The Power of One

Commencement address given by Nancy E. Betz, Professor of Psychology, to the Winter 1993 graduating class of The Ohio State University, St. John Arena, Columbus, Ohio, March 19, 1993

EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome.

OBJECTIVES: Develop recommendations for women's health issues and family planning in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). METHODS: Systematic review of evidence followed by modified Delphi method to compile questions, elicit expert opinions and reach consensus. RESULTS: Family planning should be discussed as early as possible after diagnosis. Most women can have successful pregnancies and measures can be taken to reduce the risks of adverse maternal or fetal outcomes. Risk stratification includes disease activity, autoantibody profile, previous vascular and pregnancy morbidity, hypertension and the use of drugs (emphasis on benefits from hydroxychloroquine and antiplatelets/anticoagulants). Hormonal contraception and menopause replacement therapy can be used in patients with stable/inactive disease and low risk of thrombosis. Fertility preservation with gonadotropin-releasing hormone analogues should be considered prior to the use of alkylating agents. Assisted reproduction techniques can be safely used in patients with stable/inactive disease; patients with positive antiphospholipid antibodies/APS should receive anticoagulation and/or low-dose aspirin. Assessment of disease activity, renal function and serological markers is important for diagnosing disease flares and monitoring for obstetrical adverse outcomes. Fetal monitoring includes Doppler ultrasonography and fetal biometry, particularly in the third trimester, to screen for placental insufficiency and small for gestational age fetuses. Screening for gynaecological malignancies is similar to the general population, with increased vigilance for cervical premalignant lesions if exposed to immunosuppressive drugs. Human papillomavirus immunisation can be used in women with stable/inactive disease. CONCLUSIONS: Recommendations for women's health issues in SLE and/or APS were developed using an evidence-based approach followed by expert consensus

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation

Among the 1 of 10 children who are born preterm annually in the United States, 6% are born before the third trimester. Among children who survive birth before the 28th week of gestation, the risks of autism spectrum disorder (ASD) and non-autistic social impairment are severalfold higher than in the general population. We examined the relationship between top quartile inflammation-related protein concentrations among children born extremely preterm and ASD or, separately, a high score on the Social Responsiveness Scale (SRS total score ≥65) among those who did not meet ASD criteria, using information only from the subset of children whose DAS-II verbal or non-verbal IQ was ≥70, who were assessed for ASD, and who had proteins measured in blood collected on ≥2 days (N = 763). ASD (N = 36) assessed at age 10 years is associated with recurrent top quartile concentrations of inflammation-related proteins during the first post-natal month (e.g., SAA odds ratio (OR); 95% confidence interval (CI): 2.5; 1.2–5.3) and IL-6 (OR; 95% CI: 2.6; 1.03–6.4)). Top quartile concentrations of neurotrophic proteins appear to moderate the increased risk of ASD associated with repeated top quartile concentrations of inflammation-related proteins. High (top quartile) concentrations of SAA are associated with elevated risk of ASD (2.8; 1.2–6.7) when Ang-1 concentrations are below the top quartile, but not when Ang-1 concentrations are high (1.3; 0.3–5.8). Similarly, high concentrations of TNF-α are associated with heightened risk of SRS-defined social impairment (N = 130) (2.0; 1.1–3.8) when ANG-1 concentrations are not high, but not when ANG-1 concentrations are elevated (0.5; 0.1–4.2)

Effects of immediate knowledge of results and adaptive testing on ability test performance

This study investigated the effects of immediate knowledge of results and adaptive testing on performance on a computer-administered test of verbal ability. Examinees were administered either a 50-item conventional test or an adaptive test of verbal ability; half the subjects in each group received immediate knowledge of results (KR) concerning the correctness/incorrectness of each item response, while the other half did not. Subjects within high- and low-ability subgroups were assigned randomly to one of the four resulting experimental conditions. The dependent variable was maximum likelihood ability estimates derived from item response patterns. Results indicated that for the high-ability group, mean test scores under KR conditions were significantly higher than were those under no-KR conditions on both the conventional and adaptive tests. Within the low-ability group, mean test scores were higher under KR conditions than under no-KR conditions, but the difference was statistically significant only within the conventional testing strategy. Low-ability examinees achieved higher average test scores on the adaptive test than on the conventional test, while high-ability examinees performed equally well on the adaptive and conventional tests

Research Reports, 1973, 1-4

Weiss, David J.; Betz, Nancy E.; Bejar, Isaac I.. (1973). Research Reports, 1973, 1-4. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/135270

Studies of the dimensionality, correlates, and meaning of measures of the maximizing tendency

This series of four studies was designed to clarify the underlying dimensionality and psychological well-being correlates of the major extant measures of the maximization tendency: the Maximization Scale (MS; Schwarz et al., 2002) and the Maximization Tendency Scale (MTS; Diab et al., 2008). Four studies using psychometric and factor analysis, item response theory (IRT), and an experimental manipulation all supported the following conclusions. The MS does measure three separate factors as postulated by its authors, but only two of them (alternative search and decisional difficulty) are correlated with each other and (negatively) with indices of well-being as postulated by the scale authors; high standards, the third factor, correlated strongly with the MTS, and both of these were strongly correlated with positive indices of well-being (optimism and happiness) and functioning (e.g., self-esteem and self-efficacy). The high standards subscale and MTS were related to analytical decision making style, while alternative search and decision difficulty were related to the regret-based decision making style and to procrastination. The IRT analysis indicated serious weaknesses in the measurement capabilities of existing scales, and the findings of the experimental study confirmed that alternative search and decision difficulty are related to the maximization tendency while high standards and MTS are not. Implications for further research and scale development are discussed

The Maximization Inventory

We present the Maximization Inventory, which consists of three separate scales: decision difficulty, alternative search, and satisficing. We show that the items of the Maximization Inventory have much better psychometric properties when compared to the original Maximization Scale (Schwartz et al., 2002). The satisficing scale is a new addition to the study of maximization behavior, and we demonstrate that this scale is positively correlated with positive adaptation, whereas the decision difficulty and alternative search scales are positively correlated with nonproductive decisional behavior. The Maximization Inventory was then compared to previous maximization scales and, while the decision difficulty and alternative search scales are positively correlated with similar previous constructs, the satisficing scale offers a dimension entirely different from maximizatio