Genetics of common polygenic ischaemic stroke: current understanding and future challenges.

Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only account for a proportion of stroke risk. Up to 50% of stroke risk can be attributed to genetic risk factors, although to date no single risk allele has been convincingly identified as contributing to this risk. Advances in the field of genetics, most notably genome wide association studies (GWAS), have revealed genetic risks in other cardiovascular disease and these techniques are now being applied to ischaemic stroke. This paper covers previous genetic studies in stroke including candidate gene studies, discusses the genome wide association approach, and future techniques such as next generation sequencing and the post-GWAS era. The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke

Reduction of Machine Tool Times Through a Software/Hardware Integrated Solution

Toolmaking is an industry that creates metal moulds, generally of durable tool steels, for producing vacuum-formed and injection moulded plastic parts, which are used in thousands of everyday items such as mobile phones. At present toolmaking is labour intensive with each machining operation requiring manual supervision. The FASTOOL project was a European Union funded collaboration that was aimed at reducing the manpower content of mould toolmaking, and extending the working day. This paper focuses on one element which utilised specially created scheduling and control software that operated an automated overhead gantry system and could remotely start the workshop machines. The software was completely object oriented which allows future proofing by creating new objects for new machines. The results demonstrate that this manufacturing process can be automated, leading to better working conditions for employees and an increase in efficiency and profitability.Mechanical Engineerin

The advanced receiver 2: Telemetry test results in CTA 21

Telemetry tests with the Advanced Receiver II (ARX II) in Compatibility Test Area 21 are described. The ARX II was operated in parallel with a Block-III Receiver/baseband processor assembly combination (BLK-III/BPA) and a Block III Receiver/subcarrier demodulation assembly/symbol synchronization assembly combination (BLK-III/SDA/SSA). The telemetry simulator assembly provided the test signal for all three configurations, and the symbol signal to noise ratio as well as the symbol error rates were measured and compared. Furthermore, bit error rates were also measured by the system performance test computer for all three systems. Results indicate that the ARX-II telemetry performance is comparable and sometimes superior to the BLK-III/BPA and BLK-III/SDA/SSA combinations

Residual Stress in Wheels: Comparison of Neutron Diffraction and Ultrasonic Methods, with Trends in RCF

The critical damage mechanism on many GB passenger train wheels is Rolling Contact Fatigue (RCF) cracking in the rim. Evidence from field observations suggests that RCF damage occurs much more quickly as the wheelsets near the end of their life. Wheel manufacturing processes induce a compressive hoop stress in the wheel rim; variations in residual stress through the life of a wheel may influence the observed RCF damage rates. This paper describes experiments to measure residual stresses in new and used wheel rims to identify whether this could be a significant factor, and compares the findings from neutron diffraction and ultrasonic birefringence methods. The scope goes beyond previous applications of neutron diffraction to railway wheels and identifies key considerations for future testing. Assuming that the as-manufactured stress distribution was similar for all three wheels tested, it is found that the stresses are redistributed within the wheel rim during its life as material is removed and plastic flow occurs. However, the hoop stress near the running surface remains compressive and may not have a large influence on the RCF damage rates

Fiscal Policy Design in Low-Income Countries

Fiscal policy, Macro-economic stabilization, Sub-Saharan Africa

An investigation into the feasibility of a sea water and ice based acoustic UHE neutrino telescope

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Piezoceramic Actuator Placement for Acoustic Control of Panels

Optimum placement of multiple traditional piezoceramic actuators is determined for active structural acoustic control of flat panels. The structural acoustic response is determined using acoustic radiation filters and structural surface vibration characteristics. Linear Quadratic Regulator (LQR) control is utilized to determine the optimum state feedback gain for active structural acoustic control. The optimum actuator location is determined by minimizing the structural acoustic radiated noise using a modified genetic algorithm. Experimental tests are conducted and compared to analytical results. Anisotropic piezoceramic actuators exhibit enhanced performance when compared to traditional isotropic piezoceramic actuators. As a result of the inherent isotropy, these advanced actuators develop strain along the principal material axis. The orientation of anisotropic actuators is investigated on the effect of structural vibration and acoustic control of curved and flat panels. A fully coupled shallow shell finite element formulation is developed to include anisotropic piezoceramic actuators for shell structures

Exchange Rate Regimes and Revenue Performance in Sub-Saharan Africa

It has been argued that the institutions of the CFA Franc zone may have reduced inflation but that they also induced misalignment of the real exchange rate and that this is the explanation for their dismal revenue performance. This paper uses a panel of 22 countries in sub-Saharan Africa to estimate revenue performance over the period from 1980 to 1996. It finds that the poor cumulative relative revenue performance of the franc zone countries is mainly attributable to differences in environmental and structural factors, and to their different responses to changes in the equilibrium real exchange rate, but that the misalignment of the real exchange rate also played a part.

Analysis and Testing of Plates with Piezoelectric Sensors and Actuators

Piezoelectric material inherently possesses coupling between electrostatics and structural dynamics. Utilizing linear piezoelectric theory results in an intrinsically coupled pair of piezoelectric constitutive equations. One equation describes the direct piezoelectric effect where strains produce an electric field and the other describes the converse effect where an applied electrical field produces strain. The purpose of this study is to compare finite element analysis and experiments of a thin plate with bonded piezoelectric material. Since an isotropic plate in combination with a thin piezoelectric layer constitutes a special case of a laminated composite, the classical laminated plate theory is used in the formulation to accommodated generic laminated composite panels with multiple bonded and embedded piezoelectric layers. Additionally, the von Karman large deflection plate theory is incorporated. The formulation results in laminate constitutive equations that are amiable to the inclusion of the piezoelectric constitutive equations yielding in a fully electro-mechanically coupled composite laminate. Using the finite element formulation, the governing differential equations of motion of a composite laminate with embedded piezoelectric layers are derived. The finite element model not only considers structural degrees of freedom (d.o.f.) but an additional electrical d.o.f. for each piezoelectric layer. Comparison between experiment and numerical prediction is performed by first treating the piezoelectric as a sensor and then again treating it as an actuator. To assess the piezoelectric layer as a sensor, various uniformly distributed pressure loads were simulated in the analysis and the corresponding generated voltages were calculated using both linear and nonlinear finite element analyses. Experiments were carried out by applying the same uniformly distributed loads and measuring the resulting generated voltages and corresponding maximum plate deflections. It is found that a highly nonlinear relationship exists between maximum deflection and voltage versus pressure loading. In order to assess comparisons of predicted and measured piezoelectric actuation, sinusoidal excitation voltages are simulated/applied and maximum deflections are calculated/measured. The maximum deflection as a function of time was determined using the linear finite elements analysis. Good correlation between prediction and measurement was achieved in all cases

Just in time: defining historical chronographics

The paper is historical in two respects, both concerned with visual representations of past time. Its first purpose is to enquire how visual representations of historical time can be used to bring out patterns in a museum collection. A case study is presented of the visualisation of data with sufficient subtlety to be useful to historians and curators. Such a visual analytics approach raises questions about the proper representation of time and of objects and events within it. It is argued that such chronographics can support both an externalised, objectivising point of view from ‘outside’ time and one which is immersive and gives a sense of the historic moment. These modes are set in their own historical context through original historical research, highlighting the shift to an Enlightenment view of time as a uniform container for events. This in turn prompts new ways of thinking about chronological visualisation, in particular the separation of the ‘ideal’ image of time from contingent, temporary rendered views