Tolkien\u27s New Mythology

Discusses Tolkien’s particular retelling in The Lord of the Rings of three basic mythic elements: the quest, its outcome, and the kinds of characters needed to achieve it

Zoonotic disease risk perceptions in the British veterinary profession

In human and veterinary medicine, reducing the risk of occupationally-acquired infections relies on effective infection prevention and control practices (IPCs). In veterinary medicine, zoonoses present a risk to practitioners, yet little is known about how these risks are understood and how this translates into health protective behaviour. This study aimed to explore risk perceptions within the British veterinary profession and identify motivators and barriers to compliance with IPCs. A cross-sectional study was conducted using veterinary practices registered with the Royal College of Veterinary Surgeons. Here we demonstrate that compliance with IPCs is influenced by more than just knowledge and experience, and understanding of risk is complex and multifactorial. Out of 252 respondents, the majority were not concerned about the risk of zoonoses (57.5%); however, a considerable proportion (34.9%) was. Overall, 44.0% of respondents reported contracting a confirmed or suspected zoonoses, most frequently dermatophytosis (58.6%). In veterinary professionals who had previous experience of managing zoonotic cases, time or financial constraints and a concern for adverse animal reactions were not perceived as barriers to use of personal protective equipment (PPE). For those working in large animal practice, the most significant motivator for using PPE was concerns over liability. When assessing responses to a range of different "infection control attitudes", veterinary nurses tended to have a more positive perspective, compared with veterinary surgeons. Our results demonstrate that IPCs are not always adhered to, and factors influencing motivators and barriers to compliance are not simply based on knowledge and experience. Educating veterinary professionals may help improve compliance to a certain extent, however increased knowledge does not necessarily equate to an increase in risk-mitigating behaviour. This highlights that the construction of risk is complex and circumstance-specific and to get a real grasp on compliance with IPCs, this construction needs to be explored in more depth

UAS Literary & Arts Journal

Proof copy provided by Tidal Echoes.Featuring the work of students, faculty, and staff of the University of Alaska Southeast and members of the community.A Note from Emily Wall -- Editor’s Note -- Mask -- Image of Nora, Rendering Seal Oil -- Based of course on hearsay -- Bowl with Spoon -- Gathering Indigo -- Shed -- Decay -- At the Core -- After Summer Time -- Sitka Fishing Boat -- Pericles at the Beach -- Funny Face Fido (detail) -- The Answer Dog -- Direction of the Wind -- Eagle -- An Interview with Nathan Jackson -- Water Becoming Land -- An Interview with John Straley -- Halibut Point View -- Night Monsters -- Sea Lion -- Trophy -- Humpback Flukes -- Homecoming -- Spinning Tires -- Hiking the Salt Chuck Trail -- Sitka Rose -- Columbine -- Chocolate Lily -- Bleeding Hearts -- Salmon Egg Puller—$2.15 an hour -- Granddaughters Dancing -- Sitka Sentinel -- Kootznoowoo -- Ode to Wildlife -- Dinner Party -- Floating Islands (detail) -- To My Departed Kishka -- Wisteria -- Untitled -- Fairweather Laundry -- Struggling with My Language -- “Culture” in the Juneau Museum -- Thane -- Juneau Goldbelt & 9th -- Pink Blue Leaves -- Slow Fall -- Tango -- Pacific Coast Mask with Copper Luster -- Against Confessional -- Sunday Afternoon 3:30 to 3:31 -- Downtown -- Tony, Six Flags Great Adventure, Jackson, New Jersey -- Land and Water Series -- On the Day They Buried Gus Hall -- Solju Sapnu -- Nattie -- The First Half of the Last Century -- A Church Remains -- Mexican Wall -- Eagle Reflections -- The Saving Son -- Axh Leelk’w -- Sinister Place -- Blue Halibuts -- Fishing Again -- The Masai -- Wanting to Know Water -- For Women Like Me -- Mountain Bleu -- Untitled -- Single Word Title -- Charms (detail) -- e.e isn’t Cummings back -- Mocha Gal -- Poppies -- Ideal Woman Blues -- Near the End -- Poet at Work -- Stills -- Serenity -- Lupine Bugs -- Spring Fiddleheads -- What a Piece of Work! -- Biographie

LGBTQ+ Children’s Picture Books in Ontario Public Libraries

Diverse representation in picture books is important for the wellbeing of children and families; this includes LGBTQ+ representation, a frequently contested area of literature. Our poster identifies 33 of the most frequently recommended picture books with LGBTQ+ representations and reports on their inclusion in 40 selected Ontario Public Libraries. We then compared these results with five socioeconomic factors for each library: size of population served, the size of the print collection, the size of the materials budget, the average total median household income and the last decade of provincial election results for the riding in which the main branch of the library is located. Visit this poster to see which books were the most frequently recommended and the trends impacting your local library

An Autoregulatory Mechanism Imposes Allosteric Control on the V(D)J Recombinase by Histone H3 Methylation

SummaryV(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications characteristic of active chromatin, including trimethylation of histone H3 on lysine 4 (H3K4me3). Engagement of H3K4me3 by a plant homeodomain (PHD) in RAG-2 promotes recombination in vivo and stimulates DNA cleavage by RAG in vitro. We now show that H3K4me3 acts allosterically at the PHD finger to relieve autoinhibition imposed by a separate domain within RAG-2. Disruption of this autoinhibitory domain was associated with constitutive increases in recombination frequency, DNA cleavage activity, substrate binding affinity, and catalytic rate, thus mimicking the stimulatory effects of H3K4me3. Our observations support a model in which allosteric control of RAG is enforced by an autoinhibitory domain whose action is relieved by engagement of active chromatin