PRINCIPAL FINDINGS: In this paper, we have investigated the effect of the calpain inhibitor MDL28170 on the attachment of T. cruzi epimastigotes to the luminal midgut surface of Rhodnius prolixus, as well as on the metacyclogenesis process and ultrastructure. MDL28170 treatment was capable of significantly reducing the number of bound epimastigotes to the luminal surface midgut of the insect. Once the cross-reactivity of the anti-Dm-calpain was assessed, it was possible to block calpain molecules by the antibody, leading to a significant reduction in the capacity of adhesion to the insect guts by T. cruzi. However, the antibodies were unable to interfere in metacyclogenesis, which was impaired by the calpain inhibitor presenting a significant reduction in the number of metacyclic trypomastigotes. The calpain inhibitor also promoted a direct effect against bloodstream trypomastigotes. Ultrastructural analysis of epimastigotes treated with the calpain inhibitor revealed disorganization in the reservosomes, Golgi and plasma membrane disruption. CONCLUSIONS/SIGNIFICANCE: The presence of calpain and calpain-like molecules in a wide range of organisms suggests that these proteins could be necessary for basic cellular functions. Herein, we demonstrated the effects of MDL28170 in crucial steps of the T. cruzi life cycle, such as attachment to the insect midgut and metacyclogenesis, as well as in parasite viability and morphology. Together with our previous findings, these results help to shed some light on the functions of T. cruzi calpains. Considering the potential roles of these molecules on the interaction with both invertebrate and vertebrate hosts, it is interesting to improve knowledge on these molecules in T. cruzi

Field evaluation of a new antibody-based diagnostic for Schistosoma haematobium and S. mansoni at the point-of-care in northeast Zimbabwe

BACKGROUND: Rapid diagnostic tests (RDTs) for use at the point-of-care (POC) are likely to become increasingly useful as large-scale control programmes for schistosomiasis get underway. Given the low sensitivity of the reference standard egg count methods in detecting light infections, more sensitive tests will be required to monitor efforts aimed at eliminating schistosomiasis as advocated by the World Health Assembly Resolution 65.21 passed in 2012. METHODS: A recently developed RDT incorporating Schistosoma mansoni cercarial transformation fluid (SmCTF) for detection of anti-schistosome antibodies in human blood was here evaluated in children (mean age: 7.65 years; age range: 1-12 years) carrying light S. mansoni and S. haematobium infections in a schistosome-endemic area of Zimbabwe by comparison to standard parasitological techniques (i.e. the Kato-Katz faecal smear and urine filtration). Enzyme-linked immunosorbent assays (ELISAs) incorporating S. haematobium antigen preparations were also employed for additional comparison. RESULTS: The sensitivity of the SmCTF-RDT compared to standard parasitological methods was 100% while the specificity was 39.5%. It was found that the sera from RDT “false-positive” children showed significantly higher antibody titres in IgM-cercarial antigen preparation (CAP) and IgM-soluble egg antigen (SEA) ELISA assays than children identified by parasitology as “true-negatives”. CONCLUSIONS: Although further evaluations are necessary using more accurate reference standard tests, these results indicate that the RDT could be a useful tool for the rapid prevalence-mapping of both S. mansoni and S. haematobium in schistosome-endemic areas. It is affordable, user-friendly and allows for diagnosis of both schistosome species at the POC